Cathepsin D antigenic epitopes identified by the humoral responses of ovarian cancer patients

Cancer Immunology Immunotherapy

Volumn 46, Issue 1, 1998, Pages 48-54

  Chinni, Sreenavasa R ^a   Gerçel Taylor, Çiçek ^a   Conner, Gregory E ^b   Taylor, Douglas D ^a  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Autoantigens; Cathepsin D; Epitopes

Indexed keywords

AUTOANTIGEN; CARBOHYDRATE; CATHEPSIN D; CORE PROTEIN; EPITOPE;

ARTICLE; EPITOPE MAPPING; FEMALE; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOGENICITY; OVARY CANCER; PRIORITY JOURNAL; TUMOR IMMUNOLOGY;

AMINO ACID SEQUENCE; ANTIBODY FORMATION; CATHEPSIN D; ENZYME PRECURSORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; HUMANS; MOLECULAR SEQUENCE DATA; OVARIAN NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0031892721     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050459     Document Type: Article

References (40)

1. r 52,000 cathepsin D secreted by breast cancer cells. Cancer Res 48:2688
2. Brouillet JP, Dufour F, Lemamy G, Garcia M, Schlup N, Grenier J, Mani JC, Rochefort H (1997) Increased cathepsin D level in serum of patients with metastatic breast carcinoma detected with a specific pro-cathepsin D immunoassay. Cancer 79:2132
3. Brown R, Clugston C, Burns P, Edlin A, Vasey P, Vojtesek B, Kaye SB (1993) Increased accumulation of p53 protein in cisplatin-resistant ovarian cell lines. Int J Cancer 55:678
4. Capony F, Rougeot C, Montcourrier P, Cavailles V, Salazar G, Rochefort H (1989) Increased secretion, altered processing, and glycosylation of pro-cathepsin D in human mammary cancer cells. Cancer Res 49:3904
5. Chinni SR, Falchetto R, Gercel-Taylor C, Shabanowitz J, Hunt DF, Taylor, DD (1997) Humoral immune responses to cathepsin D and glucose regulated protein-78 in ovarian cancer patients. Clin Cancer Res 3:1557
6. Conner GE (1992) The role of the cathepsin D propeptide in sorting to the lysosome. J Biol Chem 267:21738
7. Conner GE, Richo G (1992) Isolation and characterization of a stable activation intermediate of the lysosomal aspartyl protease cathepsin D. Biochemistry 31:1142
8. Disis ML, Calenoff E, McLaughlin G, Murphy AE, Chen W, Groner B, Jeschke M, Lydon N, McGlynn E, Livingston RB, Moe R, Cheever MA (1994) Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer. Cancer Res 54:16
9. Dittmer F, Pohlmann R, vonFigura K (1997) The phosphorylation pattern of oligosaccharides in secreted procathepsin D is glycosylation site-specific and independent of the expression of mannose 6-phosphate receptors. J Biol Chem 272:852
10. r 52,000 protein in primary breast cancers but not in normal breast and uterus. J Clin Endocrinol Metab 59:564
11. Garcia M, Platet N, Liaudet E, Laurent V, Derocq D, Brouillel JP, Rochefort H (1996) Biological and clinical significance of cathepsin D in breast cancer metastasis. Stem Cells 14:642
12. Hennebicq-Reig S, Kim I, Janin A, Grard G, Hemon B, Moreau O, Porchet N, Aubert JP, Degand P, Huet G (1996) Regulation of cathepsin D dependent on the colon carcinoma cells. Int J Cancer 68:479
13. Imai H, Kiyosawa K, Chan EK, Tan EM (1993) Autoantibodies in viral hepatitis related hepatocellular carcinoma. Intervirology 35:73
14. Jung S, Schluesener HJ (1991) Human T lymphocytes recognize a peptide of single point mutated oncogenic ras proteins. J Exp Med 173:273
15. Kawada A, Hara K, Kominami E, Kobayashi T, Hiruma M, Ishibashi A (1996) cathepsin B and D expression in squamous cell carcinoma. Br J Dermatol 135:905
16. Kotera Y, Fontenot D, Pecher G, Metzgar RS, Finn OJ (1994) Humoral immunity against a tandem repeat epitope of human mucin, muc-1, in sera from breast, pancreatic and colon cancer patients. Cancer Res 54:2856
17. Kutteh WH, Miller DS, Mathis JM (1996) Immunologic characterization of tumor markers in human ovarian cancer cell lines. J Soc Gynecol Invest 3:216
18. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680
19. Laury-Kleintop LD, Coronel EC, Lange MK, Tachovsky T, Long S, Tucker S, Alhadeff JA (1995) Western blotting and isoform analysis of cathepsin D from normal and malignant human breast cell lines. Breast Cancer Res Treat 35:211
20. Losch A, Kohlberger P, Gitsch G, Kaider A, Breitenecker G, Kainz C (1996) Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer. Br J Cancer 73:1525
21. r 52,000 cathepsin D in 182 breast cancer cytosols. Low correlation with other prognostic parameters. Cancer Res 48:462
22. Old LJ (1981) Cancer immunology: the search for specificity. Cancer Res 41:361
23. Owens K, Gercel-Taylor C, Taylor DD, Day TG, Doering DL (1993) Isolation and characterization of an ovarian carcinoma cell line as a model for drug resistance. Proc Am Assoc Cancer Res 34:26
24. Pupa SM, Menard S, Andreola S, Colnaghi MI (1993) Antibody response against the c-erbB-2 oncoprotein in breast carcinoma patients. Cancer Res 53:5864
25. Richo G, Conner GE (1991) Proteolytic activation of human procathepsin D. Adv Exp Mod Biol 306:289
26. Rijnboutt S, Aerts HMFG, Geuze HJ, Tager JM, Strous GJ (1991) Mannose 6-phosphate-independent membrane association of cathepsin D, glucocerebrosidase, and sphingolipid-acitvating protein in HepG2 cells. J Biol Chem 266:4862
27. Rochefort H, Liaudet E, Garcia M (1996) Alterations and role of human cathepsin D in cancer metastasis. Enzyme Protein 49:106
28. Sahin U, Tureci O, Schmitt H, Cochlovius B, Johannes T, Schmits R, Stenner F, Luo G, Schobert I, Pereundschuh M (1995) Human neoplasms elicit multiple specific immune responses in the autologous host. Proc Natl Acad Sci USA 92:11810
29. Scambia G, Panici PB, Ferrandina G, Salerno G, D'Agostino G, Distefano M, deVincenzo R, Ercoli A, Mancuso S (1994) Clinical significance of cathepsin D in primary ovarian cancer. Eur J Cancer 30A:935
30. Scarborough PE, Guruprasad K, Topham C, Richo GR, Conner GE, Blundell TL, Dunn BM (1993) Exploration of subsite binding specificity of human cathepsin D through kinetics and rule-based molecular modeling. Protein Sci 2:264
31. Schlichthoiz B, Legros Y, Gillet D, Gaillard C, Marty M, Lane D, Calvo F, Soussi T (1992) The immune response to p53 in breast cancer patients is directed against immunodominant epitopes unrelated to the mutational hot spot. Cancer Res 52:6380
32. Taylor DD, Homesley HD, Doellgast GJ (1983) Membrane-associated immunoglobulins in cyst fluid and ascites fluids of ovarian cancer patients. Am J Reprod Immunol 3:7
33. Taylor DD, Homesley HD, Doellgast GJ (1984) Identification of components responsible for the autologous humoral responses of ovarian cancer patients. Am J Reprod Immunol 6:179
34. Touitou I, Capony F, Brouillet JP, Rochefort H (1994) Missense polymorphism (C/T224) in the human cathepsin D pro-fragment determined by polymerase chain reaction-single strand conformational polymorphism analysis and possible consequences in cancer cells. Eur J Cancer 30:390
35. Tumminello FM, Leto G, Pizzolanti G, Candiloro V, Crescimanno M, Crosta L, Flandina C, Montalto G, Soresi M, Carroccio A, Bascone F, Ruggeri I, Ippolito S, Gebbia N (1996) cathepsin D, B, and L circulating levels as prognostic markers of malignant progression. Anticancer Res 16:2315
36. Vignon F, Capony F, Chambon M, Freiss G, Garcia M, Rochefort H (1986) Autocrine growth stimulation of the MCF7 breast cancer cells by the estrogen-regulated 52K protein. Endocrinology 118:1537
37. Vlock DR, Scalise D, Schwartz DR, Richter DE, Krause CJ, Baker SR, Carey TE (1989) Incidence of serum antibody reactivity to autologous head and neck cancer cell lines and augmentation of antibody reactivity following acid dissociation and ultrafiltration. Cancer Res 49:1361
38. Winter SF, Minna JD, Johnson BE, Takahashi T, Gazdar AF, Carbone DP (1992) Development of antibodies against p53 in lung cancer patients appears to be dependent on the type of p53 mutation. Cancer Res 52:4168
39. Yamamoto A, Shimizu E, Ogura T, Stone S (1996) Detection of auto-antibodies against l-myc oncogene products in sera from lung cancer patients. Int J Cancer 69:283
40. Zhu Y, Conner GE (1994) Intermolecular association of lysosomal protein precursors during biosynthesis. J Biol Chem 269:3846