O6-Methylguanine and O6-methylguanine-dna methyltransferase activity in tissues of BDF-1 mice treated with antiparasitic drugs

Toxicology Letters

Volumn 94, Issue 3, 1998, Pages 199-208

  Badawi, Alaa F ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

DNA alkylation; DNA repair; Hycanthone; Metrifonate; Oxaminiquine; Schistosomiasis

Indexed keywords

6 O METHYLGUANINE; ANTISCHISTOSOMAL AGENT; HYCANTHONE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METRIFONATE; OXAMNIQUINE; PROMUTAGEN; DRUG DERIVATIVE; GUANINE; O (6) METHYLGUANINE; O-(6)-METHYLGUANINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLADDER; CONTROLLED STUDY; DNA ALKYLATION; DNA METHYLATION; DNA REPAIR; ENZYME ACTIVITY; INTESTINE; INTRAGASTRIC DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SPLEEN; TISSUE LEVEL; ANIMAL; COMPARATIVE STUDY; DNA DAMAGE; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; MUTAGENESIS;

ANIMALS; DNA DAMAGE; GUANINE; HYCANTHONE; INTESTINES; LIVER; MALE; MICE; MUTAGENESIS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; OXAMNIQUINE; SCHISTOSOMICIDES; TRICHLORFON; URINARY BLADDER;

EID: 0031996059     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00008-3     Document Type: Article

References (54)

1. Anwar W.A. Praziquantel (antischistosomal drug): is it clastrogenic, co-clastrogenic or anticlastrogenic? Mut. Res. 305:1994;165-173.
2. Archer S., Pica-Mattoccia L., Cioli D., Seyed-Mozaffari A., Zayed A.-H. Preparation and antischistosomal and antitumour activity of hycanthone and some of its congeners. Evidence for the mode of action of hycanthone. J. Med. Chem. 31:1988;254-260.
3. Archer S., el-Hamouly W., Sayed-Mozaffari A., Butler R.H., Pica-Mattoccia L., Cioli D. Mode of action of the schistosomicide hycanthone: site of DNA alkylation. Mol. Biochem. Parasitol. 43:1990;89-95.
4. Badawi A.F., Mostafa M.H. Schistosomiasis: some health and socioeconomic aspects in the Egyptian environment. Ramazzini Newslett. 3:1992;33-44.
5. Badawi A.F., Mostafa M.H. Possible mechanisms of alteration in the capacities of carcinogen metabolizing enzymes during schistosomiasis and their role in bladder cancer induction. J. Int. Med. Res. 21:1993;281-305.
6. Badawi A.F., Mostafa M.H., O'Connor P.J. Involvement of alkylating agents in schistosome-associated bladder cancer: the possible basic mechanisms of induction. Cancer Lett. 63:1992;171-188.
7. Badawi A.F., Mostafa M.H., Aboul-Azm T., Haboubi N.Y., O'Connor P.J., Cooper D.P. Promutagenic methylation damage in bladder DNA from patients with bladder cancer associated with schistosomiasis and from normal individuals. Carcinogenesis. 13:1992;877-881.
8. Badawi A.F., Cooper D.P., Mostafa M.H., Doenhoff M.J., Probert A., Padriac F., Cooper R., O'Connor P.J. Promutagenic methylation damage in liver DNA of mice infected with Schistosoma mansoni. Carcinogenesis. 14:1993;653-657.
9. 6-Alkylguanine-DNA alkyltransferase activity in schistosomiasis-associated human bladder cancer. Eur. J. Cancer. 30:1994;1314-1319.
10. Badawi A.F., Mostafa M.H., Probert A., O'Connor P.J. Role of schistosomiasis in human bladder cancer: evidence of association and basic mechanisms of carcinogenesis. Eur. J. Cancer Prev. 4:1995;45-59.
11. Badawi A.F. Molecular and genetic events in schistosomiasis-associated human bladder cancer: Role of oncogenes and tumor suppressor genes. Cancer Lett. 105:1996;123-138.
12. Bartsch H., Kuroki T., Malaveille C., Loprieno N., Barale R., Abbondandolo A., Bonatti S., Rainaldi G., Vogel E., Davis A. Absence of mutagenicity of praziquantel, a new, effective, anti-schistosomal drug, in bacteria, yeasts, insects and mammalian cells. Mut. Res. 58:1978;133-142.
13. Bases R. Enhancement of X-ray damage in HeLa cells by exposure to leucanthone (Miracil D) following radiation. Cancer Res. 30:1970;2007-2011.
14. Brunborg G., Soderlund E.J., Holme J.A., Dybing E. Organ-specific and transplacental DNA damage and its repair in rats treated with 1,2-dibromo-3-chloropropane. Chem. Biol. Interact. 101:1996;33-48.
15. Burger H.J., Hauber G., Schlote W., Schwenk M. Comparison of isolated cells from from liver, colon, and kidney of guinea pig. Am. J. Physiol. 248:1985;C271-C278.
16. Cioli D., Pica-Mattoccia L., Rosenberg S., Archer S. Evidence for the mode of antischitosomal action of hycanthone. Life Sci. 37:1985;161-167.
17. Cioli D., Pica-Mattoccia L., Archer S. Antischistosomal drugs: past, present and future? Pharmacol. Therapeut. 68:1995;35-85.
18. Dedek W., Lohs Kh., Fischer G.W., Schmeidt R. Alkylation of guanine in mice in vivo by organophosphorus insecticides. I: Trichlorphone and butonate. Pesticide Biochem. Physiol. 6:1976;101-110.
19. 7-alkylation in mice in vivo by metrifonate: Discussion of possible genotoxic risk in mammals. Acta Phamacol. Toxicol. 49:1981;40-50.
20. El-Hamouly W., Pica-Mattoccia L., Cioli D., Schwartz H.M., Archer S. Studies on some derivatives of oxaminiquine. J. Med. Chem. 31:1988;1629-1631.
21. 6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues. Carcinogenesis. 7:1986;745-749.
22. Haese W.H., Bueding E. Long-term hepatocellular effects of hycanthone and two other antischistosomal drugs in mice oinfected with Schistosoma mansoni. compounds, with particular emphasis on thioxanthenones and benzothiopyranoindazoles. J. Toxicol. Environ. Health. 1:1976;243-270.
23. Hartmen P.E., Hulbert P.B. Genetic activity spectra of some antichistosomal compounds, with particular emphasis on thioxanthenones and benzothiopyranoindazoles. J. Toxicol. Environ. Health. 1:1975;243-270.
24. Hartman P.E. Early years of the Salmonella mutagen tester strains: Lessons from hycanthone. Environ. Mol. Mutagen. 14:1989;39-45.
25. Hall C.N., Badawi A.F., O'Connor P.J., Saffhill R. The detection of alkylation damage innthe DNA of human gastrointestinal tissues. Br. J. Cancer. 64:1991;59-63.
26. Hasegawa T., Hara K., Kenmochi T., Hata S. In vitro metabolism of dorzolamide, a novel potent carbonic anhydrase inhibitor, in rat liver microsomes. Drug Metabol. Disposit. 22:1994;916-921.
27. Holmstedt B., Nordgren I., Sandoz M., Sundwall A. Metrifonate: Summary of toxicological and pharmacological information available. Arch. Toxicol. 41:1978;3-29.
28. International Agency for Research on Cancer (1994) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Schistosomes, liver flukes, and Helicobacter pylori. International Agency for Research on Cancer, IARC, Lyon.
29. Jackson P.E., Hall C.N., Badawi A.F., O'Connor P.J., Cooper D.P., Povey A.C. Frequency of Ki-ras mutations and DNA alkylation in colorectal tissue from individuals living in Manchester. Mol. Carcinogen. 16:1996;12-19.
30. Kaku M., Kusunose E., Yamamoto S., Ichihara K., Kusunose M. Multiple forms of cytochrome P450 in rabbit colon. J. Biochem. 97:1985;663-670.
31. Kirby K.S., Cook E.A. A new method for the isolation of deoxyribonucelic acid. Biochem. J. 66:1957;495-504.
32. Knasmuller S., Kassie F., Zohrer E., Kundi M., McCoy D.G., Schulte-Hermann R. Effects of ethanol treatment on DNA damage induced in Escherichia coli K-12 in various organs of mice by N-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosopyrrolidine. Carcinogenesis. 15:1994;263-270.
33. Kramers P.G.N., Gentile J.M., Gryseels B.J.A.M., Jordan P., Katz N., Mott K.E., Mulvihill J.J., Seed J.L., Forhberg H. ICPEMC Publ. no. 18. Review of the genotoxicity and carcinogenicity of antischistosomal drugs; is there a case for a study of mutation epidemiology. A Report of Task Group on Mutagenic antischistosomals. International Commission for Protection against Environmental Mutagens and Carcinogens. Mut. Res. 257:1991;49-89.
34. Labarca C., Paigen K. A simple and sensitive DNA assay procedure. Anal. Biochem. 102:1980;344-352.
35. Martin R.J. Modes of action of anthelmintic drugs. Vet. J. 154:1997;11-34.
36. O'Connor P.J., Saffhill R., Margison G.P. N-nitroso compounds: Biochemical mechanisms of action. Emmlot P. Environmental Carcinogenesis, Occurrence, Risk Evaluation and Mechanisms. 1979;73-96 Elsevier, Amsterdam.
37. O'Connor P.J. Towards a role for promutagenic lesions in carcinogenesis. Lambert M.W., Laval I. DNA Repair Mechanisms and their Biological Implications in Mammalian Cell. 1989;61-71 Plenum Press, New York.
38. 6-alkylguanine-DNA alkyltransferase: Regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res. 50:1990;6119-6129.
39. Pica-Mattoccia L., Cioli D., Archer S. Binding of tritiated hycanthone and hycanthone N-methylcarbamate to macromolecules of drug-sensitive and drug-resistant schistosomes. Mol. Biochem. Parasitol. 31:1988;87-96.
40. Pica-Mattoccia L., Cioli D., Archer S. Binding of oxaminiquine to the DNA of schistosomes. Trans. R. Soc. Trop. Med. Hyg. 83:1989;373-376.
41. Reen R.K., Ramakanth S., Wiebel F.J., Jain M.P., Singh J. Dealkylation of 7-methylcoumarin as assay for measuring constitutive and phenobarbital-induced cytochrome P-450s. Anal. Biochem. 194:1991;243-249.
42. Rune W., Lofroth G. Formation of 7-methylguanine by dichlorvos in bacteria and mice. Chem. Biol. Interact. 8:1974;339-348.
43. 6-methylguanine in human DNA. IARC Sci Publ. 89:1988;301-305.
44. Sasaki Y.F., Tsuda S., Izumiyama F., Nishidate E. Detection of chemically induced DNA lesions in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow) using the alkaline single cell gel electrophoresis (Comet) assay. Mut. Res. 388:1997;33-44.
45. Soeishi Y., Matsushima H., Teraya Y., Watanabe T., Higuchi S., Kaniwa H. Metabolism of tamsulosin in rat and dog. Xenobiotica. 26:1996;355-365.
46. 6-methylguanine in human blood leukocytes DNA during exposure to procarbazine and its relationship with dose and repair. Cancer Res. 50:1990;2759-2764.
47. Tsuda H., Sarma D.S.R., Rajalakshmi S., Zubroff J., Farber E., Batzinger R.P., Cha Y., Bueding E. Induction of hepatic neoplastic lesions in mice with a single dose of hycanthone methanesulfonate after partial hepatectomy. Cancer Res. 39:1979;4491-4496.
48. 6-methyldeoxyguanosine in oesophageal DNA among individuals at high risk of oesophageal cancer. Int. J. Cancer. 36:1985;53-57.
49. 6-methyl-deoxyguanosine in DNA of cells alkylated in vitro and in vivo. Carcinogenesis. 4:1983;1605-1609.
50. Wooder M.F., Wright A.S., King L.J. In vivo alkylation studies with dichlorvos at practical use concentrations. Chem. Biol. Interact. 19:1977;25-46.
51. World Health Organization (1984) Report of the scientific working group on the biochemistry and chemotherapy of schistosomiasis. Technical Report Series no TDR/SCH-SWG(5)/84.1, WHO, Geneva.
52. Public health impact of schistosomiasis: disease and mortality. Bull. WHO. 71:1993;657 - 662.
53. 6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis. Mut. Res. 145:1985;1-16.
54. Zaidi N.H., Potten C.S., Margison G.P., Cooper D.P., O'Connor P.J. Tissue and cell specific methylation, repair and synthesis of DNA in the upper gastrointestinal tract of Wister rats treated with N-methyl-N'-nitro-N-nitrosoguanidine via the drinking water. Carcinogenesis. 14:1993;1991-2001.