Improving 5-FU with A Novel Dihydropyrimidine Dehydrogenase Inactivator

ONCOLOGY

Volumn 12, Issue 3 SUPPL. 4, 1998, Pages 51-56

  Diasio, Robert B ^a  

^a University of Alabama at Birmingham ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 ETHYNYLURACIL; DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROURACIL;

ANTINEOPLASTIC ACTIVITY; BONE MARROW TOXICITY; CANCER CHEMOTHERAPY; CIRCADIAN RHYTHM; CLINICAL TRIAL; DRUG BIOAVAILABILITY; DRUG POTENTIATION; DRUG RESISTANCE; GASTROINTESTINAL TOXICITY; HEALTH ECONOMICS; HUMAN; NONHUMAN; ORAL DRUG ADMINISTRATION; PRACTICE GUIDELINE; QUALITY OF LIFE; REVIEW; VASCULAR ACCESS;

ANTIMETABOLITES, ANTINEOPLASTIC; CLINICAL TRIALS; DIHYDROURACIL DEHYDROGENASE (NADP); DRUG SYNERGISM; ENZYME INHIBITORS; FLUOROURACIL; HUMANS; OXIDOREDUCTASES; URACIL;

EID: 0031971045     PISSN: 08909091     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Daher GC, Harris BE, Diasio RB: Metabolism of pyrimidine analogues and their nucleosides, in Powis, G (ed): The International Encyclopedia of Pharmacology and Therapeutics. Oxford, Pergamon Press, 1994.
2. Diasio RB, Harris BE: Clinical pharmacology of 5-fluorouracil. Clin Pharmacokinet 16:215-237, 1989.
3. Lu Z-H, Zhang R, Diasio RB: Purification and characterization of dihydropyrimidine dehydrogenase from human liver. J Biol Chem 267:17102-17109, 1992.
4. Van J, Tyring SK, McCrary MM, et al: The effect of sorivudine on dihydropyrimidine dehydrogenase activity in patients with acute herpes zoster. Clin Pharmacol Ther 61:563-573, 1997.
5. Johnson MJ, Yan J, Albin N, et al: Rapid screening for dihydropyrimidine dehydrogenase (DPD) deficiency, a condition associated with 5-fluorouracil toxicity. J Chromatogr Biomed Appl 696:183-191, 1997.
6. Harris BE, Song R, He Y, et al: Circadian rhythm of rat liver dihydropyrimidine dehydrogenase: Possible relevance to fluoropyrimidine chemotherapy. Biochem Pharm 37:4759-4763, 1988.
7. Harris BE, Song R, Soong S-J, et al. Circadian variation of 5-fluorouracil catabolism in isolated perfused rat liver. Cancer Res 49, 6610-6614, 1989.
8. Harris BE, Song R, Soong SJ, et al: Relationship of dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels: Evidence for circadian variation of 5-fluorouracil levels in cancer patients receiving protracted continuous infusion. Cancer Res 50: 197-201, 1990.
9. Zhang R, Diasio RB. Pharmacologic basis for circadian pharmacodynamics. in Hrushesky WJM (ed): The Scientific Basis for Optimized Cancer Therapy. Boca Raton, CRC Press, 1994.
10. Lu Z, Zhang R, Diasio RB: Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver. Population characteristics, newly identified patients, and clinical implication in 5-fluorouracil chemotherapy. Cancer Res 53:5433-5438, 1993.
11. Lu Z, Zhang R, Diasio RB: Dihydropyrimidine dehydrogenase activity in human liver: Population characteristics and clinical implication in 5-FU chemotherapy. Clin Pharmacol Ther 58: 512-522, 1995.
12. Heggie GD, Sommadossi JP, Cross DS, et al: Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile. Cancer Res 47:2203-2206, 1987.
13. Diasio RB, Beavers TL, Carpenter JT: Familial deficiency of dihydropyrimidine dehydrogenase: Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity. J Clin Invest 81:47-51, 1988
14. Harris BE, Carpenter JT, Diasio RB. Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency: A potentially more common pharmacogenetic syndrome. Cancer 68:499-501, 1991.
15. Takimoto CH, Lu Z-H, Zhang R, et al: Severe neurotoxicity following 5 fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency. Clin Cancer Res 2: 477-481, 1996.
16. Lu Z, Diasio RB: Polymorphic Drug metabolizing enzymes, in Schilsky RL, Milano GA, Ratain MJ (eds): Principles of Antineoplastic Drug Development and Pharmacology. New York, Marcel Dekker, 1996
17. Baccanari DP, Davis ST, Knick VC, et al: 5-Ethynyluracil: Effects on the pharmacokinetics and antitumor activity of 5-fluorouracil. Proc Natl Acad Scr 90: 11064-11068, 1993.
18. Jiang W, Lu Z, He Y, et al: Dihydropyrimidine dehydrogenase activity in hepatocellular carcinoma; Implication for 5-fluorouracil-based chemotherapy. Clin Cancer Res 3:395-399, 1997.
19. Naguib FNM, el Kouni MH, Cha S: Enzymes of uracil catabolism in normal and neoplastic human tissues. Cancer Res 45:5405-5412, 1985.
20. Spector T, Harrington JA, Porter DJT: 5-Ethynyluracil: Inactivation of dihydropyrimidine dehydrogenase in vivo. Biochem Pharmacol 46.2243-2248, 1993.
21. Cao S, Rustum YM, Spector T: 5-Ethynyluracil (776C85) Modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal cancer. Cancer Res 54:1507-1510, 1994.
22. Spector T, Porter DJT, Nelson DJ, et al: 5-Ethynyluracil (776C85), a modulator of the therapeutic activity of 5-fluorouracil. Drugs Future 19:566-571, 1994.
23. Paff MT, De La Mata MA, Nelson DJ: Pharmacokinetics and metabolism of 5-ethynyluracil, an inhibitor of 5-fluorouracil in catabolism of CD-1 mice. Proc Am Assoc Can Res 35:321, 1994.
24. Baker SD, Khor SP, Adjei AA, et al: Pharmacokinetics, oral bioavailability, and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase. J Clin Oncol 14:3085-3096, 1996.
25. Schilsky RL, Burris H, Ratain M, et al: Phase I clinical and pharmacologic study of 776C85 plus 5-fluorouracil in patients with advanced cancer. J Clin Oncol, 1998 (in press)