Detection of bcl-2 and p53 in thymoma: Expression of bcl-2 as reliable marker of tumor aggressiveness

Human Pathology

Volumn 27, Issue 10, 1996, Pages 1089-1092

  Chen, Fen Fen ^a   Yan, Jing Jou ^a   Jin, Ying Tai ^a   Su, Ih Jen ^a  

^a NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

bcl 2; immunohistochemistry; p53; thymoma

Indexed keywords

PROTEIN P53;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MYASTHENIA GRAVIS; ONCOGENE; THYMOCYTE; THYMOMA; TUMOR DIAGNOSIS; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

EID: 0029907955     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(96)90289-0     Document Type: Article

References (23)

1. Rosai J, Levine FD: Tumors of the thymus, in Fiminger HI (ed): Atlas of Tumor Pathology (second series, fasc. 13). Washington, DC, Armed Forces Institute of Pathology, 1976, pp 34-161
2. Marino M, Müller-Hermelink NK: Thymoma and thymic carcinoma: Relation of thymoma epithelial cells to the cortical and medullary differentiation of thymus. Virchows Arch [A] Pathol Anat Histopathol 407:119-149, 1985
3. Pan CC, Wu HP, Yang CF, et al: The clinicopathological correlation of epithelial subtyping in thymoma: A study of 112 consecutive cases. HUM PATHOL 25:893-899, 1994
4. Suster S, Rosai J: Thymic carcinoma: A clinicopathologic study of 60 cases. Cancer 67:1025-1032, 1991
5. Lu QL, Elia G, Lucas S, et al: Bcl-2 proto-oncogene expression in Epstein-Barr-virus-associated nasopharyngeal carcinoma. Int J Cancer 53:29-35, 1993
6. Korsmeyer SJ: bcl-2 Initiates a new category of oncogenes: Regulators of cell death. Blood 80:879-886, 1992
7. Tsujimoto Y, Finger LR, Yunis J, et al: Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 226:1097-1099, 1984
8. Cleary ML, Smith ST, Sklar J: Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell 47:19-28, 1986
9. Pezzella F, Tse AGD, Cordell JL, et al: Expression of the bcl-2 oncogene protein is not specific for the 14; 18 chromosomal translocation. Am J Pathol 137:225-232, 1990
10. Reed JC: bcl-2 And the regulation of programmed cell death. J Cell Biol 124:1-6, 1994
11. Haldar S, Negrini M, Monne M, et al: Down-regulation of bcl-2 by p53 in breast cancer cells. Cancer Res 2095-2097, 1994
12. Le PT, Maecker HT, Cook JE: In situ detection and characterization of apoptotic thymocytes in human thymus: Expression of bcl-2 in vivo does not prevent apoptosis. J Immunol 154:4371-4378, 1995
13. Hueber AO, Raposo G, Pierres M, et al: Thy-1 triggers mouse thymocyte apoptosis through a bcl-2-resistant mechanism. J Exp Med 179:785-796, 1994
14. Hayashi Y, Ishii N, Obayashi C, et al: Thymoma: Tumour type related to expression of epidermal growth factor (EGF), EGF-receptor, p53, v-erb B and ras p21. Virchows Arch 426:43-50, 1995
15. Brocheriou I, Carnot F, Briere J: Immunohistochemical detection of bcl-2 protein in thymoma. Histopathology 27:251-255,1995
16. Levine GD, Rosai J: Thymic hyperplasia and neoplasia: A review of current concepts. HUM PATHOL 9:495-515, 1978
17. LeBrun DP, Warnke RA, Cleary M: Expression of bcl-2 in fetal tissues suggests a role in morphogenesis. Am J Pathol 142:743-753, 1993
18. Lu QL, Poulsom R, Leslie W, et al: bcl-2 Expression in adult and embryonic non-hematopoietic tissues. J Pathol 169:431-437, 1993
19. Hockenbery DM, Zutter M, Hickey W, et al: bcl-2 Protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci U S A 88:6961-6965, 1991
20. Levine GD, Rosai J: Thymic hyperplasia and neoplasia: A review of current concepts. HUM PATHOL 9:495-515, 1978
21. Maggi G, Giaccone G, Donadio M, et al: Thymomas: A review of 169 cases, with particular reference to results of surgical treatment. Cancer 58:765-776, 1986
22. Wick MR, Scheithauer BW, Weiland LH, et al: Primary thymic carcinomas. Am J Surg Pathol 6:613-630, 1982
23. Kornstein MJ, deBlois GG: Pathology of the Thymus and Mediastinum: Major Problems in Pathology Series, vol 33. Philadelphia, PA, Saunders, 1995, pp 67-113