Cathepsin D, B and L circulating levels as prognostic markers of malignant progression

Anticancer Research

Volumn 16, Issue 4 B, 1996, Pages 2315-2319

  Tumminello, F M ^a,b   Leto, G ^a   Pizzolanti, G ^a   Candiloro, V ^a   Crescimanno, M ^a   Crosta, L ^a   Flandina, C ^a   Montalto, G ^a   Soresi, M ^a   Carroccio, A ^a   Bascone, F ^a   Ruggeri, I ^a   Ippolito, S ^a   Gebbia, N ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

Cathepsin B; Cathepsin D; Cathepsin L; Chronic pancreatitis; Cirrhosis; Hepatocellular carcinoma; Pancreatic cancer; Tumor progression

Indexed keywords

CATHEPSIN B; CATHEPSIN D; CATHEPSIN L;

ADULT; AGED; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CHRONIC PANCREATITIS; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; ENZYME IMMUNOASSAY; FEMALE; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROGNOSIS;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; CATHEPSIN B; CATHEPSIN D; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; FEMALE; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 9444250436     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Johnson PJ, Williams K: Cirrhosis and aetiology of hepatocellular carcinoma. J Hepatol 4: 140-147, 1987.
2. Ekhom A, McLaughlin JK, Karlsson B-M, Nyren O, Gridley G, Adami H-O, Fraumeni JF, Jr: Pancreatitis and Pancreatic Cancer: a Population-Based Study. J Natl Cancer Inst 6: 625-627, 1994.
3. Duffy MJ: The role of proteolytic enzymes in cancer invasion and metastasis.Clin Exp Met 10: 145-155, 1992.
4. Taketa K: Alpha-fetoprotein: reevaluation in hepatology. Hepatol 12: 1420-1432, 1990.
5. Steinberg W: The clinical utility of the CA19-9 tumor associated antigen. Am J Gastroenterol 85(4): 350-355, 1990.
6. Pasquali C, Sperti C, Alfano D'Andrea A, Costantino V, Filipponi C and Pedrazzoli S: CA50 as a serum marker for pancreatic carcinoma: Comparison with CA19-9. Eur J Cancer 30A: 1042-1043, 1994.
7. Panucci A, Fabris C, Del Favero G, Basso D, Marchioro L, Piccoli A, Naccarato R: Tissue polypeptide antigen (TPA) in pancreatic cancer diagnosis. Br J Cancer 52: 801-803, 1985.
8. Tatsuta M, Yamamura H, Iishi H, Kasugai H, Okuda S: Value of Serum Alpha-Fetoprotein and Ferritin in the Diagnosis of Hepatocellular Carcinoma. Oncology 43: 306-310, 1986.
9. Fabris C, Basso DA, Leandro G, Meggiato T, Elba S, Panozzo MP, Del Favero G, Fogar P, Di Mario F and Naccarato R: Serum CA19-9 and Alpha-fetoprotein Levels in Primary Hepatocellular Carcinoma and Liver Cirrhosis. Cancer 68: 1795-1798, 1991.
10. Pugh RNH, Murray Lyon IM, Dawson JL, Pietroni MC, Williams R: Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 60: 646-649, 1973.
11. Fortner JG: Regional panereatectomy for cancer of the pancreas, ampulla and other related sites. Tumor staging and results. Ann Surg 199: 418-425, 1984.
12. Rozhin J, Honn KV and Sloane BF: Release of native Cathepsin L from murine tumor cells. Proc Am Ass Cancer Res 32: 71, 1991.
13. Maguchi S, Taniguchi N and Makita A: Elevated activity and increased mannose-6-phosphate in the carbohydrate moiety of Cathepsin D from human hepatoma. Cancer Res 48: 362-367, 1988.
14. Brouillet JP, Hanslick B, Maudelonde T, Pivat MP, Grenier J, Blanc F and Rochefort H: Increased plasma Cathepsin D Concentrations in Hepatic Carcinoma and Cirrhosis but not in Breast Cancer. Clin Biochem 24: 491-496, 1991.
15. Yamaguchi N, Chung SM, Shiroeda O, Koyama K and Imanishi J: Characterization of a Cathepsin L-like enzyme secreted from human pancreatic cancer cell lines HPC-YP. Cancer Res 50: 658-663, 1990.
16. Ohsawa T, Higashi T, and Tsuji T: The secretion of high molecular weight Cathepsin B from cultured human liver cancer. Acta Med Okayama 43(1): 9-15, 1989.
17. Leto G, Tumminello FM, Pizzolanti G, Montalto G, Soresi M, Ippolito S and Gebbia N: Cathepsin B, L and D serum levels in patients with pancreatic cancer and nonmalignant pancreatic diseases. Proc Am Ass Cancer Res 36: 93, 1995.
18. Mach L, Schwihla H, Stuwe K, Rowan A, Mort JS and Glossl J: Activation of procathepsin B in human hepatoma cells: the conversion into the mature enzymes relies on the action of cathepsin B itself. Biochem J 293: 437-442, 1993.
19. Buck M, Karustis DG, Day NA, Honn KV and Sloane BF: Degradation of extracellular-matrix proteins by human Cathepsin B from normal and tumor tissues. Biochem J 282: 273-278, 1992.
20. Hirano T and Takeuchi S: Pancreatic subcellular redistribution of lysosomal enzymes and their augmented pancreatic secretion induced by the carcinogen di-isopropanol nitrosoamine in syrian golden hamsters. Med Sci Res 22: 13-15, 1994.
21. Ohta T, Terada T, Nagakawa T, Tajima H, Ito H, Fonseca L and Miyazaki I: Pancreatic trypsinogen and Cathepsin B in human pancreatic carcinomas and associated metastatic lesion. Br J Cancer 69: 152-156, 1994.
22. Murawaki Y, Yamada S, Koda M and Hyrayama C: Collagenase and collagenolytic Cathepsin in normal and fibrotic rat liver. J Biochem 108: 241-244, 1990.