Mutations in the MHC Class II Binding Domains of Staphylococcal Enterotoxin A Differentially Affect T Cell Receptor Vβ Specificity

Journal of Immunology

Volumn 157, Issue 9, 1996, Pages 3988-3994

  Newton, Duane W ^a,b   Dohlsten, Mikael ^c   Olsson, Christina ^c   Segrén, Sverker ^c   Lundin, Knut E A ^d   Lando, Peter A ^c   Kalland, Terje ^c   Kotb, Malak ^a,b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c Pharmacia & Upjohn AB   (Sweden)

^d UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; ENTEROTOXIN; ENTEROTOXIN A, STAPHYLOCOCCAL; HLA D ANTIGEN; HYBRID PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; SUPERANTIGEN;

ARTICLE; BINDING SITE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CLONE; CHEMISTRY; COMPARATIVE STUDY; GENETICS; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PROTEIN BINDING; SITE DIRECTED MUTAGENESIS; STAPHYLOCOCCUS AUREUS;

ANTIGENS, BACTERIAL; BINDING SITES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CLONE CELLS; ENTEROTOXINS; HLA-D ANTIGENS; HUMANS; LYMPHOCYTE ACTIVATION; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECOMBINANT FUSION PROTEINS; STAPHYLOCOCCUS AUREUS; SUPERANTIGENS;

EID: 0030293453     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Marrack, P., and J. Kappler. 1990. The staphylococcal enterotoxins and their relatives. Science 248:705.
2. Herman, A., J. Kappler, P. Marrack, and A. Pullen. 1991. Superantigens: mechanism of T-cell stimulation and role in immune responses. Ann. Rev. Immunol. 9:745.
3. Janeway, C., S. Rath, and J. Yagi. 1991. V beta selective elements: self and nonself. Behring Inst. Mitt. 88:177.
4. Irwin, M., K. Hudson, K. Ames, J. Fraser, and N. Gascoigne. 1993. T cell receptor beta-chain binding to enterotoxin superantigens. Immunol. Rev. 131:61.
5. Mollick, J., R. Cook, and R. Rich. 1989. Class II MHC molecules are specific receptors for staphylococcal enterotoxin A. Science 244:817.
6. Dellabona, P., J. Peccoud, J. Kappler, P. Marrack, C. Benoist, and D. Mathis. 1990. Superantigens interact with MHC class II molecules outside of the antigen groove. Cell 62:1115.
7. Panina-Bordignon, P., X. Fu, A. Lanzavecchia, and R. Karr. 1992. Identification of HLA-DRα chain residues critical for binding of the toxic shock syndrome toxin superantigen. J. Exp. Med. 176:1779.
8. Karp, D. 1993. Analyses of the staphylococcal toxin binding sites on MHC class II molecules. Res. Immunol. 144:181.
9. Kotb, M. 1995. Bacterial pyrogenic exotoxins as superantigens. Clin. Microbiol. Rev. 8-411.
10. Andersson, J., S. Nagy, L. Bjork, J. Abrams, S. Holm, and U. Andersson. 1992. Bacterial toxin-induced cytokine production studied at the single-cell level. Immunol. Rev. 127:69.
11. Johnson, H., J. Russell, and C. Pontzer. 1992. Superantigens in human disease. Sci. Am. 266:92.
12. Kotzin, B., D. Leung, J. Kappler, and P. Marrack. 1993. Superantigens and their potential role in human disease. Adv. Immunol. 54:99.
13. Schlievert, P. 1993. Role of superantigens in human diseases. J. Infect. Dis. 167:997.
14. Kotb, M. 1992. Role of superantigens in the pathogenesis of infectious diseases and their sequelae. Curr. Opin. Infect. Dis. 5:364.
15. Kotb, M. 1994. Infection and autoimmunity: a story of the host, the pathogen, and the co-pathogen. Clin. Immunol. Immunopathol. 74:10.
16. Dohlsten, M., G. Hedlund, and T. Kalland. 1991. Staphylococcal-enterotoxin-dependent cell-mediated cytotoxicity. Immunol. Today 12:147.
17. Pontzer, C., J. Russell, and H. Johnson. 1989. Localization of an immune functional site on staphylococcal enterotoxin A using the synthetic peptide approach. J. Immunol. 143:280.
18. Hedlund, G., M. Dohlsten, T. Herrmann, G. Buell, P. A. Lando, S. Segrén, J. Schrimsher, H. MacDonald, H. Sjögren, and T. Kalland. 1991. A recombinant C-terminal fragment of staphylococcal enterotoxin A binds to human MHC class II products but does not activate T cells. J. Immunol. 147:4082.
19. Pontzer, C., J. Russell, and H. Johnson. 1991. Structural basis for differential binding of staphylococcal enterotoxin A and toxic shock syndrome toxin 1 to class II major histocompatibility molecules. Proc. Natl. Acad. Sci. USA 88: 125.
20. Hudson, K., H. Robinson, and J. Fraser. 1993. Two adjacent residues in staphylococcal enterotoxins A and E determine T cell receptor Vβ specificity. J. Exp. Med. 177:175.
21. Abrahmsén, L., M. Dohlsten, S. Segrén, P. Björk, E. Jonsson, and T. Kalland. 1995. Characterization of two distinct MHC class II binding sites in the superantigen staphylococcal enterotoxin A. EMBO J. 14:2978.
22. Hudson, K., R. Tiedemann, R. Urban, S. Lowe, J. Strominger, and J. Fraser. 1995. Staphylococcal enterotoxin A has two cooperative binding sites on major histocompatibility complex class II. J. Exp. Med. 182:711.
23. Kozono, H., D. Parker, J. White, P. Marrack, and J. Kappler. 1995. Multiple binding sites for bacterial superantigens on soluble class II MHC molecules. Immunity 3:187.
24. Irwin, M., K. Hudson, J. Fraser, and N. Gascoigne. 1992. Enterotoxin residues determining T-cell receptor Vβ binding specificity. Nature 359:841.
25. Mollick, J., R. McMasters, D. Grossman, and R. Rich. 1993. Localization of a site on bacterial superantigens that determines T cell receptor β chain specificity. J. Exp. Med. 177:283.
26. Harris, T., D. Grossman, J. Kappler, P. Marrack, R. Rich, and M. Betley. 1993. Lack of complete correlation between emetic and T-cell-stimulatory activities of staphylococcal enterotoxins. Infect. Immun. 61:3175.
27. Harris, T., and M. Betley 1993. Biological activities of staphylococcal enterotoxin type A mutants with N-terminal substitutions. Infect. Immun. 63:2133.
28. Hoffman, M., M. Tremaine, J. Mansfield, and M. Betley. 1996. Biochemical and mutational analysis of the histidine residues of staphylococcal enterotoxin A. Infect. Immun. 64:885.
29. Kotb, M., R. Watanabe-Ohnishi, B. Wang, M. Tomai, H L. Le Gros, P. Schlievert, M. El Demellawy, and A. Geller. 1993. Analysis of the TCR Vβ specificities of bacterial superantigens using PCR. Immunomethods 2:33.
30. Tomai, M., J. Aelion, M. Dockter, G. Majumdar, D. Spinella, and M. Kotb. 1991. T cell receptor V gene usage by human T cells stimulated with the superantigen streptococcal M protein. J. Exp. Med. 174:285.
31. Lundin, K. E. A., J. E. Brinchmann, and T. Hansen. 1994. Interactions between staphylococcal superantigens and human T cell clones are predominantly but not exclusively governed by their T cell receptor Vβ usage. Scand. J. Immunol. 39:387.
32. Surman, S., A. Deckhut, M. Blackman, and D. Woodland. 1994. MHC-specific recognition of a bacterial superantigen by weakly reactive T cells. J. Immunol. 152:4893.
33. Daly, K., P. Nguyen, D. Hankley, W. Zhang, D. Woodland, and M. Blackman. 1995. Contribution of the TCR alpha-chain to the differential recognition of bacterial and retroviral superantigens. J. Immunol. 155:27.
34. Fraser, J., R. Urban, J. Strominger, and H. Robinson. 1992. Zin c regulates the function of two superantigens. Proc. Natl. Acad. Sci. USA 89:5507.
35. Karp, D., and E. Long. 1992. Identification of HLA-DR1 beta chain residues critical for binding staphylococcal enterotoxins A and E. J. Exp. Med. 175: 415.
36. Schad, E., I. Zaitseva, V. Zaitsev, M. Dohlsten, T. Kalland, P. Schlievert, D. Ohlendorf, and L. Svensson. 1995. Crystal structure of the superantigen staphylococcal enterotoxin type A. EMBO J. 14:3292.
37. Kappler, J., A. Herman, J. Clements, and P. Marrack. 1992. Mutations defining functional regions of the superantigen staphylococcal enterotoxin B. J. Exp. Med. 175:387.
38. Swaminathan, S., W. Furey, J. Pletcher, and M. Sax. 1992. Crystal structure of staphylococcal enterotoxin B, a superantigen. Nature 359:801.
39. Jardetzky, T., J. Brown, J. Gorga, J. Stern, R. Urban, Y. Chi, C. Stauffacher. J. Strominger, and D. Wiley. 1994. Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen. Nature 368:711.
40. Kotb, M., G. Majumdar, M. Tomai, and E. Beachey. 1990. Accessory cell-independent stimulation of human T cells by streptococcal M protein superantigen. J. Immunol. 145:1332.
41. O'Heir, R., and J. Lamb. 1990. Induction of specific clonal anergy in human T lymphocytes by Staphylococcus aureus enterotoxins. Proc. Natl. Acad. Sci. USA 87:8884.
42. Ohnishi, H., T. Tanaka, J. Takahara, and M. Kotb. 1993. CD28 delivers costimulatory signals for superantigen-induced activation of antigen-presenting cell-depleted human T lymphocytes. J. Immunol. 150:3207.
43. Lando, P., M. Dohlsten, G. Hedlund, T. Brodin, D. Sansom, and T. Kalland. 1993. Co-stimulation with B7 and targeted superantigen is required for MHC class II-independent T-cell proliferation but not cytotoxicity. Immunology 80: 236.
44. Seth, A., L. Stern, T. H. M. Ottenhoff, I. Engel, M. Owen, J. Lamb, R. Klausner, and D. Wiley. 1994. Binary and ternary complexes between T cell receptor, class II MHC and superantigen in vitro. Nature 369:324.
45. Ohnishi, H., J. Ledbetter, S. Kanner, P. Linsley, T. Tanaka, A. Geller, and M. Kotb. 1995. CD28 cross-linking augments TCR-mediated signals and co-stimulates superantigen responses. J. Immunol. 154:3180.
46. Green, J., L. Turka, C. June, and C. Thompson. 1992. CD28 and staphylococcal enterotoxins synergize to induce MHC-independent T cell proliferation. Cell. Immunol. 145:11.
47. Grossman, D., M. Van, J. Mollick, S. Highlander, and R. Rich. 1991. Mutation of the disulfide loop in staphylococcal enterotoxin A: consequences for T cell recognition. J. Immunol. 147:3274.
48. Fraser, J., S. Lowe, M. Irwin, N. Gascoigne, and K. Hudson. 1993. Structural model of staphylococcal enterotoxin A interaction with MHC class II antigens. In Current Communications in Cell and Molecular Biology, B. Huber and E. Palmer, eds. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. p. 7.
49. Wen, R., M. Blackman, and D. Woodland. 1995. Variable influence of MHC polymorphism on the recognition of bacterial superantigens by T cells. J. Immunol. 155:1884.
50. Malchiodi, E., E. Eisenstein, B. Fields, D. Ohlendorf, P. Schlievert, K. Karjalainen, and R. Mariuzza. 1995. Superantigen binding to a T cell receptor β chain of known three-dimensional structure. J. Exp. Med. 182:1833.
51. 2 trimers in solution. Proc. Natl. Acad. Sci. USA 92:12156.