Multiple signals regulate the intracellular trafficking of HLA-DM in B- lymphoblastoid cells

Immunology

Volumn 93, Issue 4, 1998, Pages 505-510

  Copier, J ^a   Potter, P ^a   Sacks, S H ^a   Kelly, A P ^a  

^a GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TYROSINE;

ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOBLAST; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; CYTOPLASM; ENDOCYTOSIS; HELA CELL; HUMAN; HUMAN CELL; LYSOSOME; PRIORITY JOURNAL; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; B-LYMPHOCYTES; BLOTTING, WESTERN; CENTRIFUGATION, DENSITY GRADIENT; DIMERIZATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLOW CYTOMETRY; HELA CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-D ANTIGENS; HLA-DR ANTIGENS; HUMANS; SIGNAL TRANSDUCTION;

EID: 0031945502     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1998.00461.x     Document Type: Article

References (25)

1. FLING S.P., ARP B. & PIOS D. (1994) HLA-DMA and -DMB gene are both required for MHC class II/peptide complex formation in antigen-presenting cells. Nature 368, 554.
2. MORRIS P., SHAMAN J., ATTAYA M. et al. (1994) An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules. Nature 368, 551.
3. MELLINS E., SMITH L., ARP B., COTNER T., CELIS E. & PIOUS D. (1990) Defective processing and presentation of exogenous antigens in mutants with normal HLA class II antigens. Nature 343, 71.
4. RIBERDY J.M. & CRESSWELL P. (1992) The antigen processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation. J Immunol 148, 2586.
5. RIBERDY J.M., NEWCOMB J.R., SURNAM M.J., BARBOSA J.A. & CRESSWELL P. (1992) HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides. Nature 360, 474.
6. SANDERSON F., KLEIJMEER M.J., KELLY A. et al. (1994) Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments. Science 266, 1566.
7. SANDERSON F., THOMAS C., NEEFJES J. & TROWSDALE J. (1996) Association between HLA-DM and HLA-DR in vivo. Immunity 4, 87.
8. KROPSHOFER H., VOGT A.B., MOLDENHAUER G., HAMMER J., BLUM J.S. & HAMMERLING G.J. (1996) Editing of the HLA DR-peptide repertoire by HLA-DM. EMBO J 15, 6144.
9. SLOAN V.S., CAMERON P., PORTER G. et al. (1995) Mediation by HLA-DM of dissociation of peptides from HLA-DR. Nature 375, 802.
10. VAN HAM M.S., GRUNEBERG U., MALCHEREK G., BROKER I., MELMS A. & TROWSDALE J. (1996) Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs. J Exp Med 184, 2019.
11. VOGT A.B., KROPSHOFER H., MOLDENHAUER G. & HAMMERLING G.J. (1996) Kinetic analysis of peptide loading onto HLA-DR molecules mediated by HLA-DM. Proc Natl Acad Sci USA 93, 9724.
12. BAKKE O. & DOBBERSTEIN B. (1990) MHC class II-associated invariant chain contains a sorting signal for endosomal compartments. Cell 63, 707.
13. LOTTEAU V., TEYTON L., PELERAUX A. et al. (1990) Intracellular transport of class II molecules directed by the invariant chain. Nature 348, 600.
14. MARKS M.S., ROCHE P.A., DONSELAAR E., WOODRUFF L., PETERS P.J. & BONIFACINO J.S. (1995) A lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments. J Cell Biol 131, 351.
15. LINDSTEDT R., LILJEDAHL M., PILERAUX A., PETERSON P.A. & KARLSSON L. (1995) The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motif. Immunity 3, 561.
16. COPIER J., KLEIJMEER M.J., PONNAMBALAM S. et al. (1996) Targeting signal and subcellular compartments involved in the intracellular trafficking of HLA-DMB. J Immunol 157, 1017.
17. LAMPSON L.A. & LEVY R. (1980) Two populations of Ia-like molecules on a human cell line. J Immunol 125, 293.
18. JOHNSON J.P., MEO T., RIETHMULLER G., SCHENDEL D.J. & WANK R. (1982) Direct demonstration of an HLA-DR allotypic determinant on low molecular weight (Beta) subunit using a mouse monoclonal specific for DR. Exp Med 156, 104.
19. DENZIN L.K., ROBBINS N.F., CARBOY-NEWCOMB C. & CRESSWELL P. (1994) Assembly and intracellular transport of HLA-DM and correction of class II antigen-processing defect in T2 cells. Immunity 1, 1.
20. PIOUS D., HAWLEY P. & FORREST G. (1973) Isolation and characterisation of HLA-A variants in cultured human lymphoid cells. Proc Natl Acad Sci USA 70, 1397.
21. RAMACHANDRA L., KOVATS S., EASTMAN S. & RUDENSKY A.Y. (1996) Variation in HLA-DM expression influences conversion of MHC class II αβ: class II-associated invariant chain peptide complexes to mature peptide-bound class II αβ dimers in a normal B cell line. J Immunol 156, 2196-2204.
22. ZHONG G., CASTELLINO F., ROMAGNOLI P. & GERMAIN R.N. (1996) Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of the class II-associated invariant chain peptides (CLIP). J Exp Med 184, 2061.
23. KARLSSON L., PELERAUX A., LINDSTEDT R., LILJEDAHL M. & PETERSON P.A. (1994) Reconstitution of an operational MHC class II compartment in non antigen presenting cells. Science 266, 1569.
24. SANDERSON F., THOMAS C., NEEFJES J. & TROWSDALE J. (1996) Association between HLA-DM and HLA-DR in vivo. Immunity 4, 87.
25. LILJEDAHL M., KUWANA T., FUNG-LUNG, W.-P., JACKSON M.R., PETERSON P.A. & KARLSSON L. (1996) HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport. EMBO J 15, 4817.