Expression of Apo-1/Fas (CD95), Bcl-2, Bax and Bcl-x in myeloma cell lines: Relationship between responsiveness to anti-Fas mab and p53 functional status

British Journal of Haematology

Volumn 97, Issue 2, 1997, Pages 418-428

  Egle, Alexander ^a   Villunger, Andreas ^a   Marschitz, Ingrid ^a   Kos, Marion ^a   Hittmair, Anton ^a   Lukas, Peter ^a   Grünewald, Kurt ^a   Greil, Richard ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Apo 1 Fas (CD 95); Bax; Bcl 2; myeloma; p53

Indexed keywords

FAS ANTIGEN; MONOCLONAL ANTIBODY; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN P53; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; HUMAN; HUMAN CELL; MYELOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0030960349     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.382680.x     Document Type: Article

References (53)

1. Bae, I., Fan, S., Bhatia, K., Kohn, K.W., Fornace, A.J., Jr & O'Connor, P.M. (1995) Relationships between G1 arrest and stability of the p53 and p21Cip1/Waf1 proteins following gamma-irradiation of human lymphoma cells. Cancer Research, 55, 2387-2393.
2. Bargou, R.C., Daniel, P.T., Mapara, M.Y., Bommert, K., Wagener, C., Kallinich, B., Royer, H.D. & Dorken, B. (1995) Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expression in tumor cells correlates with resistance towards apoptosis. International Journal of Cancer, 60, 854-859.
3. Boise, L.H., Gonzalez Garcia, M., Postema, C.E., Ding, L., Lindsten, T., Turka, L.A., Mao, X., Nunez, G. & Thompson, C.B. (1993) bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell, 74, 597-608.
4. Boise, L.H., Minn, A.J., Noel, P.J., June, C.H., Accavitti, M.A., Lindsten, T. & Thompson, C.B. (1995) CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity, 3, 87-98.
5. Boulakia, C.A., Chen, G., Ng, F.W.H., Teodoro, J.G., Branton, P.E., Nicholson, D.W., Poirier, G.G. & Shore, G.C. (1996) Bcl-2 and adenovirus E1B 19 kDa protein prevent E1A-induced processing of CPP32 and cleavage of poly(ADP-ribose) polymerase. Oncogene, 12, 529-535.
6. Chiu, V.K., Walsh, C.M., Liu, C.C., Reed, J.C. & Clark, W.R. (1995) Bcl-2 blocks degranulation but not fas-based cell-mediated cytotoxicity. Journal of Immunology, 154, 2023-2032.
7. Cory, S. (1995) Regulation of lymphocyte survival by the bcl-2 gene family. Annual Reviews of Immunology, 13, 513-543.
8. Fan, S., el Deiry, W.S., Bae, I., Freeman, J., Jondle, D., Bhatia, K., Fornace, A.J., Jr, Magrath, I., Kohn, K.W. & O'Connor, P.M. (1994) p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents. Cancer Research, 54, 5824-5830.
9. Friesen, C., Herr, I., Krammer, P.H. & Debatin, K.M. (1996) Involvement of the CD95 (Apo-1/Fas) receptor/ligand system in drug-induced apoptosis in leukaemia cells. Nature Medicine, 2, 574-577.
10. Gruber, J., Geisen, F., Sgonc, R., Egle, A., Villunger, A., Boeck, G., Konwalinka, G. & Greil, R. (1996) 2′2′-Difluorodeoxycytidine (gemcitabine) induces apoptosis in myeloma cell lines resistant to steroids and 2-chlorodeoxyadenosin. Stem Cells, 14, 351-362.
11. Hata, H., Matsuzaki, H., Takeya, M., Yoshida, M., Sonoki, T., Nagasaki, A., Kuribayashi, N., Kawano, F. & Takatsuki, K. (1995) Expression of Fas/Apo-1 (CD95) and apoptosis in tumor cells from patients with plasma cell disorders. Blood, 86, 1939-1945.
12. Imamura, J., Miyoshi, I. & Koeffler, H.P. (1994) p53 in hematologic malignancies. Blood, 84, 2412-2421.
13. Itoh, N., Tsujimoto, Y. & Shigekatsu, N. (1993) Effect of bcl-2 on Fas antigen mediated cell death. Journal of Immunology, 151, 621-627.
14. Iwai, K., Miyawaki, T., Takizawa, T., Konno, A., Ohta, K., Yachie, A., Seki, H. & Taniguchi, N. (1994) Differential expression of bcl-2 and susceptibility to anti-Fas-mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils. Blood, 84, 1201-1208.
15. Jaattela, M., Benedict, M., Tewari, M., Shayman, J.A. & Dixit, V.M. (1995) Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. Oncogene, 10, 2297-2305.
16. Kondo, S., Barna, B.R. Morimura, T., Takeuchi, J., Yuan, J., Akbasak, A. & Barnett, G.H. (1995) Interleukin-1 beta-converting enzyme mediates cisplatin-induced apoptosis in malignant glioma cells. Cancer Research, 55, 6166-6171.
17. Lacronique, V., Mignon, A., Fabre, M., Viollet, B., Rouquet, N., Molina, T., Porteu, A., Henrion, A., Bouscary, D., Varlet, P. & Kahn, A. (1996) Bcl-2 protects from lethal hepatic apoptosis induced by anti-Fas antibody in mice. Nature Medicine, 2, 80-86.
18. Los, M., Van de Craen, M., Penning, L.C., Schenk, H., Westendorp, M., Baeuerle, P.A., Droge, W., Krammer, P.H., Fiers, W. & Schulze Osthoff, K. (1995) Requirement of an ICE/CED-3 protease for Fas/ APO-1-mediated apoptosis. Nature, 375, 81-83.
19. Lowe, S.W., Ruley, H.E., Jacks, T. & Housman, D.E. (1993) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74, 957-967.
20. Lowin, B., Hahne, M., Mattmann, C. & Tschopp, J. (1994) Cytolytic T-cell cytotoxicity is mediated through perform and Fas lytic pathways. Nature, 370, 650-652.
21. Macleod, K.F., Sherry, N., Hannon, G., Beach, D., Tokino, T., Kinzler, K., Vogelstein, B. & Jacks, T. (1995) p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes and Development, 9, 935-944.
22. Mapara, M.Y., Bargou, R., Zugck, C., Dohner, H., Ustaoglu, F., Jonker, R.R., Krammer, P.H. & Dorken, B. (1993) APO-1 mediated apoptosis or proliferation in human chronic B lymphocytic leukaemia: correlation with bcl-2 oncogene expression. European Journal of Immunology, 23, 702-708.
23. Memon, S.A., Moreno, M.B., Petrak, D. & Zacharchuk, C.M. (1995) Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma. Journal of Immunology, 155, 4644-4652.
24. Minn, A.J., Boise, L.H. & Thompson, C.B. (1996) Bcl-x(S) anatagonizes the protective effects of Bcl-x(L). Journal of Biological Chemistry, 271, 6306-6312.
25. Miyashita, T., Krajewski, S., Krajewska, M., Wang, H., Lin, K., Liebermann, D., Hoffmann, B. & Reed, J. (1994) Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene, 9, 1799-1805.
26. Miyashita, T. & Reed, J.C. (1993) Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood, 81, 151-157.
27. Miyashita, T. & Reed, J.C. (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell, 80, 293-299.
28. Neri, A., Baldini, L., Trecca, D., Cro, L., Polli, K. & Maiolo, A.T. (1993) p53 gene mutations in multiple myeloma are associated with advanced forms of malignancy. Blood, 81, 128-135.
29. Newcomb, E.W. (1995) P53 gene mutations in lymphoid diseases and their possible relevance to drug resistance. Leukemia and Lymphoma, 17, 211-221.
30. Nicoletti, L., Migliorati, G., Pagliacci, M.C., Grignani, F. & Riccardi, C. (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. Journal of Immunological Methods, 139, 271-279.
31. Nishiuchi, R., Yoshino, T., Matsuo, Y., Sakuma, I., Cao, L., Seino, Y., Takahashi, K. & Akagi, T. (1996) The Fas antigen is detected on immature B cells and the representative cell lines show Fas-mediated apoptosis. British Journal of Haematology, 92, 302-307.
32. Nunez, G., London, L., Hockenbery, D., Alexander, M., McKearn, J.P. & Korsmeyer, S.J. (1990) Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. Journal of Immunology 144, 3602-3610.
33. Oehm, A., Behrmann, I., Falk, W., Pawlita, M., Maier, G., Klas, C., Li Weber, M., Richards, S., Dhein, J., Trauth, B.C., Panstung, H. & Krammer, P.H. (1992) Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily: sequence identity with the Fas antigen. Journal of Biological Chemistry, 267, 10709-10715.
34. Oltvai, Z.N., Milliman, C.L. & Korsmeyer, S.J. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell, 74, 609-619.
35. Owen Schaub, L.B., Radinsky, R., Kruzel, E., Berry, K. & Yonehara, S. (1994) Anti-Fas on nonhematopoietic tumors: levels of Fas/APO-1 and bcl-2 are not predictive of biological responsiveness. Cancer Research, 54, 1580-1586.
36. Owen Schaub, L.B., Zhang, W., Cusack, J.C., Angelo, L.S., Santee, S.M., Fujiwara, T., Roth, J.A., Deisseroth, A.B., Zhang, W.W., Kruzel, E. & Radinsky, R. (1995) Wild type human p53 and a temperature-sensitive mutant induce Fas/Apo-1 expression. Molecular and Cellular Biology, 15, 3032-3040.
37. Prives, C. (1994) How loops, beta sheets, and alpha helices help us to understand p53. Cell, 78, 543-546.
38. Ritts, R.E., Jr. Ruiz Arguelles, A., Weyl, K.G., Bradley, A.L., Weihmeir, B., Jacobsen, D.J. & Strehlo, B.L. (1983) Establishment and characterization of a human non-secretory plasmacytoid cell line and its hybridization with human B cells. International Journal of Cancer, 31, 133-141.
39. Rodriguez, I., Matsuura, K., Khatib, K., Reed, J.C., Nagata, S. & Vassalli, P. (1996) A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas-antibody injection. Journal of Experimental Medicine, 183, 1031-1036.
40. Shima, Y., Nashimoto, N., Ogata, A., Fuji, Y., Yoshizaki, K. & Kishimoto, T. (1995) Myeloma cells express Fas antigen/Apo-1 (CD-95), but only some are sensitive to anti-Fas-antibody resulting in apoptosis. Blood, 85, 757-764.
41. Srivastava, P., Sladek, T.L., Goodman, M.N. & Jacobberger, J.W. (1992) Streptavidin-based quantitative staining of intracellular antigens for flow cytometry analysis. Cytometry, 13, 711-721.
42. Strasser, A., Harris, A.W., Huang, D.C., Krammer, P.H. & Cory, S. (1995) Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO Journal, 14, 6136-6147.
43. Suda, T., Okazaki, T., Naito, Y., Yokota, T., Arai, N., Ozaki, S., Nakao, K. & Nagata, S. (1995) Expression of the Fas ligand in cells of T cell lineage. Journal of Immunology, 154, 3806-3813.
44. Suda, T., Takahashi, T., Golstein, P. & Nagata, S. (1993) Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family. Cell, 75, 1169-1178.
45. Trauth, B.C., Klas, C., Peters, A.M., Matzku, S., Moller, P., Falk, W., Debatin, K.M. & Krammer, P.H. (1989) Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science, 245, 301-305.
46. Tsujimoto, Y. & Croce, C.M. (1986) Analysis of the structure, transcripts, and protein products of Bcl-2, the gene involved in follicular lymphoma. Proceedings of the National Academy of Sciences of the United States of America, 83, 5214-5218.
47. Villunger, A., Egle, A., Kos, M., Hittmair, A., Maly, K. & Greil, R. (1996) Constituents of autocrine IL-6 loops in myeloma cell lines and their targeting for suppression of neoplastic growth by antibody strategies. International Journal of Cancer, 65, 498-505.
48. Weller, M., Malipiero, U., Rensing Ehl, A., Barr, P.J. & Fontana, A. (1995) Fas/APO-1 gene transfer for human malignant glioma. Cancer Research, 55, 2936-2944.
49. Westendorf, J.J., Lammert, J.M. & Jelinek, D.F. (1995) Expression and function of Fas (APO-1/CD95) in patient myeloma cells and myeloma cell lines. Blood, 85, 3566-3576.
50. Wyllie, H. (1993) Apoptosis (The 1992 Frank Rose Memorial Lecture). British Journal of Cancer, 67, 205-208.
51. Yin, X.M., Oltval, Z.N. & Korsmeyer, S.J. (1994) BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature, 369, 321-323.
52. Yonehara, S., Ishii, A. & Yonehara, M. (1989) A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. Journal of Experimental Medicine, 169, 1747-1756.
53. Yoshino, T., Kondo, E., Cao, L., Takahashi, K., Hayashi, K., Nomura, S. & Akagi, T. (1994) Inverse expression of bcl-2 protein and Fas antigen in lymphoblasts in peripheral lymph nodes and activated peripheral blood T and B lymphocytes. Blood, 83, 1856-1861.