Intercellular and intracellular events following the MHC-unrestricted TCR recognition of a tumor-specific peptide epitope on the epithelial antigen MUC1

Journal of Immunology

Volumn 160, Issue 7, 1998, Pages 3111-3120

  Magarian Blander, Julie ^a,c   Ciborowski, Pawel ^a   Hsia, Shyuan ^b   Watkins, Simon C ^a   Finn, Olivera J ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b ALLEGHENY GENERAL HOSPITAL   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; OKT 3; T LYMPHOCYTE RECEPTOR; TUMOR ANTIGEN;

ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; HUMAN; HUMAN CELL; LYMPHOCYTE CULTURE; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE ACTIVATION; TUMOR CELL; TUMOR CELL CULTURE; TUMOR IMMUNOLOGY;

AMINO ACID SEQUENCE; ANTIGENS, CD58; BIOLOGICAL TRANSPORT; BREAST NEOPLASMS; CA-15-3 ANTIGEN; CALCIUM; CELL NUCLEUS; DNA-BINDING PROTEINS; EPITOPES; EXTRACELLULAR SPACE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTRACELLULAR FLUID; LYMPHOCYTE ACTIVATION; MICROSPHERES; MOLECULAR SEQUENCE DATA; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PEPTIDES; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, CYTOTOXIC; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TYROSINE; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 0032055962     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Germain, R. N. 1994. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76:287.
2. Janeway, C. A., Jr., and K. Bottomly. 1994. Signals and signs for lymphocyte responses. Cell 76:275.
3. Qian, D., and A. Weiss. 1997. T cell antigen receptor signal transduction. Curr. Opin. Cell Biol. 9:205.
4. - mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid. Nature 339:226.
5. Janis, E. M., S. H. E. Kaufman, R. H. Schwartz, and D. M. Pardoll. 1989. Activation of gamma delta T cells in the primary immune response to Mycobacterium tuberculosis. Science 244:713.
6. Wright, A., J. E. Lee, M. P. Link, S. D. Smith, W. Carroll, R. Levy, C. Clayberger, and A. M. Krensky. 1989. Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor delta chain. J. Exp. Med. 169:1557.
7. Sciammas, R., R. M. Johnson, A. I. Sperling, W. Brady, P. S. Linsley, P. G. Spear, F. W. Fitch, and J. A. Bluestone. 1994. Unique antigen recognition by a herpes virus-specific TCR-γδ cell. J. Immunol. 152:5392.
8. Morita, C. T., E. M. Beckman, J. F. Bukowski, Y. Tanaka, H. Band, B. R. Bloom, D. E. Golan, and M. B. Brenner. 1996. Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells. Immunity 3:495.
9. Altman, D. M., O. Lider, D. C. Douek, and I. R. Cohen. 1987. Activation of specific T cell lines by the antigens avidin and myelin basic protein in the absence of antigen-presenting cells. Eur. J. Immunol. 17:1635.
10. + cytolytic T lymphocytes. J. Immunol. 143:3444.
11. Rao, A., W. W.-P. Ko, S. J. Faas, and H. Cantor. 1984. Binding of antigen in the absence of histocompatibility proteins by arsonate-reactive T-cell clones. Cell 36:879.
12. Siliciano, R., A. D. Keegan, R. Z. Dintzis, H. M. Dintzis, and H. S. Shin. 1985. The interaction of nominal antigen with T cell antigen receptors. I. Specific binding of multivalent nominal antigen to cytolytic T cell clones. J. Immunol. 135: 906.
13. Siliciano, R. F., T. J. Hemesath, J. C. Pratt, R. Z. Dintzis, H. M. Dintzis, O. Acuto, H. S. Shin, and E. L. Reinherz. 1986. Direct evidence for the existence of nominal antigen binding sites on T cell surface Ti α-β heterodimers of MHC-restricted T cell clones. Cell 47:161.
14. b-binding peptides generates carbohydrate-specific unrestricted cytotoxic T cells. Eur. J. Immunol. 26:544.
15. Barnd, D. L., M. S. Lan, R. S. Metzgar, and O. J. Finn. 1989. Specific, major histocompatibility complex-unrestricted recognition of tumor-associated mucins by human cytotoxic T cells. Proc. Natl. Acad. Sci. USA 86:7159.
16. Jerome, K. R., N. Domenech, and O. J. Finn. 1993. Tumor-specific cytotoxic T lymphocyte clones from patients with breast and pancreatic adenocarcinoma recognize EBV-immortalized B cells transfected with polymorphic epithelial mucin cDNA. J. Immunol. 151:1654.
17. Gendler, S. J., A. P. Spicer, E.-N. Lalani, T. Duhig, N. Peat, J. Burchell, L. Pemberton, M. Boshell, and J. Taylor-Papadimitriou. 1991. Structure and biology of a carcinoma-associated mucin, MUC1. Am. Rev. Respir. Dis. 144:S42.
18. Fontenot, J. D., N. Tjandra, D. Bu, C. Ho, R. C. Montelaro, and O. J. Finn. 1993. Biophysical characterization of one-, two-, and three-tandem repeats of human mucin (muc-1) protein core. Cancer Res. 53:5386.
19. Fontenot, J. D., S. V. Santhana Mariappan, P. Catasti, N. Domenech, O. J. Finn, and G. Gupta. 1995. Structure of a tumor associated antigen containing a tandemly repeated immunodominant epitope. J. Biomol. Struct. Dyn. 13:245.
20. Eldridge, J. H., J. K. Staas, J. A. Meulbroek, T. R. Tice, and R. M. Gilley. 1991. Biodegradable and biocompatible poly (DL-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies. Infect. Immun. 59:2978.
21. Poland, P. A., C. L. Kinlough, M. D. Rokaw, J. Magarian-Blander, O. J. Finn, and R. P. Hughey. 1997. Differential glycosylation of MUC1 in tumors and transfected epithelial and lymphoblastoid cell lines. Glycoconj. J. 14:89.
22. 2+ signals and immunosuppression. Nature 383:837.
23. Salter, R. D., and P. Cresswell. 1986. Impaired assembly and transport of HLA-A and -B antigens in a mutant T×B cell hybrid. EMBO J. 5:943.
24. Magarian-Blander, J., R. P. Hughey, C. Kinlough, P. A. Poland, and O. J. Finn. 1996. Differential expression of MUC1 on transfected cell lines influences its recognition by MUC1 specific T cells. Glycoconj. J. 13:749.
25. Kuan, S. F., J. C. Byrd, C. Basbaum, and Y. S. Kim. 1989. Inhibition of mucin glycosylation by aryl-N-acetyl-α-galactosaminides in human colon cancer cells. J. Biol. Chem. 264:19271.
26. Springer, T. A. 1990. Adhesion receptors of the immune system. Nature 346:425.
27. Negulescu, P. A., T. B. Krasieva, A. Khan, H. H. Kerschbaum, and M. D. Cahalan. 1996. Polarity of T cell shape, motility, and sensitivity to antigen. Immunity 4:421.
28. Iwashima, M., B. Irving, A. Chan, and A. Weiss. 1993. The sequential interaction of the T cell antigen receptor with two distinct cytoplasmic tyrosine kinases. Science 263:1136.
29. Northrop, J. P., S. N. Ho, L. Chen, D. J. Thomas, L. A. Timmerman, G. P. Nolan, A. Admon, and G. R. Crabtree. 1994. NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 369:497.
30. Finn, O. J. 1992. Antigen-specific, MHC-unrestricted T cells. Biotherapy 4:239.
31. Ioannides, C. G., B. Fisk, K. R. Jerome, T. Irimura, J. T. Wharton, and O. J. Finn. 1993. Cytotoxic T cells from ovarian malignant tumors can recognize polymorphic epithelial mucin core peptides. J. Immunol. 151:3693.
32. Finn, O. J., K. R. Jerome, R. A. Henderson, G. Pecher, N. Domenech, J. Magarian-Blander, and S. Barratt-Boyes. 1995. MUC1 epithelial tumor mucin-based immunity and cancer vaccines. Immunol. Rev. 145:61.
33. Sloan-Lancaster, J., A. S. Shaw, J. B. Rothbard, and P. M. Allen. 1994. Partial T cell signaling: altered phospho-ζ and lack of Zap70 recruitment in APL-induced T cell anergy. Cell 79:913.
34. Madrenas, J., R. L. Wange, J. L. Wang, N. Isakov, L. E. Samelson, and R. N. Germain. 1995. ζ phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267:515.
35. Sloan-Lancaster, J., T. H. Steinberg, and P. M. Allen. 1996. Selective activation of the calcium signaling pathway by altered peptide ligands. J. Exp. Med. 184: 1525.
36. Hull, S. R., A. Bright, K. Carraway, M. Abe, D. F. Hayes, and D. W. Kufe. 1989. Oligosaccharide differences in the DF-3 sialomucin antigen from normal human milk and the BT-20 human breast carcinoma cell line. Cancer Commun. 1:261.
37. lck with cytoplasmic domains of CD4 and CD8 mediated by cysteine motifs. Cell 60:755.
38. lck. Nature 350:62.
39. Valitutti, S., M. Dessing, K. Aktories, H. Gallati, and A. Lanzavecchia. 1995. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy: role of T cell actin cytoskeleton. J. Exp. Med. 181:577.
40. 2+. J. Immunol. 150:5338.
41. Goldsmith, M. A., and A. Weiss. 1988. Early signal transduction by the antigen receptor without commitment to T cell activation. Science 240:1029.
42. Van Seventer, G. A., Y. Shimizu, and S. Shaw. 1991. Roles of multiple accessory molecules in T cell activation. Curr. Opin. Immunol. 3:294.
43. Miceli, M. C., and J. R. Parnes. 1993. Role of CD4 and CD8 in T cell activation and differentiation. Adv. Immunol. 53:59.
44. Hünig, T., G. Tiefenthaler, K.-H. Meyer zum Büschenfelde, and S. C. Meuer. 1987. Alternative pathway activation of T cells by binding of CD2 to its cell-surface ligand. Nature 326:298.
45. O'Rourke, A. M., and M. F. Mescher. 1992. Cytotoxic T-lymphocyte activation involves a cascade of signalling and adhesion events. Nature 358:253.
46. Valitutti, S., S. Muller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375:148.
47. Litvinov, S. V., and J. Hilkens. 1993. The epithelial sialomucin, Episialin, is sialylated during recycling. J. Biol. Chem. 268:21364.
48. Ligtenberg, M. J. L., F. Buijs, H. L. Vos, and J. Hilkens. 1992. Suppression of cellular aggregation by high levels of episialin. Cancer Res. 52:2318.
49. Van de Wiel-van Kemenade, E., M. J. L. Ligtenberg, A. J. de Boer, F. Buijs, H. L. Vos, C. J. M. Melief, J. Hilkens, and C. G. Figdor. 1993. Episialin (MUC1) inhibits cytotoxic lymphocyte-target cell interaction. J. Immunol. 151:767.
50. Shaw, A. S., and M. L. Dustin. 1997. Making the T cell receptor go the distance: a topological view of T cell activation. Immunity 6:361.