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Volumn 9, Issue 2, 1998, Pages 109-115

Aminoethyl-isothiourea, a selective inhibitor of inducible nitric oxide synthase activity, improves liver circulation and oxygen metabolism in a porcine model of endotoxemia

Author keywords

[No Author keywords available]

Indexed keywords

AMINOETHYLISOTHIOURONIUM; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE SYNTHASE; OXYGEN; THIOUREA;

EID: 0031989243     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-199802000-00006     Document Type: Article
Times cited : (40)

References (35)
  • 1
    • 0028248331 scopus 로고
    • The role of the L-arginine: Nitric oxide pathway in circulatory shock
    • Thiemermann C: The role of the L-arginine: Nitric oxide pathway in circulatory shock. Adv Pharmacol 28:45-79, 1994.
    • (1994) Adv Pharmacol , vol.28 , pp. 45-79
    • Thiemermann, C.1
  • 2
    • 0029460592 scopus 로고
    • Selective inhibition of the activity of inducible nitric oxide synthase in septic shock
    • Thiemermann C: Selective inhibition of the activity of inducible nitric oxide synthase in septic shock. Prog Clin Biol Res 392:383-392, 1995.
    • (1995) Prog Clin Biol Res , vol.392 , pp. 383-392
    • Thiemermann, C.1
  • 3
    • 0028999596 scopus 로고
    • Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
    • published erratum appears in 1995 Cell 81:1170
    • MacMicking JD, Nathan C, Horn G, et al: Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase [published erratum appears in 1995 Cell 81:1170]. Cell 81:641-650, 1995.
    • (1995) Cell , vol.81 , pp. 641-650
    • MacMicking, J.D.1    Nathan, C.2    Horn, G.3
  • 4
    • 0028848015 scopus 로고
    • Isothioureas: Potent inhibitors of nitric oxide synthases with variable isoform selectivity
    • Southan GJ, Szabo C, Thiemermann C: Isothioureas: Potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br J Pharmacol 114:510-516, 1995.
    • (1995) Br J Pharmacol , vol.114 , pp. 510-516
    • Southan, G.J.1    Szabo, C.2    Thiemermann, C.3
  • 5
    • 0030583291 scopus 로고    scopus 로고
    • Prevention of the expression of inducible nitric oxide synthase by aminoguanidine or aminoethyl-isothiourea in macrophages and in the rat
    • Ruetten H, Thiemermann C: Prevention of the expression of inducible nitric oxide synthase by aminoguanidine or aminoethyl-isothiourea in macrophages and in the rat. Biochem Biophys Res Commun 225:525-530, 1996.
    • (1996) Biochem Biophys Res Commun , vol.225 , pp. 525-530
    • Ruetten, H.1    Thiemermann, C.2
  • 7
    • 0026729192 scopus 로고
    • Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of NO synthesis
    • Meyer J, Traber LD, Nelson S, et al: Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of NO synthesis. J Appl Physiol 73:324-328, 1992.
    • (1992) J Appl Physiol , vol.73 , pp. 324-328
    • Meyer, J.1    Traber, L.D.2    Nelson, S.3
  • 8
    • 33750817896 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibition reduces venous return in porcine endotoxemia
    • Sætre T, Smiseth OA, Scholz T, et al: Nitric oxide synthase inhibition reduces venous return in porcine endotoxemia. Am J Physiol 271:H1325-H1332, 1996.
    • (1996) Am J Physiol , vol.271
    • Sætre, T.1    Smiseth, O.A.2    Scholz, T.3
  • 9
    • 0028855814 scopus 로고
    • Effects of nitric oxide synthase inhibition combined with nitric oxide inhalation in a porcine model of endotoxin shock
    • Klemm P, Thiemermann C, Winklmaier G, Martorana PA, Henning R: Effects of nitric oxide synthase inhibition combined with nitric oxide inhalation in a porcine model of endotoxin shock. Br J Pharmacol 114: 363-368, 1995.
    • (1995) Br J Pharmacol , vol.114 , pp. 363-368
    • Klemm, P.1    Thiemermann, C.2    Winklmaier, G.3    Martorana, P.A.4    Henning, R.5
  • 11
    • 0027402115 scopus 로고
    • Selective inhibition of the inducible nitric oxide synthase by aminoguanidine
    • Misko TP, Moore WM, Kasten TP, et al: Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur J Pharmacol 233:119-125, 1993.
    • (1993) Eur J Pharmacol , vol.233 , pp. 119-125
    • Misko, T.P.1    Moore, W.M.2    Kasten, T.P.3
  • 12
    • 0028577721 scopus 로고
    • Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase
    • Szabo C, Southan GJ, Thiemermann C: Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proc Natl Acad Sci USA 91:12472-12476, 1994.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12472-12476
    • Szabo, C.1    Southan, G.J.2    Thiemermann, C.3
  • 13
    • 0028799424 scopus 로고
    • The multiple organ dysfunction syndrome caused by endotoxin in the rat: Attenuation of liver dysfunction by inhibitors of nitric oxide synthase
    • Thiemermann C, Ruetten H, Wu CC, Vane JR: The multiple organ dysfunction syndrome caused by endotoxin in the rat: Attenuation of liver dysfunction by inhibitors of nitric oxide synthase. Br J Pharmacol 116: 2845-2851, 1995.
    • (1995) Br J Pharmacol , vol.116 , pp. 2845-2851
    • Thiemermann, C.1    Ruetten, H.2    Wu, C.C.3    Vane, J.R.4
  • 14
    • 0023244887 scopus 로고
    • Systemic and regional hemodynamic changes after intraperitoneal endotoxin in rabbits: Development of a new model of the clinical syndrome of hyperdynamic sepsis
    • Fink MP, Fiallo V, Stein KL, Gardiner WM: Systemic and regional hemodynamic changes after intraperitoneal endotoxin in rabbits: Development of a new model of the clinical syndrome of hyperdynamic sepsis. Circ Shock 22:73-81, 1987.
    • (1987) Circ Shock , vol.22 , pp. 73-81
    • Fink, M.P.1    Fiallo, V.2    Stein, K.L.3    Gardiner, W.M.4
  • 15
    • 0027920980 scopus 로고
    • Pathogenetic mechanisms of septic shock
    • Parrillo JE: Pathogenetic mechanisms of septic shock [see comments]. N Engl J Med 328:1471-1477, 1993.
    • (1993) N Engl J Med , vol.328 , pp. 1471-1477
    • Parrillo, J.E.1
  • 17
    • 0029888272 scopus 로고    scopus 로고
    • Oxygen delivery and consumption during sepsis
    • Chittock DR, Russell JA: Oxygen delivery and consumption during sepsis. Clin Chest Med 17:263-278, 1996.
    • (1996) Clin Chest Med , vol.17 , pp. 263-278
    • Chittock, D.R.1    Russell, J.A.2
  • 19
    • 0025925235 scopus 로고
    • G-monomefhyl-L-arginine (NMA) restores arterial blood pressure but reduces cardiac output in a canine model of endotoxic shock
    • G-monomefhyl-L-arginine (NMA) restores arterial blood pressure but reduces cardiac output in a canine model of endotoxic shock. Biochem Biophys Res Commun 178:1135-1140, 1991.
    • (1991) Biochem Biophys Res Commun , vol.178 , pp. 1135-1140
    • Klabunde, R.E.1    Ritger, R.C.2
  • 21
    • 0028061310 scopus 로고
    • Role of nitric oxide in the regulation of oxygen consumption in conscious dogs
    • Shen W, Xu X, Ochoa M, Zhao G, Wolin MS, Hintze TH: Role of nitric oxide in the regulation of oxygen consumption in conscious dogs. Circ Res 75:1086-1095, 1994.
    • (1994) Circ Res , vol.75 , pp. 1086-1095
    • Shen, W.1    Xu, X.2    Ochoa, M.3    Zhao, G.4    Wolin, M.S.5    Hintze, T.H.6
  • 22
    • 0029081364 scopus 로고
    • Sodium nitroprusside does not influence tissue oxygen extraction capabilities during a critical reduction in oxygen delivery
    • Zhang H, Nguyen DN, Spapen H, Moock M, Maciel F, Vincent JL: Sodium nitroprusside does not influence tissue oxygen extraction capabilities during a critical reduction in oxygen delivery. Cardiovasc Res 30:240-245, 1995.
    • (1995) Cardiovasc Res , vol.30 , pp. 240-245
    • Zhang, H.1    Nguyen, D.N.2    Spapen, H.3    Moock, M.4    Maciel, F.5    Vincent, J.L.6
  • 24
    • 0029934194 scopus 로고    scopus 로고
    • Role of poly ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite
    • Szabo C, Zingarelli B, Salzman AL: Role of poly ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite. Circ Res 78: 1051-1063, 1996.
    • (1996) Circ Res , vol.78 , pp. 1051-1063
    • Szabo, C.1    Zingarelli, B.2    Salzman, A.L.3
  • 25
    • 0026602489 scopus 로고
    • Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis
    • Hotchkiss RS, Karl IE: Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis. J Am Med Assoc 267:1503-1510, 1992.
    • (1992) J Am Med Assoc , vol.267 , pp. 1503-1510
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 26
    • 0027414224 scopus 로고
    • Hepatic microvasculature: Dynamic structure and its regulation
    • McCuskey RS, Reilly FD: Hepatic microvasculature: Dynamic structure and its regulation. Semin Liver Dis 13:1-12, 1993.
    • (1993) Semin Liver Dis , vol.13 , pp. 1-12
    • McCuskey, R.S.1    Reilly, F.D.2
  • 27
    • 0028254620 scopus 로고
    • Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia
    • Nishida J, McCuskey RS, McDonnell D, Fox ES: Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia. Am J Physiol 267:G1135-G1141, 1994.
    • (1994) Am J Physiol , vol.267
    • Nishida, J.1    McCuskey, R.S.2    McDonnell, D.3    Fox, E.S.4
  • 28
    • 0028722015 scopus 로고
    • Inhibition of endothelium-dependent vasodilation by Escherichia coli endotoxemia
    • Parker JL, Myers PR, Zhong Q, Kim K, Adams HR: Inhibition of endothelium-dependent vasodilation by Escherichia coli endotoxemia. Shock 2:451-458, 1994.
    • (1994) Shock , vol.2 , pp. 451-458
    • Parker, J.L.1    Myers, P.R.2    Zhong, Q.3    Kim, K.4    Adams, H.R.5
  • 29
    • 0030032721 scopus 로고    scopus 로고
    • Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform
    • Southan GJ, Zingarelli B, O'Connor M, Salzman AL, Szabo C: Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform. Br J Pharmacol 117:619-632, 1996.
    • (1996) Br J Pharmacol , vol.117 , pp. 619-632
    • Southan, G.J.1    Zingarelli, B.2    O'Connor, M.3    Salzman, A.L.4    Szabo, C.5
  • 31
    • 0027411110 scopus 로고
    • Adequacy of gut oxygenation in endotoxemia and sepsis
    • Fink MP: Adequacy of gut oxygenation in endotoxemia and sepsis. Crit Care Med 21(Suppl):S4-S8, 1993.
    • (1993) Crit Care Med , vol.21 , Issue.SUPPL.
    • Fink, M.P.1
  • 32
    • 0029842220 scopus 로고    scopus 로고
    • The NO donor sodium nitroprusside reverses the negative effect on hepatic arterial flow induced by endotoxin and the NO synthase inhibitor L-NAME
    • Gundersen Y, Sætre T, Scholz T, Carlsen H, Kjekshus H, Smiseth AO: The NO donor sodium nitroprusside reverses the negative effect on hepatic arterial flow induced by endotoxin and the NO synthase inhibitor L-NAME. Eur Surg Res 28:323-332, 1996.
    • (1996) Eur Surg Res , vol.28 , pp. 323-332
    • Gundersen, Y.1    Sætre, T.2    Scholz, T.3    Carlsen, H.4    Kjekshus, H.5    Smiseth, A.O.6
  • 33
    • 0027947675 scopus 로고
    • New insights into the regulation of inducible nitric oxide synthesis
    • Morris SM Jr, Billiar TR: New insights into the regulation of inducible nitric oxide synthesis. Am J Physiol 266:E829-E839, 1994.
    • (1994) Am J Physiol , vol.266
    • Morris S.M., Jr.1    Billiar, T.R.2
  • 34
    • 0025189864 scopus 로고
    • Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
    • Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA: Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87: 1620-1624, 1990.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1620-1624
    • Beckman, J.S.1    Beckman, T.W.2    Chen, J.3    Marshall, P.A.4    Freeman, B.A.5
  • 35
    • 0030026515 scopus 로고    scopus 로고
    • Peroxynitrite-mediated DNA strand breakage activates poly adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide
    • Zingarelli B, O'Connor M, Wong H, Salzman AL, Szabo C: Peroxynitrite-mediated DNA strand breakage activates poly adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide. J Immunol 156:350-358, 1996.
    • (1996) J Immunol , vol.156 , pp. 350-358
    • Zingarelli, B.1    O'Connor, M.2    Wong, H.3    Salzman, A.L.4    Szabo, C.5


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