Association of polymorphism in the alcohol dehydrogenase 2 gene with alcohol-related organ injuries, especially liver cirrhosis

Addiction Biology

Volumn 3, Issue 2, 1998, Pages 151-157

  Yamauchi, Masayoshi ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE; ISOENZYME;

ALCOHOL LIVER CIRRHOSIS; ALCOHOL METABOLISM; ALCOHOLISM; ALLELE; ARTICLE; ETHNIC DIFFERENCE; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; HUMAN; INHERITANCE; PRIORITY JOURNAL;

EID: 0031892936     PISSN: 13556215     EISSN: None     Source Type: Journal    
DOI: 10.1080/13556219872218     Document Type: Article

References (42)

1. Bosron WF, Li T-K. Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism. Hepatology 1986;6:502-10.
2. Bosron WF, Lumeng L, Li T-K. Genetic polymorphism of enzymes of alcohol metabolism and susceptibility to alcoholic liver disease. Molec Aspects Med 1988;10:147-58.
3. 2 allele is dominant. J Clin Invest 1989;83:314-16.
4. Singh S, Fritze G, Fang B, et al. Inheritance of mitochondrial aldehyde dehydrogenase: genotyping in Chinese, Japanese and South Korean families reveals dominance of the mutant allele. Hum Genet 1989;83:119-21.
5. Mizoi Y, Ijiri I, Tatsuno Y, et al. Relationship between facial flushing and blood acetaldehyde levels after alcohol intake. Pharmacol Biochem Behav 1979;10:303-11.
6. Harada S, Misawa S, Agarwal DP, Goedde HW. Liver alcohol dehydrogenase and aldehyde dehydrogenase in the Japanese: isoenzyme variation and its possible role in alcohol intoxication. Am J Hum Genet 1980;32:8-15.
7. Lieber CS. Alcohol and the liver: 1994 update. Gastroenterology 1994;10:1085-105.
8. Harada S, Agarwal DP, Goedde HW. Possible protective role against alcoholism for aldehyde dehydrogenase deficiency in Japan. Lancet 1982; 2:827.
9. Thomasson HR, Edenberg HJ, Crabb DW, et al. Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet 1991;48:677-81.
10. Chao YC, Liou SR, Chung YY, Tang HS, Hsu CT, Li T-K, Yin SJ. Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients. Hepatology 1994;19: 360-6.
11. Shibuya A, Yoshida A. Genotypes of alcohol metabolizing enzymes in Japanese with alcohol liver disease. A strong correlation of the unusual Caucasian type aldehyde dehydrogenase gene (ALDH2-1) with the disease. Am J Hum Genet 1988;43:744-8.
12. Higuchi S. Polymorphisms of ethanol metabolizing enzyme genes an alcoholism. In Saunders JB, Whitfield JB, editors. The biology of alcohol problems. Oxford: Elsevier Science; 1994:29-34.
13. Maezawa Y, Yamauchi M, Gotaro T, Suzuki H, Sakurai S. Alcohol-metabolizing enzyme polymorphisms and alcoholism in Japan. Alcohol Clin Exp Res 1995;19:951-4.
14. Xiao Q, Weiner H, Crabb DW. The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion. J Clin Invest 1996;98:2027-32.
15. Thomasson HR, Crabb DW, Edenberg HJ, Li T-K. Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism. Behav Genet 1993;23: 13-136.
16. Thomasson HR, Crabb DW, Edenberg HJ, et al. Low frequency of the ADH2-2 allele among Atayal natives of Taiwan with alcohol use disorders. Alcohol Clin Exp Res 1994;18:640-3.
17. Tanaka F, Shiratori Y, Yokosuka O, Imazeki F, Tsukada Y, Omata M. High incidence of ADH2*a/ALDH2*1 gene among Japanese alcohol dependants and patients with alcoholic liver disease. Hepatology 1996;23:234-9.
18. Goedde HW, Agarwal DP, Fritze G, et al. Distribution of ADH2 and ALDH2 genotypes in different populations. Hum Genet 1992;88:344-6.
19. Fleury B, Couzigou P, Coutelle C, Nalpas B, Poupon RE. Comparative genetic polymorphism of alcohol dehydrogenase (ADH) in alcoholics and controls in France. Alcohol Clin Exp Res 1990;14: 288 (Abstr).
20. Gilder FJ, Hodgkinson S, Murray RM. ADH and ALDH genotype profiles in Caucasians with alcohol-related problems and controls. Addiction 1993;88:383-8.
21. Pares X, Moreno A, Farres J, et al. Liver and stomach alcohol dehydrogenase in normal and alcoholic individuals from Barcelona. ISBRA 1992 Satellite Symposium Genetics and alcohol-rated disease, June 18-19, 1992, Bordeaux, France.
22. Thomasson HR, Beard JD, Li T-K. ADH2 gene polymorphisms are determinants of alcohol pharmacokinetics, Alcohol Clin Exp Res 1995;19: 1494-9.
23. Couzigou P, Fleury B, Groppi A, Cassaigne A, Begueret J, Iron A. Genotyping study of alcohol dehydrogenase class I polymorphism in French patients with alcoholic cirrhosis. Alcohol Alcohol 1990;25:623-6.
24. Day, CP, Bashir R, James OFW, et al. Investigation of the role of polymorphisms at the alcohol and aldehyde dehydrogenase loci in genetic predisposition to alcohol-related end-organ damage. Hepatology 1991;14:798-801.
25. Poupon RE, Nalpas B, Coutelle C, et al. and the French Group for Research on Alcohol and Liver. Polymorphism of alcohol dehydrogenase, alcohol and aldehyde dehydrogenase activities: implication in alcoholic cirrhosis in white patients. Hepatology 1992;15:1017-22.
26. Sherman DI, Ward RJ, Warren-Perry M, Williams R, Peters TJ. Association of restriction fragment length polymorphism in alcohol dehydrogenase 2 gene with alcohol induced liver damage. Br Med J 1993;307:1388-90.
27. Yamauchi M, Maezawa Y, Toda G, Suzuki H, Sakurai S. Association of a restriction fragment length polymorphism in the alcohol dehydrogenase 2 gene with Japanese alcoholic liver cirrhosis. J Hepatology 1995;23:519-23.
28. Poupon RE, Ward, P. Balkau, B. Alcohol dehydrogenase polymorphisms and predisposition to alcoholic cirrhosis. Hepatology 1993;18:231-2.
29. Wermuth B, Ernet E, Von Wartburg T-P, Speck R, Schwarzenbach F, Lauterburg B. Bestimmung des alcohol dehydrogenase genotyps: keine correlation zwischen isoenzymmuster und leberzirrhose. Schweiz med Wochenschr 1991;121:1880-2.
30. Yamauchi M, Maezawa Y, Mizuhara Y, et al. Polymorphisms in alcohol metabolizing enzyme genes and alcoholic cirrhosis in Japanese patients: a multi-variate analysis. Hepatology 1995;22:1136-42.
31. Yamauchi M, Maezawa Y, Ohata M, Nakajima H, Ichikawa M, Toda G. Risk factors for development of alcoholic liver cirrhosis. In: Yamanaka M, Okabe K, Toda G, editors. Progress in hepatology, vol 1. Cellular and molecular biology. Amsterdam: Elsevier Science; 1995, pp. 119-31.
32. Veech RL, Guynn R, Veloso D. The time-course of the effects of ethanol on the redox and phosphorylation states of rat liver. Biochem J 1972;127: 387-97.
33. Higuchi S, Matsushita S, Muramatsu T, Hayashida M. Alcohol and aldehyde dehydrogenase genotypes and drinking behavior in Japanese. Alcohol Clin Exp Res 1996;20:493-7.
34. Domschke S, Domschke W, Lieber CS. Hepatic redox state: attenuation of the acute effects of ethanol induced by chronic ethanol consumption. Life Sci 1974;15:1327-34.
35. Savolainen ER, Leo NA, Timpl R, Lieber CS. Acetaldehyde and lactate stimulate collagen synthesis of cultured baboon liver myofibroblasts. Gastroenterology 1994;87:777-87.
36. Coutelle C, Dumas F, Fleury B, Gerolami A, Groppi A, Cassaigne A, Couzigou P. Role of alcohol dehydrogenase polymorphism in alcoholic patients with chronic pancreatitis. Alcohol Alcohol 1993; 28:234 (Abstr).
37. Yamauchi M, Maezawa Y, Nishikawa F, Mizuhara Y, Ohata M, Toda G. Association between restriction fragment length polymorphisms in alcohol dehydrogenase 2 gene with alcohol induced hyperuricemia in patients with alcoholic liver disease. Hepatology 1994;20:318A (Abstr).
38. Yamauchi M, Maezawa Y, Searashi Y, et al. Polymorphisms in alcohol dehydrogenase 2 gene and alcoholic organ injuries in Japanese alcoholics. Int Hepatol Commun 1995; 3 (suppl): S11 (Abstr).
39. Maezawa Y, Yamauchi M, Searashi Y, et al. Association of restriction fragment-length polymorphisms in the alcohol dehydrogenase 2 gene with alcoholic brain atrophy. Alcohol Clin Exp Res 1996;20: 29A-32A.
40. Matsumoto M, Takahashi H, Maruyama K, et al. Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in Japanese alcoholics. Alcohol Clin Exp Res 1996; 20:29A-292A.
41. Chao YC, Young TH, Tang HS, Hsu CT. Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients. Hepatology 1997;25:112-17.
42. Lieber CS, Jones DP, Losowsky MS, Davidson CS. Interrelation of uric acid and ethanol metabolism in man. J Clin Invest 1962;41:1863-970.