Association of central obesity and insulin resistance with high prevalence of diabetes and cardiovascular disease in an elderly population with low fat intake and lower than normal prevalence of obesity: The Indian paradox

Coronary Artery Disease

Volumn 9, Issue 9, 1998, Pages 559-565

  Singh, Ram B ^a,c   Rastogi, Shanti S ^a   Niaz, Mohammad A ^a   Postiglione, Alfredo ^b  

^a Medical Hospital   (India)

^b Inst of Int Med and Metab Dis   (Italy)

^c Heart Research Laboratory   (India)

Author keywords

Central obesity; Dietary fat intake; Hyperinsulinaemia; Obesity; Tinsulin resistance

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID;

ADULT; AGED; ARTICLE; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; DIABETES MELLITUS; DISEASE ASSOCIATION; FAT INTAKE; FEMALE; GLUCOSE INTOLERANCE; HUMAN; HYPERTENSION; HYPERTRIGLYCERIDEMIA; INDIA; INSULIN RESISTANCE; MALE; NORMAL HUMAN; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REGRESSION ANALYSIS; RURAL AREA; URBAN AREA;

EID: 0031792498     PISSN: 09546928     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019501-199809090-00002     Document Type: Article

References (28)

1. McKeigue PM, Shah B, Marmot MG. Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in south Asians. Lancet 1991; 337:382-386.
2. Singh RB, Niaz MA, Ghosh S, Gupta S, Bishnoi I, Agarwal P, et al. Epidemiologic study of diet and coronary risk factors in relation to central obesity and insulin levels in the rural and urban populations of north India. Int J Cardiol 1995; 47:245-255.
3. Snehalata C, Ramachandra A, Vijay V, Vishwanathan M. Differences in plasma insulin responses in urban and rural Indians: a study in south Indians. Diabetic Med 1994; 11:445-448.
4. Singh RB, Rastogi SS, Niaz MA, Rastogi V, Madhu SV, Chen M, et al. Blood pressure trends, plasma insulin levels and risk factors in rural and urban elderly populations of north India. Coronary Artery Dis 1997; 8:463-468.
5. Ramachandran A, Vishwanathan V, Snehlatha C, Vishwanathan M, Shyamala P. High prevalence of NIDDM and IGT in an elderly south Indian population with low rate of obesity. Diabetes Care 1994; 17:13-18.
6. World Health Organization Study Group. Epidemiology and prevention of cardiovascular disease in elderly people. Geneva: World Health Organization; 1995.
7. Ferrara A, Barrett-Connor EL, Edelstein SL. Hyperinsulinemia does not increase the risk of fatal cardiovascular disease in elderly men or women without diabetes: the Rancho Bernardo Study, 1984-1991. Am J Epidemiol 1994; 140:857-869.
8. Welin L, Eriksson H, Larsson B. Hyperinsulinemia is not a major coronary risk factor in elderly men. The study of men born in 1913. Diabetologia 1992; 35:766-770.
9. Edwards KL, Austin MA, Newman B, Mayer E, Krauss RM, Sethy JV. Multivariate analysis of the insulin resistance syndrome in women. Arterioscler Thromb 1994; 14:1940-1945.
10. Ferrannini E, Haffer SM, Mitchel BD, Stern MP. Hyperinsulinemia, the key feature of a cardiovascular and metabolic syndrome. Diabetologia 1991; 34:416-422.
11. Indian Consensus Group. Indian consensus for prevention of hypertension and coronary artery disease: a joint scientific statement of Indian Society of Hypertension and International College of Nutrition. J Nutr Environ Med 1996; 6:309-318.
12. Rose G, Blackburn H, Gillum RF, Prineas RJ. Cardiovascular survey methods. Geneva: World Health Organization; 1982.
13. Narsingrao BS, Deosthale YG, Pant KC. Nutrient composition of Indian foods. Hyderabad: National Institute of Nutrition; 1989.
14. Singh RB, Sharma JP, Rastogi V, Niaz MA, Ghosh S, Beegom R, et al. Social class and coronary artery disease in a rural population of north India. The Indian Social Class and Heart Survey. Eur Heart J 1997; 18:588-595.
15. Paffenberger RS, Hyde RI, Wing AL, Lee IM, Jung DL, Kamphed JB. The association of changes in physical activity level and other lifestyle characteristics with mortality among men. N Engl J Med 1993; 328:538-545.
16. Yalow RS, Berson SA. Immunoassay of endogenous plasma insulin in man. J Clin Invest 1960; 39:1157-1175.
17. Nilsoon P. Diabetes and syndrome X in hypertension - population aspects. J Hum Hypertens 1996; 10 (suppl):81-84.
18. Reaven GM. Role of insulin resistance in human disease [Lecture]. Diabetes 1988; 37:1595-1607.
19. Donahue RP, Abbott RD, Bloom E, Reed DM. Central obesity and coronary heart disease in men. Lancet 1987; i:821-824.
20. Simopoulos AP. Is insulin resistance influenced by dietary linoleic acid, trans fatty acids? Free Radicals Biol Med 1994; 17;367-372.
21. Feskens EJM, Loeber JG, Kromhont D. Diet and physical activity as determinants of hyperinsulinemia. The Zutphen Elderly Study. Am J Epidemiol 1994; 140:350-360.
22. Maron DJ, Fair JM, Haskell WL. Saturated fat intake and insulin resistance in men with coronary artery disease. The Stanford Risk Intervention Project Investigators. Circulation 1981; 84:2020-2027.
23. Singh RB, Niaz MA, Ghosh S, Beegom R, Rastogi V, Sharma JP, et al. Association of trans fatty acids (vegetable ghee) and clarified butter (Indian ghee) intake with higher risk of coronary artery disease in rural and urban populations with low fat consumption. Int J Cardiol 1996; 56:289-298.
24. Stein CE, Fall CHD, Kumaran K, Osmond C, Cox V, Barker DJP. Fetal growth and coronary heart disease in south India. Lancet 1996; 348:1269-1273.
25. Kissebah AH, Vydelingum N, Murray R. Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab 1982; 52:254-260.
26. Yki-Jarvinen H, Taskinen MR. Interrelationships among insulin's antilipolytic and glucoregulatory effects and plasma triglycerides in nondiabetic and diabetic patients with endogenous hypertriglyceridemia. Diabetes 1988; 37:1271-1278.
27. Singh RB, Rastogi V, Rastogi SS, Niaz MA, Beegom R. Effect of diet and moderate exercise on central obesity and associated disturbances, myocardial infarction and mortality in patients with and without coronary artery disease. J Am Coll Nutr 1996; 15:592-595.
28. Krentz AJ. Insulin resistance. BMJ 1996; 313:1385-1389.