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of special interest Endres R, Luz A, Schulze H, Neubauer H, Futterer A, Holland SM, Wagner H, Pfeffer K. Listeriosis in p47(phox-/-) and TRp55-/- mice: protection despite absence of ROI and susceptibility despite presence of RNI. Immunity. 7:1997;419-432 References [18-20] are three recent studies that use knockout mice to investigate the mechanisms of antilisterial immunity. The results of all three studies suggest the possibility of an unknown bactericidal immune mechanism.
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of special interest. References [18-20] are three recent studies that use knockout mice to investigate the mechanisms of antilisterial immunity. The results of all three studies suggest the possibility of an unknown bactericidal immune mechanism.
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of special interest Dai WJ, Bartens W, Kohler G, Hufnagel M, Kopf M, Brombacher F. Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes-infected IFN-gamma receptor-deficient mice. J Immunol. 158:1997;5297-5304 References [18-20] are three recent studies that use knockout mice to investigate the mechanisms of antilisterial immunity. The results of all three studies suggest the possibility of an unknown bactericidal immune mechanism.
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of special interest Fehr T, Schoedon G, Odermatt B, Holtschke T, Schneemann M, Bachmann MF, Mak TW, Horak I, Zinkernagel RM. Crucial role of interferon consensus sequence binding protein, but neither of interferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosis. J Exp Med. 185:1997;921-931 References [18-20] are three recent studies that use knockout mice to investigate the mechanisms of antilisterial immunity. The results of all three studies suggest the possibility of an unknown bactericidal immune mechanism.
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Perforin-deficient CD8(+) T cells provide immunity to Listeria monocytogenes by a mechanism that is independent of CD95 and IFN-gamma but requires TNF-alpha
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+ T cells mediate antilisterial immunity. It shows that protection can occur independent of killing mediated by perforin and Fas/Fas-ligand and, in the absence of perforin, TNF-α is a critical factor.
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of special interest Bhardwaj V, Kanagawa O, Swanson PE, Unanue ER. Chronic Listeria infection in SCID mice: Requirements for the carrier state and the dual role of T cells in transferring protection or suppression. J Immunol. 160:1998;376-384 This study examines the basic parameters of natural resistance in chronically infected mice with severe combined immunodeficiency (SCID) and the ability of T cells to transfer sterilizing immunity.
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of special interest. This study describes massive lymphocyte depletion during the early phase of infection with Listeria monocytogenes and provides evidence that the depletion is due to in situ lymphocyte apoptosis.
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of special interest Merrick JC, Edelson BT, Bhardwaj V, Swanson PE, Unanue ER. Lymphocyte apoptosis during early phase of Listeria infection in mice. Am J Pathol. 151:1997;785-792 This study describes massive lymphocyte depletion during the early phase of infection with Listeria monocytogenes and provides evidence that the depletion is due to in situ lymphocyte apoptosis.
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of special interest Barsig J, Kaufmann SH. The mechanism of cell death in Listeria monocytogenes-infected murine macrophages is distinct from apoptosis. Infect Immun. 65:1997;4075-4081 This paper shows that macrophages infected with Listeria monocytogenes do not undergo apoptosis, but die of delayed necrosis after extensive bacterial replication.
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The Listeria monocytogenes-secreted p60 protein is an N-end rule substrate in the cytosol of infected cells. Implications for major histocompatibility complex class I antigen processing of bacterial proteins
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of special interest Sijts AJ, Pilip I, Pamer EG. The Listeria monocytogenes-secreted p60 protein is an N-end rule substrate in the cytosol of infected cells. Implications for major histocompatibility complex class I antigen processing of bacterial proteins. J Biol Chem. 272:1997;19261-19268 References [34-38] are a series of recent studies by Pamer's group which examine the effect of antigen presentation efficiency on T cell responses in vivo.
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of special interest Vijh S, Pamer EG. Immunodominant and subdominant CTL responses to Listeria monocytogenes infection. J Immunol. 158:1997;3366-3371 References [34-38] are a series of recent studies by Pamer's group which examine the effect of antigen presentation efficiency on T cell responses in vivo.
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of special interest. References [34-38] are a series of recent studies by Pamer's group which examine the effect of antigen presentation efficiency on T cell responses in vivo.
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of special interest Sijts AJ, Pamer EG. Enhanced intracellular dissociation of major histocompatibility complex class I-associated peptides: a mechanism for optimizing the spectrum of cell surface-presented cytotoxic T lymphocyte epitopes. J Exp Med. 185:1997;1403-1411 References [34-38] are a series of recent studies by Pamer's group which examine the effect of antigen presentation efficiency on T cell responses in vivo.
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of special interest Busch DH, Pamer EG. MHC class I/peptide stability: implications for immunodominance, in vitro proliferation and diversity of responding CTL. J Immunol. 160:1998;4441-4448 References [34-38] are a series of recent studies by Pamer's group which examine the effect of antigen presentation efficiency on T cell responses in vivo.
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