Increased cathepsin D level in the serum of patients with metastatic breast carcinoma detected with a specific pro-cathepsin D immunoassay

Cancer

Volumn 79, Issue 11, 1997, Pages 2132-2136

  Brouillet, Jean Paul ^a   Dufour, Franck ^a   Lemamy, Guy ^b   Garcia, Marcel ^b   Schlup, Nicolas ^a   Grenier, Jean ^c   Mani, Jean Claude ^d   Rochefort, Henri ^b  

^a HÔPITAL ARNAUD DE VILLENEUVE   (France)

^b INSERM   (France)

^c CENTRE VAL D AURELLE   (France)

^d CNRS   (France)

Author keywords

breast carcinoma; cathepsin D; immunoassay; mannose 6 phosphate insulin like growth factor II receptor; serum marker

Indexed keywords

CATHEPSIN D; ENZYME PRECURSOR; MANNOSE 6 PHOSPHATE; SOMATOMEDIN B; SOMATOMEDIN B RECEPTOR; TUMOR MARKER;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME RELEASE; FEMALE; HUMAN; IMMUNOASSAY; METASTASIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN INTERACTION; RADIOIMMUNOASSAY;

ADULT; BREAST NEOPLASMS; CA-15-3 ANTIGEN; CATHEPSIN D; ENZYME PRECURSORS; FEMALE; HUMANS; MIDDLE AGED; NEOPLASM METASTASIS; RADIOIMMUNOASSAY; REFERENCE VALUES; TUMOR MARKERS, BIOLOGICAL;

EID: 0030978333     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19970601)79:11<2132::AID-CNCR10>3.0.CO;2-X     Document Type: Article

References (18)

1. Rochefort H. Cathepsin D in breast cancer: a tissue marker associated with metastasis. Eur J Cancer 1992;28A:1780-3.
2. Garcia M, Capony F, Derocq D, Simon D, Pau B, Rochefort H. Characterization of monoclonal antibodies to the estrogen-regulated Mr 52,000 glycoprotein and their use in MCF7 cells. Cancer Res 1985;45:709-16.
3. Brouillet JP, Hanslik B, Maudelonde T, Vaucher E, Piva T, Grenier J, et al. Increased plasma cathepsin D concentration in hepatic carcinoma and cirrhosis but not in breast cancer. Clin Biochem 1991;24:491-6.
4. Zuhlsdorf F, Imort M, Hasilik A, Von Figura K. Molecular forms of B-hexosaminidase and cathepsin D in serum and urine of healthy subjects and patients with elevated activity of lysosomal enzymes. Biochem J 1983;213:733-40.
5. Freiss G, Vignon F, Rochefort H. Characterization and properties of two monoclonal antibodies specific for the Mr 52,000 precursor of cathepsin D in human breast cancer cells. Cancer Res 1988;48:3709-15.
6. Brouillet JP, Spyratos F, Hacene K, Fauque J, Freiss G, Dupont F, et al. Immunoradiometric assay of pro-cathepsin D in breast cancer cytosol: relative prognostic value versus total cathepsin D. Eur J Cancer 1993;29A:1248-51.
7. Brouillet JP, Theillet C, Maudelonde T, Defrenne A, Simony-Lafontaine J, Sertour J, et al. Cathepsin D assay in primary breast cancer and lymph nodes: relationship with c-myc, c-erb-B-2 and int-2 oncogene amplification and node invasiveness. Eur J Cancer 1990;26:437-41.
8. Sahagian GG, Distler JJ, Jourdian GW. Membrane receptor for phosphomannosyl residues. Methods Enzymol 1982; 83:392-6.
9. Malmqvist M. Biospecific interaction analysis using biosensor technology. Nature 1993;361:186-7.
10. Allauzen S, Mani JC, Granier C, Pau B, Bouanani M. Epitope mapping and binding analysis of insulin-specific monoclonal antibodies using a biosensor approach. J Immunol Methods 1995;183:27-32.
11. 1-antichymotrypsin and soluble IGF-II/Man-6-P receptor from MCF7 breast cancer cells. Endocrinology 1995;136:3759-66.
12. Kiess W, Greenstein LA, White RM, Lee L, Rechler MM, Nissley P. Type II insulin-like growth factor receptor is present in rat serum. Proc Natl Acad Sci USA 1987;84:7720-4.
13. Capony F, Rougeot C, Montcourrier P, Cavaillès V, Salazar G, Rochefort H. Increased secretion and altered processing and glycosylation of pro-cathepsin D in human mammary cancer cells. Cancer Res 1989;49:3904-9.
14. Jarosz DE, Hamer PJ, Tenne DY, Zabrecky JR. Elevated levels of pro-cathepsin D in the plasma of breast cancer patients. Int J Oncol 1995;6:859-65.
15. Hayes DF, Tondini C, Kufe DW. Clinical applications of CA 15-3. In: Sell S, editor. Serological cancer markers. Totowa: The Humana Press, 1992:281-307.
16. Westley B, Rochefort H. A secreted glycoprotein induced by estrogen in human breast cancer cell lines. Cell 1980;20:352-62.
17. Montcourrier P, Silver IA, Farnoud R, Bird I, Rochefort H. Breast cancer cells have a high capacity to acidify extracellular milieu by a dual mechanism. Clin Exp Metastasis. In press.
18. Rochefort H, Liaudet E, Garcia M. Alterations and role of human cathepsin D in cancer metastasis. Enzyme Protein 1996;49:106-16.