Investigation of the genes for RET and its ligand complex, GDNF/GFRα- 1, in small cell lung carcinoma

Genes Chromosomes and Cancer

Volumn 21, Issue 4, 1998, Pages 326-332

  Mulligan, Lois M ^a   Timmer, Tineke ^b   Ivanchuk, Stacey M ^a   Campling, Barbara G ^a   Young, Leah C ^a   Rabbitts, Pamela H ^c   Sundaresan, Vasi ^c   Hofstra, Robert M W ^b   Eng, Charis ^d  

^a QUEEN S UNIVERSITY   (Canada)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; LIGAND; MESSENGER RNA; PROTEIN TYROSINE KINASE; RECEPTOR;

ARTICLE; CONTROLLED STUDY; DENATURING GRADIENT GEL ELECTROPHORESIS; ENZYME ACTIVATION; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; LUNG SMALL CELL CANCER; MITOGENESIS; MULTIPLE ENDOCRINE NEOPLASIA; NEUROENDOCRINE TUMOR; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; PROTO ONCOGENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYROID MEDULLARY CARCINOMA;

CARCINOMA, SMALL CELL; DNA PRIMERS; DNA, NEOPLASM; DROSOPHILA PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; HUMANS; LIGANDS; LUNG NEOPLASMS; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; RNA, NEOPLASM; SEQUENCE ANALYSIS, DNA; TUMOR CELLS, CULTURED;

EID: 0031960348     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199804)21:4<326::AID-GCC6>3.0.CO;2-0     Document Type: Article

References (63)

1. Asai N, Iwashita T, Matsuyama M, Takahashi M (1995) Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations. Mol Cell Biol 15:1613-1619.
2. Avantaggiato V, Dathan N, Grieco M, Fabien N, Lazzaro D, Fusco A, Simeone A, Santoro M (1994) Developmental expression of the RET protooncogene. Cell Growth Differ 5:305-311.
3. Baloh RH, Tamsey MG, Golden JP, Creedon DJ, Heuckeroth RO, Keek CL, Zimonjic DB, Popeseu NC, Johnson KM, Milbrandt J (1997) TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Neuron 18:793-802.
4. Bär KJ, Facer P, Williams NS, Tam PKH, Anand P (1997) Glialderived neurotrophic factor in human adult and fetal intestine and in Hirschsprung's disease. Gastroenterology 112:1381-1385.
5. Bevilacqua A, Erickson RP, Hieber V (1988) Antisense RNA inhibits endogenous gene expression in mouse preimplantation embryos: lack of double-stranded RNA "melting" activity. Proc Natl Acad Sci USA 85:831-835.
6. Bracey LT, Paigen K (1987) Changes in translational yield regulate tissue-specific expression of β-glucuronidase. Proc Natl Acad Sci USA 84:9020-9024.
7. Buj-Bello A, Adu J, Piñón LGP, Horton A, Thompson J, Rosenthal A, Chinchetru M, Buchman VL, Davies AM (1997) Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase. Nature 387:721-724.
8. Campling BG, Haworth AC, Baker HM, Greer DL, Holden JJA, Bradley WEC, Pym J, Dexter DF (1992) Establishment and characterization of a panel of human lung cancer cell lines. Cancer 69:2064-2074.
9. Carbone DP, Minna JD (1992) The molecular genetics of lung cancer. Adv Intern Med 37:153-171.
10. Ceccherini I, Hofstra RMW, Luo Y, Stulp RP, Barone V, Stelwagen T, Bocciardi R, Nijveen H, Bolino A, Seri M, Ronchetto P, Pasini B, Bozzano M, Buys CHCM, Romeo G (1994) DNA polymorphisms and conditions for SSCP analysis of the 20 exons of the Ret proto-oncogene. Oncogene 9:3025-3029.
11. Chakravarti A (1996) Endothelin receptor-mediated signaling in Hirschsprung disease. Hum Mol Genet 5:303-307.
12. Choi-Lundberg DL, Bohn MC (1995) Ontogeny and distribution of glial cell line-derived neurotrophic factor (GDNF) mRNA in rat. Devel Brain Res 85:80-88.
13. Durbec PL, Larsson-Blomberg LB, Schuchardt A, Costantini F, Pachnis V (1996) Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts. Development 122:349-358.
14. Eng C, Clayton D, Schuffenecker I, Lenoir G, Cote G, Gagel RF, Ploos van Amstel H-K, Lips CJM, Nishisho I, Takai S-I, Marsh DJ, Robinson BG, Frank-Raue K, Raue F, Xu F, Noll WW, Romei C, Pacini F, Fink M, Niederle B, Zedenius J, Nordenskjöld M, Komminoth P, Hendy G, Gharib H, Thibodeau S, Lacroix A, Frilling A, Ponder BAJ, Mulligan LM (1996) The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2: International RET Mutation Consortium. JAMA 276:1575-1579.
15. Eng C, Mulligan LM (1997) Mutations of the RET proto-oncogene in the multiple endocrine neoplasia type 2 syndromes, related sporadic tumors and Hirschsprung disease. Hum Mutat 9:97-109.
16. Futami H, Egawa S, Yamaguchi K (1994) A novel point mutation of the RET proto-oncogene in small cell lung carcinoma cell lines. Proc Jpn Acad 70B:210-214.
17. Futami H, Egawa S-I, Tsukada T, Maruyama K, Bandoh S, Noguchi M, Yamaguchi K (1995) A novel somatic point mutation of the RET proto-oncogene in tumor tissues of small cell lung cancer patients. Jpn J Cancer Res 86:1127-1130.
18. Gardner E, Mulligan L, Eng C, Healey C, Kwok J, Ponder M, Ponder B (1994) Haplotype analysis of MKN 2 mutations. Hum Mol Genet 3:1771-1774.
19. Gattei V, Celetti A, Cerrato A, Degan M, De Iuliis A, Rossi FM, Chiappetta G, Consales C, Improta S, Zagonel V, Aldinucci D, Agosti V, Santoro M, Vecchio G, Pinto A, Grieco M (1997) Expression of the RET receptor tyrosine kinase and GDNFRα in normal and leukemic human hematopoietic cells and stromal cells of the bone marrow microenvironment. Blood 89:2925-2937.
20. Gazdar AF (1994) The molecular and cellular basis of human lung cancer. Anticancer Res 13:261-268.
21. Gazdar AF, Bunn PA, Minna JD, Baylin SB (1985) Origin of human small cell lung cancer. Science 229:679-680.
22. GFRα Nomenclature Committee (1997) Nomenclature of GPIlinked receptors for the GDNF ligand family. Neuron 19:485.
23. Hellmich HL, Kos L, Cho ES, Mahon KA, Zimmer A (1996) Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions. Mech Dev 54:95-105.
24. Hofstra RMW, Landsvater RM, Ceccherini I, Stulp RP, Stelwagen T, Luo Y, Pasini B, Höppener JWM, Ploos van Amstel HK, Romeo G, Lips CJM, Buys CHCM (1994) A mutation in the RET protooncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. Nature 367:375-376.
25. Hofstra RMW, Cheng NC, Hansen C, Stulp RP, Stelwagen T, Clausen N, Tommerup N, Caron H, Westerveld A, Versteeg R, Buys CHCM (1996a) No mutations found by RET mutation scanning in sporadic and hereditary neuroblastoma. Hum Genet 97:362-364.
26. Hofstra RMW, Sijmons RH, Stelwagen T, Stulp RP, Kouseff BG, Lips CJM, Steylen PM, van Voorst Vader PC, Buys CHCM (1996h) RET mutation screening in familial cutaneous lichen amyloidosis and in skin amyloidosis associated with multiple endocrine neoplasia type 2A. J Invest Derm 107:215-218.
27. Huebner K, Hadaczek P, Siprashvili Z, Druck T, Croce CM (1997) The FHIT gene, a multiple tumor suppressor gene encompassing the carcinogen sensitive chromosome fragile site, FRA3B. Biochim Biophys Acts 1332:M65-M70.
28. Ibson JM, Waters JJ, Twentyman PR, Bleehen NM, Rabbitts PH (1987) Oncogene amplification and chromosome abnormalities in small cell lung carcinoma. J Cell Biochem 33:267-288.
29. Ivanchuk SM, Eng C, Cavenee WK, Mulligan LM (1997) The expression of RET and its multiple splice forms in developing human kidney. Oncogene 14:1811-1818.
30. Jing S, Wen D, Yu Y, Holst PL, Luo Y, Fang M, Tamir R, Antonio L, Hu Z, Cupples R, Louis J-C, Hu S, Altrock BW, Fox GM (1996) GDNF-induced activation of the Ret protein tyrosine kinase is mediated by GDNFR-α, a novel receptor for GDNF. Cell 85:1113-1124.
31. Klein RD, Sherman D, Ho W-H, Stone D, Bennett GL, Moffat B, Vandlen R, Simmons L, Gu Q, Hongo J-A, Devaux B, Poulsen K, Armanini M, Nozaki C, Asai N, Goddard A, Phillips H, Henderson CE, Takahashi M, Rosenthal A (1997) A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. Nature 387:717-721.
32. Kok K, Naylor SL, Buys CHCM (1997) Deletions of the short arm of chromosome 3 in solid tumours and the search for suppressor, genes. Advan Canc Res 71:27-92.
33. Komminoth P, Roth J, Muletta-Feurer S, Saremaslani P, Seelentag WK, Heitz PU (1996) RET proto-oncogene point mutations in sporadic neuroendocrine tumors. J Clin Endo Metab 81:2041-2046.
34. Kotzbauer PT, Lampe PA, Heuckeroth RO, Golden JP, Creedon DJ, Johnson EM, Milbrandt J (1996) Neurturin, a relative of glial-cellline derived neurotrophic factor. Nature 384:467-470.
35. Kwok JBJ, Gardner K, Warner JP, Ponder BAJ, Mulligan LM (1993) Structural analysis of the human ret proto-oncogene using exon trapping. Oncogene 8:2575-2582.
36. Leij L, Postmus PE, Buys CHCM, Elema JD, Ramaeker F, Poppema S, Brouwer M, van der Veen AY, Mesander G, The TH (1985) Characterisation of three new variant type cell lines derived from small cell carcinoma of the lung. Cancer Res 45:6024-6033.
37. Lin L-FH, Doherty DH, Lile JD, Bektesh S, Collins F (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260:1130-1132.
38. Lindsay RM, Yancopoulos GD (1996) GDNF in a bind with a known orphan: accessory implicated in new twist. Neuron 17:571-574.
39. Miya A, Yumamoto M, Morimoto H, Tanakn N, Shin E, Karakawa K, Toyoshima K, Ishizaka Y, Mori T, Takai S-I (1992) Expression of the ret proto-oncogene in human medullary thyroid carcinomas and pheochromocytomas of MEN 2A. Henry Ford Hosp Med J 40:215-219.
40. Mulligan LM, Kwok JBJ, Healey CS, Elsdon MJ, Eng C, Gardner K, Love DR, Mole SE, Moore JK, Papi L, Ponder MA, Telenius H, Tunnacliffe A, Ponder BAJ (1993) Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature 363:458-460.
41. Mulligan LM, Eng C, Attié T, Lyonnet S, Marsh DJ, Hyland VJ, Robinson BG, Frilling A, Verellen-Dumoulin C, Safar A, Venter DJ, Munnich A, Ponder BAJ (1994a) Diverse phenotypes associated with exon 10 mutations of the RET proto-oneogene. Hum Mol Genet 3:2163-2167.
42. Mulligan LM, Eng C, Healey CS, Clayton D, Kwok JBJ, Gardner E, Ponder MA, Frilling A, Jackson CE, Lehnert H, Neumann HPH, Thibodeau SN, Ponder BAJ (1994b) Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC. Nature Genet 6:70-74.
43. Mulligan LM, Marsh DJ, Robinson BG, Schuffenecker I, Zedenius J, Lips CJM, Gagel RF, Takai S-I, Noll WW, Fink M, Raue F, Lacroix A, Thibodeau SN, Frilling A, Ponder BAJ, Eng C, International RET Mutation Consortium (1995) Genotypephenotype correlation in multiple endocrine neoplusia type 2: report of the International RET Mutation Consortium. J Intern Med 238:343-346.
44. Nakamura T, Ishizaka Y, Nagao M, Hara M, Ishikawa T (1994) Expression of the ret proto-oncogene product in human normal and neoplastic tissues of neural crest origin. J Pathol 172:255-260.
45. Oshima A, Kyle JW, Miller RD, Hoffmann JW, Powell PP, Grubb JH, Sly WS, Tropak M, Guise KS, Gravel RA (1987) Cloning, sequencing and expression of cDNA for human β-glucuronidase. Proc Natl Acad Sci USA 84:685-689.
46. Pachnis V, Mankoo B, Costantini F (1993) Expression of the c-ret proto-oncogenc during mouse embryogenesis. Development 119: 1005-1017.
47. Rossel M, Pasini A, Chappuis S, Geneste O, Fournier L, Schuffenecker I, Takahashi M, van Grunsven LA, Urdiales JL, Rudkin BB, Lenoir GM, Billaud M (1997) Distinct biological properties of two RET isoforms activated by MEN 2A/FMTC and MEN 2B mutations. Oncogene 14:265-275.
48. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Second ed. New York: Cold Spring Harbor Laboratory Press.
49. Sanicola M, Hession C, Worley D, Carmillo P, Ehrenfels C, Walus L, Robinson S, Jarworski G, Wei H, Tizard R, Whitty A, Pepinsky RB, Cate RL (1997) Glial cell line-derived neurotrophic factor dependent RET activation can he mediated by two different cell-surface accessory proteins. Proc Natl Acad Sci USA 94:6238-6243.
50. Santoro M, Rosati R, Grieco M, Berlingieri MT, D'Amato GLC, deFranciscis V, Fusco A (1990) The RET proto-oncogene is consistently expressed in human pheochromocytomas and thyroid medullary carcinomas. Oncogene 5:1595-1598.
51. Santoro M, Carlomagno F, Romano A, Bottaro DP, Dathan NA, Grieco M, Fusco A, Vecchio G, Matoskova B, Kraus MH, Di Fiore PP (1995) Activation of RET as a dominant transforming gene by germline mutations of MEN 2A and MEN 2B. Science 267:381-383.
52. Schuchardt A, D'Agati V, Larsson-Blomberg L, Costantini F, Pachnis V (1994) Detects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature 367:380-383.
53. Suter-Cruzzolara C, Unsicker K (1994) GDNF is expressed in two forms in many tissues outside the CNS. NeuroReport 5:2486-2488.
54. Suvanto P, Wartiovaara K, Lindahl M, Arumäe U, Moshnyakov M, Horelli-Kuitunen N, Airaksinen MS, Palotie A, Sariola H, Saarma M (1997) Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor β, a homologue of GDNFR-α. Hum Molec Genet 6:1267-1273.
55. Takahashi M, Buma Y, Iwamoto T, Inaguma Y, Ikeda H, Hiai H (1988) Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Oncogene 3:571-578.
56. Takahashi M, Buma Y, Taniguchi M (1991) Identification of the ret proto-oncogene products in neuroblastoma and leukemia cells. Oncogene 6:297-301.
57. Treanor JJS, Goodman L, de Sauvage F, Stone DM, Poulsen KT, Beck CD, Gray C, Armanini MP, Pollock RA, Hefti F, Phillips HS, Goddard A, Moore MVV, Buj-Bello A, Davies AM, Asai N, Takahashi M, Vanillen R, Henderson CE, Rosenthal A (1996) Characterization of a multicomponent receptor for GDNF. Nature 382:80-83.
58. Trupp M, Rydén M, Jörnvall H, Funakoshi H, Timmusk T, Arenas K, Ibäñnez C (1995) Peripheral expression and biological activities of GDNK a new neurotrophic factor for avian and mammalian peripheral neurons. J Cell Biol 130:137-148.
59. Trupp M, Belluardo N, Funakoshi H, Ibáñez CF (1997) Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-α indicates multiple mechanisms of trophic actions in the adult rat CNS. J Neurosci 17:3554-3567.
60. Tsuzuki T, Takahashi M, Asai N, Iwashita T, Matsuyama M, Asai J (1995) Spatial and temporal expression of the ret proto-oncogene product in embryonic, infant and adult rat tissues. Oncogene 10:191-198.
61. Unsicker K (1996) GDNF: a cytokine at the interface of TGF-βs and neurotrophins. Cell Tissue Res 286:175-178.
62. Vega Q, Worby C, Lechner M, Dixon J, Dressier G (1996) Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis. Proc Natl Acad Sci USA 93:10657-10661.
63. Waters JJ, Ibson JM, Twentyman PR, Blechen NM, Rabbitts PH (1988) Cytogenetic abnormalities in human small cell lung carcinoma: cell lines characterised for myc gene amplification. Cancer Genet Cytogenet 30:213-223.