Sonic hedgehog is not required for polarising activity in the Doublefoot mutant mouse limb bud

Development

Volumn 125, Issue 3, 1998, Pages 351-357

  Hayes, Christopher ^a   Brown, Jennifer M ^a   Lyon, Mary F ^b   Morriss Kay, Gillian M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

Author keywords

Apical ectodermal ridge (AER); Doublefoot (Dbf); Fgf4; Limb bud; Mouse; Sonic hedgehog (Shh); Zone of polarising activity (ZPA)

Indexed keywords

ARTICLE; CELL POLARITY; DEVELOPMENTAL GENETICS; EMBRYO; GENE MUTATION; GENE TARGETING; HUMAN TISSUE; LIMB BUD; MESENCHYME; MOUSE; NONHUMAN; POLYDACTYLY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; BODY PATTERNING; BONE MORPHOGENETIC PROTEINS; CHICK EMBRYO; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; LIMB BUD; MEMBRANE PROTEINS; MESODERM; MICE; MICE, MUTANT STRAINS; MORPHOGENESIS; MUTATION; ONCOGENE PROTEINS; POLYDACTYLY; PROTEINS; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

ERINACEIDAE; MAMMALIA;

EID: 0031913336     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Alexandre, C., Jacinto, A. and Ingham, P. W. (1996). Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev. 10, 2003-2013
2. Chan, D. C., Laufer, E., Tabin, C. and Leder, P. (1995). Polydactylous limbs in Strongs luxoid mice results from ectopic polarizing activity. Development 121, 1971-1978
3. Chen, Y. and Struhl, G. (1996). Dual roles for Patched in sequestering and transducing hedgehog. Cell 87, 553-563
4. Duprez, D. M., Kostakopoulou, K., Francis-West, P. H., Tickle, C. and Brickell, P. M. (1996). Activation of Fgf-4 and HoxD gene expression by BMP-2 expressing cells in the developing chick limb. Development 122, 1821-1828
5. Francis, P. H., Richardson, M. K., Brickell, P. M. and Tickle, C. (1994). Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb. Development 120, 209-218
6. 3) limb buds: their relationships in the signalling cascade involved in limb patterning. Dev. Dynam. 203, 187-197
7. Goodrich, L. V., Johnson, R. L., Milenkovic, L., McMahon, J. A. and Scott, M. P. (1996). Conservation of the hedgehog/patched signalnig pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev. 10, 301-312
8. Hamburger, V. and Hamilton. H. L. (1951). A series of normal stages in the development of the chick embryo. J. Morph. 88, 49-92
9. Hammerschmidt, M., Bitgood, M. J. and McMahon, A. P., (1996). Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo. Genes Dev. 10, 647-658
10. Hinchliffe, J. R. and Sansom, A. (1985). The distribution of the polarizing zone (ZPA) in the leg of the chick embryo. J.Embryol. Exp. Morphol. 86, 169-175
11. Hepker, J., Wang, Q.-T., Motzny, C. K., Holmgren, R. and Vales Orenic, T. (1997). Drosophila cubitus interruptus forms a negatice feedback loop with patched and regulates expression of Hedgehog target genes. Development 124, 549-558
12. Hogan, B. L. M. (1996). Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 10, 1580-1594
13. Honig, L. S. and Summerbell, D. (1985). Maps of strength of positional signalling activity in the developing chick wing. J. Embryol. Exp. Morph. 87, 163-174
14. Ingham, P. W., Taylor, A.M. and Nakano, Y., (1991). Role of the Drosophila patched gene in positional signaling. Nature 318, 439-445
15. Izpisua-Belmonte, J.-C., Tickle, C., Dollé, P., Wolpert, L. and Duboule, D. (1991a). Expression of the homeobox Hox4 genes and the specification of position in chick wing development. Nature 350, 585-589
16. Izpisua-Belmonte, J.-C. Brown, J. M., Crawley, A., Duboule, D. and Tickle, C. (1991b). Hox-4 gene expression in mouse/chicken heterospecific grafts of signalling regions to limb buds reveals similarities in patterning mechanisms. Development 115, 553-560.
17. Jiang, J. and Struhl, G., (1995). Protein kinase A and Hedgehog signaling in Drosophila limb development. Cell 80, 563-572
18. Laufer, E., Nelson, C. E., Johnson, R. L., Morgan, B. A. and Tabin, C. (1994). Sonic hedgehog and FGF-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb. Cell 79, 1757-1668
19. Lee, J., Platt, K. A., Censullo, P. and Ruiz i Altaba, A. (1997). Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 124, 2537-2552
20. Lyon, M. F., Quinney, R., Glenister, P. H., Kerscher, S., Guillot, P. and Boyd, Y. (1996). Doublefoot: a new mouse mutant affecting development of the limbs and head. Gen. Res. 68, 221-231.
21. Marigo, V., Davey, R. A., Zuo, Y., Cunningham, J. M. and Tabin, C. J. (1996a). Biochemical evidence that Patched is the Hedgehog receptor. Nature 384, 176-179
22. Marigo, V., Scott, M. P., Johnson, R. L., Goodrich, L. V. and Tabin, C. J. (1996b). Conservation in hedgehog signalling: induction of a chick patched homologue by Sonic hedgehog in the developing limb. Development 122, 1225-1233
23. Marigo, V., Johnson, R. L., Vortkamp, A. and Tabin, C. J. (1996c). Sonic hedgehog differentially regulates the expression of Gli and Gli3 during limb development. Dev. Biol. 180, 273-283
24. Martí, E., Takada, R., Bumcrot, D. A., Sasaki, H. and McMahon, A. P. (1995). Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo. Development 121, 2537-2547.
25. Masuya, H., Sagai, T., Wakana, S., Moriwaki, K. and Shiroishi, T. (1995). A duplicated zone of polarizing activity in polydactylous mouse mutants. Genes Dev. 9, 1645-1653
26. Masuya, H., Sagai, T., Moriwaki, K. and Shiroishi, T. (1997). Multigenic control of the localization of the zone of polarizing activity in limb morphogenesis in the mouse. Dev. Biol. 182, 42-52.
27. Niswander, L. and Martin, G. R. (1992). Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse. Development 114, 755-768.
28. Oro, A. E., Higgins, K. M., Hu, Z., Bonifas, J. M., Epstein, E. H. and Scott, M. P. (1997). Basal cell carcinomas in mice overexpressing sonic hedgehog. Science 276, 817-821.
29. Perrimon, N. (1995). Hedgehog and beyond. Cell 80, 517-520.
30. Porter, J. A. et al., (1995). The product of hedgehog autoproteolytic cleavage active in local and long-range signalling. Nature 374, 363-366.
31. Porter, J. A., Young, K. E. and Beachy, P. A. (1996). Cholesterol modification of hedgehog signaling proteins in animal development. Science 274, 255-259.
32. Riddle, R. D., Johnson. R. L., Luafer, E. and Tabin, C. (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.
33. Robbins, D. J. et al., (1997). Hedgehog elicits signal transduction by means of a large complex containg the kinesin-related protein Costal2. Cell 90, 225-234.
34. Ruiz i Altaba, A. (1997). Catching a Gli-mpse of hedgehog. Cell 90, 193-196.
35. Saunders, J. W. and Gasseling, M. T. (1968). In Epithelial-Mesenchymal Interactions, (ed.R. Fleischmajer, and R.E. Billingham, R.E.), pp. 78-97, Baltimore: Williams & Wilkins.
36. Stone. D. M., et al., (1996). The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384, 129-134.
37. Tickle, C., Shellswell, G., Crawley, A. and Wolpert, L. (1976). Positional signalling by mouse limb polarising region in the chick wing bud. Nature 259, 396-397.
38. Van den Heuvel, M. and Ingham, P. W. (1996). smoothened encodes a serpintine protein required for hedgehog signalling. Nature 382, 547-551.
39. Von Ohlen, T., Lessing, D., Nusse, R. and Hooper, J. E., (1997). Hedgehog signaling regulates transcription through cubitus interruptus, a sequence specific DNA binding protein. Proc. Natl Acad. Sci. USA 94, 2404-2409.
40. Watson, A. G. (1977). In toto alcian blue staining of the cartilaginous skeleton in mammalian embryos. Anat. Rec. 187, 743.
41. Wilkinson, D. G. (1992). In situ hybridisation. (IRL Press, Oxford).