Stem cell biology for the transfusionist

Vox Sanguinis

Volumn 74, Issue SUPPL. 2, 1998, Pages 91-94

  Lansdrop, Peter M ^a,b  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CD38 ANTIGEN; CYTOKINE; TELOMERASE;

BONE MARROW; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CELL SURVIVAL; CONFERENCE PAPER; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; METAPHASE CHROMOSOME; PRIORITY JOURNAL; STEM CELL; TELOMERE; TURNOVER TIME;

EID: 0031848192     PISSN: 00429007     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1423-0410.1998.tb05402.x     Document Type: Conference Paper

References (32)

1. Zijlmans JMJM, Visser JWM, Later Veer L, Kleiverda K, Heemskerk DPM, Kluin PM, Willemze R, Fibbe WE: The early phase of engraftment after murine blood cell transplantation is mediated by hematopoietic stem cells. Proc Natl Acad Sci USA 1998;95:725-729.
2. Lansdorp PM, Dragowska W, Mayani H: Ontogeny-related changes in proliferative potential of human hematopoietic cells. J Exp Med 1993;178:787-791.
3. Vaziri H, Dragowska W, Allsopp RC, Thomas TE, Harley CB, Lansdorp PM: Evidence for a mitotic clock in human hematopoietic stem cells: Loss of telomeric DNA with age. Proc Natl Acad Sci USA 1994;91:9857-9860.
4. Chiu C-P, Dragowska W, Kim NW, Vaziri H, Yui J, Thomas TE, Harley CB, Lansdorp PM: Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow. Stem Cells 1996;14:239-248.
5. Yui J, Chiu C-P, Lansdorp PM: Telomerase activity in candidate stem cells from fetal liver and adult bone marrow. Blood (in press).
6. Lansdorp PM, Verwoerd NP, van de Rijke FM, Dragowska V, Little M-T, Dirks RW, Raap AK, Tanke HJ: Heterogeneity in telomere length of human chromosomes. Hum Mol Genet 1996;5:685-691.
7. Martens UM, Zijlmans JMJM, Poon SSS, Dragowska W, Yui J, Chavez EA, Ward RK, Lansdorp PM: Short telomeres on human chromosome 17p. Nature Genetics 1998;18:76-80.
8. Rufer N, Dragowska W, Dumont-Girard F, Chapuis B, Roosnek E, Lansdorp PM: Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry (submitted).
9. Brummendorf TH, Dragowska W, Zijlmans JMJM, Thornbury G, Lansdorp PM: Asymmetric cell divisions sustain long-term hematopoiesis from single sorted human fetal liver cells (submitted).
10. Sauvageau G, Lansdorp PM, Eaves CJ, Hogge DE, Dragowska WH, Reid DS, Largman C, Lawrence HJ, Humphries RK: Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. Proc Natl Acad Sci USA 1994;91:12223-12227.
11. Sauvageau G, Thorsteinsdottir U, Eaves CJ, Lawrence HJ, Largman C, Lansdorp PM, Humphries RK: Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev 1995;9:1753-1765.
12. Harley CB, Futcher AB, Greider CW: Telomeres shorten during ageing of human fibroblasts. Nature 1990;345:458-460.
13. Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC: Telomere reduction in human colorectal carcinoma and with ageing. Nature 1990;346:866-868.
14. Harley CB, Kim NW, Prowse KR, Weinrich SL, Hirsch KS, West MD, Bacchetti S, Hirte HW, Counter CM, Greider CW, Wright WE, Shay JW: Telomerase, cell immortality, and cancer; in Cold Spring Harbor Symposia on Quantitative Biology. Cold Spring Harbor Laboratory Press, 1994, vol 59, pp 307-315.
15. Shay JW, Wright WE: Telomerase activity in human cancer. Curr Opin Oncol 1996;8:66-71.
16. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu C-P, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE: Extension of life-span by introduction of telomerase into normal human cells. Science 1998;279:349-353.
17. Blackburn EH: Telomeres: No end in sight. Cell 1994;77:621-623.
18. Zakian VA: Telomeres: Beginning to understand the end. Science 1995;270:1601-1607.
19. Lansdorp PM: Developmental changes in the function of hematopoietic stem cells. Exp Hematol 1995;23:187-191.
20. Lansdorp PM: Self-renewal of stem cells: The intrinsic timetable model; in Monroe JG, Rothenberg E (ed): The Molecular Biology of B-Cell and T-Cell Development. Totowa, NJ: Humana Press (in press).
21. Potten CS, Loeffler M: Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 1990;10:1001-1020.
22. Pawliuk R, Eaves C, Humphries RK: Evidence of both ontogeny and transplant dose-regulated expansion of hematopoietic stem cells in vivo. Blood 1996;88:2852-2858.
23. Lansdorp PM: Telomere length and proliferation potential of hematopoietic stem cells. J Cell Sci 1995;108:1-6.
24. Notaro R, Cimmino A, Tabarini D, Rotoli B, Luzzatto L: In vivo telomere dynamics of human hematopoietic stem cells. Proc Natl Acad Sci USA 1997;94:13782-13785.
25. Wynn RF, Cross MA, Hatton C, Will AM, Lashford LS, Dexter TM, Testa NG: Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants. Lancet 1998;351:178-181.
26. Greider CW, Blackburn EH: Identification of a specific telomere terminal transferase activity in Tetrhymena extracts. Cell 1985;43:405-413.
27. de Lange T: Activation of telomerase in a human tumor. Proc Natl Acad Sci USA 1994;91:2882-2885.
28. Hiyama K, Hirai Y, Kyoizumi S, Akiyama M, Hiyama E, Piatyszek MA, Shay JW, Ishioka S, Yamakido M: Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J Immunol 1995;155:3711-3715.
29. Weng N-P, Levine BL, June CH, Modes RJ: Regulated expression of telomerase activity in human T lymphocyte development and activation. J Exp Med 1996;183:2471-2479.
30. Zijlmans JMJM, Martens UM, Poon SSS, Raap AK, Tanke HJ, Ward RK, Lansdorp PM: Telomeres in the mouse have large interchromosomal variations in the number of T2AG3 repeats. Proc Natl Acad Sci USA 1997;94:7423-7428.
31. Blasco MA, Lee H-W, Hande MP, Samper E, Lansdorp PM, DePinho RA, Greider CW: Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997;91:25-34.
32. Slagboom PE, Droog S, Boomsma DI: Genetic determination of telomere size in humans: A twin study of three age groups. Am J Hum Genet 1994;55:876-882.