Induction of apoptosis in leukemia U937 cells by 5'-deoxy-5'- methylthioadenosine, a potent inhibitor of protein carboxylmethyltransferase

Experimental Cell Research

Volumn 240, Issue 2, 1998, Pages 282-292

  Lee, Sung Ho ^a   Cho, Young Dong ^a  

^a Yonsei University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

5' METHYLTHIOADENOSINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL NUCLEUS MEMBRANE; CELL VIABILITY; HUMAN; HUMAN CELL; LEUKEMIA; METHYLATION; PRIORITY JOURNAL;

EID: 0031856088     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1998.4000     Document Type: Article

References (53)

1. Pegg A. E., Williams-Ashman H. G. Phosphate-stimulated breakdown of 5′-methylthioadenosine by rat ventral prostate. Biochem. J. 115:1969;241-247.
2. Lee S. H., Cho Y. D. Purification and properties of 5′-deoxy-5′-methylthioadenosine phosphorylase from rat spleen. Korean Biochem. J. 26:1993;440-444.
3. Ferro A., Vandenbark A. A., Marchitto K. The role of 5′-methylthioadenosine phosphorylase in 5′-methylthioadenosine-mediated inhibition of lymphocyte transformation. Biochim. Biophys. Acta. 588:1979;294-301.
4. Wolford R. W., MacDonald M. R., Zehfus B., Rogers T. J., Ferro A. Effect of 5′-methylthioadenosine and its analogs on murine lymphoid cell proliferation. Cancer Res. 41:1981;3035-3039.
5. Christa L., Thuillier L., Perignon J. 5′-deoxy-5′-methylthioadenosine inhibition of rat T lymphocyte phosphodiesterase: Correlation with inhibition of con A induced proliferation. Biochem. Biophys. Res. Commun. 113:1983;425-432.
6. Law R. E., Stimmel J. B., Damore M. A., Carter C., Clarke S., Wall R. Lipopolysaccharide-induced NF-kB activation in mouse 70Z/3 pre-B lymphocytes is inhibited by mevinolin and 5′-methylthioadenosine: Roles of protein isoprenylation and carboxyl methylation reactions. Mol. Cell. Biol. 12:1992;103-111.
7. Enouf J., Lawrence F., Tempete C., Robert-Gero M., Lederer E. Relationship between inhibition of protein methylase I and inhibition of Rous sarcoma virus-induced cell transformation. Cancer Res. 39:1979;4497-4502.
8. Oliva A., Galletti P., Zappia V. Studies on substrate specificity ofS-adenosylmethionine:protein-carboxyl methyltransferase from calf brain. Eur. J. Biochem. 104:1980;595-602.
9. Vandenbark A. A., Ferro A. J., Barney C. L. Inhibition of lymphocyte transformation by a naturally occurring metabolite: 5′-methylthioadenosine. Cell. Immunol. 49:1980;26-33.
10. Hibasami H., Borchardt R. T., Chen S. Y., Coward J. K., Pegg A. E. Studies of inhibition of rat spermidine synthase and spermine synthase. Biochem. J. 187:1980;419-428.
11. Wolberg G., Zimmerman T. P., Schmitges C. J., Duncan G. S., Deeprose R. D. Inhibition of lymphocyte cyclic AMP phosphodiesterase and lymphocyte function by 5′-methyl-thioadenosine. Biochem. Pharmacol. 31:1982;2201-2203.
12. Ferro A. J., Vandenbark A. A., MacDonald M. R. Inactivation ofS-adenosylhomocysteine hydrolase by 5′-deoxy-5′-methylthioadenosine. Biochem. Biophys. Res. Commun. 100:1981;523-531.
13. Greenberg M. E., Greene L. A., Ziff E. B. Nerve growth factor and epidermal growth factor and induce rapid transient changes in proto-oncogene transcription in PC12 cells. J. Biol.Chem. 260:1988;14101-14110.
14. Seeley P. A., Rukenstein A., Connolly J. L., Greene L. A. Differential inhibition of nerve growth factor and epidermal growth factor effects on the PC12 pheochromocytoma line. J. Cell Biol. 98:1984;417-426.
15. Maher P. A. Nerve growth factor induces protein tyrosine phosphorylation. Proc. Natl. Acad. Sci. USA. 85:1988;6788-6791.
16. Smith D. S., King C. S., Pearson E., Gittinger C. K., Landreth G. E. Selective inhibition of nerve growth factor-stimulated protein kinases by K-252a and 5′-S-methyladenosine in PC12 cells. J. Neurochem. 53:1989;800-806.
17. Philips M. R., Pillinger M. H., Staud R., Volker C., Rosenfeld M. G., Weissman G., Stock J. B. Carboxyl methylation of Ras-related proteins during signal transduction in neutrophils. Science. 259:1993;977-980.
18. Volker C., Mijller R. A., McCleary W. R., Rao A., Poenie M., Backcr J. M., Stock J. B. Effects of farnesylcysteine analogs on protein carboxyl methylation and signal transduction. J. Biol. Chem. 266:1991;21515-51522.
19. Hrycyna C. A., Clarke S. Modification of eukaryotic signaling proteins by C-terminal methylation reactions. Pharmacol. Ther. 59:1993;281-300.
20. Clarke S. Protein isoprenylation and methylation at carboxyl-terminal cysteine residues. Annu. Rev. Biochem. 61:1992;355-386.
21. Cox A. D., Der C. J. Protein prenylation: More than just glue. Curr. Opin. Cell Biol. 4:1992;1008-1016.
22. Kitten G. T., Nigg E. A. The Caax motif is required for isoprenylation, carboxylmethylation, and nuclear membrane association of Lamin B2. J. Cell Biol. 113:1991;13-23.
23. Chelsky D., Sobotka C., O'Neill C. L. Lamin B methylation and assembly into the nuclear envelope. J. Biol. Chem. 264:1989;7637-7643.
24. Lazebnik Y. A., Takahashi A., Moir R. D., Goldman R. D., Poirier G. G., Kaufmann S. H., Earnshaw W. C. Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc. Natl. Acad. Sci. USA. 92:1995;9042-9046.
25. Kaufmann S. H. Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin,and other cytotoxic anticancer drugs: A cautionary note. Cancer Res. 49:1989;5870-5878.
26. Ucker D. S., Meyers J., Obermiller P. S. Activation-driven T cell death. II. Quantitiative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death. J. Immunol. 149:1992;1583-1592.
27. Neamati N., A. Fernandez, S. Wright, Kiefer J., McConkey D. J. Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei. J. Immunol. 154:1995;3788-3795.
28. Rao L., Perez D., White E. Lamin proteolysis facilitates nuclear events during apoptosis. J. Cell Biol. 135:1996;1441-1455.
29. Chelsky D., Olson J. F., Koshland D. E. Jr. Cell cycle-dependent methyl esterification of lamin B. J. Biol. Chem. 262:1987;4303-4309.
30. Lederer E. D., Jacobs A. A., Hoffman J. L., Harding G. B., Robishaw J. D., McLeish K. R. Role of carboxylmethylation in chemoattractant receptor-stimulated G protein activiation and functional responses. Biochem. Biophys. Res. Commun. 200:1994;1604-1614.
31. Pike M. C., DeMeester C. A. Inhibition of phosphoinositide metabolism in human polymorphonuclear leukocytes by S-adenosylhomocysteine. J. Biol. Chem. 263:1988;3592-3599.
32. Sapperstein S., Berkower C., Michaelis S. Nucleotide sequence of the yeast STE14 gene, which encodes farnesylcysteine carboxylmethyltransferase, and demonstration of its essential role in a-factor export. Mol. Cell Biol. 14:1994;1438-1449.
33. Chelsky D., Sobotka C., O'Neill C. L. Lamin B methylation and assembly into the nuclear envelope. J. Biol. Chem. 264:1989;7637-7643.
34. Leiser M., Efrat S., Fleisher N. Evidence that Rap1 carboxylmethylation is involved in regulated insulin secretion. Endocrinology. 136:1995;2521-2530.
35. Kowluru A., Seavey S. E., Rabaglia M. E., Nesher R., Metz S. A. Carboxylmethylation of the catalytic subunit of protein phosphatase 2A in insulin-secreting cells: Evidence for functional consequences on enzyme activity and insulin scretion. Endocrinology. 137:1996;2315-2323.
36. Wyllie A. H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature. 284:1980;555-556.
37. Cohen J. J., Duke R. C. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J. Immunol. 132:1984;38-42.
38. Schwartzman R. A., Cidlowski J. A. Apoptosis: The biochemistry and molecular biology of programmed cell death. Endocr. Rev. 14:1993;133-151.
39. Oberhammer F., Wilson J. W., Dive C., Morris I. D., Hickman J. A., Wakeling A. E., Walker P. R., Sikorska M. Apoptotic death in epithelial cells: Cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J. 12:1993;3679-3684.
40. Cohen G. M., Sun X. M., Fearnhead H., MacFarlane M., Brown D. G., Snowden R. T., Dinsdale D. Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes. J. Immunol. 153:1994;507-516.
41. Darzynkiewicz Z., Bruno S., Delbino G., Gorczyca W., Hotz M. A., Lassota P., Traganos F. Features of apoptotic cells measured by flow cytometry. Cytometry. 13:1992;795-808.
42. Dini L., Coppola S., Ruzittu M. T., Ghibelli L. Multiple pathways for apoptotic nuclear fragmentation. Exp. Cell Res. 223:1996;340-347.
43. McConkey D. J. Calcium-dependent, interleukin 1 converting enzyme inhibitor-insensitive degradation of lamin B1 and DNA fragmentation in isolated thymocyte nuclei. J. Biol. Chem. 271:1996;22398-22406.
44. Tewari M., Quan L., O'Rourke K., Desnoyers S., Zeng Z., Beidler D. R., Poirier G. G., Salvesen G. S., Dixit V. M. Yama a mammalian homolog of Ced-3, is a Crm A-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell. 81:1995;801-809.
45. Wang X., Zelenski N. G., Yang J., Sakai J., Brown M. S., Goldstein J. L. Cleavage of stend regulatory element binding proteins (SREBPs) by cpp32 during apoptosis. EMBO J. 15:1996;1012-1020.
46. Na S., Chuang T. H., Cunningham A., Turi T. G., Hanke J. H., Bokoch G. M., Danley D. E. D4-GEI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis. J. Biol. Chem. 271:1996;11209-11213.
47. Goldberg Y. P., Nicholson D. W., Rasper D. M., Kalchman M. A., Koide N. A., Vaillancourt J. P., Hayden M. R. Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. Nat. Genet. 13:1996;442-449.
48. Song Q., Lees-Mjiller S. P., Kumar S., Zhang Z., Chan D. W., Smith G. C., Jackson S. P., Alnemri E. S., Litwack G., Khanna K. K., Larin M. F. DNA-dependent protein kinase catalytic subunit: A target for an ICE-like protease in apoptosis. EMBO J. 15:1996;3238-3246.
49. Fraser A., Evan G. A license to kill. Cell. 85:1996;781-784.
50. Martin J. S., Green R. D. Protease activation during apoptosis: Death by a thousand cuts. Cell. 82:1995;349-352.
51. Liu X., Zou H., Slaughter C., Wang X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell. 89:1997;175-184.
52. Wang X., Studzinski G. P. Antiapoptotic action of 1,25-dihydroxyvitamin D3 is associated with increased mitochondrial MCL-1 and RAF-1 proteins and reduced release of cytochrome C. Exp.Cell Res. 235:1997;210-217.
53. Yang J., Liu X., Bhalla K., Kim C. N., Ibrado A. M., Cai J., Peng T., Jones D. P., Wang X. Prevention of apoptosis by BcI-2: Release of cytochrome C from mitochondria blocked. Science. 275:1997;1129-1132.