Accumulation of somatic hypermutation and antigen-driven selection in rapidly cycling surface Ig+ germinal center (GC) B cells which occupy GC at a high frequency during the primary antihapten response in mice

European Journal of Immunology

Volumn 27, Issue 1, 1997, Pages 268-279

  Kimoto, Hiroshi ^a   Nagaoka, Hitoshi ^a   Adachi, Yoshihiro ^a   Mizuochi, Toshiaki ^a   Azuma, Takachika ^b   Yagi, Takenori ^a   Sata, Tetsutaro ^a   Yonehara, Shin ^c   Tsunetsugu Yokota, Yasuko ^a   Taniguchi, Masaru ^d   Takemori, Toshitada ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d CHIBA UNIVERSITY   (Japan)

Author keywords

Antigen presentation; Cell cycle; Germinal center; Selection; Somatic mutation

Indexed keywords

B7 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; LYMPHOCYTE MEMBRANE IMMUNOGLOBULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; GERMINAL CENTER; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOMATIC MUTATION; T LYMPHOCYTE ACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY DIVERSITY; ANTIBODY FORMATION; ANTIGENS; ANTIGENS, CD45; APOPTOSIS; BASE SEQUENCE; CELL CYCLE; FEMALE; GERMINAL CENTER; HAPTENS; IMMUNOPHENOTYPING; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUTATION; RECEPTORS, ANTIGEN, B-CELL; SEQUENCE ALIGNMENT; T-LYMPHOCYTES; TIME FACTORS;

EID: 15144351999     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.1830270140     Document Type: Article

References (61)

1. Jacob, J., Kassir, R. and Kelsoe, G., J. Exp. Med. 1991. 173: 1165.
2. Liu, Y-J., Zhang, J., Lane, P. J. L., Chan, E. Y-T. and MacLennan, I. C. M., Eur. J. Immunol. 1991. 21: 2951.
3. Jacob, J. and Kelsoe, G., J. Exp. Med. 1992. 176: 679.
4. van Essen, Kikutani, H. and Gray, D., Nature 1995. 378: 620.
5. Jacob, J., Przylepa, J., Miller, C. and Kelsoe, G., J. Exp. Med. 1993. 178: 1293.
6. McHeyzer-Williams, M. G., McLean, M. J., Lalor, P. A. and Nossal, G. J. V., J. Exp. Med. 1993. 178: 295.
7. MacLennan, I. C. M., Liu, Y-J., Oldfield, S., Zhang, J. and Lane, P. J. L., Curr. Top. Microbiol. Immunol. 1990. 159: 37.
8. Zhang, J., MacLennan, I. C. M., Liu, Y.-J. and Lane, P., Immunol. Lett. 1988. 18: 297.
9. Kueppers, R., Zhao, M., Hansman, M.-L. and Rajewsky, K., EMBO J. 1993. 12: 4955.
10. Kelsoe, G., Immunol. Today 1995. 16: 324.
11. Berek, C., Berger, A. and Apel, M., Cell 1991. 67: 1121
12. Jacob, J., Kelsoe, G., Rajewsky, K. and Weiss, U., Nature 1991. 354: 389.
13. Pascual, V., Liu, Y.-J., Magalski, A., de Bouteiller, O., Banchereau, J. and Capra, J. D., J. Exp. Med. 1994. 180: 329.
14. Ziegner, M., Steinhauser, G. and Berek, C., Eur. J. Immunol. 1994. 24: 2393.
15. Berek, C. and Milstein, C., Immunol. Rev. 1988. 105: 5.
16. Weiss, U. and Rajewsky, K., J. Exp. Med. 1990. 172: 1681.
17. Betz, A. G., Rada, C., Pannell, R., Milstein, C. and Neuberger, M. S., Proc. Natl. Acad. Sci. USA 1993. 90: 2385.
18. Yelamos, J., Klix, N., Goyenechea, B., Lozano, F., Chul, Y. L., Gonzales Fernandez, A., Pannell, R., Neuberger, M. S. and Milstein, C., Nature 1995. 376: 225.
19. Sharper, M. J., Milstein, C., Jarvis, J. M. and Neuberger, M. S., EMBO J. 1991. 10: 2139.
20. Betz, A. G., Milstein, C., Gonzalez-Fernandez, A., Pannell, R., Larson, T. and Neuberger, M. S., Cell 1994. 77: 239.
21. Neuberger, M. S. and Milstein, C., Curr. Opin. Immunol. 1995. 7: 248.
22. Brenner, S. and Milstein, C., Nature 1996. 211: 242.
23. Liu, Y.-J., Johnson, G. D. J., Gordon, J. and MacLennan, I. C. M., Immunol. Today 1992. 13: 17.
24. McKean, D., Hupp, K., Bell, M., Staudt, L. and Weigert, M., Proc. Natl. Acad. Sci. USA 1984. 81: 3180.
25. Sablitzky, F., Wildner, G. and Rajewsky, K., EMBO J. 1985. 4: 345.
26. Cleary, M. L., Meeker, T. C., Levy, S., Lee, E., Trela, M., Sklar, J. and Levy, R., Cell 1986. 44: 97.
27. Kocks, C. and Rajewsky, K., Annu. Rev. Immunol. 1989. 7: 537.
28. Kepler, T. B. and Perelson, A. S., Immunol. Today 1993. 14: 412.
29. Han, S., Zheng, B., Dal Porto, Z. and Kelsoe. G., J. Exp. Med. 1995. 182: 1635.
30. Rose, M. L., Birbeck, M. S. C., Wallis, V. J., Forrester, J. A. and Davis, A. J. S., Nature 1980. 284: 364.
31. Coico, R. F., Bhogal, B. S. and Thorbecke, G. J., J. Immunol. 1983. 131: 2254.
32. Lalor, P. A., Nossal, G. J. V., Sanderson, R. D. and McHeyzer-Williams, M. G., Eur. J. Immunol. 1992. 22: 3001.
33. Reth, M., Imanishi-Kari, T. and Rajewsky, K., Eur. J. Immunol. 1979. 9: 1004.
34. Stall, A. M. and Loken, M. R., J. Immunol. 1984. 132: 787.
35. Yokota, T.-Y., Mizuochi, T., Hashimoto, H., Szikaradkiewicz, A., Yagita, H., Yano, A. and Takemori, T., Immunol. Lett. 1994. 40: 73.
36. Allen, D., Simon, T., Sablitzsky, F., Rajewsky, K. and Cumano, A., EMBO J. 1988. 7: 1995.
37. Hayakawa, K., Hardy, R. R., Parks, D. R. and Herzenberg, L. A., J. Exp. Med. 1983. 157: 202.
38. Wells, S. M., Kantor, A. B. and Stall, A. M., J. Immunol. 1994. 153: 5503.
39. Cadol, N., Peacock, M. A. and Adult, K. A., Blood 1988. 71: 1048.
40. Moeller, P., Henne, C., Leithaeuser, F., Eichelmann, A., Schmidt, A., Bruederlein, S., Dhein, J. and Krammer, P., Blood 1993. 81: 2067.
41. Smith, K. G., Nossal, G. J. and Tarlinton, D. M., Proc. Natl. Acad. Sci. USA 1995. 92: 11628.
42. Watanabe, D., Suda, T. and Nagata, S., Int. Immunol. 1995. 7: 1949.
43. Christoph, T., Rickert, R. and Rajewsky, K., Int. Immunol. 1994. 6: 1203.
44. Trauth, K., Mutschler, B., Jenkins, N. A., Gilgert, D. J., Copeland, N. G. and Klempnauer, K. H., EMBO J. 1994. 13: 5994.
45. Cattoretti, G., Chang, C.-C., Cechova, K., Zhang, J., Ye, B.-H., Falini, B., Louie, D. C., Offit, K., Chaganti, R. S. K. and Dalla-Favera, R., Blood 1995. 86: 45.
46. Foester, I., Vieira, P. and Rajewsky, K., Int. Immunol. 1989. 1: 321.
47. Rodriquez-Tarduchy, G., Collins, M. and Lopez-Rivas, A., EMBO J. 1990. 9: 2997.
48. Gorczyca, W., Gong, J. and Darzynkiewicz, Z., Cancer Res. 1993. 53: 1945.
49. Weiss, U., Zoebelein, R. and Rajewsky, K., Eur. J. Immunol. 1992. 22: 511.
50. Kosco, M. H., Szakal, A. K. and Tew, J. G., J. Immunol. 1988. 140: 354.
51. Liu, Y.-J., Barthelemy, C., de Bouteiller, O., Arpin, C., Durand, I. and Banchereau, J., Immunity 1995. 2: 239.
52. Clark, E. A. and Ledbetter, J. A., Nature 1994. 367: 425.
53. Pulendran, B., Karavelas, M. and Nossal, G. J. V., Proc. Natl. Acad. Sci. USA 1995. 91: 2639.
54. Pulendran, B., Smith, K. G. C. and Nossal, G. J. V., J. Immunol. 1995. 155: 1141.
55. Casamayor-Palleja, M., Kahn, M. and MacLennan, I. C. M., J. Exp. Med. 1995. 181: 1293.
56. Fuller, K. A., Kanagawa, O. and Nahm, M. H., J. Immunol. 1993. 151: 4505.
57. Miller, C., Stedra, J., Kelsoe, G. and Cerny, J., J. Exp. Med. 1995. 181: 1319.
58. Kaellberg, E., Jainandunsing, S., Gray, D. and Leanderson, T., Science 1996. 271: 1285.
59. Han, S., Hathcock, K. Zheng, B., Kepler, T. B., Modes, R. and Kelsoe, G., J. Immunol. 1995. 155: 556.
60. Minegishi, Y., Okawa, H., Sugamura, K. and Yata, J., Int. Immunol. 1994. 6: 1709.
61. Kabat, E. A., Wu, T. T., Perry, H. M., Gottesman, K. S. and Foeller, C., Sequences of Proteins of Immunological Interest, US Department Health and Human Service, Washington 1991.