Oral-antigen delivery by way of a multiple emulsion system enhances oral tolerance

Annals of the New York Academy of Sciences

Volumn 778, Issue , 1996, Pages 156-162

  Elson, Charles O ^a,d   Tomasi, Maurizio ^a   Dertzbaugh, Mark T ^b   Thaggard, Gregory ^a   Hunter, Robert ^c   Weaver, Casey ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; BOVINE SERUM ALBUMIN; OVALBUMIN;

ANIMAL EXPERIMENT; ARTICLE; EMULSION; FEMALE; IMMUNOLOGICAL TOLERANCE; LYMPH FOLLICLE; MOUSE; NONHUMAN; PEYER PATCH; TRANSGENIC MOUSE;

EID: 0029867057     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb21124.x     Document Type: Article

References (21)

1. ELSON, C. O. 1985. Induction and control of the gastrointestinal immune system. Scand. J. Gastroenterol. 114S: 1-15.
2. BRUCE, M. G. & C. O. ELSON. 1989. Oral immunization and oral tolerance. In Immunology and Immunopathology of the Liver and Gastrointestinal Tract. S. R. Targan & F. Shanahan, Eds.: 171-182. Igaku-Shoin Medical Publishers, Inc. New York.
3. MOWAT, A. M. 1994. Oral Tolerance. In Handbook of Mucosal Immunology. P. L. Ogra, J. Mestecky, M. E. Lamm, W. Strober, J. R. McGhee & J. Bienenstock, Eds.: 391-402. Academic Press. San Diego.
4. WEINER, H. L., A. FRIEDMAN, A. MILLER, S. J. KHOURY, A. AL-SABBAGH, L. SANTOS, M. SAYEGH, R. B. NUSSENBLATT, D. E. TRENTHAM & D. A. HAFLER. 1994. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu. Rev. Immunol. 12: 809-837.
5. STOKES, C. R., T. J. NEWBY, J. H. HUNTLEY, D. PATEL & F. J. BOURNE. 1979. The immune response of mice to bacterial antigens given by mouth. Immunology 38: 497-502.
6. KHOURY, S. J., O. LIDER, A. AL-SABBAGH & H. L. WEINER. 1990. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. III. Synergistic effect of lipopolysaccharide. Cell. Immunol. 131: 302-10.
7. SUN, J.-B., J. HOMGREN & C. CZERKINSKY. 1994. Cholera toxin B subunit: an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance. Proc. Natl. Acad. Sci. USA 91: 10795-10799.
8. SANTOS, L. M., A. AL-SABBAGH, A. LONDONO & H. L. WEINER. 1994. Oral tolerance to myelin basic protein induces regulatory TGF-beta-secreting T cells in Peyer's patches of SJL mice. Cell. Immunol. 157: 439-47.
9. BLAND, P. W. & D. M. KAMBARAGE. 1991. Antigen handling by the epithelium and lamina propria macrophages. Gastroenterol. Clin. North Am. 20: 577-96.
10. MAYER, L., D. EISENHARDT & R. SHLIEN. 1988. Selective induction of antigen nonspecific suppressor cells with normal gut epithelium as accessory cells. Monogr. Allergy 24: 78-80.
11. SANDERSON, I. R., A. J. OUELLETTE, E. A. CARTER, W. A. WALKER & P. R. HARMATZ. 1993. Differential regulation of B7 mRNA in enterocytes and lymphoid cells. Immunology 79: 434-438.
12. FRIEDMAN, A. & H. L. WEINER. 1994. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc. Natl. Acad. Sci. USA 91: 6688-92.
13. HERBERT, W. J. 1965. Multiple emulsions. A new form of mineral-oil antigen adjuvant. Lancet 2: 771.
14. HUNTER, R. L. 1991. Nonionic block copolymers: new preparations and review of the mechanism of action. In Topics in Vaccine Adjuvant Research. D. R. Spriggs & W. C. Koff, Eds.: 89-97. CRC Press. Boca Rotan, FL.
15. DERTZBUAGH, M. T. & C. O. ELSON. 1993. Comparative effectiveness of the cholera toxin B subunit and alkaline phosphatase as carriers for oral vaccines. Infect. Immun. 61: 48-55.
16. lo thymocytes in vivo. Science 250: 1720-1723.
17. HUSBY, S., J. MESTECKY, Z. MOLDOVEANU, S. HOLLAND & C. O. ELSON. 1994. Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding. J. Immunol. 152: 4663-70.
18. THOMPSON, H. S. G. & N. A. STAINES. 1990. Could oral tolerance be a therapy for autoimmune disease? Immunol. Today 11: 396-9.
19. WEINER, H. L. 1993. Treatment of autoimmune diseases by oral tolerance to autoantigens. Autoimmunity 15: 6-7.
20. WEINER, H. L., G. A. MACKIN, M. MATSUI, E. J. ORAV, S. J. KHOURY, D. M. DAWSON & D. A. HAFLER. 1993. Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis [see comments]. Science 259: 1321-4.
21. TRENTHAM, D. E., R. A. DYNESIUS-TRENTHAM, E. J. ORAV, D. COMBITCHI, C. LORENZO, K. L. SEWELL, D. A. HAFLER & H. L. WEINER. 1993. Effects of oral administration of type II collagen on rheumatoid arthritis. Science 261: 1727-1730.