Identification of an overexpressed yeast gene which prevents aminoglycoside toxicity

Microbiology

Volumn 142, Issue 12, 1996, Pages 3407-3414

  Prezant, Toni R ^a   Chaltraw Jr , William E ^a   Fischel Ghodsian, Nathan ^a  

^a BURNS AND ALLEN RESEARCH INSTITUTE   (United States)

Author keywords

Aminoglycoside; Cation ATPase; Overexpression; Saccharomyces cerevisiae; Toxicity

Indexed keywords

ABRIN; ADENOSINE TRIPHOSPHATASE (CALCIUM); AMINOGLYCOSIDE; GENE PRODUCT; MEMBRANE PROTEIN; MITOCHONDRIAL RNA; NEOMYCIN;

AMINO TERMINAL SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; DRUG BINDING; DRUG HYPERSENSITIVITY; GENE ISOLATION; GENE MAPPING; GENE MUTATION; GENE OVEREXPRESSION; GENETIC SUSCEPTIBILITY; MUTAGENESIS; NONHUMAN; PERCEPTION DEAFNESS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SEQUENCE HOMOLOGY; YEAST CELL;

EID: 0030460674     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/13500872-142-12-3407     Document Type: Article

References (54)

1. von Ahsen, U. & Noller, H. F. (1993). Footprinting the sites of interaction of antibiotics with catalytic group I intron RNA. Science 260, 1500-1503.
2. von Ahsen, U., Davies, J. & Schroeder, R. (1991). Antibiotic inhibition of group I ribozyme function. Nature 353, 368-370.
3. Altschul, S. F., Gish, W., Miller, W., Myers, E. W. & Lipman, D. J. (1990). Basic local alignment search tool. J Mol Biol 215, 403-410.
4. Bairoch, A. (1991). PROSITE: a dictionary of sites and patterns in proteins. Nucleic Acids Res 19 (suppl.), 2241-2245.
5. Bairoch, A. & Boeckmann, B. (1991). The SWISS-PROT protein sequence data bank. Nucleic Acids Res 19 (suppl.), 2247-2249.
6. Bacino, C., Prezant, T. R., Bu, X., Fournier, P. & Fischel-Ghodsian, N. (1995). Susceptibility mutations in the mitochondrial small ribosomal RNA gene in aminoglycoside induced deafness. Pharmacogenetics 5, 165-172.
7. Balzi, E., Wang, M., Leterme, S., Van Dyck, L. & Goffeau, A. (1994). PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1. J Biol Chem 269, 2206-2214.
8. Bissinger, P. H. & Kuchler, K. (1994). Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product: a yeast ABC transporter conferring mycotoxin resistance. J Biol Chem 269, 4180-4186.
9. Botstein, D., Falco, S. C., Stewart, S. E., Brennan, M., Scherer, S., Stinchcomb, D. T., Struhl, K. & Davis, R. W. (1979). Sterile host yeasts (SHY): a eukaryotic system of biological containment for recombinant DNA experiments. Gene 8, 17-24.
10. Carlson, M. & Botstein, D. (1982). Two differentially regulated mRNAs with different 5′ ends encode secreted with intracellular forms of yeast invertase. Cell 28, 145-154.
11. Chaddock, J. A., Lord, J. M., Hartley, M. R. & Roberts, L. M. (1994). Pokeweed antiviral protein (PAP) mutations which permit E. coli growth do not eliminate catalytic activity towards prokaryotic ribosomes. Nucleic Acids Res 22, 1536-1540.
12. Chernoff, Y. O., Vincent, A. & Liebman, S. W. (1994). Mutations in eukaryotic 18S ribosomal RNA affect translational fidelity and resistance to aminoglycoside antibiotics. EMBO J 13, 906-913.
13. Dayhoff, M. O., Schwartz, R. M. & Orcutt, B. C. (1978). A model of evolutionary change in proteins. In Atlas of Protein Sequence and Structure, vol. 5, suppl. 3, pp. 89-99. Edited by M. O. Dayhoff. Washington, DC: National Biomedical Research Foundation.
14. Dean, N. (1995). Yeast glycosylation mutants are sensitive to aminoglycosides. Proc Natl Acad Sci USA 92, 1287-1291.
15. Endo, Y., Mitsui, K., Motizuki, M. & Tsurugi, K. (1987). The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28S ribosomal RNA caused by the toxins. J Biol Chem 262, 5908-5912.
16. Evensen, G., Mathiesen, A. & Sundan, A. (1991). Direct molecular cloning and expression of two distinct abrin A-chains. J Biol Chem 266, 6848-6852.
17. Garetz, S. L., Rhee, D. J. & Schacht, J. (1994). Sulfhydryl compounds and antioxidants inhibit cytotoxicity to outer hair cells of a gentamicin metabolite in vitro. Hearing Res 77, 75-80.
18. Higashi, K. (1989). Unique inheritance of streptomycin-induced deafness. Clin Genet 35, 433-436.
19. Hornig, H., Woolley, P. & Luhrman, R. (1987). Decoding at the ribosomal A site: antibiotics, misreading and energy of aminoacyl-tRNA binding. Biochimie 69, 803-818.
20. Hu, D.-N., Qiu, W.-Q., Wu, B.-T., Fang, L.-Z., Zhou, F., Gu, Y.-P., Zhang, Q.-H., Yan, J.-H., Ding, Y.-Q. & Wong, H. (1991). Genetic aspects of antibiotic induced deafness: mitochondrial inheritance. J Med Genet 28, 79-83.
21. Hung, C.-H., Lee, M.-C., Lee, T.-C. & Lin, J.-Y. (1993). Primary structure of three distinct isoabrins determined by cDNA sequencing. Conservation and significance. J Mol Biol 229, 263-267.
22. Hutchin, T., Haworth, I. Higashi, K., Fischel-Ghodsian, N., Stoneking, M., Saha, N., Arnos, C. & Cortopassi, G. (1993). A molecular basis for human hypersensitivity to aminoglycoside antibiotics. Nucleic Acids Res 21, 4174-4179.
23. Ito, H., Fukuda, Y., Murata, K. & Kimura, A. (1983). Transformation of intact yeast cells treated with alkali cations. J Bacteriol 153, 163-168.
24. Kim, Y. & Robertus, J. D. (1992). Analysis of several key active site residues of ricin A chain by mutagenesis and X-ray crystallography. Protein Eng 5, 775-779.
25. Kyte, J. & Doolittle, R. F. (1982). A simple method for displaying the hydropathic character of a protein. J Mol Biol 157, 105-132.
26. Leppert, G., McDevitt, R., Falco, S. C., Van Dyk, T. K., Ficke, M. B. & Golin, J. (1990). Cloning by gene amplification of two loci conferring multiple drug resistance in Saccharomyces. Genetics 125, 13-20.
27. Li, M., Tzagoloff, A., Underbrink-Lyon, K. & Martin, N. C. (1982). Identification of the paromomycin-resistance mutation in the 15S rRNA gene of yeast mitochondria. J Biol Chem 257, 5921-5928.
28. McCusker, J. H., Perlin, D. S. & Haber, J. E. (1987). Pleiotropic plasma membrane ATPase mutations of Saccharomyces cerevisiae. Mol Cell Biol 7, 4082-4088.
29. Marbois, B. N., Hsu, A., Pillai, R., Colicelli, J. & Clarke, C. F. (1994). Cloning of a rat cDNA encoding dihydroxypolyprenylbenzoate methyltransferase by functional complementation of a Saccharomyces cerevisiae mutant deficient in ubiquinone biosynthesis. Gene 138, 213-217.
30. Moazed, D. & Noller, H. F. (1987). Interaction of antibiotics with functional sites in 16S ribosomal RNA. Nature 327, 389-394.
31. Monzingo, A. F. & Robertus, J. D. (1992). X-ray analysis of substrate analogs in the ricin A-chain active site. J Mol Biol 227, 1136-1145.
32. Monzingo, A. F., Collins, E. J., Ernst, S. R., Irvin, J. D. & Robertus, J. D. (1993). The 2.5 Å structure of pokeweed antiviral protein. J Mol Biol 233, 705-715.
33. Nakai, K. & Kanehisa, M. (1992). A knowledge base for predicting protein localization sites in eukaryotic cells. Genomics 14, 897-911.
34. Pearson, W. R. & Lipman, D. J. (1988). Improved tools for biological sequence comparison. Proc Natl Acad Sci USA 85, 2444-2448.
35. Pedersen, P. L & Carafoli, E. (1987). Ion motive ATPases. I. Ubiquity, properties, and significance to cell function. Trends Biochem Sci 12, 146-150.
36. Perlin, D. S., Brown, C. L. & Haber, J. E. (1988). Membrane potential defect in hygromycin B-resistant pma1 mutants of Saccharomyces cerevisiae. J Biol Chem 263, 18118-18122.
37. Perlin, D. S., Harris, S. L., Seto-Young, O. & Haber, J. E. (1989). Defective H(+)-ATPase of hygromycin B-resistant pma1 mutants from Saccharomyces cerevisiae. J Biol Chem 264, 21857-21864.
38. Prezant, T. R., Agapian, J. V., Bohlman, M. C. & 9 other authors (1993). Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness. Nature Genet 4, 289-294.
39. Ready, M. P., Kim, Y. & Robertus, J. D. (1991). Site-directed mutagenesis of ricin A-chain and implications for the mechanism of action. Proteins 10, 270-278.
40. Ripmaster, T. L., Vaughn, G. P. & Woolford, J. L., Jr (1993). DRS1 to DRS7, novel genes required for ribosome assembly and function in Saccharomyces cerevisiae. Mol Cell Biol 13, 7901-7912.
41. Rothstein, R. (1991). Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. Methods Enzymol 194, 281-301.
42. 2+ ATPase family. Cell 58, 133-145.
43. Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B. & Erlich, H. A. (1988). Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239, 487-491.
44. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989). Molecular Cloning: a Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
45. Sandbaken, M. G., Lupisella, J. A., DiDomenico, B. & Chakraburtty, K. (1990). Protein synthesis in yeast. Structural and functional analysis of the gene encoding elongation factor 3. J Biol Chem 265, 15838-15844.
46. Sande, M. A. & Mandell, G. L. (1990). Antimicrobial agents. In The Pharmacological Basis of Therapeutics, 8th edn, pp. 1098-1116. Edited by A. G. Gilman, T. W. Rall, A. S. Nies & P. Taylor. Elmsfotd, NY: Pergamon Press.
47. Schacht, J. & Weiner, N. (1986). Aminoglycoside-induced hearing loss: a molecular hypothesis. J Oto-Rhino-Laryngol & Related Specialties 48, 116-123.
48. Serrano, R. (1991). Transport across yeast vacuolar and plasma membranes. In The Molecular and Cellular Biology of the Yeast Saccharomyces: Genome Dynamics, Protein Synthesis, and Energetics, pp. 523-586. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
49. Sherman, F., Fink, G. R. & Hicks, J. B. (1983). Methods in Yeast Genetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
50. Sikorski, R. S. & Hieter, P. (1989). A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122, 19-27.
51. Singh, A., Ursic, D. & Davies, J. (1979). Phenotypic suppression and misreading in Saccharcmyces cerevisiae. Nature 277, 146-148.
52. Strathern, J. N. & Higgins, D. R. (1991). Recovery of plasmids from yeast into Escherichia coli: shuttle vectors. Methods Enzymol 194, 319-328.
53. Ulaszewski, S., Balzi, E. & Goffeau, A. (1987). Genetic and molecular mapping of the pma1 mutation conferring vanadate resistance to the plasma membrane ATPase from Saccharomyces cerevisiae. Mol Gen Genet 207, 38-46.
54. Wood, K. A., Lord, J. M., Wawrzynczak, E. J. & Piatak, M. (1991). Preproabrin: genomic cloning, characterisation and the expression of the A-chain in Escherichia coli. Eur J Biochem 198, 723-732.