Mediation of cimetidine secretion by P-glycoprotein and a novel H+ -coupled mechanism in cultured renal epithelial monolayers of LLC-PK1 cells

British Journal of Pharmacology

Volumn 117, Issue 6, 1996, Pages 1139-1144

  Dudley, Adam J ^a   Brown, Colin D A ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

LLC PK1 cells; Organic cation transport; P glycoprotein; Proton coupled transport

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; CIMETIDINE; GLYCOPROTEIN P; NIFEDIPINE; PROTON; VERAPAMIL;

APICAL MEMBRANE; ARTICLE; CELL MEMBRANE TRANSPORT; CELL SECRETION; CELL STRAIN; KIDNEY CELL CULTURE; KIDNEY EPITHELIUM; MONOLAYER CULTURE; PRIORITY JOURNAL;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; ANIMALS; BIOLOGICAL TRANSPORT; CELL MEMBRANE PERMEABILITY; CIMETIDINE; EPITHELIUM; HYDROGEN-ION CONCENTRATION; KIDNEY; LLC-PK1 CELLS; NIFEDIPINE; P-GLYCOPROTEIN; SWINE; VERAPAMIL;

EID: 0029928648     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb16708.x     Document Type: Article

References (31)

1. BOOM, S.P.A., MOONS, M.M. & RUSSEL, F.G.M. (1994). Renal tubular transport of cimetidine in the isolated perfused kidney of rat. Drug. Metab. Dispos. 22, 148-153.
2. BOOM, S.P.A. & RUSSEL, F.G.M. (1993). Cimetidine uptake and interactions with cationic drugs in freshly isolated proximal tubular cells of rat. J. Pharmacol. Exp. Ther., 267, 1039-1044.
3. BRÄNDLE, E. & GREVEN, J. (1991). Transport of cimetidine across the basolateral membrane of rabbit kidney proximal tubules: Characterization of transport mechanisms. J. Pharmacol. Exp. Ther., 258, 1038-1045.
4. CACINI, W., KELLER, M.B. & GRUND, V.R. (1982). Accumulation of cimetidine by kidney cortex slices. J. Pharmacol. Exp. Ther., 221, 342-346.
5. DELLINGER, M., PRESSMAN, B.C., CALDERON-HIGGINSON, C., SAVARAJ, N., TAPIERO, H., KOLONIAS, D. & LAMPIDIS, T.J. (1992). Structural requirements of simple organic cations for recognition by multidrug-resistant cells. Cancer Res., 52, 6385-6389.
6. DUDLEY, A.J. & BROWN, C.D.A. (1995). pH dependent transport of procainamide in cultured renal epithelial monolayers of OK cells: consistent with nonionic diffusion. Br. J. Pharmacol., 117, 1685-1691.
7. DUTT, A., HEATH, L.A. & NELSON, J.A. (1994). P-glycoprotein and organic cation secretion by the mammalian kidney. J. Pharmacol. Exp. Ther., 269, 1254-1260.
8. GISCLON, L.G., BOYD, R.A., WILLIAMS, R.L. & GIACOMINI, K.M. (1989). The effect of probenecid on the renal elimination of cimetidine. Clin. Pharmacol. Ther., 45, 444-452.
9. GISCLON, L.G., WONG, F.M. & GIACOMINI, K.M. (1987). Cimetidine secretion by rabbit tubules in vitro. Am. J. Physiol., 253, F1-10.
10. GOTTESMAN, M.M. & PASTAN, I. (1988). The multidrug transporter, a double edged sword. J. Biol. Chem., 263, 12163-12166.
11. GRÜNDEMANN, D., GORBOULEV, V., GAMBARYAN, S., VEYHL, M. & KOEPSELL, H. (1994). Drug excretion mediated by a new prototype of polyspecific transporter. Nature, 372, 549-552.
12. HOLOHAN, P.D., WHITE, K.E., SOKOL, P.P & REBBEOR, J. (1992). Photoaffinity labeling of the OC/H exchanger in renal brush border membrane vesicles. J. Biol. Chem., 267, 13513-13519.
13. HORIO, M., GOTTESMAN, M.M. & PASTAN, I. (1988). ATP-dependent transport of vinblastine in vesicles from human multidrug resistant cells. Proc. Natl. Acad. Sci. U.S.A., 85, 3580-3584.
14. HORIO, M , PASTAN, J., GOTTESMAN, M.M. & HANDLER, J.S. (1990). Transepithelial transport of vinblastine by kidney-derived cell lines. Application of a new kinetic model to estimate in situ Km of the pump. Biochim. Biophys. Acta, 1027, 116-122.
15. HUNTER, J., JEPSON, M.A., TSURUO, T., SIMMONS, N.L & HIRST, B.H. (1993). Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators J. Biol. Chem., 268, 14991-14993.
16. 1. Biochem. J., 227, 199-203.
17. MCKINNEY, T.D., DELEON, C. & SPEEG, K.V. (1988). Organic cation uptake by a cultured renal epithelium. J. Cell. Physiol., 137, 513-520.
18. MCKINNEY, T.D. & KUNNEMANN, M.E. (1987). Cimetidine transport in rabbit renal cortical brush-border membrane vesicles. Am. J. Physiol., 252, F525-F535.
19. MCKINNEY, T.D., MYERS, P. & SPEEG, K.V. (1981). Cimetidine secretion by rabbit renal tubules in vitro. Am. J. Physiol., 241, F69-F76.
20. NELSON, J.A. (1988). A physiological function for multidrug-resistant glycoproteins: A hypothesis regarding the renal organic cation-secretory system. Cancer Chemother. Pharmacol., 22, 92-93.
21. OTT, R.J., HUI, A.C., YUAN, G. & GIACOMINI, K.M. (1990). Organic cation transport in human renal brush border membrane vesicles. Am. J. Physiol., 261, F443-F451.
22. PAN, B-F., DUTT, A. & NELSON, J.A. (1994). Enhanced transepithelial flux of cimetidine by Madin-Darby canine kidney cells overexpressing human P-glycoprotein. J. Pharmacol. Exp. Ther., 270, 1-7.
23. PRITCHARD, J.B. & MILLER, D. (1993). Mechanisms mediating renal secretion of organic anions and organic cations. Physiol. Rev., 7, 765-797.
24. SIMMONS, N.L. (1990). Tissue culture of established cell lines. Methods Enzymol., 191, 426-436.
25. SOMOGYI, A. & GUGLER, R. (1983). Clinical pharmokinetics of cimetidine. Clin. Pharmacokinet., 8, 463-495.
26. SPEEG, K.V., DELEON, C. & MCGUIRE, W.L. (1992). Uptake of the noncytotoxic probe procainamide in the Chinese hamster ovary model of multidrug resistance. Cancer Res., 52, 3539-3546.
27. THIEBAUT, F., TSURUO, T., HAMADA, H., GOTTESMAN, M.M., PASTAN, I. & WILLINGHAM, M.C. (1987). Cellular localization of the multidrug resistance gene product P-glycoprotein in normal human tissues. Proc. Natl. Acad. Sci. U.S.A., 84, 7735-7738.
28. THOMAS, J.A., BUSHBAUM, R.N , ZIMNIAK, A. & RACKER, E. (1979). Intracellular pH measurements in Erlich Ascites tumor cells utilizing spectroscopic probes generated in situ. Biochemistry, 18, 2230-2238.
29. + coupled carriers at both apical and basolateral membranes. J. Biol. Chem., 268, 7640-7642.
30. ULLRICH, K.J. (1994). Specificity of transporters for 'organic anions' and 'organic cations' in the kidney. Biochim. Biophys. Acta, 1197, 45-62.
31. + exchanger of rabbit renal brush border membranes. Pflügers Arch., 429, 313-324.