Immunosuppression after Endotoxin Shock: The Result of Multiple Anti-inflammatory Factors

Journal of Trauma - Injury, Infection and Critical Care

Volumn 40, Issue 5, 1996, Pages 702-708

  Junger, Wolfgang G ^a,b   Hoyt, David B ^a   Liu, Forrest C ^a   Loomis, William H ^a   Coimbra, Raul ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UCSD MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 4; PROSTAGLANDIN E2; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ENZYME IMMUNOASSAY; IMMUNE DEFICIENCY; IMMUNOPATHOGENESIS; IMMUNOREGULATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SECRETION; RABBIT; SEPTIC SHOCK;

ANIMALS; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, ION EXCHANGE; DINOPROSTONE; DISEASE MODELS, ANIMAL; ESCHERICHIA COLI INFECTIONS; IMMUNE TOLERANCE; INTERLEUKIN-10; INTERLEUKIN-4; MALE; RABBITS; SHOCK, SEPTIC; SUPPRESSOR FACTORS, IMMUNOLOGIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 0029999112     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/00005373-199605000-00004     Document Type: Article

References (31)

1. Hoyt DB, Junger WG, Loomis WH, et al: Effects of trauma on immune cell function: impairment of intracellular calcium signalling. Shock 2:23, 1994
2. Junger WG, Hoyt DB, Cardoza TA, et al: Immunosuppressive activity in septic trauma patient serum is sustained and correlates with severity of multi-organ failure. Circ Shock (Suppl 1) 40:9, 1993
3. Hoyt DB, Ozkan AN, Easter D, et al: Isolation of an immunosuppressive trauma peptide and its relationship to fibronectin. J Trauma 28:907, 1988
4. Ozkan AN, Hoyt DB, Ninnemann JL: Generation and activity of suppressor peptides following traumatic injury. J Burn Care Rehabil 8:527, 1987
5. Ozkan AN, Hoyt DB, Tompkins S, et al: Immunosuppressive effects of a trauma-induced suppressor active peptide. J Trauma 28:589, 1988
6. Ozkan AN, Tompkins S, Gregory S, et al: Immunologic mechanisms of a trauma associated glycopeptide. J Leukoc Biol 44:300, 1988
7. Deitch EA, Winterton J, Li M, et al: The gut as a portal of entry for bacteria. Ann Surg 205:681, 1987
8. Deitch EA, Ma W-J, Berg R, et al: Endotoxin-induced bacterial translocation: A study of mechanisms. Surgery 160:292, 1989
9. Epstein MD, Tchervenkov JI, Alexander JW, et al: Increased gut permeability following burn trauma. Arch Surg 126:198, 1991
10. Sori AJ, Rush BF, Lysz TW, et al: The gut as a source of sepsis after hemorrhagic shock. Am J Surg 155:187, 1988
11. Koziol JM, Rush BF, Smith SM, et al: Occurence of bacteremia during hemorrhagic shock. J Trauma 28:10, 1988
12. Xiao G-X, Chopra RK, Adler WH, et al: Altered expression of lymphocyte IL-2 receptors in burn patients. J Trauma 28:1669, 1988
13. Roderick JL, Michie HR, Moss NM, et al: In vivo infusion of a single dose of endotoxin in healthy humans causes in vitro alterations of both T-cell and adherent cell functions. In Faist E, Ninnemann J, Green D (eds): Immune Consequences of Trauma, Shock, and Sepsis: Mechanisms and Therapeutic Approaches. Berlin, Springer-Verlag, 1989, pp 475-483
14. Dinarello CA, Rosenwasser LJ, Wolff SM: Demonstration of a circulating suppressor factor of thymocyte proliferation during endotoxin fever in humans. J Immunol 127:2517, 1981
15. Chaudry IH, Ayala A: Immunological Aspects of Hemorrhage. Austin-Georgetown, RG Landes Company, 1992, pp 1-132
16. 2)-dependent suppression of interleukin a (IL-2) production in patients with major trauma. J Trauma 27:837, 1987
17. Miller-Graziano CL, Fink M, Wu J, et al: Mechanisms of altered monocyte prostaglandin E2 production in severely injured patients. Arch Surg 123:293, 1988
18. Martinez OM, Gibbons RS, Garovoy MR, et al: IL-4 inhibits IL-2 receptor expression and IL-2-dependent proliferation of human T-cells. J Immunol 144:2211, 1990
19. Taga K, Tosato G: IL-10 inhibits human T cell proliferation and IL-2 production. J Immunol 148:1143, 1992
20. Wahl SM, Hunt DA, Wong HL, et al: Transforming growth factor-beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation. J Immunol 140:3026, 1988
21. Ayala A, Meldrum DR, Perrin MM, et al: The release of transforming growth factor-β following haemorrhage: Its role as a mediator of host immunosuppression. Immunology 79:479, 1993
22. Ayala A, Deol ZK, Lehman DL, et al: Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2/IFN-γ release while increasing IL-4/IL-10 production. J Surg Res 56:579, 1994
23. Miller-Graziano CL, Szabo G, Griffey K, et al: Role of elevated monocyte transforming growth factorβ (TGFβ) production in posttrauma immunosuppression. J Clin Immunol 11:95, 1991
24. Junger WG, Hoyt DB, Redl H, et al: Tumor necrosis factor antibody treatment of septic baboons reduces the production of sustained T-cell suppressive factors. Shock 3:173, 1995
25. Stiekema FEM, Kapsenberg ML: Accessory cell requirements in mitogen-induced rabbit lymphocyte proliferation in an improved tissue culture system. In Vitro Cell Dev Biol 23:253, 1987
26. Engelberts I, Möller A, Schoen GJM, et al: Evaluation of measurement of human TNF in plasma by ELISA. Lymphokine Cytokine Res 10:69, 1991
27. Minakuchi R, Wacholtz MC, Davis LS, et al: Delineation of the mechanism of inhibition of human T cell activation by PGE2. J Immunol 145:2616, 1990
28. Morris HG, Sherman NA, Shepperdson FT: Variables associated with radioimmunoassay of prostaglandins in plasma. Prostaglandins 21:771, 1981
29. 2 in human plasma. Eur J Clin Invest 5:311, 1975
30. Goodwin JS, Messner RP, Peake GT: Prostaglandin suppression of mitogen-stimulated lymphocytes in vitro. J Clin Invest 62:753, 1978
31. 2)-induced T-cell suppression. Shock 4:45, 1995