The NO donor sodium nitroprusside reverses the negative effects on hepatic arterial flow induced by endotoxin and the no synthase inhibitor L-NAME

European Surgical Research

Volumn 28, Issue 5, 1996, Pages 323-332

  Gundersen, Y ^a,b   Saetre T ^a,b   Scholz, T ^a,b   Carlsen, H ^a,b   Kjekshus, H ^a,b   Smiseth, O A ^a,b   Lilleaasen, P ^a,b   Aasen, A O ^a,b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Endotoxemia; Hepatic arterial buffer response; Hepatic blood flow; Liver circulation; Nitric oxide; Sepsis; Sodium nitroprusside

Indexed keywords

ENDOTOXIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM;

ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLE; ARTERY BLOOD FLOW; ARTERY RESISTANCE; ARTICLE; ENDOTOXEMIA; FEMALE; HEART OUTPUT; LIVER BLOOD FLOW; LIVER CIRCULATION; MALE; NONHUMAN; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; SEPSIS; SWINE;

EID: 0029842220     PISSN: 0014312X     EISSN: 14219921     Source Type: Journal    
DOI: 10.1159/000129473     Document Type: Article

References (36)

1. Parrillo JE: Pathogenetic mechanisms of septic shock. N Engl J Med 1993;328:1471-1477.
2. Kilbourn RG, Gross SS, Jubran A, Adams J, Griffith OW, Levi R, Lodato RF: Ng-methyl-L-argininc inhibits tumor necrosis factor-induced hypotension: Implications for the involvement of nitric oxide. Proc Natl Acad Sei USA 1990:8:3629-3632.
3. Evans T, Carpenter A, Kinderman H, Cohen J: Evidence of increased nitric oxide production in patients with the sepsis syndrome. Circ Shock 1993;41:77-81.
4. Preiser JC, Zhang H, Wachel D, Boeynaems JM, Buurman W, Vincent J-L: Is endotoxin-induced hypotension related to nitric oxide formation? Eur Surg Res 1994:26:10-18.
5. Matuschak GM, Mattingly ME, Tredway TL, Lechner AJ: Liver-lung interactions during E. coli en-dotoxemia: TNF-alpha:lcukotricnc axis. Am J Rcspir Crit Care Med 1994;149:41-49.
6. Lautt WW, Legare DJ, d'Almeida MS: Adenosine as putative regulator of hepatic arterial flow (the hepatic arterial buffer response). Am J Physiol 1985; 248:H331-H338.
7. Matuschak GM, Rinaldo JE: Organ interactions in the adult respiratory distress syndrome during sepsis: Role of the liver in host defense. Chest 1988; 94:400-406.
8. Parker JL. Myers PR, Zhong Q, Kim K, Adams HR: Inhibition of endothelium-dependent vasodilation by Escherichia coli endotox-emia. Shock 1994; 2:451-458.
9. Moncada S, Higgs A: The L-argi-nine-nitric oxide pathway. N Engl J Med 1993;329:2002-2012.
10. Vane JR, Änggärd EE, Bolting RM: Regulatory functions of the vascular endothelium. N Engl J Med 1990: 323:27-36.
11. Nishida J, McCuskey RS, McDonnell D, Fox ES: Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia. Am J Physiol 1994;267:G1135-G1141.
12. Stadler J, Billiar TR, Curran RD, Stuehr DJ, Ochoa JB, Simmons RL: Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes. Am J Physiol 1991;260:C910-C916.
13. Nava E, Palmer RMJ, Moncada S: Inhibition of nitric oxide synthesis in septic shock: How much is beneficial? Lancet 1991:338:1555-1557.
14. Wright CE, Rees DD, Moncada S: Protective and pathological roles of nitric oxide in endotoxin shock. Cardiovasc Res 1992;26:48-57.
15. Meyer J, Traber LD, Neson S, Lentz CW, Nakazawa H, Herndon DN, Noda H, Traber DL: Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of NO synthesis. J Appl Physiol 1992;73:324-328.
16. Traber DL, Adair TH, Adams T: Hemodynamic consequences of endotoxemia in sheep. Circ Shock 1981;8:551-561.
17. Fink MP, Antonsson JB. Wang H. Rothschild HR: Etiology of increased intestinal permeability in endotoxic pigs: Limited role for mesenteric hypoperfusion. Arch Surg 1991;126:211-218.
18. Voerman H, Stchouwer C, van Kamp G, van Schijndel J, Groene-veld A, Thijs L: Plasma cndothclin levels are increased during septic shock. Crit Care Med 1992;20: 1097-1101.
19. McCuskey RS: Hepatic microvascular response to endotoxemia and sepsis: in Messmer K. Mcngcr MD (eds): Liver Microcirculation and Hepatobiliary Function. Prog Appl Microcirc. Basel. Karger. 1993, vol 19, pp 76-84.
20. Nordstoga K, Aasen AO: Hepatic changes in late canine endotoxin shock: A light and electron microscopic investigation. Acta Pathol Microbiol Scand 1979:87:335-346.
21. Kawada N, Tran-Thi T, Klein H, Decker K: The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances: Possible involvement of endothclin and nitric oxide in the regulation of sinusoidal tonus. Eur J Biochem 1993:213: 815-823.
22. McCuskey RS, Reilly FD: Hepatic microvasculature: Dynamic structure and its regulation, Semin Liver Dis 1993:13:1-12.
23. Lautt WW, Greenway CV, Legare DJ: Localization of intrahepatic vascular resistance. Am J Physicl 1986: 25L G375-G381.
24. Lautt WW, Legare DJ: Passive auloregulation of portal venous pressure: Distensible hepatic resistance. Am J Physiol 1992;263:G702-G708.
25. Goresky CA: Cell membrane transport processes: Their role in hepatic uptake; in Aries I. Popper H, Schacter D, Schafritz DA (cds): The Liver: Biology and Pathobiology. New York, Raven Press. 1982. pp 581-599.
26. Lainc GA, Hall JT, Laine SH, Granger HJ: Transsinusoidal fluid dynamics in canine liver during venous hypertension. Circ Res 1979; 45:317-323.
27. Kubes P, Granger DN: Nitric oxide modulates microvascular permeability. Am J Physiol 1992;262: H611-H615.
28. Lautt WW: Mechanism and role of intrinsic regulation of hepatic arterial blood flow': hepatic arterial buffer response. Am J Physiol 1985;249: G549-G556.
29. Schiffer ERC, Mentha G, Schwieger IM, Morel DR: Sequential changes in the splanchnic circulation during continuous endotoxin infusion in sedated sheep: Evidenve for a selective increase of hepatic artery blood flow and loss of the hepatic arterial buffer response. Acta Physiol Scand 1993;147:251-261.
30. Ayuse T, Brienza N, Revelly J, O'Donnell CP, Boitnott JK, Robotham JL: Alterations in liver hemodynamics in an intact porcine model of endotoxin shock. Am J Physiol 1995; 268:H1106-H1114.
31. Berne RM: The role of adenosine in the regulation of coronary blood flow. Circ Res 1980:47:807-813.
32. Ralevic V, Burnstock G: Roles of P-purinoceptors in the cardiovascular system. Circulation 1991:84: 1-13.
33. Parker JL, Adams HR: Selective inhibition of endothelium-dependent vasodilator capacity by Escherichia coli endotoxemia. Circ Res 1993:72: 539-551.
34. Halvorsen L, Roth R, Gunther RA, Firoozmand E, Buoncristiani AM. Kramer GC: Liver hemodynamics during portal venous endotoxemia in swine. Circ Shock 1993:41:166-175.
35. Wang Y, Mathews WR, Guido DM, Farhood A, Jaeschke H: Inhibition of nitric oxide synthesis aggravates reperfusion injury after hepatic ischemia and endotoxemia. Shock 1995: 4:282-288.
36. McKie LD, Bass BL, Dunkin BJ, Harmon JW: Nitric oxide mediates the blood flow response to intravenous adenosine in the rabbit. Circ Shock 1994; 43:103-106.