Suppression of rat hepatic microsomal cytochromes P450 by cyclophosphamide is correlated with plasma thyroid hormone levels and displays differential strain sensitivity

Journal of Pharmacology and Experimental Therapeutics

Volumn 276, Issue 1, 1996, Pages 258-264

  Kraner, James C ^a   Morgan, Edward T ^b   Poet, Torka S ^a   Born, Stephanie L ^a   Burnett, Vicki L ^a   Halpert, James R ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; CYTOCHROME P450; THYROXINE;

ANIMAL EXPERIMENT; ARTICLE; CALORIC INTAKE; DOSE RESPONSE; DRUG PROTEIN BINDING; DRUG SENSITIVITY; ENZYME INDUCTION; ENZYME INHIBITION; FEMALE; GENE EXPRESSION REGULATION; LIVER MICROSOME METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT; STRAIN DIFFERENCE; THYROID HORMONE BLOOD LEVEL; WEIGHT REDUCTION;

ANIMALS; BODY WEIGHT; CATALYSIS; CYCLOPHOSPHAMIDE; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; ISOENZYMES; MALE; MICROSOMES, LIVER; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; SEX FACTORS; SPECIES SPECIFICITY; TESTOSTERONE; THYROXINE; TRIIODOTHYRONINE;

EID: 0029935753     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. CHANG, T. K. H. AND WAXMAN, D. J.. Cyclophosphamide modulates rat hepatic cytochrome P450 2C11 and steroid 5α-reductase activity and messenger RNA levels through the combined action of acrolein and phosphoramide mustard. Cancer Res. 53: 2490-2497, 1993.
2. HODGSON, E.: Chemical and environmental factors affecting metabolism of xenobiotics. In Introduction to Biochemical Toxicology, ed. by E. Hodgson and P. E. Levi, pp. 153-175, Appleton and Lange, Norwalk, 1994.
3. KRANER, J. C., MORGAN, E. T. ANB HALPERT, J. R : Selective suppression of cytochrome P460 2C11 by chloramphenicol. J. Pharmacol. Exp. Ther. 270: 1367-1372, 1994.
4. LAEMMLI, U. K.: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.) 227: 680-685, 1970.
5. LEBLANC, G. A. AND WAXMAN, D. J.: Mechanisms of cyclophosphamide action on hepatic P-450 expression. Cancer Res. 50: 6720-5726, 1990.
6. MA, Q., DANNAN, G. A., GUENGERICH, F. P AND YANG, C. S.: Similarities and differences in the regulation of hepatic cytochrome P-450 enzymes by diabetes and fasting in male rats. Biochem. Pharmacol. 38: 3179-3184, 1989
7. MANJGALADZE, M., CHEN, S., FRAME, L. T., SENG, J. E., DUFFY, P. H., FEURS, R. J., HART, R. W. AND LEAKEY, J. E. A.: Effects of caloric restriction on rodent drug and carcinogen metabolizing enzymes: Imputations for mutagenesis and cancer. Mutation Res. 295: 201-222, 1993.
8. MODE, A., TOLLET, P , STROM, A., LEGRAVEREND, C., LIDDLE, C. AND GUSTAFSSON. J.-Å. Growth hormone regulation of hepatic cytochrome P450 expression in the rat. Adv. Enzyme Regul. 32: 255-263, 1992.
9. MORGAN, E. T., MACGEOCH, C. AND GUSTAFSSON, J.-Å.: Hormonal and developmental regulation of expression of hepatic microsomal 16α-hydroxylase cytochrome P-450 apoprotein in the rat. J. Biol. Chem. 260: 11895-11898, 1985
10. MORGAN, E. T., RONNHOLM, M. AND GUSTAFSSON, J.-Å.. Preparation and characterization of monoclonal antibodies recognizing unique epitopes on sexually differentiated rat liver cytochrome P-450 isozymes Biochemistry 26: 4193-4200, 1987.
11. NICOLOFF, J. T. AND LOPRESTI, J. S.: Nonthyroidal illness. In The Thyroid: A Fundamental and Clinical Text, ed. by L. E. Braverman and R. D. Utiger, pp. 357-368, J. B. Lipincott, Philadelphia, 1991.
12. OKEY, A. B.: Enzyme induction in the cytochrome P450 system. Pharmacol. Ther. 45: 241-297, 1990.
13. OMURA, T. AND SATO, R.: The carbon-monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem. 239: 2370-2378, 1964.
14. PHILLIPS, A. H. AND LANGDON, R. G.: Hepatic triphoso-pyridine nucleotide-cytochrome c reductase: Isolation, characterization, and kinetic studies. J Biol. Chem. 237: 2652-2660, 1962.
15. RODRIGUEZ, M., RODRIGUEZ, F. AND JOLIN, T.: Effect of restricted feeding, fasting. and diabetes on the relationship between thyroid hormone receptor occupancy, growth hormone induction, and inhibition of thyrotropin release in thyroidectomized rats. Endocrinology 131: 1612-1618, 1992.
16. RONIS, M. J. AND CUNNY, H. C.: Physiological (endogenous) factors affecting the metabolism of xenobiotics. In Introduction to Biochemical Toxicology, ed. by E. Hodgson and P. E. Levi, pp. 133-151, Appleton and Lange, Norwalk, 1994.
17. SALMON, S E. AND SARTORELLI, A. C.: Cancer Chemotherapy. In Basic and Clinical Pharmacology, ed by B G. Katzung, pp. 665-701, Appleton and Lange, Norwalk, 1987.
18. SCHENKMAN, J B., REMMER, H. AND ESTABROOK, R. W.: Spectral studies of drug interaction with hepatic microsomal cytochrome. Mol. Pharmacol. 3: 113-123, 1967.
19. SHAPIRO, B. H., MACLEOD, J. N., PAMPORI, N. A., MORRISSEY, J. J., LAPENSON, D. P. AND WAXMAN, D. J.: Signalling elements in the ultradian rhythm of circulating growth hormone regulating expression of sex-dependent forms of hepatic cytochrome P450 Endocrinology 125: 2935-2944, 1989.
20. SLADEK, N. E.: Metabolism and pharmacokinetic behavior of cyclophosphamide and related oxazaphosphorines In Anticancer Drugs: Reactive /Metabolism and Drug Interactions, ed. by G. Powis, pp. 79-156, Pergamon Press, Oxford, 1994.
21. TOWBIN, H., STEAHELIN, T. AND GORDON, J.: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedures and some applications. Proc. Natl. Acad. Sci. U.S.A 76: 4350-4354, 1979.
22. VAN DER HOEVEN, T. A. AND COON, M. J.: Preparation and properties of partially purified cytochrome P450 and reduced nicotinamide adenine dinucleotide phosphate-cytochrome P450 reductase from rabbit liver microsomes. J. Biol. Chem 249: 6302-6310, 1974.
23. WAXMAN, D. J.: P-450 catalyzed steroid hydroxylation: Assay and product identification by thin-layer chromatography. In Methods in Enzymology, ed by M. R. Waterman and E. F. Johnson, pp. 462-476, Academic Press Inc., San Diego, 1991.
24. WAXMAN, D. J.: Regulation of liver-specific steroid metabolizing cytochromes P450. Cholesterol 7α-hydroxylase, bile acid 6β-hydroxylase, and growth hormone-responsive steroid hormone hydrosylases. J. Steroid Biochem. Mol. Biol 43: 1055-1072, 1992.
25. WAXMAN, D. J., RAM, P. A., NOTANI, G., LEBLANC, G. A., ALBERTA, J. A., MORRISSEY, J. J. AND SUNDSETH, S.S.: Pituitary regulation of the male-specific steroid 6β-hydroxylase P-450 2a (gene product IIIA2) in adult rat liver. Suppressive influence of growth hormone and thyrosine acting at a pretranslational level. Mol Endocrinol. 4: 447-454, 1990.
26. YAMAZOE, Y., LING, X., MURAYAMA, N , GONG, D., NAGATA, K. AND KATO, R.. Modulation of hepatic level of microsomal testosterone 7α-hydroxylase, P450a (P450IIA), by thyroid hormone and growth hormone in rat liver. J. Biochem. 108: 599-603, 1990.