A small protein (Ags1p) and the Pho80p-Pho85p kinase complex contribute to aminoglycoside antibiotic resistance of the yeast Saccharomyces cerevisiae

Journal of Bacteriology

Volumn 180, Issue 7, 1998, Pages 1887-1894

  Wickert, Stephan ^a   Finck, Markus ^a   Herz, Britta ^a   Ernst, Joachim F ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; CARBOXYPEPTIDASE C; HYGROMYCIN B; VANADIC ACID;

ANTIBIOTIC RESISTANCE; ARTICLE; CENTROMERE; CHROMOSOME ANALYSIS; ENZYME ACTIVITY; GENETIC ANALYSIS; GLYCOSYLATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SACCHAROMYCES CEREVISIAE;

NEGIBACTERIA; PROKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 0031922045     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.180.7.1887-1894.1998     Document Type: Article

References (49)

1. Abeijon, C., K. Yanagisawa, E. C. Mandon, A. Häusler, K. Moremen, C. B. Hischberg, and P. W. Robbins. 1993. Guanosine diphosphatase is required for protein and sphingolipid glycosylation in the Golgi lumen of Saccharomyces cerevisiae. J. Cell Biol. 122:307-323.
2. Adoutte-Panvier, A., and J. E. Davies. 1984. Studies of ribosomes of yeast species: susceptibility to inhibitors of protein synthesis in vivo and in vitro. Mol. Gen. Genet. 194:310-317.
3. Ballou, C. 1990. Isolation, characterization and properties of Saccharomyces cerevisiae mnn mutants with nonconditional protein glycosylation defects. Methods Enzymol. 185:440-470.
4. Ballou, L., L. M. Hernandez, E. Alvarado, and C. E. Ballou. 1990. Revision of the oligosaccharide structures of yeast carboxypeptidase Y. Proc. Natl. Acad. Sci. USA 87:3368-3372.
5. Ballou, L., R. A. Hitzeman, M. S. Lewis, and C. E. Ballou. 1991. Vanadate-resistant yeast mutants are defective in protein glycosylation. Proc. Natl. Acad. Sci. USA 88:3209-3212.
6. Bisson, L. F., and J. Thorner. 1982. Mutations in the PHO80 gene confer permeability to 5′-mononucleotides in Saccharomyces cerevisiae. Genetics 102:341-359.
7. Boles, E., H. W. H. Göhlmann, and F. K. Zimmermann. 1996. Cloning of a second gene encoding 6-phosphofructo-2-kinase in yeast, and characterization of mutant strains without fructose-2,6-bisphosphate. Mol. Microbiol. 20:65-76.
8. Chernoff, Y. O., A. Vincent, and S. W. Liebman. 1994. Mutations in eukaryotic 18S ribosomal RNA affect translational fidelity and resistance to aminoglycoside antibiotics. EMBO J. 13:906-913.
9. Chi, J. H., J. Roos, and N. Dean. 1996. The OST4 gene of Saccharomyces cerevisiae encodes an unusually small protein required for normal levels of oligosaccharyltransferase activity. J. Biol. Chem. 271:3132-3140.
10. Cui, Y., J. D. Dinman, and S. W. Peltz. 1996. mof4-1 is an allele of the UPF1/IFS2 gene which affects both mRNA turnover and -1 ribosomal frameshifting efficiency. EMBO J. 15:5726-5736.
11. Cumming, D. A. 1991. Glycosylation of recombinant protein therapeutics: control and functional implications. Glycobiology 1:115-130.
12. Davies, J. E. 1983. Resistance to amonoglycosides: mechanisms and frequency. Rev. Infect. Dis. 5:S261-S266.
13. Dean, N. 1995. Yeast glycosylation mutants are sensitive to aminoglycosides. Proc. Natl. Acad. Sci. USA 92:1287-1291.
14. De Stasio, E. A., D. Moazed, H. F. Noller, and A. E. Dahlberg. 1989. Mutations in 16S ribosomal RNA disrupt antibiotic-RNA interactions. EMBO J. 8:1213-1216.
15. Ernst, J. F., and R. K. Chan. 1985. Characterization of Saccharomyces cerevisiae mutants supersensitive to aminoglycoside antibiotics. J. Bacteriol. 163:8-14.
16. Gietz, R. D., and A. Sugino. 1988. New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base restriction sites. Genes 74:527-534.
17. Gilliquet, V., M. Legrain, G. Berben, and F. Hilger. 1990. Negative regulatory elements of the Saccharomyces cerevisiae PHO system: interaction between PHO80 and PHO85 proteins. Gene 96:181-188.
18. Gritz, L., and J. Davies. 1983. Plasmid-encoded hygromycin B phosphotransferase gene and its expression in Escherichia coli and Saccharomyces cerevisiae. Gene 25:179-188.
19. Güldener, U., S. Heck, T. Fiedler, J. Beinhauer, and J. H. Hegemann. 1996. A new efficient gene disruption cassette for repeated use in budding yeast. Nucleic Acids Res. 24:2519-2524.
20. Huang, D., I. Farkas, and P. J. Roach. 1996. Pho85p, a cyclin-dependent protein kinase, and the Snf1p protein kinase act antagonistically to control glycogen accumulation in Saccharomyces cerevisiae. Mol. Cell. Biol. 16:4357-4365.
21. Huffaker, T. C., and P. W. Robbins. 1983. Yeast mutants deficient in protein glycosylation. Proc. Natl. Acad. Sci. USA 80:7466-7470.
22. Ito, H., Y. Fukuda, K. Murata, and A. Kimura. 1983. Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153:163-168.
23. Jones, E. 1990. Vacuolar proteases in yeast Saccharomyces cerevisiae. Methods Enzymol. 185:372-386.
24. Lenburg, M. E., and E. K. O'Shea. 1996. Signaling phosphate starvation. Trends Biochem. Sci. 21:383-387.
25. Li, M., A. Tzagoloff, K. Underbrink-Lyon, and N. C. Martin. 1982. Identification of the paromomycin-resistance mutation in the 15S rRNA gene of yeast mitochondria. J. Biol. Chem. 257:5921-5928.
26. Liebman, S. W., and M. Cavenagh. 1980. An antisuppressor that acts on omnipotent suppressors in yeast. Genetics 95:49-61.
27. Madden, S. L., C. L. Creasy, V. Srinivas, W. Fawcett, and L. W. Bergman. 1988. Structure and expression of the PHO80 gene of Saccharomyces cerevisiae. Nucleic Acids Res. 16:2625-2637.
28. McCusker, J. H., and J. E. Haber. 1988. crl mutants of Saccharomyces cerevisiae resemble both mutants affecting general control of amino acid biosynthesis and omnipotent translational suppressor mutants. Genetics 119: 317-327.
29. Measday, V., L. Moore, J. Ogas, M. Tyers, and B. Andrews. 1994. The PCL2 (ORFD)-PHO85 cyclin-dependent kinase complex: a cell cycle regulator in yeast. Science 266:1391-1395.
30. Measday, V., L. Moore, R. Retnakaran, J. Lee, M. Donovell, A. M. Neiman, and B. Andrews. 1997. A family of cyclin-related proteins that interact with the Pho85 cyclin-dependent kinase. Mol. Cell. Biol. 17:1212-1223.
31. Moazed, D., and H. F. Noller. 1987. Interaction of antibiotics with functional sites in 16S ribosomal RNA. Nature 327:389-394.
32. Nakayama, K., T. Nagasu, Y. Shimma, J. Kuromitsu, and Y. Jigami. 1992. OCH1 encodes a novel membrane bound mannosyltransferase: outer chain elongation of asparagine-linked oligosaccharides. EMBO J. 11:2511-2519.
33. Nasmyth, K., and S. Reed. 1980. Isolation of genes by complementation in yeast: molecular cloning of a cell-cycle gene. Proc. Natl. Acad. Sci. USA 77:2119-2123.
34. Oliver, S. G. 1997. From gene to screen with yeast. Curr. Opin. Genet. Dev. 7:405-409.
35. Orlean, P., M. J. Kuranda, and C. F. Albright. 1991. Analysis of glycoproteins from Saccharomyces cerevisiae. Methods Enzymol. 194:682-697.
36. Oshima, Y., N. Ogawa, and S. Harashima. 1996. Regulation of phosphatase synthesis in Saccharomyces cerevisiae - a review. Gene 179:171-177.
37. Palmer, E., J. M. Wilhelm, and F. Sherman. 1979. Phenotypic suppression of nonsense mutants in yeast by aminoglycoside antibiotics. Nature 277:148-150.
38. Perlin, D. S., C. L. Brown, and J. E. Haber. 1988. Membrane potential defect in hygromycin B-resistant pma1 mutants of Saccharomyces cerevisiae. J. Biol. Chem. 263:18118-18122.
39. Prezant, T. R., W. E. Chaltraw, Jr., and N. Fischel-Ghodsian. 1996. Identification of an overexpressed yeast gene which prevents aminoglycoside toxicity. Microbiology 142:3407-3414.
40. Rank, G. H., A. J. Robertson, and K. L. Phillips. 1974. Modification and inheritance of pleiotropic cross resistance and collateral sensitivity in Saccharomyces cerevisiae. Genetics 80:483-493.
41. Rose, M., and P. Novick. 1987. A Saccharomyces cerevisiae plasmid bank based on a centromere-containing shuttle vector. Gene 60:237-243.
42. Schmitt, M. E., T. A. Brown, and B. L. Trumpower. 1990. A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae. Nucleic Acids Res. 18:3091-3092.
43. Sherman, F., G. Fink, and J. Hicks. 1981. Methods in yeast genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
44. Singh, A., D. Ursic, and J. Davies. 1979. Phenotypic suppression and misreading in Saccharomyces cerevisiae. Nature 277:146-148.
45. Timblin, B. K., K. Tatchell, and L. W. Bergman. 1996. Deletion of the gene encoding the cyclin-dependent protein kinase Pho85 alters glycogen metabolism in Saccharomyces cerevisiae. Genetics 143:57-66.
46. Timpel, C., and J. F. Ernst. Unpublished results.
47. Von Aasen, U., and H. F. Noller. 1993. Footprinting the sites of interaction of antibiotics with catalytic group I intron RNA. Science 260:1500-1503.
48. Zapp, M. L., S. Stern, and M. R. Green. 1993. Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production. Cell 74:969-978.
49. Zufferey, R., R. Knauer, P. Burda, I. Stagljar, S. te Heesen, L. Lehle, and M. Aebi. 1995. STT3, a highly conserved protein required for yeast oligosaccharyl transferase in vivo. EMBO J. 14:4949-4960.