Dissociation between the potency and reversibility of the insulinotropic action of two meglitinide analogues

Pharmacological Research

Volumn 34, Issue 3-4, 1996, Pages 105-108

  Jijakli, H ^a   Ulusoy, S ^a   Malaisse, W J ^a  

^a FREE UNIVERSITY OF BRUSSELS   (Belgium)

Author keywords

Insulin release; Meglitinide analogues; Pancreatic islets

Indexed keywords

2 METHOXY 4 [2 [2 (3,5 DIMETHYL 1 PIPERIDINYL)NICOTINAMIDO]ETHYL]BENZOIC ACID; ANTIDIABETIC AGENT; CALCIUM 45; GLUCOSE; INSULIN; MEGLITINIDE; REPAGLINIDE; RUBIDIUM 86; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG ACTIVITY; EXTRACELLULAR CALCIUM; FEMALE; INSULIN LIKE ACTIVITY; INSULIN RELEASE; ION TRANSPORT; ISOTOPE LABELING; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; RAT;

EID: 0030239968     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1996.0072     Document Type: Article

References (17)

1. 1. Geisen K, Hübner M, Kitzel V, Hrstka VE, Pfaff W, Bosies E, Regitz G, Kühnle HF, Schmidt FH, Weyer R. Acylaminoalkyl-substituierte Benzoe- und Phenylalakansäuren mit blutglukose-sendkender Wirkung. Arzneim-Forsch 1978; 28: 1081-3.
2. 2. Geisen K, Hitzel V, Ökomonopoulos R, Pünter J, Weyer R, Summ H-D. Inhibition of 3H-glibenclamide binding to sulfonylurea receptors by oral antidiabetics. Arzneim-Forsch 1985; 35: 707-12.
3. 3. Malaisse WJ. Stimulation of insulin release by non-sulfonylurea hypoglycemic agents: the meglitinide family. Horm Metab Res 1995; 27: 263-6.
4. 4. Deleers M, Malaisse WJ. Binding of hypoglycaemic sulfonylureas to an artificial phospholipid bilayer. Diabetologia 1984; 26: 55-9.
5. 5. Bakkali Nadi A, Malaisse-Lagae F, Malaisse WJ. Insulinotropic action of meglitinide analogs: concentration-response relationship and nutrient dependency. Diab Res 1994; 27: 81-7.
6. +-ATPase activity in pancreatic islets ? Am J Physiol 1985; 248: E=491-9.
7. 2+ influx into the pancreatic B-cell. Diabetes 1982; 31: 1010-5.
8. 8. Malaisse WJ, Lebrun P. Iterative stimulation of pancreatic islets by glipizide. Pharmacology 1993; 46: 43-9.
9. 9. Lebrun P, Malaisse WJ. Cationic and secretory effects of glimepiride and glibenclamide in perifused rat islets. Pharmacol Toxicol 1992; 70: 357-60.
10. 10. Malaisse WJ, Lebrun P, Sener A. Modulation of the insulinotropic action of glibenclamide and glimepiride by nutrient secretagogues in pancreatic islets from normoglycemic and hyperglycemic rats. Biochem Pharmacol 1993; 45: 1845-9.
11. 11. Jijakli H, Ulusoy S, Malaisse WJ. Dynamics of the cationic and secretory response to gliquidone in rat perifused islets. Med Sci Res 1996; 24: 425-6.
12. 12. Malaisse WJ, Sato F. Insulinotropic action of (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate. I. Secretory and cationic aspects. Gen Pharmac 1995; 26: 1313-8.
13. 13. Jijakli H, Ulusoy S, Malaisse WJ. Dynamics of the cationic and secretory responses to A-4166 in perifused pancreatic islets. Arch Int Pharmacodyn 1996; Submitted for publication.
14. 14. Herchuelz A, Malaisse WJ. Regulation of calcium fluxes in pancreatic islets: dissociation between calcium and insulin release. J Physiol (London) 1978; 283: 409-24.
15. 15. Leclercq-Meyer V, Marchand J, Woussen-Colle M-C, Giroix M-H, Malaisse WJ. Multiple effects of leucine on glucagon, insulin and somatostatin secretion from the perfused rat pancreas. Endocrinology 1985; 116: 1168-74.
16. 16. Bakkali Nadi A, Malaisse-Lagae F, Malaisse WJ. Ionophoretic activity of meglitinide analogues. Diab Res 1994; 27: 61-71.
17. 17. Bakkali Nadi A, Malaisse-Lagae F, Malaisse WJ. Ionophoretic properties of the non-sulphonylurea hypoglycaemic agents A-4166 and KAD-1229. Res Comm Mol Pathol Pharmacol 1995; 88: 339-47.