Catalytic antibodies

Current Opinion in Chemical Biology

Volumn 2, Issue 1, 1998, Pages 138-144

  Wentworth Jr , Paul ^a   Janda, Kim D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY;

BIOTECHNOLOGY; CATALYSIS; CHEMISTRY; HUMAN; REVIEW;

ANTIBODIES; BIOTECHNOLOGY; CATALYSIS; HUMANS;

EID: 0031995582     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(98)80046-X     Document Type: Article

References (37)

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4. Blackburn GM, Datta A, Denham H, Wentworth P Jr: Catalytic antibodies. Adv Phys Org Chem 1997, in press. This article provides the most recent comprehensive review to date of catalytic antibodies.
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10. Charbonnier J-P, Golinelli-Pimpaneau B, Gigant B, Tawfik DS, Chap R, Schindler DG, Kim S-H, Green BS, Eshhar Z, Knossow M: Structural convergence in the active sites of a family of catalytic antibodies. Science 1997, 275:1140-1142. This article documents structural analyses of a family of catalyic antibodies.
11. Wirsching P, Ashley JA, Lo C-HL, Janda KD, Lerner RA: Reactive immunization. Science 1995, 270:1775-1782.
12. Lo C-HL, Wentworth P Jr, Jung KW, Yoon J, Ashley JA, Janda KD: Reactive immunization strategy generates antibodies with high catalytic proficiencies. J Am Chem Soc 1997, in press. The utility of the reactive immunization strategy and its ability to elicit antibodies with high catalytic proficiencies is demonstrated in this article.
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14. Lerner RA, Barbas III CF: Using the process of reactive immunisation to induce catalytic antibodies with complex mechanisms: aldolases. Acta Chem Scand 1996, 50:672-678.
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16. Zhong G, Hoffmann T, Lerner RA, Danishefsky S, Barbas CF III: Antibody-catalyzed enantioselective Robinson annulation. J Am Chem Soc 1997, 119:8131-8132. This paper outlines an antibody elicited by reactive immunization in a synthetically interesting transformation.
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18. Janda KD, Lo L-C, Lo C-HL, Sim M-M, Wang R, Wong C-H, Lerner RA: Chemical selection for catalysis in combinatorial antibody libraries. Science 1997, 275:945-948. This article describes a new selection strategy that could have wide applicability for highlighting antibodies for the catalysis of difficult hydrolysis processes.
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21. Weiner DP, Wiemann T, Wolfe MM, Wentworth P Jr, Janda KD: A pentacoordinate oxorhenium(V) metallochelate elicits antibody catalysts for phosphodiester cleavage. J Am Chem Soc 1997, 119:4088-4089. The first example of antibody-catalyzed phosphodiester hydrolysis is reported herein.
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23. Rosenblum JS, Lo L-C, Li T, Janda KD, Lerner RA: Antibody-catalysed phosphate triester hydrolysis. Angew Chem Int Ed 1995, 34:2275-2277.
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25. Lavey BJ, Janda KD: Catalytic antibody mediated hydrolysis of Paraoxon. J Org Chem 1996, 61:7633-7636.
26. Hasserodt J, Janda KD, Lerner RA: Antibody catalyzed terpenoid cyclization. J Am Chem Soc 1996, 118:11654-11655. This article describes the first example of antibody-catalyzed terpenoid cyclization.
27. Li T, Janda KD, Lerner RA: Cationic cyclopropanation by antibody catalysis. Nature 1996, 379:326-327. This article describes the first example of antibody-catalyzed cyclopropanation.
28. Hasserodt J, Janda KD, Lerner RA: Formation of bridge-methylated decalins by antibody-catalyzed tandem cationic cyclization. J Am Chem Soc 1997, 119:5993-5998. This article describes the first example of antibody-catalyzed decalin formation, the product distribution offering a unique insight into the antibody-mediated process.
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31. Wentworth P Jr, Datta A, Blakey D, Boyle T, Partridge LJ, Blackburn GM: Towards antibody directed abzyme prodrug therapy, ADAPT: carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell-killing. Proc Natl Acad Sci USA 1996, 93:799-803. This report describes the most well-developed example of a catalytic antibody with medical potential.
32. Wentworth P Jr, Datta A, Smith S, Marshall A, Partridge LJ, Blackburn GM: Antibody catalysis of BAc2 aryl carbamate ester hydrolysis: a highly disfavored chemical process. J Am Chem Soc 1997, 119:2315-2316. This paper offers compelling kinetic evidence for antibody-catalysis of a highly disfavored reaction.
33. Bahr N, Güller R, Reymond J-L, Lerner RA: A nitroxyl synthase catalytic antibody. J Am Chem Soc 1996, 118:3550-3555.
34. Yli-Kauhaluoma JT, Ashley JA, Lo C-HL, Coakley J, Wirsching P, Janda KD: Catalytic antibodies with peptidyl-prolyl cis-trans isomerase activity. J Am Chem Soc 1996, 118:5496-5497.
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36. Yoon SS, Oei Y, Sweet E, Schultz PG: An antibody-catalyzed [2,3]-elimination reaction. J Am Chem Soc 1996, 118:11686-11687.
37. Zhou ZS, Jiang N, Hilvert D: An antibody-catalyzed selenoxide elimination. J Am Chem Soc 1997, 119:3623-3624.