Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells

Immunity

Volumn 3, Issue 4, 1995, Pages 495-507

  Morita, Craig T ^a,b   Beckman, Evan M ^a,b   Bukowski, Jack F ^a,b   Tanaka, Yoshimasa ^e   Band, Hamid ^a,b   Bloom, Barry R ^e   Golan, David E ^b,c,d   Brenner, Michael B ^a,b  

^a Rheumatology and Immunology Division Department of Medicine Brigham ^*  (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Hematology Oncology Division Department of Medicine Brigham ^*  (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD1 ANTIGEN; ISOPENTENYL DIPHOSPHATE; MAJOR HISTOCOMPATIBILITY ANTIGEN; MYCOBACTERIUM ANTIGEN; PHOSPHORIC ACID ETHYL ESTER; PRENYL PYROPHOSPHATE; PYROPHOSPHATE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN PRESENTATION; ARTICLE; HELPER CELL; HUMAN; HUMAN CELL; MYCOBACTERIOSIS; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTIGEN PRESENTATION; ANTIGENS, BACTERIAL; CELL LINE; DIPHOSPHATES; HUMAN; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COOPERATION; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES;

EID: 0028829424     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/1074-7613(95)90178-7     Document Type: Article

References (79)

1. Human B cell variants immunoselected against a single la antigen subset have lost expression of several la antigen subsets
2. Resident pulmonary lymphocytes expressing the γ/δ T-cell receptor
3. + antigen receptors are present in increased proportions in a fraction of patients with tuberculosis or with sarcoidosis
4. γδ T lymphocytes in human tuberculosis
5. Preferential expansion of Vγ9Vδ2 T cells following stimulation of peripheral blood lymphocytes with extracts of Plasmodium falciparum
6. + γ/δ T cells by group A, B and C but not group D or F streptococci
7. Class II-antigen-negative patient and mutant B-cell lines represent at least three and probably four distinct genetic defects defined by complementation analysis
8. Lymphocytes bearing the γδ T cell receptor in acute Brucella melitensis infection
9. Vγ2Vδ2 TCR-dependent recognition of non-peptide antigens and Daudi cells analyzed by TCR gene transfer
10. Stimulation of human γδ T cells by nonpeptidic mycobacterial ligands
11. 2m gene expression
12. Close correlation between Daudi and mycobacterial antigen recognition by human γδ T cells and expression of V9JPC1γ/V2DJCδ-encoded T cell receptors
13. Selection by two powerful antigens may account for the presence of the major population of human peripheral γδ T cells
14. A trans-acting class II regulatory gene unlinked to the MHC controls exp ression of HLA class II genes
15. Homozygous deletions that simultaneously eliminate expressions of class I and class II antigens of EBV-transformed B-lymphoblastoid cells. I. Reduced proliferative responses of autologous and allogeneic T cells to mutant cells that have decreased expression of class II antigens
16. Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells
17. Induction of γ/δ T cells in murine salmonellosis by an avirulent but not by a virulent strain of Salmonella choleraesuis
18. Differential production of interferon-γ and interleukin-4 in response to Thl- and Th2-stimulating pathogens by γδ T cells in vivo
19. Recognition by human Vγ9/Vδ2 T cells of a GroEL homolog on Daudi Burkitt's lymphoma cells
20. Gamma interferon and interleukin 2, but not intedeukin 4, are detectable in γ/δ T-cell cultures after activation with bacteria
21. In vivo response of murine γδ T cells to a heat shock protein-derived peptide
22. The biochemistry and cell biology of antigen processing and presentation
23. Stable variants affecting B cell alloantigens in human lymphoid cells
24. Human lymphocytes bearing T cell receptor γ/δ are phenotypically diverse and evenly distributed throughout the lymphoid system
25. Gamma/delta cells
26. Predominant activation and expansion of Vγ9-bearing γδ T cells in vivo as well as in vitro in Salmonella infection
27. Superantigens: mechanism of T-cell stimulation and role in immune responses
28. A protective role of γ/δ T cells in primary infection with Listeria monocytogenes in mice
29. Increased γδ T cells in acute Plasmodium falciparum malaria
30. − mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid
31. Dual antigenic recognition by cloned human γδ T cells
32. MHC-independent presentation of mycobacteria to human γδ T cells
33. Class I-restricted presentation occurs without internalization or processing of exogenous antigenic peptides
34. Early appearing γ/δ-bearing T cells during infection with Calmétte Guérin bacillus
35. Activation of γδ T cells in the primary immune response to Mycobacterium tuberculosis
36. + cytotoxic lymphocyte precursors activated by allogeneic or autologous stimulator cells
37. + T cells is activated by Mycobacterium tuberculosis but not by its 65-kD heat shock protein
38. + T cells to Mycobacterium tuberculosis is restricted to Vγ9-bearing cells
39. + T lymphocytes recognize tetanus toxoid in an MHC-restricted fashion
40. T-cell presentation of antigen requires cell-to-cell contact for proliferation and energy induction: differential MHC requirements for super-antigen and autoantigen
41. 2-isopentenyl pyrophosphate
42. Lymphocytes bearing antigen-specific γδ T-cell receptors accumulate in human infectious disease lesions
43. Different roles of αβ and γδ T cells in immunity against an intracellular bacterial pathogen
44. Introduction of soluble protein into the class I pathway of antigen processing and presentation
45. Arsonate-specific murine T cell clones. III. Correlation between clonotype expression and fine specificity for analogs of l-tyrosine-p-azobenzenearsonate
46. Functionally distinct subsets of human γ/δ T cells
47. T cell receptor usage and functional capabilities of human γδ T cells at birth
48. Target cell lysis and IL-2 secretion by γ/δ T lymphocytes after activation with bacteria
49. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis
50. A predominance of the T cell receptor Vγ2/Vδ2 subset in human mycobacteria-responsive T cells suggests germline gene encoded recognition
51. Transient increase in circulating γ/δ T cells during Plasmodium vivax malarial paroxysms
52. Primary responses of human T cells to mycobacteria: a frequent set of γ/δ T cells are stimulated by protease-resistant ligands
53. T cells as antigen-presenting cells
54. Biology of the human γδ T-cell receptor
55. − T lymphocytes to a microbial antigen
56. Calnexin retains unassembled major histocompatibility complex class I free heavy chains in the endoplasmic reticulum
57. Analogs that compete for antigen binding to an arsonate-reactive T-cell clone inhibit the functional response to arsonate
58. Binding of antigen in the absence of histocompatibility proteins by arsonatereactive T-cell clones
59. CDR3 length in antigen-specific immune receptors
60. Antigen recognition by MHCincompatible cells of a human mismatched chimera
61. Specific recognition of staphylococcal enterotoxin A by human T cells bearing receptors with the Vγ9 region
62. Specific antigen-la activation of transferred human T cells expressing murine Ti αβ-human T3 receptor complexes
63. The nature of major histocompatibility complex recognition by γδ T cells
64. Phosphate is essential for stimulation of Vγ9Vδ2 T lymphocytes by mycobacterial low molecular weight ligand
65. Unique antigen recognition by a herpesvirus-specific TCR-γδ cell
66. Extracellular processing of peptide antigens that bind class I major histocompatibility molecules
67. Production of human cells expressing individual transferred HLA-A, -B, -C genes using an HLA-A, -B, -C null human cell line
68. Direct evidence for the existence of nominal antigen binding sites on T cell surface Ti α-β heterodimers of MHC-restricted T cell clones
69. A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules
70. A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway
71. − T cell receptor-y6 clones from peripheral blood
72. + cytotoxic T lymphocytes is due to fratricide
73. Peptide epitope induced apoptosis of human cytotoxic T lymphocytes: implications for peripheral T cell deletion and peptide vaccination
74. Predominant expansion of Vγ9Vδ2 T cells in a tularemia patient
75. Natural and synthetic non-peptide antigens recognized by human γδ T cells
76. Nonpeptide ligands for human γδ T cells
77. γδ T cells contribute to immunity against the liver stages of malaria in αβ T-cell-deficient mice
78. Discrimination of human CD4 T cell clones based on their reactivity with antigen-presenting T cells
79. Cell biology of antigen processing and presentation to major histocompatibility complex class I molecule-restricted T lymphocytes