Inhibition of brain G(z) GAP and other RGS proteins by palmitoylation of G protein α subunits

Science

Volumn 278, Issue 5340, 1997, Pages 1132-1135

  Tu, Yaping ^a   Wang, Jun ^a   Ross, Elliott M ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN SUBUNIT; DITHIOTHREITOL; GNAZ PROTEIN, HUMAN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; GUANOSINE TRIPHOSPHATE; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; PALMITIC ACID; PALMITOYL COENZYME A; PHOSPHOPROTEIN; PROTEIN; REGULATOR OF G PROTEIN SIGNALLING 19; REGULATOR OF G-PROTEIN SIGNALLING 19; RGS PROTEIN; RGS10 PROTEIN, HUMAN; RGS4 PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; ENZYME INHIBITION; MYRISTYLATION; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; ANIMAL; CELL LINE; DRUG ANTAGONISM; HYDROLYSIS; KINETICS; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; DITHIOTHREITOL; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEINS; GTPASE-ACTIVATING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATE; HETEROTRIMERIC GTP-BINDING PROTEINS; HYDROLYSIS; KINETICS; PALMITIC ACID; PALMITOYL COENZYME A; PHOSPHOPROTEINS; PROTEINS; RGS PROTEINS; SIGNAL TRANSDUCTION;

EID: 0030611942     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.278.5340.1132     Document Type: Article

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46. 3H]Pal-CoA, D. Berman for RGS4 protein and for GAIP cDNA, S. Popov for purified RGS10, P. Chidiac for advice, K. Chapman and J. Woodson for expert technical assistance, C. Slaughter and S. Afendis for peptide sequencing, and M. Cobb, S. Mukhopadhyay, and S. Sprang for comments on the manuscript. Supported by NIH grant GM30355, R. A. Welch Foundation grant I-0982, and a postdoctoral fellowship to J.W. from Cadus Pharmaceutical Corp.