Induction of NO synthesis in macrophages by Newcastle disease virus is associated with activation of nuclear factor-κB

International Immunology

Volumn 8, Issue 4, 1996, Pages 491-498

  Umansky, Victor ^a   Shatrov, Vladimir A ^a   Lehmann, Volker ^a   Schirrmacher, Volker ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Macrophages; Newcastle disease virus; NF B activation; NO induction; Signal transduction

Indexed keywords

5' NUCLEOTIDASE; ADENOSINE DEAMINASE; ANTIOXIDANT; BUTYLATED HYDROXYANISOLE; ENZYME INHIBITOR; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NITRIC OXIDE; STAUROSPORINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; IMMUNOSTIMULATION; MACROPHAGE; MOUSE; NEWCASTLE DISEASE PARAMYXOVIRUS; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE DEAMINASE; ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED DBA; N-GLYCOSYL HYDROLASES; NEWCASTLE DISEASE; NEWCASTLE DISEASE VIRUS; NF-KAPPA B; NITRIC OXIDE; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; SPLEEN;

EID: 0029865872     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.4.491     Document Type: Article

References (48)

1. Fidler, I J and Schroit, A J. 1988 Recognition and destruction of neoplastic cells by activated macrophages: discrimination of altered self Biochim Biophys. Acta 948:151.
2. Ziegler-Heitbrock, H W L 1989. The biology of the monocyte system Eur. J. Cell Biol 49.1.
3. Hibbs, J. B., Taintor, R R , Vavrin, Z and Rachlin, E. M 1988 Nitric oxide a cytotoxic activated macrophage effector molecule Biochem. Biophys Res. Commun 157:87.
4. Stuehr, D. J and Nathan, C F. 1989. Nitric oxide A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells J Exp. Med 169:1543
5. Marletta, M. A , Yoon, P S., Lyengar, R., Leaf, C. D and Wishnok, J S 1988 Macrophage oxidation of L-arginine to nitrite and nitrate nitric oxide is an intermediate. Biochemistry 27 8706.
6. Kurose, I , Miura, S , Fukumura, D , Yonei, Y , Saito, H , Tada, S., Suematsu, M and Tsuchiya, M 1993. Nitric oxide mediates Kupffer cell-induced reduction of mitochondrial energization in hepatoma cells A comparison with oxidative burst Cancer Res 53 2676
7. Kwon, N S , Stuehr, D J and Nathan, C F 1991 Inhibition of tumor cell ribonucleotide ribonuclease by macrophage-derived nitric oxide J Exp Med 174 761
8. Lepoivre M., Fieschi, F , Coves, J., Thelander, L and Fontecave, M 1991 Inactivation of ribonucleotide reductase by nitric oxide. Biochem Biophys Res. Commun. 179 442.
9. Moncada, S , Palmer, R M J and Higgs, E A 1991 Nitric oxide: physiology, pathophysiology and pharmacology Pharmacol Rev 43:109
10. Drapier, J. C., Wietzebrin, J and Hibbs, J B 1988 Interferon-γand tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages. Eur J Immunol 18:1587.
11. Deng, W , Thiel, B , Tannenbaum, C. S , Hamilton, T. A and Stuehr, D J. 1993. Synergistic cooperation between T cell lymphokines for induction of the nitric oxide synthase gene in murine peritoneal macrophages. J. Immunol 151:322.
12. Hamburg, S I., Manejias, R. E. and Rabinovitch, M 1978. Macrophage activation: increased ingestion of IgG-coated erythrocytes after administration of interferon inducers to mice. J Exp Med. 147 593
13. Hamburg, S I., Cassell, G. H and Rabinovitch, M. 1980. Relationship between enhanced phagocytic activity and the induction of interferon by Newcastle disease virus in mice. J. Immunol 124:1360
14. Zawatzky, R , Wurmbaeck, H , Falk, W. and Homfeld, A. 1991. Endogenous interferon specifically regulates Newcastle disease virus-induced cytokine gene expression in mouse macrophages. J. Virol 65:4839.
15. Fisher, S. N , Kim, Y. U and Shin, M. L 1994. Tyrosine kinase activation by Newcastle disease virus is required for TNF-α gene induction in astrocytes J Immunol 153:3210.
16. Baeuerle, P. A and Henkel, T. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141.
17. Baeuerle, P. A. and Baltimore, D. 1988. IκB: a specific inhibitor of the NF-κB transcription factor Science 242:540.
18. Muller, J. M., Ziegler-Heitbrock, H W. L. and Baeuerle, P A. 1993. Nuclear factor kappa B, a mediator of lipopolysaccharide effects. Immunobiology 187 233.
19. Xie, Q-W , Kashiwabara, Y. and Nathan, C. 1994. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase. J. Biol Chem 269.4705
20. Schulze-Osthoff, K , Beyaert, R., Vandervoorde, V , Haegeman, G and Fiers, W. 1993 Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene inductive effects of TNF EMBO J 12 3095
21. Bergmann, S , Shatrov, V , Ratter, F , Schiemann, S., Schulze-Osthoff, K and Lehmann, V 1994 Adenosine and homocysteine together enhance TNF-mediated cytotoxicity but do not alter activation of nuclear factor-κB in L929 cells J Immunol. 153:1736.
22. Anderson, M.T , Staal, F J T , Gitler, C , Herzenberg, L A. and Herzenberg, L A 1994 Separation of oxidant-initiated and redox-regulated steps in the NF-κB signal transduction pathway Proc Natl Acad. Sci USA 91 11527.
23. von Hoegen, P , Weber, E and Schirrmacher, V 1988 Modification of tumor cells by a low dose of Newcastle disease virus Augmentation of the tumor-specific T cell response in the absence of an anti-viral response Eur. J Immunol. 18.1159.
24. 15N) nitrate in biological fluids Anal Biochem 126:131.
25. Morahan, P., Edelson, P. and Gass, K. 1980. Changes in macrophage ectoenzymes associated with antitumor activity J. Immunol 125 1312.
26. Dmitrenko, N P., Komissarenko, S. V and Umansky, V Y 1980. Activity of enzymes of adenine-nucleotide metabolism and adenosine deaminase in rat thymic and splenic lymphocytes Doklady Biol. Sci (Proc Acad. Sci. USSR) 251:179
27. Zabel, U , Schreck, R and Baeuerle, P A 1991 DNA binding of purified transcription factor NF-κB. J Biol. Chem 266:252
28. Jurianz, K , Haas, C , Hubbe, M., Ertel, C , Brunner, G., Altevogt, P., Schirrmacher, V and von Hoegen, P 1995. Adhesive function of Newcastle Disease Virus hemagglutinin in tumor-host interaction Int J Oncol 7.539
29. Suzuki, Y., Mizuno, M and Packer, L. 1994. Signal transduction for nuclear factor-κB activation Proposed location of antioxidant-inhibitable step. J Immunol 153:5008
30. Westendorp, M O., Shatrov, V. A , Schulze-Osthoff, K., Frank, R , Kraft, M , Los, M., Krammer, P H., Droge, W. and Lehmann, V 1995. HIV-1 Tat potentiates TNF-induced NF-κB activation and cytotoxicity by altering the cellular redox state. EMBO J. 14 546.
31. Muroi, M and Suzuki, T 1993. Role of protein kinase A in LPS-induced activation of NF-κB proteins of a mouse macrophage-like cell line, J774 Cell. Signal 5:289
32. Dong, Z., Qi, X., Xie, K. and Fidler, I. J 1993 Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide-responsive and lipopolysaccharide-nonresponsive murine macrophages. J. Immunol. 151:2717
33. Schirrmacher, V , Ahlert, T., Heicappell, R , Appelhans, B and von Hoegen, P 1986. Successful application of non-oncogenic viruses for antimetastatic cancer immunotherapy Cancer Rev 519
34. Suzuki, Y , Suzuki, T , Matsunaga, M. and Matsumoto, M. 1985. Gangliosides as paramyxovirus receptor. Structural requirement of sialo-oligosaccharides in receptors for haemagglutinating virus of Japan (Sendai virus) and Newcastle disease virus. J Biochem. 97:1189.
35. Reichard, K. W , Lorence, R M and Cascino, C J 1992. Newcastle disease virus selectively kills human tumor cells J Surg Res. 52:448.
36. Csatary, L., Eckhardt, S and Kukosza, I 1993. Attenuated veterinary virus vaccine for the treatment of cancer. Cancer Detect. Prevent. 17:619
37. Cassel, W A and Murray, D R. 1992 A ten-year follow up on stage II malignant melanoma patients treated postsurgically with Newcastle Disease Virus oncolysate Med Oncol Tumor Pharmacother. 9 169.
38. Kenney, S. and Pagano, J. S. 1994 Editorial Viruses as oncolytic agents: a new age for 'therapeutic' viruses? J Natl Cancer Inst 86.1185
39. Ertel, C , Millar, N S , Emmerson, P. T. Schirrmacher, V and von Hoegen, P. 1993. Viral hemagglutinin augments peptide-specific cytotoxic T cell responses Eur J Immunol 23 2592
40. Cronstein, B M and Hirschorn, R 1990 Adenosine and host defence Modulation through metabolism and receptor-mediated mechanisms In Williams, M , ed , Adenosine Receptors, p 475 Human Press, New York
41. Trisch, G , and Niswander, P 1981 Adenosine deaminase activity and superoxide formation during phagocytosis and membrane perturbation of macrophages Immunol Commun 10 1.
42. Mulligan, M S , Hevel, J. M , Marletta, M. A. and Ward, P A 1991 Tissue injury caused by deposition of immune complexes is L-arginine dependent. Proc Natl Acad. Sci. USA 88 6338.
43. Staal, F. J. T. Roederer, M , Herzenberg, L. A. and Herzenberg, L. A 1990. Intracellular thiols regulate activation of nuclear factor κB and transcription of human immunodeficiency virus Proc Natl Acad Sci USA 87:9943
44. Schreck, R , Rieber P. and Baeuerle, P. A 1991. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1 EMBO J 10 2247
45. Schreck, R and Baeuerle, P A 1990 NF-κB as inducible transcriptional activator of the granulocyte-macrophage colony-stimulating factor gene. Mol Cell Biol 10.1281.
46. Shakhov, A. N., Collart, M A , Vassali, P., Nedospasov, S A and Jongeneel, C. V. 1990. Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor-alpha gene in primary macrophages J Exp. Med. 171.35
47. Libermann, T A and Baltimore, D 1990 Activation of interleukin-6 gene expression through the NF-κB transcription factor. Mol. Cell Biol 10.2327.
48. Lander, H M , Sehajpal, P. K. and Novogrodsky, A. 1993 Nitric oxide signaling a possible role for G proteins J Immunol 151.7182