Synthesis of duocarmycin SA by way of methyl 4-(Methoxycarbonyl)oxy-3H- pyrrolo[3,2-f]quinoline-2-carboxylate as a tricyclic heteroaromatic intermediate

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 3, 1998, Pages 400-412

  Muratake, Hideaki ^a   Tonegawa, Miyuki ^a   Natsume, Mitsutaka ^a  

^a Kawasaki   (Japan)

Author keywords

Duocarmycin SA; Formal synthesis; Methyl ketone arylation; Palladium catalyzed reaction; Potent antitumor substance; Stille reaction

Indexed keywords

4 (METHOXYCARBONYL)OXY 3H PYRROLO[3,2]QUINOLINE 2 CARBOXYLIC ACID METHYL ESTER; CARBOXYLIC ACID DERIVATIVE; DUOCARMYCIN A; TRICYCLIC AROMATIC COMPOUND; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COUPLING FACTOR; DRUG SYNTHESIS; EPOXIDATION; HYDROGEN BOND; HYDROXYLATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS;

EID: 0031978519     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.400     Document Type: Article

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