The paradoxical effects of interleukin 10 in the immunoregulation of autoimmune diabetes

Journal of Autoimmunity

Volumn 9, Issue 2, 1996, Pages 283-286

  Balasa, Balaji ^a   Sarvetnick, Nora ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

IDDM; IL 10; NOD; T helper; Transgenic

Indexed keywords

INTERLEUKIN 10;

ANIMAL EXPERIMENT; ANIMAL MODEL; AUTOIMMUNITY; CONFERENCE PAPER; DISEASE PREDISPOSITION; HELPER CELL; IMMUNOREGULATION; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

EID: 0029942029     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1996.0036     Document Type: Conference Paper

References (34)

1. Kikutani H., Makino S. 1992. The murine autoimmune diabetes model: NOD and related strains. Adv. Immunol. 51: 285-322
2. Bach J-F. 1995. Insulin-dependent diabetes mellitus as a β-cell targeted disease of immunoregulation. J. Autoimmunity 8: 439-463
3. Makino S., Kunomoto K., Muraoka Y., Mizushima Y., Katagiri K., Tochino Y. 1980. Breeding of a non-obese diabetic strain of mice. Exp. Anim. 29: 1-13
4. Kaufman D.L., Clare-Salzler M., Tian J., Forsthuber T., Ting G.S.P., Robinson P., Atkinson M.A., Sercarz E.E., Tobin A.J., Lehmann P.V. 1993. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366: 69-72
5. Tisch R., Yang X., Singer S.M., Liblau R.S., Fugger L., McDevitt H.O. 1993. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366: 72-75
6. Opdenakker G., Damme J.V. 1994. Cytokine-regulated proteases in autoimmune diseases. Immunol. Today 15: 103-107
7. Sarvetnick N., Liggit D.P., Pitts S.L., Hansen S.E., Stewart T.A. 1988. Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-γ. Cell 11: 773-782
8. Mason D., Fowell D. 1992. T cell subsets and autoimmunity. Curr. Opin. Immunol. 4: 728-732
9. Moore K.W., O'Garra A., Malefyt R.D.W., Vieira P., Mosmann T.R. 1993. Interleukin-10. Annu. Rev. Immunol. 11: 165-190
10. Ding L., Shevach E.M. 1992. IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function. J. Immunol. 148: 3133-3139
11. Wogensen L., Huang X., Sarvetnick N. 1993. Leukocyte extravasation into the pancreatic interleukin 10 in the islets of Langerhans. J. Exp. Med. 178: 175-185
12. Wogensen L., Lee M-S., Sarvetnick N. 1994. Production of interleukin 10 by islet cells accelerates immune-mediated destruction of β-cells in nonobese diabetic mice. J. Exp. Med. 179: 1379-1384
13. Moritani M., Yoshimoto K., Tashiro F., Hashimoto C., Miyazaki J., Li S. et al. 1994. Transgenic expression of IL-10 in pancreatic islet A cells accelerates autoimmune insulitis and diabetes in non-obese diabetic mice. Int. Immunol. 6: 1927-1936
14. Pennline K., Roque-Gaffany E., Monahan M. 1994. Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin. Immunol. Immunopathol. 71: 169-175
15. Fava R.A., Olsen N.J., Postlethwaite A.E., Broadley K.N., Davidson J.M., Nanney L.B., Lucas C., Townes A.S. 1991. Transforming growth factor beta 1 (TGF-β1) induced neutrophil recruitment to synovial tissues: implications for TGF-β-driven synovial inflammation and hyperplasia. J. Exp. Med. 173: 1121-1132
16. Brandes M.E., Allen J.B., Ogawa Y., Wahl S.M. 1991. Transforming growth factor beta 1 suppresses acute and chronic arthritis in experimental animals. J. Clin. Invest. 87: 1108-1113
17. Rosenbaum J.T., Angell E. 1995. Paradoxical effects of IL-10 in endotoxin-induced Uveitis. J. Immunol. 155: 4090-4094
18. Silva A.T., Bayston K.F., Cohen J. 1990. Prophylactic and therapeutic effects of a monoclonal antibody to tumor necrosis factor-alpha in experimental Gram-negative shock. J. Infect. Dis. 162: 421-427
19. Alexander H.R., Sheppard B.C., Jensen J.C., Langstein H.N., Curesh C.M., Venzon D., Walker E.C., Fraker D.L., Stovroff M.C., Norton J.A. 1991. Treatment with recombinant human tumor necrosis factor-alpha protects rats against the lethality, hypotension, and hypothermia of Gram-negative sepsis. J. Clin. Invest. 88: 34-39
20. Kasner L., Chan C.-C., Whitcup S.M., Gery I. 1993. The paradoxical effect of tumor necrosis factor alpha (TNF-α) in endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci. 34: 2911 (Abstr.)
21. Chen W.-F., Zlotnik A. 1991. IL-10: A novel cytotoxic T cell differentiation factor. J. Immunol. 147: 528-534
22. Nagata M., Santamaria P., Kawamura T., Utsugi T., Yoon J-W. 1994. Evidence for the role of CD8+ cytotoxic T cells in the destruction of pancreatic b-cells in nonobese diabetic mice. J. Immunol. 152: 2042-2050
23. Katz J., Benoist C., Mathis D. 1993. Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice. Eur. J. Immunol. 23: 3358-3360
24. + islet-specific T-cell clone. Diabetes 41: 1603-1608
25. Go N.F., Castle B.E., Barrett R., Kastelein R., Dang W., Mosmann T.R., Moore K.W., Howard M. 1990. Interleukin 10, a novel B cell stimulatory factor: Unresponsiveness of X chromosome-linked immunodeficiency B cells. J. Exp. Med. 172: 1625-1631
26. Durie F.H., Fava R.A., Foy T.M., Aruffo A., Ledbetter J.A., Noelle R.J. 1993. Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40. Science 261: 1328-1330
27. Sarvetnick N., Shizuru J., Liggit D., Martin L., McIntyre B., Gregory A., Parslow T., Stewart T. 1990. Loss of pancreatic islet tolerance induced by β-cell expression of inteferon-g. Nature 346: 844-847
28. Allison J., Malcolm L., Chosich N., Miller J.F.A.P. 1992. Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin-2 in islet βcells. Eur. J. Immunol. 22: 1115-1121
29. Higuchi Y., Herrera P., Muniesa P., Huarte J., Belin D., Ohashi P., Aichele P., Orci L., Vassalli J.-D., Vassalli P. 1992. Expression of a tumor necrosis factor a transgene in murine pancreatic β cells results in severe and permanent insulitis without evolution towards diabetes. J. Exp. Med. 176: 1719-1731
30. Picarella D.E., Kratz A., Li C-B., Ruddle N.H., Flavell R.A. 1993. Transgenic tumor necrosis factor (TNF)-α production in pancreatic islets leads to insulitis, not diabetes: Distinct patterns of inflammation in TNF-α and TNF-β transgenic mice. J. Immunol. 150: 4136-4150
31. Flavell R.A. 1995. Paper presented at The 34th Midwinter Conference of Immunologists, Pacific Grove, CA, Jan 28
32. Stewart T.A., Hultgren B., Huang X., Pitts-Meek S., Hully J., MacLachlan N.J. 1993. Induction of type I diabetes by interferon-a in transgenic mice. Science 260: 1942-1946
33. Campbell I.L., Hobbs M.V., Dockter J., Oldstone M.B.A., Allison J. 1994. Islet inflammation and hyperplasia induced by the pancreatic islet-specific overexpression of interleukin-6 in transgenic mice. Am. J. Pathol. 145: 157-166
34. Lee M-S., Gu D., Feng L., Curriden S., Arnush M., Krahl T., Gurushanthaiab D., Wilson C., Loskutoff D.L., Fox H., Sarvetnick N. 1995. Accumulation of extracellular matrix and developmental dysregulation in the pancreas by transgenic production of transforming growth factor-b1. Am. J. Pathol. 147: 42-52