Absence of mutagenic effects of sodium dichloroacetate

Fundamental and Applied Toxicology

Volumn 32, Issue 1, 1996, Pages 87-95

  Fox, Anthony W ^a   Yang, Xiaoqing ^a   Murli, Hemathala ^b   Lawlor, Timothy E ^b   Cifone, Maria A ^b   Reno, Frederick E ^c  

^a Cypros Pharmaceutical Corporation   (United States)

^b UK   (United States)

^c Consultant in Toxicology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DICHLOROACETIC ACID;

ANIMAL CELL; ARTICLE; CHO CELL; CHROMOSOME ABERRATION; CONTROLLED STUDY; ESCHERICHIA COLI; FEMALE; LYMPHOMA CELL; METABOLIC ACTIVATION; MUTAGEN TESTING; MUTAGENIC ACTIVITY; MUTAGENICITY; NONHUMAN; SALMONELLA TYPHIMURIUM;

EID: 26944489113     PISSN: 02720590     EISSN: None     Source Type: Journal    
DOI: 10.1006/faat.1996.0110     Document Type: Article

References (26)

1. Abemayor, E., Kovachich, G. B., and Haugaard, N. (1984). Effects of dichloroacetate on brain pyruvate dehydrogenase. J. Neurochem. 42, 38-42.
2. Ames, B. N., McCann, J., and Yamaski, E. (1975). Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mut. Res. 31, 347-364.
3. Barsan, W. G., Hedges, J. R., Syverud, S. A., Dronen, S. C., and Dimlich, R. (1987). Effects of dichloroacetate in spinal stroke in the rabbit. Life Sci. 41, 1065-1069.
4. Chang, L.-H., Shimuzu, H., Abiko, H., Swanson, R. A., Faden, A. I., James, T. L., and Weinstein, P. R. (1992). Effect of dichloroacetate on recovery of brain lactate, phosphorus energy metabolites, and glutamate during reperfusion after complete cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 12, 1030-1038.
5. Clive, D., Caspary, W., Kirby, P. E., Krehl, R., Moore, M., Mayo, J., and Oberly, T. J. (1987). Guide for performing the mouse lymphoma assay for mammalian cell mutagenicity. Mutat. Res. 147, 237-242.
6. Colohan, A. R., Welsh, F. A., Miller, E. D., and Kassell, N. F. (1986). The effect of dichloroacetate on brain lactate levels following incomplete ischemia in the hyperglycemic rat. Stroke 17, 525-528.
7. Curry, S. H., Chu, P., Baumgartner, T. G., and Stacpoole, P. W. (1985). Plasma concentrations and metabolic effects of intravenous sodium dichloroacetate. Clin. Pharmacol. Ther. 37, 89-93.
8. Dimlich, R. V. W., and Marangos, P. J. (1994). Dichloroacetate on neuronal damage in a gerbil model of brain ischemia. J. Mol. Neurosci. 5, 69-81.
9. Evans, H. J. (1962). Chromosomal aberrations produced by ionizing radiation. Int. Rev. Cytol. 13, 221-231.
10. Gelernt, M. D., and Herbert, V. (1982). Mutagenicity of diisopropylamine dichloroacetate, the "active" constituent of vitamin B15 (Pangamic acid). Nutr. Cancer 3, 129-133.
11. Goto, K., Maseda, S., Kano, Y., and Sugiyama, T. (1978). factors involved in differential Giemsa staining. Chromosoma 66, 351-359.
12. + reversion in Escherichia coli. Mut. Res. 76, 169-190.
13. Heddle, J. A., Hite, M., Kirkhart, B., Larsen, K., MacGregor, J. T., Newell, G. W., and Salamone, M. F. (1983). The induction of micronuclei as a measure of genotoxicity. Mut. Res. 123, 61-118.
14. Herbert, V., Gardner, A., and Colman, N. (1980). Mutagenicity of dichloroacetate, an ingredient of some formulations of pangamic acid (trade-named "vitamin B15"). Am. J. Clin. Nutr. 33, 1179-1182.
15. Maron, D. M., and Ames, B. (1983). revised methods for the Salmonella mutagenicity test. Mutat. Res. 113, 173-215.
16. Matsuda, H., Ose, Y., Nagase, H., Sato, T., Kito, H., and Sumida, K. (1991). Mutagenicity of ozonation and chlorination products from p-hydroxybenzaldehyde. Sci. Total Environ. 103, 141-149.
17. Ono, Y., Somiya, I., and Kawamura, M. (1991). The evaluation of genotoxicity using DNA repairing test for chemicals produced in chlorination and ozonation processes. Water Sci. Technol. 23, 329-338.
18. Perry, P., and Wolff, S. (1974). New Giemsa method for the differential staining of sister chromatids. Nature 251, 156-158.
19. Schmid, W. (1975). The micronucleus test. Mutat. Res. 31, 9-15.
20. Stacpoole, P. W., Harman, E. M., Curry, S. H., Baumgartner, T. G., and Misbin, R. I. (1983). Treatment of lactic acidosis with dichloroacetate. N. Engl. J. Med. 309, 390-396.
21. Stacpoole, P. W., Wright, E. C., Baumgartner, T. G., Bersin, R. M., Buchalter, S., Curry, S. H., Duncan, C. A., Harman, E. M., Henderson, G. N., Jenkinson, S., Lachin, J. M., Lorenz, A., Schneider, S. H., Siegel, J. H., Summer, W. R., Thompson, D., Wolfe, C. L., Zorovich, B., and the Dichloroacetate-Lactic Acidosis Study Group (1992). A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. N. Engl. J. Med. 327, 1564-1569.
22. Terasima, T., and Tolmach, L. J. (1961). Changes in X-ray sensitivity of HeLa cells during the division cycle. Nature 190, 1210-1211.
23. Vogel, H. J., and Bonner, D. M. (1956). Acetylornithase of E. coli: Partial purification and some properties. J. Biol. Chem. 218, 97-106.
24. Waskell, L. (1978). A study of the mutagenicity of anesthetics and their metabolites. Mutat. Res. 57, 141-153.
25. Whitehouse, S., and Randle, P. J. (1973). Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate. Biochem. J. 134, 651-653.
26. Whitehouse, S., Cooper, R. H., and Randle, P. J. (1974). Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids. Biochem. J. 141, 761-774.