Expression of p53, p21/WAF/CIP, Bcl-2, Bax, Bcl-x, and Bak in radiation- induced apoptosis in testicular germ cell tumor lines

International Journal of Radiation Oncology Biology Physics

Volumn 41, Issue 2, 1998, Pages 415-424

  Burger, Herman ^a   Nooter, Kees ^a   Boersma, Antonius W m ^a   Kortland, Christine J ^a   Van Den Berg, Ad P ^a   Stoter, Gerrit ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Bcl 2 Bax protein family; Clonogenic survival; p53; Radiation induced apoptosis; Testicular germ cell tumors

Indexed keywords

PROTEIN P21; PROTEIN P53; TUMOR MARKER;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DISEASE MARKER; GENE EXPRESSION REGULATION; GERM CELL TUMOR; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MARKER GENE; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION INJURY; RADIOSENSITIVITY; SEQUENCE ANALYSIS; TESTIS TUMOR;

APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, RADIATION; GENES, P53; GERMINOMA; HUMANS; MALE; MEMBRANE PROTEINS; NEOPLASM PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TESTICULAR NEOPLASMS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0032076197     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(98)00065-0     Document Type: Article

References (45)

1. Einhorn L.H. Treatment of testicular cancer A new and improved model . J. Clin. Oncol. 8:1990;1777-1781.
2. Dive C., Hickman J.A. Drug-target interactions Only the first step in the commitment to a programmed cell death? Br. J. Cancer. 64:1991;192-196.
3. Fisher D.E. Apoptosis in cancer therapy Crossing the threshold . Cell. 78:1994;539-542.
4. Kerr J.F.R., Winterford C.M., Harmon B.V. Apoptosis Its significance in cancer and cancer chemotherapy . Cancer. 73:1994;2013-2026.
5. Ulbright T.M. Germ cell neoplasms of the testis. Am. J. Surg. Pathol. 17:1993;1075-1091.
6. Boersma A.W.M., Nooter K., Burger H., Kortland C.J., Stoter G. Bax upregulation is an early event in cisplatin-induced apoptosis in human testicular germ cell tumor cell line NT2, as quantitated by flow cytometry. Cytometry. 27:1997;275-282.
7. Burger H., Nooter K., Boersma A.W.M., Kortland C.J., Stoter G. Lack of correlation between cisplatin-induced apoptosis, p53 status, and expression of Bcl-2 family proteins in testicular germ cell tumor cell lines. Int. J. Cancer. 73:1997;592-599.
8. Cresta C.M., Masters J.R.W., Hickman J.A. Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio. Cancer Res. 56:1996;1834-1841.
9. Huddart R.A., Titley J., Robertson D., Williams G.T., Horwich A., Cooper C.S. Programmed cell death in response to chemotherapeutic agents in human germ cell tumor lines. Eur. J. Cancer. 31A:1995;739-746.
10. Masters J.R.W., Osborne E.J., Walker M.C., Parris C.N. Hypersensitivity of human testis tumor cell lines to chemotherapeutic drugs. Int. J. Cancer. 53:1993;340-346.
11. Blank K.R., Rudoltz M.S., Kao G.D., Muschel R.J., McKenna W.G. The molecular regulation of apoptosis and implications for radiation oncology. Int. J. Radiat. Biol. 71:1997;455-466.
12. Dewey W.C., Ling C.C., Meyn R.E. Radiation-induced apoptosis Relevance to radiotherapy . Int. J. Oncol. Biol. Phys. 33:1995;781-796.
13. Bristow R.G., Benchimol S., Hill R.P. The p53 gene as a modifier of intrinsic radiosensitivity implications for radiotherapy . Radiother. Oncol. 40:1996;197-223.
14. Clarke A.R., Purdie C.A., Harrison D.J., Morris R.G., Bird C.C., Hooper M.L., Wyllie A.H. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature. 362:1993;849-852.
15. Harris C.C. Structure and function of the p53 tumor suppressor gene Clues for rational cancer therapeutic strategies . J. Natl. Cancer Inst. 88:1996;1442-1452.
16. Lowe S.W., Schmitt E.M., Smith S.W., Osborne B.A., Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature. 362:1993;847-849.
17. Lowe S.W., Bodis S., McClatchey A., Remington L., Ruley H.E., Fisher D.E., Housman D.E., Jacks T. p53 status and the efficacy of cancer therapy in vivo. Science. 266:1994;807-810.
18. Lotem J., Sachs L. Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents. Blood. 82:1993;1092-1096.
19. Dee S., Haas-Kogan D.A., Israel M.A. Inactivation of p53 is associated with decreased levels of radiation-induced apoptosis in medulloblastoma cell lines. Cell Death Different. 2:1995;267-275.
20. Fan S., El-Deiry W.S., Bae I., Freeman J., Jondle D., Bhatia K., Fornace A.J. Jr, Magrath I., Kohn K.W., O'Connor P.M. p53 Gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents. Cancer Res. 54:1994;5824-5830.
21. Lee J.M., Bernstein A. p53 mutations increase resistance to ionizing radiation. Proc. Natl. Acad. Sci. USA. 90:1993;5742-5746.
22. Korsmeyer S.J. Bcl-2 initiates a new category of oncogenes Regulators of cell death . Blood. 80:1992;879-886.
23. Reed J.C., Miyashita T., Takayama S., Wang H-G., Sato T., Krajewski S., Aimé-Sempé C., Bodrug S., Kitada S., Hanada M. Bcl-2 family proteins Regulators of cell death involved in the pathogenesis of cancer and resistance therapy . J. Cell. Biochem. 60:1996;23-32.
24. Farrow S.N., Brown R. New members of the Bcl-2 family and their protein partners. Curr. Op. Gen. Dev. 6:1996;45-49.
25. Oltvai Z.N., Korsmeyer S.J. Checkpoints of duelling dimers foil death wishes. Cell. 79:1994;189-192.
26. Miyashita T., Krajewski S., Krajewski M., Wang H.G., Lin H.K., Liebermann D.A., Hofmann B., Reed J.C. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 9:1994;1799-1805.
27. Peng H.Q., Hogg D., Malkin D., Bailey D., Gallie B.L., Bulbul M., Jewett M., Buchanan J., Gross P.E. Mutations of the p53 gene do not occur in testis cancer. Cancer Res. 53:1993;3574-3578.
28. Wang N., Perkins K.L., Bronson D.L., Fraley E.E. Cytogenetic evidence for premeiotic transformation of human testicular cancers. Cancer Res. 41:1981;2135-2140.
29. Damjanov I., Horvat B., Gibas Z. Retinoic acid-induced differentiation of the developmentally pluripotent human germ cell tumor-derived cell line, NCCIT. Lab. Invest. 68:1993;220-232.
30. Kaufmann S.C., Desnoyers S., Ottaviano Y., Davidson N.E., Poirier G.G. Specific proteolytic cleavage of poly(ADP)-ribose polymerase an early marker of chemotherapy-induced apoptosis . Cancer Res. 53:1993;3976-3985.
31. Martin S.J., Green D.R. Protease activation during apoptosis Death by a thousand cuts? Cell. 82:1995;349-352.
32. El-Deiry W.S., Tokino T., Velculescu V.E., Levy D.B., Parsons R., Trent J.M., Lin D., Mercer E., Kinzler K.W., Vogelstein B. WAF1, a potent mediator of p53 tumor suppression. Cell. 75:1993;817-825.
33. Malaise E.P., Fertil B., Chavaudra N., Guichard M. Distribution of radiation sensitivity for human tumor cells of specific histological types Comparison of in vitro to in vivo data . Int. J. Radiat. Oncol. Biol. Phys. 12:1986;617-624.
34. Hall E.J. Repair of radiation damage and the dose-rate effect. Hall E.J. Radiobiology for the radiologist. 4:1994;107-131 Lippincott, Philadelphia.
35. Radford I.R. Radiation response of mouse lymphoid and myeloid cell lines. Part I. Sensitivity to killing by ionizing radiation, rate of loss of viability, and cell type of origin. Int. J. Radiat. Biol. 65:1994;203-215.
36. Ling C.C., Chen C.H., Fuks Z. An equation for the dose response of radiation-induced apoptosis Possible incorporation witth the LQ model . Radiother. Oncol. 33:1994;17-22.
37. Haas-Kogan D.A., Yount G., Haas M., Levi D., Kogan S.S., Hu L., Vidair C., Deen D.F., Dewey W.C., Israel M.A. p53-Dependent G1 arrest and p53-independent apoptosis influence the radiobiological response of glioblastoma. Int. J. Radiat. Oncol. Biol. Phys. 36:1996;95-103.
38. Aldridge D.R., Arends M.J., Radford I.R. Increasing the susceptibility of the rat 208F fibroblast cell line to radiation-induced apoptosis does not alter its clonogenic survival dose-response. Br. J. Cancer. 71:1995;571-577.
39. Wang X.W., Vermeulen W., Coursen J.D., Gibson M., Lupold S.E., Forrester K., Xu G., Elmore L., Yeh H., Hoeijmakers J.H.J., Harris C.C. The XPB and XPD helicases are components of the p53-mediated apoptosis pathway. Genes Dev. 10:1996;1219-1232.
40. Strasser A., Harris A.W., Jacks T., Corry S. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell. 79:1994;329-339.
41. Bracey T.S., Miller J.C., Preece A., Paraskeva C. γ-Radiation-induced apoptosis in human colorectal adenoma and carcinoma cell lines can occur in the absence of wild type p53. Oncogene. 10:1995;2391-2396.
42. Wu G.S., El-Deiry W.S. Apoptotic death of tumors correlates with chemosensitivity, independent of p53 or Bcl-2. Clin. Cancer Res. 2:1996;623-633.
43. Khanna K.K., Wie T., Song Q., Burrows S.R., Moss D.J., Krajewski S., Reed J.C., Lavin M.F. Expression of p53, bcl-2, bax, bcl-x2 and c-myc in radiation-induced apoptosis in Burkitt's lymphoma cells. Cell Death Different. 3:1996;315-322.
44. Kuczyk M.A., Serth J., Bokemeyer C., Jonassen J., Machtens S., Werner M., Jonas U. Alterations of the p53 tumor suppressor gene in carcinoma in situ of the testis. Cancer. 78:1996;1958-1966.
45. Lee J., Richburg J.H., Younkin S.C., Boekelheide K. The Fas system is a key regulator of germ cell apoptosis in the testis. Endocrinology. 138:1997;2081-2088.