-
1
-
-
0014692015
-
Suppression of malignancy by cell fusion
-
Harris H, Miller OJ, Klein G, et al. Suppression of malignancy by cell fusion. Nature 1969;223:363-368.
-
(1969)
Nature
, vol.223
, pp. 363-368
-
-
Harris, H.1
Miller, O.J.2
Klein, G.3
-
2
-
-
0015043748
-
Mutation and cancer: Statistical study of retinoblastoma
-
Knudson AG. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 1971;68:820-823.
-
(1971)
Proc Natl Acad Sci USA
, vol.68
, pp. 820-823
-
-
Knudson, A.G.1
-
3
-
-
0003070027
-
Tumor suppressor genes
-
Volgestein B, Kinzler KW, eds. New York: McGraw-Hill
-
Fearon ER. Tumor suppressor genes. In: Volgestein B, Kinzler KW, eds. The genetic basis of human cancer. New York: McGraw-Hill, 1998:229-236.
-
(1998)
The Genetic Basis of Human Cancer
, pp. 229-236
-
-
Fearon, E.R.1
-
4
-
-
0029977751
-
E2F and cell proliferation: A world turned upside down
-
Weinberg RA. E2F and cell proliferation: a world turned upside down. Cell 1996;85:457-459.
-
(1996)
Cell
, vol.85
, pp. 457-459
-
-
Weinberg, R.A.1
-
5
-
-
0030839584
-
Tumor-suppressor genes: Evolving definitions in the genomic age
-
Haber D, Harlow E. Tumor-suppressor genes: evolving definitions in the genomic age. Nat Genet 1997;16:320-322.
-
(1997)
Nat Genet
, vol.16
, pp. 320-322
-
-
Haber, D.1
Harlow, E.2
-
6
-
-
0017167185
-
The clonal evolution of tumor cell populations
-
Nowell PC. The clonal evolution of tumor cell populations. Science 1976;194:23-28.
-
(1976)
Science
, vol.194
, pp. 23-28
-
-
Nowell, P.C.1
-
7
-
-
0027194766
-
Gene and chromosomal alterations associated with the development of human gliomas
-
Collins VP, James CD. Gene and chromosomal alterations associated with the development of human gliomas. FASEB J 1993;7:926-930.
-
(1993)
FASEB J
, vol.7
, pp. 926-930
-
-
Collins, V.P.1
James, C.D.2
-
9
-
-
0029582746
-
Genetics and malignant progression of human brain tumours
-
Furnari FB, Huang HJ, Cavenee WK. Genetics and malignant progression of human brain tumours. Cancer Surv 1995;25: 233-275.
-
(1995)
Cancer Surv
, vol.25
, pp. 233-275
-
-
Furnari, F.B.1
Huang, H.J.2
Cavenee, W.K.3
-
10
-
-
0000180377
-
Genetics of glioma progression and the definition of primary and secondary glioblastoma
-
Kleihues P, Ohgaki H. Genetics of glioma progression and the definition of primary and secondary glioblastoma. Brain Pathol 1997;7:1131-1136.
-
(1997)
Brain Pathol
, vol.7
, pp. 1131-1136
-
-
Kleihues, P.1
Ohgaki, H.2
-
11
-
-
0015383455
-
Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
-
Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239-257.
-
(1972)
Br J Cancer
, vol.26
, pp. 239-257
-
-
Kerr, J.F.1
Wyllie, A.H.2
Currie, A.R.3
-
12
-
-
0018830636
-
Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
-
Wyllie AH. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 1980;284:555-556.
-
(1980)
Nature
, vol.284
, pp. 555-556
-
-
Wyllie, A.H.1
-
13
-
-
0025784539
-
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
-
Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A, Oren M. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 1991;352: 345-347.
-
(1991)
Nature
, vol.352
, pp. 345-347
-
-
Yonish-Rouach, E.1
Resnitzky, D.2
Lotem, J.3
Sachs, L.4
Kimchi, A.5
Oren, M.6
-
14
-
-
0024431245
-
High incidence of lung, bone and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene
-
Lavigueur A, Maltby V, Mock D, et al. High incidence of lung, bone and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol Cell Biol 1989;9: 3982-3991.
-
(1989)
Mol Cell Biol
, vol.9
, pp. 3982-3991
-
-
Lavigueur, A.1
Maltby, V.2
Mock, D.3
-
15
-
-
0029845760
-
Structure and function of the p53 tumor suppressor gene: Clues for rational cancer therapeutic strategies
-
Harris CC. Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies. J Natl Cancer Inst 1996;88:1442-1455.
-
(1996)
J Natl Cancer Inst
, vol.88
, pp. 1442-1455
-
-
Harris, C.C.1
-
16
-
-
0024387728
-
Mutations in the p53 gene occur in diverse human tumour types
-
Nigro JM, Baker SJ, Preisinger AC. Mutations in the p53 gene occur in diverse human tumour types. Nature 1989;342: 705-708.
-
(1989)
Nature
, vol.342
, pp. 705-708
-
-
Nigro, J.M.1
Baker, S.J.2
Preisinger, A.C.3
-
17
-
-
0026517069
-
p53 mutations in human malignant gliomas: Comparison of loss of heterozygosity with mutation frequency
-
Frankel RH, Bayona W, Koslow M, Newcomb EW. p53 mutations in human malignant gliomas: comparison of loss of heterozygosity with mutation frequency. Cancer Res 1992;52: 1427-1433.
-
(1992)
Cancer Res
, vol.52
, pp. 1427-1433
-
-
Frankel, R.H.1
Bayona, W.2
Koslow, M.3
Newcomb, E.W.4
-
18
-
-
0026547577
-
p53 mutations and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression
-
Fults D, Brockmeyer D, Tullous MW, Pedone CA, Cawtnon RM. p53 mutations and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression. Cancer Res 1992;52:674-679.
-
(1992)
Cancer Res
, vol.52
, pp. 674-679
-
-
Fults, D.1
Brockmeyer, D.2
Tullous, M.W.3
Pedone, C.A.4
Cawtnon, R.M.5
-
19
-
-
0026569818
-
Clonal expansion of p53 mutant cells is associated with brain tumour progression
-
Sidransky D, Mikkelsen T, Schwechheimer K, Rosenblum ML, Cavenee W, Volgestein B. Clonal expansion of p53 mutant cells is associated with brain tumour progression. Nature 1992;355:846-847.
-
(1992)
Nature
, vol.355
, pp. 846-847
-
-
Sidransky, D.1
Mikkelsen, T.2
Schwechheimer, K.3
Rosenblum, M.L.4
Cavenee, W.5
Volgestein, B.6
-
20
-
-
0025633582
-
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
-
Malkin D, Li FP, Strong LC, et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 1990;250:1933-1938.
-
(1990)
Science
, vol.250
, pp. 1933-1938
-
-
Malkin, D.1
Li, F.P.2
Strong, L.C.3
-
21
-
-
0028221553
-
Germ line p53 gene mutations in subsets of glioma patients
-
Kyritsis AP, Bondy ML, Xiao M, et al. Germ line p53 gene mutations in subsets of glioma patients. J Natl Cancer Inst 1994;86:344-349.
-
(1994)
J Natl Cancer Inst
, vol.86
, pp. 344-349
-
-
Kyritsis, A.P.1
Bondy, M.L.2
Xiao, M.3
-
22
-
-
0025040367
-
Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53
-
Mercer WE, Shields MT, Amin M, et al. Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53. Proc Natl Acad Sci USA 1990;87:6166-6170.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 6166-6170
-
-
Mercer, W.E.1
Shields, M.T.2
Amin, M.3
-
23
-
-
0029077104
-
Gene transfer of wild-type p53 results in restoration of tumor suppressor function in a medulloblastoma cell line
-
Rosenfeld MR, Meneses P, Dalmau J, Drobjnak M, Cordon-Cardo C, Kaplitt MG. Gene transfer of wild-type p53 results in restoration of tumor suppressor function in a medulloblastoma cell line. Neurology 1994;45:1533-1539.
-
(1994)
Neurology
, vol.45
, pp. 1533-1539
-
-
Rosenfeld, M.R.1
Meneses, P.2
Dalmau, J.3
Drobjnak, M.4
Cordon-Cardo, C.5
Kaplitt, M.G.6
-
24
-
-
0028855751
-
Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells
-
Van Meir EG, Roemer K, Diserens A-C, et al. Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells. Proc Natl Acad Sci USA 1995;92:1008-1012.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 1008-1012
-
-
Van Meir, E.G.1
Roemer, K.2
Diserens, A.-C.3
-
25
-
-
0030020689
-
Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis
-
Gomez-Manzano C, Fueyo J, Kyritsis AP, et al. Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis. Cancer Res 1996;56:694-699.
-
(1996)
Cancer Res
, vol.56
, pp. 694-699
-
-
Gomez-Manzano, C.1
Fueyo, J.2
Kyritsis, A.P.3
-
26
-
-
0030838479
-
Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis
-
Gomez-Manzano C, Fueyo J, Kyritsis AP, et al. Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis. J Natl Inst Cancer 1997;14:1036-1044.
-
(1997)
J Natl Inst Cancer
, vol.14
, pp. 1036-1044
-
-
Gomez-Manzano, C.1
Fueyo, J.2
Kyritsis, A.P.3
-
27
-
-
0027359827
-
WAF1, a potential mediator of p53 tumor suppression
-
El-Deiry WS, Tokino T, Velculescu VE, et al. WAF1, a potential mediator of p53 tumor suppression. Cell 1993;75:817-825.
-
(1993)
Cell
, vol.75
, pp. 817-825
-
-
El-Deiry, W.S.1
Tokino, T.2
Velculescu, V.E.3
-
28
-
-
0028883179
-
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
-
Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995;80: 293-299.
-
(1995)
Cell
, vol.80
, pp. 293-299
-
-
Miyashita, T.1
Reed, J.C.2
-
29
-
-
0032054738
-
Overexpressed WAF1/Cip1 render glioblastoma cells resistant to chemotherapy agents, 1,3 bis (2-chloroethyl)-1-nitrosourea and cisplatin
-
Ruan S, Okcu MF, Pen PJ, et al. Overexpressed WAF1/Cip1 render glioblastoma cells resistant to chemotherapy agents, 1,3 bis (2-chloroethyl)-1-nitrosourea and cisplatin. Cancer Res 1998;58:1538-1543.
-
(1998)
Cancer Res
, vol.58
, pp. 1538-1543
-
-
Ruan, S.1
Okcu, M.F.2
Pen, P.J.3
-
30
-
-
0028973586
-
Increased levels of p21WAF1/Cip1 in human brain tumors
-
Jung J-M, Bruner JM, Ruan S, et al. Increased levels of p21WAF1/Cip1 in human brain tumors. Oncogene 1995;11: 2021-2028.
-
(1995)
Oncogene
, vol.11
, pp. 2021-2028
-
-
Jung, J.-M.1
Bruner, J.M.2
Ruan, S.3
-
31
-
-
0029902618
-
The bax gene maps to the glioma candidate region at 19q13.3, but is not altered in human gliomas
-
Chou D, Miyashita T, Mohrenweiser HW, et al. The bax gene maps to the glioma candidate region at 19q13.3, but is not altered in human gliomas. Cancer Genet Cytogenet 1996;88: 136-140.
-
(1996)
Cancer Genet Cytogenet
, vol.88
, pp. 136-140
-
-
Chou, D.1
Miyashita, T.2
Mohrenweiser, H.W.3
-
32
-
-
0028935145
-
Human gliomas with wild-type p53 express bcl-2
-
Alderson IM, Castleberg RL, Griffith RH, Louis DN, Henson JW. Human gliomas with wild-type p53 express bcl-2. Cancer Res 1995;55:909-1001.
-
(1995)
Cancer Res
, vol.55
, pp. 909-1001
-
-
Alderson, I.M.1
Castleberg, R.L.2
Griffith, R.H.3
Louis, D.N.4
Henson, J.W.5
-
33
-
-
0029849620
-
Cancer cell cycles
-
Sherr CJ. Cancer cell cycles. Science 1996;274:1672-1677.
-
(1996)
Science
, vol.274
, pp. 1672-1677
-
-
Sherr, C.J.1
-
34
-
-
0029993450
-
Role of the INK4a locus in tumor suppression and cell mortality
-
Serrano M, Lee H-W, Chin L, et al. Role of the INK4a locus in tumor suppression and cell mortality. Cell 1996;85:27-37.
-
(1996)
Cell
, vol.85
, pp. 27-37
-
-
Serrano, M.1
Lee, H.-W.2
Chin, L.3
-
35
-
-
0028618304
-
Deletion of p 16 and p15 genes in brain tumors
-
Jen J, Harper JW, Bigner SH, et al. Deletion of p 16 and p15 genes in brain tumors. Cancer Res 1994;54:6353-6358.
-
(1994)
Cancer Res
, vol.54
, pp. 6353-6358
-
-
Jen, J.1
Harper, J.W.2
Bigner, S.H.3
-
36
-
-
0030032928
-
Mutations of the p16 gene in gliomas
-
Kyritsis AP, Zhang B, Zhang W, et al. Mutations of the p16 gene in gliomas. Oncogene 1996;12:63-67.
-
(1996)
Oncogene
, vol.12
, pp. 63-67
-
-
Kyritsis, A.P.1
Zhang, B.2
Zhang, W.3
-
37
-
-
0029967152
-
Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation
-
Costello JF, Berger MS, Huang H-JS, Cavenee WK. Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Res 1996;56:2405-2410.
-
(1996)
Cancer Res
, vol.56
, pp. 2405-2410
-
-
Costello, J.F.1
Berger, M.S.2
Huang, H.-J.S.3
Cavenee, W.K.4
-
38
-
-
0029959177
-
Hypermethylation of the CpG island of p16/CDKN2 correlates with gene inactivation in gliomas
-
Fueyo J, Gomez-Manzano C, Bruner JM, et al. Hypermethylation of the CpG island of p16/CDKN2 correlates with gene inactivation in gliomas. Oncogene 1996;13:1615-1619.
-
(1996)
Oncogene
, vol.13
, pp. 1615-1619
-
-
Fueyo, J.1
Gomez-Manzano, C.2
Bruner, J.M.3
-
39
-
-
0028929988
-
Replacement of the p16/CDKN2 gene suppresses human glioma cell growth
-
Arap W, Nishikawa R, Furnari FB, Cavenee WK, Huang H-SS. Replacement of the p16/CDKN2 gene suppresses human glioma cell growth. Cancer Res 1995;55:1351-1354.
-
(1995)
Cancer Res
, vol.55
, pp. 1351-1354
-
-
Arap, W.1
Nishikawa, R.2
Furnari, F.B.3
Cavenee, W.K.4
Huang, H.-S.S.5
-
40
-
-
0030033729
-
Adenovirus-mediated p16/CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells
-
Fueyo J, Gomez-Manzano C, Yung WKA, et al. Adenovirus-mediated p16/CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells. Oncogene 1996;12:103-110.
-
(1996)
Oncogene
, vol.12
, pp. 103-110
-
-
Fueyo, J.1
Gomez-Manzano, C.2
Yung, W.K.A.3
-
41
-
-
0030726538
-
Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro
-
Chintala SK, Fueyo J, Gomez-Manzano C, et al. Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro. Oncogene 1997;15:2049-2057.
-
(1997)
Oncogene
, vol.15
, pp. 2049-2057
-
-
Chintala, S.K.1
Fueyo, J.2
Gomez-Manzano, C.3
-
42
-
-
0030614944
-
Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death
-
Sandig V, Brand K, Herwing S, Lukas J, Bartek J, Strauss M. Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death. Nat Med 1997;3: 313-319.
-
(1997)
Nat Med
, vol.3
, pp. 313-319
-
-
Sandig, V.1
Brand, K.2
Herwing, S.3
Lukas, J.4
Bartek, J.5
Strauss, M.6
-
43
-
-
0027943938
-
The retinoblastoma gene is involved in malignant progression of astrocytomas
-
Henson JW, Schnitker BL, Correa KM, et al. The retinoblastoma gene is involved in malignant progression of astrocytomas. Ann Neurol 1994;36:714-721.
-
(1994)
Ann Neurol
, vol.36
, pp. 714-721
-
-
Henson, J.W.1
Schnitker, B.L.2
Correa, K.M.3
-
44
-
-
0031813862
-
Suppression of human glioma growth by adenovirus-mediated Rb gene transfer
-
Fueyo J, Gomez-Manzano C, Yung WKA, et al. Suppression of human glioma growth by adenovirus-mediated Rb gene transfer. Neurology 1998;50:1307-1315.
-
(1998)
Neurology
, vol.50
, pp. 1307-1315
-
-
Fueyo, J.1
Gomez-Manzano, C.2
Yung, W.K.A.3
-
45
-
-
0031749470
-
Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo
-
Fueyo J, Gomez-Manzano C, Yung WKA, et al. Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo. Nat Med 1998;4:685-690.
-
(1998)
Nat Med
, vol.4
, pp. 685-690
-
-
Fueyo, J.1
Gomez-Manzano, C.2
Yung, W.K.A.3
-
46
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast and prostate cancer
-
Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast and prostate cancer. Science 1997;275:1943-1946.
-
(1997)
Science
, vol.275
, pp. 1943-1946
-
-
Li, J.1
Yen, C.2
Liaw, D.3
-
47
-
-
17144436629
-
Identification of a candidate tumor suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
-
Steck PA, Pershouse MA, Jasser SA, et al. Identification of a candidate tumor suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997;15:356-362.
-
(1997)
Nat Genet
, vol.15
, pp. 356-362
-
-
Steck, P.A.1
Pershouse, M.A.2
Jasser, S.A.3
-
48
-
-
0030879478
-
DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumors
-
Mollenhauer J, Weimann S, Scheurlen W, et al. DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumors. Nat Genet 1997;17:32-39.
-
(1997)
Nat Genet
, vol.17
, pp. 32-39
-
-
Mollenhauer, J.1
Weimann, S.2
Scheurlen, W.3
-
49
-
-
14444271600
-
Identification of a human homologue of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region
-
Nakamura H, Yoshida M, Tsuiki H, et al. Identification of a human homologue of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region. Oncogene 1997;16:1009-1019.
-
(1997)
Oncogene
, vol.16
, pp. 1009-1019
-
-
Nakamura, H.1
Yoshida, M.2
Tsuiki, H.3
|