-
1
-
-
15444339513
-
The connection between anti-malarial action and chemical structure in the acridine series
-
Edward Arnold, London
-
Albert, A. (1966) The connection between anti-malarial action and chemical structure in the acridine series. In: The Acridines, Their Preparation, Properties and Uses. 2nd edn, Edward Arnold, London, pp 469-492
-
(1966)
The Acridines, Their Preparation, Properties and Uses. 2nd Edn
, pp. 469-492
-
-
Albert, A.1
-
3
-
-
0029850335
-
Molecular electronic properties of a series of 4-quinolincarbinolamines define anti-malarial activity profile
-
Bhattacharjee, A. K., Karl, J. M. (1996) Molecular electronic properties of a series of 4-quinolincarbinolamines define anti-malarial activity profile. J. Med. Chem. 39: 4622-4629
-
(1996)
J. Med. Chem.
, vol.39
, pp. 4622-4629
-
-
Bhattacharjee, A.K.1
Karl, J.M.2
-
4
-
-
0004323992
-
-
Biosym Technologies, San Diego, California
-
Biosym (1993) Insight II, Version 2.3.0, Biosym Technologies, San Diego, California 92121-2777
-
(1993)
Insight II, Version 2.3.0
, pp. 92121-92777
-
-
-
5
-
-
0025368577
-
Reactions of a free radical intermediate in the oxidation of amodiaquine
-
Bisby, R. H. (1990) Reactions of a free radical intermediate in the oxidation of amodiaquine. Biochem. Pharmacol. 39: 2051-2055
-
(1990)
Biochem. Pharmacol.
, vol.39
, pp. 2051-2055
-
-
Bisby, R.H.1
-
6
-
-
0027500822
-
Further evidence for the interaction of the anti-malarial drug amodiaquine with ferritoprotoporphyrin-IX
-
Blauer, G., Akkawi, M., Bauminger, E. R. (1993) Further evidence for the interaction of the anti-malarial drug amodiaquine with ferritoprotoporphyrin-IX. Biochem. Pharmacol. 46: 1573-1576
-
(1993)
Biochem. Pharmacol.
, vol.46
, pp. 1573-1576
-
-
Blauer, G.1
Akkawi, M.2
Bauminger, E.R.3
-
7
-
-
0019188940
-
Ferriprotoporphyrin IX fulfils the criteria for identification as the chloroquine receptor of malaria parasites
-
Chou, A. C., Chevli, R., Fitch, C. D. (1980) Ferriprotoporphyrin IX fulfils the criteria for identification as the chloroquine receptor of malaria parasites. Biochemistry 19: 1543-1549
-
(1980)
Biochemistry
, vol.19
, pp. 1543-1549
-
-
Chou, A.C.1
Chevli, R.2
Fitch, C.D.3
-
8
-
-
0000161699
-
UV-visible and carbon NMR studies of chloroquine binding to urohemin (I) chloride and uroporphyrin (I) in aqueous solutions
-
Constantinidis, I., Saterlee, J. D. (1988) UV-visible and carbon NMR studies of chloroquine binding to urohemin (I) chloride and uroporphyrin (I) in aqueous solutions. J. Am. Chem. Soc. 110: 4391-4395
-
(1988)
J. Am. Chem. Soc.
, vol.110
, pp. 4391-4395
-
-
Constantinidis, I.1
Saterlee, J.D.2
-
9
-
-
0029076503
-
Adverse-effects of chemotherapeutic-agents used in tropical medicine
-
Cook, G. C. (1995) Adverse-effects of chemotherapeutic-agents used in tropical medicine. Drug Safety 13: 31-45
-
(1995)
Drug Safety
, vol.13
, pp. 31-45
-
-
Cook, G.C.1
-
10
-
-
0003068398
-
Major animal models in malaria research: Rodent
-
Wernsdorfer, W. H., McGregor, I. (eds), Churchill Livingstone, Edinburgh
-
Cox, F. E. G. (1988) Major animal models in malaria research: rodent. In: Wernsdorfer, W. H., McGregor, I. (eds) Malaria-Principles and Practice of Malariology. Volume 2, Churchill Livingstone, Edinburgh, pp 1503-1543
-
(1988)
Malaria-Principles and Practice of Malariology
, vol.2
, pp. 1503-1543
-
-
Cox, F.E.G.1
-
11
-
-
0030483601
-
Aminoquinolines that circumvent resistance in Plasmodium falciparum in-vitro
-
De, D. Y., Krogstad, F. M., Cogswell, F. B., Krogstad, D. J. (1996) Aminoquinolines that circumvent resistance in Plasmodium falciparum in-vitro. Am. J. Trop. Med. Hyg. 55: 579-583
-
(1996)
Am. J. Trop. Med. Hyg.
, vol.55
, pp. 579-583
-
-
De, D.Y.1
Krogstad, F.M.2
Cogswell, F.B.3
Krogstad, D.J.4
-
12
-
-
0021315438
-
Inhibition of the reactions carried out by a type I topoisomerase and a catenating enzyme of Trypanosoma cruzi by DNA-intercalating drugs. Preferential inhibition of catenating reaction
-
Douc-Rasy, S., Kayser, A., Riou, G. F. (1984) Inhibition of the reactions carried out by a type I topoisomerase and a catenating enzyme of Trypanosoma cruzi by DNA-intercalating drugs. Preferential inhibition of catenating reaction. EMBO J. 3: 11-16
-
(1984)
EMBO J.
, vol.3
, pp. 11-16
-
-
Douc-Rasy, S.1
Kayser, A.2
Riou, G.F.3
-
13
-
-
15444354324
-
Crystallography and molecular mechanics in designing drugs with unknown receptor structure
-
Bugg, C. E., Ealick, S. E. (eds). Springer, Heidelberg
-
Duchamp, D. J. (1990) Crystallography and molecular mechanics in designing drugs with unknown receptor structure. In: Bugg, C. E., Ealick, S. E. (eds) Crystallographic and Modern Methods in Molecular Design. Springer, Heidelberg, pp 161-174
-
(1990)
Crystallographic and Modern Methods in Molecular Design
, pp. 161-174
-
-
Duchamp, D.J.1
-
14
-
-
0025986905
-
Efficacy of amodiaquine against chloroquine-resistant malaria in Cameroon
-
Fadat, G., LeBras, J., Hengy, C., Louis, J. P., Gimou, M. M., Verdier, F. (1991) Efficacy of amodiaquine against chloroquine-resistant malaria in Cameroon. Lancet 338: 1092
-
(1991)
Lancet
, vol.338
, pp. 1092
-
-
Fadat, G.1
LeBras, J.2
Hengy, C.3
Louis, J.P.4
Gimou, M.M.5
Verdier, F.6
-
15
-
-
0000031451
-
The United Kingdom Chemical Database Service
-
Fletcher, D. A., McMeeking, R. F., Parkin, D. (1996) The United Kingdom Chemical Database Service. J. Chem. Inf. Comput. Sci. 36: 746-749
-
(1996)
J. Chem. Inf. Comput. Sci.
, vol.36
, pp. 746-749
-
-
Fletcher, D.A.1
McMeeking, R.F.2
Parkin, D.3
-
16
-
-
15444354388
-
1-diethyl-1,4-pentanediamine-an X-ray diffraction study of chloroquine phosphate hydrate
-
1-diethyl-1,4-pentanediamine-an X-ray diffraction study of chloroquine phosphate hydrate. Acta Chem. Scand. 44: 741-745
-
(1990)
Acta Chem. Scand.
, vol.44
, pp. 741-745
-
-
Furuseth, S.1
Karlsen, J.2
Mostad, A.3
Romming, C.4
Salmen, R.5
Tonnesen, H.H.6
-
17
-
-
0028360131
-
Synthesis and in-vitro activity of 9-anilino-3,6-diaminoacridines active against a multi-drug resistant strain of the malaria parasite Plasmodium falciparum
-
Gamage, S. A., Tepsiri, M., Wilairat, P., Wojick, S. J., Figgit, D. P., Ralph, R. K., Denny, W. A. (1994) Synthesis and in-vitro activity of 9-anilino-3,6-diaminoacridines active against a multi-drug resistant strain of the malaria parasite Plasmodium falciparum. J. Med. Chem. 37: 1486-1494
-
(1994)
J. Med. Chem.
, vol.37
, pp. 1486-1494
-
-
Gamage, S.A.1
Tepsiri, M.2
Wilairat, P.3
Wojick, S.J.4
Figgit, D.P.5
Ralph, R.K.6
Denny, W.A.7
-
18
-
-
0025046280
-
Kinetic modelling of the response of Plasmodium falciparum to chloroquine and its experimental testing in-vitro. Implications for mechanism of action of and resistance to the drug
-
Geary, T. G., Divo, A. D., Jensen, J. B., Zangwill, M., Ginsburg, H. (1990) Kinetic modelling of the response of Plasmodium falciparum to chloroquine and its experimental testing in-vitro. Implications for mechanism of action of and resistance to the drug. Biochem. Pharmacol. 40: 685-691
-
(1990)
Biochem. Pharmacol.
, vol.40
, pp. 685-691
-
-
Geary, T.G.1
Divo, A.D.2
Jensen, J.B.3
Zangwill, M.4
Ginsburg, H.5
-
19
-
-
0026585915
-
Quinoline-containing anti-malarials - Mode of action, drug resistance and its reversal: An update with unresolved puzzles
-
Ginsburg, H., Krugliak, M. (1992) Quinoline-containing anti-malarials - mode of action, drug resistance and its reversal: an update with unresolved puzzles. Biochem. Pharmacol. 43: 63-70
-
(1992)
Biochem. Pharmacol.
, vol.43
, pp. 63-70
-
-
Ginsburg, H.1
Krugliak, M.2
-
20
-
-
0026546128
-
The mechanism of bioactivation and antigen formation of amodiaquine in the rat
-
Harrison, A. C., Kitteringham, N. R., Clarke, J. B., Park, K. P. (1992) The mechanism of bioactivation and antigen formation of amodiaquine in the rat. Biochem. Pharmacol. 43: 1421-1430
-
(1992)
Biochem. Pharmacol.
, vol.43
, pp. 1421-1430
-
-
Harrison, A.C.1
Kitteringham, N.R.2
Clarke, J.B.3
Park, K.P.4
-
22
-
-
0029787728
-
An exploration of the structure activity relationships of 4-aminoquinolines: Novel anti-malarials with activity in-vivo
-
Ismail, F. M. D., Dascombe, M. J., Carr, P., North, S. E. (1996) An exploration of the structure activity relationships of 4-aminoquinolines: novel anti-malarials with activity in-vivo. J. Pharm. Pharmacol. 48: 841-850
-
(1996)
J. Pharm. Pharmacol.
, vol.48
, pp. 841-850
-
-
Ismail, F.M.D.1
Dascombe, M.J.2
Carr, P.3
North, S.E.4
-
23
-
-
0028939017
-
Role of hepatic-metabolism in the bioactivation and detoxication of amodiaquine
-
Jewell, H., Maggs, J. L., Harrison, A. C., O'Neill, P. M., Ruscoe, J. E., Park, B. K. (1995) Role of hepatic-metabolism in the bioactivation and detoxication of amodiaquine. Xenobiotica 25: 199-217
-
(1995)
Xenobiotica
, vol.25
, pp. 199-217
-
-
Jewell, H.1
Maggs, J.L.2
Harrison, A.C.3
O'Neill, P.M.4
Ruscoe, J.E.5
Park, B.K.6
-
24
-
-
0026580108
-
Energy-dependence of chloroquine accumulation and chloroquine efflux in Plasmodium falciparum
-
Krogstad, D. J., Gluzman, I. Y., Herwaldt, B. L., Schlesinger, P. H., Wellems, T. E. (1992) Energy-dependence of chloroquine accumulation and chloroquine efflux in Plasmodium falciparum. Biochem. Pharmacol. 43: 57-62
-
(1992)
Biochem. Pharmacol.
, vol.43
, pp. 57-62
-
-
Krogstad, D.J.1
Gluzman, I.Y.2
Herwaldt, B.L.3
Schlesinger, P.H.4
Wellems, T.E.5
-
25
-
-
0030828787
-
QSAR and 3D QSAR in drug design Part 2: Applications and problems
-
Kubinyi, H. (1997) QSAR and 3D QSAR in drug design Part 2: Applications and problems. Drug Discov. Today 2: 538-546
-
(1997)
Drug Discov. Today
, vol.2
, pp. 538-546
-
-
Kubinyi, H.1
-
26
-
-
0023039117
-
Cardiovascular toxicity and distribution kinetics of intravenous chloroquine
-
Looareesuwan, S., White, N. J., Chantavanich, P., Edwards, G., Nicholl, D. D., Bunchand, C., Warell, D. A. (1986) Cardiovascular toxicity and distribution kinetics of intravenous chloroquine. Br. J. Clin. Pharmacol. 22: 31-36
-
(1986)
Br. J. Clin. Pharmacol.
, vol.22
, pp. 31-36
-
-
Looareesuwan, S.1
White, N.J.2
Chantavanich, P.3
Edwards, G.4
Nicholl, D.D.5
Bunchand, C.6
Warell, D.A.7
-
27
-
-
0011834054
-
-
Version 4.0, Columbia University, New York, NY 10027
-
MacroModel (1993) Version 4.0, Still, W. C., Columbia University, New York, NY 10027
-
(1993)
MacroModel
-
-
Still, W.C.1
-
28
-
-
0023855476
-
Drug protein conjugates XIV. Mechanisms of formation of protein-arylating intermediates from amodiaquine a myletoxin and hepatoxin in man
-
Maggs, J. L., Tingle, M. D., Kitteringham, N. R., Park, B. K. (1988) Drug protein conjugates XIV. Mechanisms of formation of protein-arylating intermediates from amodiaquine a myletoxin and hepatoxin in man. Biochem. Pharmacol. 37: 303-311
-
(1988)
Biochem. Pharmacol.
, vol.37
, pp. 303-311
-
-
Maggs, J.L.1
Tingle, M.D.2
Kitteringham, N.R.3
Park, B.K.4
-
29
-
-
85038603986
-
-
H.N.D. Project, Division of Chemical Sciences, University of Hertfordshire, UK
-
Marie, C. (1993) Preparation of 4-Aryl-substituted Quinolines. H.N.D. Project, Division of Chemical Sciences, University of Hertfordshire, UK
-
(1993)
Preparation of 4-Aryl-substituted Quinolines
-
-
Marie, C.1
-
30
-
-
0029087801
-
Verapamil reversal of chloroquine resistance in the malaria parasite: Plasmodium falciparum is specific for resistant parasites and independent of the weak base effect
-
Martiney, J. A., Cerami, A., Slater, A. F. G. (1995) Verapamil reversal of chloroquine resistance in the malaria parasite: Plasmodium falciparum is specific for resistant parasites and independent of the weak base effect. J. Biol. Chem. 270: 22393-22398
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 22393-22398
-
-
Martiney, J.A.1
Cerami, A.2
Slater, A.F.G.3
-
31
-
-
0029839738
-
Is haemozoin a target for anti-malarial drugs?
-
Meshnick, S. R. (1996) Is haemozoin a target for anti-malarial drugs? Ann. Trop. Med. Parasitol. 90: 367-372
-
(1996)
Ann. Trop. Med. Parasitol.
, vol.90
, pp. 367-372
-
-
Meshnick, S.R.1
-
32
-
-
84986437005
-
MacroModel - An integrated software system for modelling organic and bioorganic molecules using molecular mechanics
-
Mohamadi, F., Richards, N. G. J., Guida, W. C., Liskamp, R., Caufield, C., Chang, G., Hendrickson, T., Still, W. C. (1990) MacroModel - an integrated software system for modelling organic and bioorganic molecules using molecular mechanics. J. Comput. Chem. 11: 440-467
-
(1990)
J. Comput. Chem.
, vol.11
, pp. 440-467
-
-
Mohamadi, F.1
Richards, N.G.J.2
Guida, W.C.3
Liskamp, R.4
Caufield, C.5
Chang, G.6
Hendrickson, T.7
Still, W.C.8
-
33
-
-
9244225096
-
A randomized trial of chloroquine, amodiaquine and pyrimethamine-sulfadoxine in Gambian children with uncomplicated malaria
-
Muller, O., Vashensbroek, M. B., Jaffar, S., Drakeley, C., Okorie, C., Joof, D., Pinder, M., Greenwood, B. (1996) A randomized trial of chloroquine, amodiaquine and pyrimethamine-sulfadoxine in Gambian children with uncomplicated malaria. Trop. Med. Int. Health. 1: 124-132
-
(1996)
Trop. Med. Int. Health.
, vol.1
, pp. 124-132
-
-
Muller, O.1
Vashensbroek, M.B.2
Jaffar, S.3
Drakeley, C.4
Okorie, C.5
Joof, D.6
Pinder, M.7
Greenwood, B.8
-
34
-
-
0022655075
-
Amodiaquine induced agranulocytosis and liver damage
-
Neftel, K. A., Woodtly, W., Schmid, M., Frick, P. G., Fehr, J. (1986) Amodiaquine induced agranulocytosis and liver damage. Br. Med. J. 292: 721-723
-
(1986)
Br. Med. J.
, vol.292
, pp. 721-723
-
-
Neftel, K.A.1
Woodtly, W.2
Schmid, M.3
Frick, P.G.4
Fehr, J.5
-
35
-
-
0029807475
-
Systematic review of amodiaquine treatment in uncomplicated malaria
-
Olliaro, P., Nevil, C., LeBras, J., Ringwald, P., Mussano, P., Garner, P., Brasseur, P. (1996) Systematic review of amodiaquine treatment in uncomplicated malaria. Lancet 348: 1196-1201
-
(1996)
Lancet
, vol.348
, pp. 1196-1201
-
-
Olliaro, P.1
Nevil, C.2
LeBras, J.3
Ringwald, P.4
Mussano, P.5
Garner, P.6
Brasseur, P.7
-
36
-
-
0031055744
-
Synthesis, anti-malarial activity, and molecular modelling of tebuquine analogues
-
O'Neill, P. M., Willock, D. J., Hawley, S. R., Bray, P. G., Storr, R. C., Ward, S. A., Park, B. K. (1997) Synthesis, anti-malarial activity, and molecular modelling of tebuquine analogues. J. Med. Chem. 40: 437-448
-
(1997)
J. Med. Chem.
, vol.40
, pp. 437-448
-
-
O'Neill, P.M.1
Willock, D.J.2
Hawley, S.R.3
Bray, P.G.4
Storr, R.C.5
Ward, S.A.6
Park, B.K.7
-
39
-
-
0030753506
-
Minor groove-directed and intercalative ligand-DNA interactions in the poisoning of human DNA topoisomerase I by protoberberine analogs
-
Pilch, D. S., Yu, C., Makhey, D., La Voie, E. J., Srinivasan, A. R., Olson, W. K., Sauers, R. R., Breslauer, K. J., Geacintov, N. E., Liu, L. F. (1997) Minor groove-directed and intercalative ligand-DNA interactions in the poisoning of human DNA topoisomerase I by protoberberine analogs. Biochemistry 36: 12542-12553
-
(1997)
Biochemistry
, vol.36
, pp. 12542-12553
-
-
Pilch, D.S.1
Yu, C.2
Makhey, D.3
La Voie, E.J.4
Srinivasan, A.R.5
Olson, W.K.6
Sauers, R.R.7
Breslauer, K.J.8
Geacintov, N.E.9
Liu, L.F.10
-
40
-
-
0028058059
-
Anti-malarial 4-aminoquinolines: Mode of action and pharmacokinetics
-
Pussard, E., Verdier, F. (1994) Anti-malarial 4-aminoquinolines: mode of action and pharmacokinetics. Fundam. Clin. Pharmacol. 8: 1-17
-
(1994)
Fundam. Clin. Pharmacol.
, vol.8
, pp. 1-17
-
-
Pussard, E.1
Verdier, F.2
-
41
-
-
9444258557
-
4-Aminoquinoline analogs of chloroquine with shortened side-chains retain activity against chloro-quine-resistant Plasmodium falciparum
-
Ridley, R. G., Hofheinz, W., Matile, H., Jaquet, C., Dorn, A., Masciadri, R., Jolidon, S., Richter, W. F., Guenzi, A., Girometta, M. A., Urwyler, H., Huber, W., Thaithong, S., Peters, W. (1996) 4-Aminoquinoline analogs of chloroquine with shortened side-chains retain activity against chloro-quine-resistant Plasmodium falciparum. Antimicrob. Agents Chemother. 40: 1846-1854
-
(1996)
Antimicrob. Agents Chemother.
, vol.40
, pp. 1846-1854
-
-
Ridley, R.G.1
Hofheinz, W.2
Matile, H.3
Jaquet, C.4
Dorn, A.5
Masciadri, R.6
Jolidon, S.7
Richter, W.F.8
Guenzi, A.9
Girometta, M.A.10
Urwyler, H.11
Huber, W.12
Thaithong, S.13
Peters, W.14
-
42
-
-
0031018611
-
2-bis(7-chloroquinolin-4-yl)cyclohexane-1,2-diamine: Comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737
-
2-bis(7-chloroquinolin-4-yl)cyclohexane-1,2-diamine: comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737. Antimicrob. Agents Chemother. 41: 677-686
-
(1997)
Antimicrob. Agents Chemother.
, vol.41
, pp. 677-686
-
-
Ridley, R.G.1
Matile, H.2
Jaquet, C.3
Dorn, A.4
Hofheinz, W.5
Leupin, W.6
Masciadri, R.7
Theil, F.P.8
Richter, W.F.9
Girometta, M.A.10
Guenzi, A.11
Urwyler, H.12
Gocke, E.13
Potthast, J.M.14
Csato, M.15
Thomas, A.16
Peters, W.17
-
43
-
-
0028920789
-
The effect of chemical substitution on the metabolic activation, metabolic detoxification and pharmacological activity of amodiaquine in the mouse
-
Ruscoe, J. E., Jewel, H., Maggs, J. L., O'Neill, P. M., Storr, R. C., Ward, S. A., Park, B. K. (1995) The effect of chemical substitution on the metabolic activation, metabolic detoxification and pharmacological activity of amodiaquine in the mouse. J. Pharmacol. Exp. Ther. 273: 393-404
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.273
, pp. 393-404
-
-
Ruscoe, J.E.1
Jewel, H.2
Maggs, J.L.3
O'Neill, P.M.4
Storr, R.C.5
Ward, S.A.6
Park, B.K.7
-
44
-
-
0347933768
-
Intercalation mechanisms with dsDNA: Binding modes and energy contributions with benzene, naphthalene, quinoline and indole derivatives including some anti-malarials
-
Sartorius, J., Schneider, H.-J. (1997) Intercalation mechanisms with dsDNA: binding modes and energy contributions with benzene, naphthalene, quinoline and indole derivatives including some anti-malarials. J. Chem. Soc. Perkin. Trans. 2 2319-2327
-
(1997)
J. Chem. Soc. Perkin. Trans. 2
, pp. 2319-2327
-
-
Sartorius, J.1
Schneider, H.-J.2
-
45
-
-
0030985218
-
Characterization of simian malarial parasite (Plasmodium knowlesi)-induced putrescine transport in rhesus monkey erythrocytes - A novel putrescine conjugate arrests in vitro growth of simian malarial parasite (Plasmodium knowlesi) and cures multidrug resistant murine malaria (Plasmodium yoelii) infection in-vivo
-
Singh, S., Puri, S. K., Singh, S. K., Srivastava, R., Gupta, R. C., Pandey, V. C. (1997) Characterization of simian malarial parasite (Plasmodium knowlesi)-induced putrescine transport in rhesus monkey erythrocytes - a novel putrescine conjugate arrests in vitro growth of simian malarial parasite (Plasmodium knowlesi) and cures multidrug resistant murine malaria (Plasmodium yoelii) infection in-vivo. J. Biol. Chem. 272: 13506-13511
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 13506-13511
-
-
Singh, S.1
Puri, S.K.2
Singh, S.K.3
Srivastava, R.4
Gupta, R.C.5
Pandey, V.C.6
-
46
-
-
0027315687
-
Chloroquine-mechanism of drug action and resistance in Plasmodium falciparum
-
Slater, A. F. G. (1993) Chloroquine-mechanism of drug action and resistance in Plasmodium falciparum. Pharmacol. Ther. 57: 203-235
-
(1993)
Pharmacol. Ther.
, vol.57
, pp. 203-235
-
-
Slater, A.F.G.1
-
47
-
-
85038604799
-
Enzymatic antioxidant defence system in malaria parasites
-
Jpn Soc. Trop. Med., Nagasaki
-
Slomianny, C., Clarebout, G., Gamain, B., Gratepanche, S., Dive, D. (1996) Enzymatic antioxidant defence system in malaria parasites. XIVth International Congress for Tropical Medicine and Malaria, Jpn Soc. Trop. Med., Nagasaki, B-26-1
-
(1996)
XIVth International Congress for Tropical Medicine and Malaria
-
-
Slomianny, C.1
Clarebout, G.2
Gamain, B.3
Gratepanche, S.4
Dive, D.5
-
48
-
-
0030867351
-
pH-dependent regulation of camptothecin-induced cytotoxicity and cleavable complex formation by the anti-malarial agent chloroquine
-
Sorensen, M., Sehested, M., Jensen, P. B. (1997) pH-dependent regulation of camptothecin-induced cytotoxicity and cleavable complex formation by the anti-malarial agent chloroquine. Biochem. Pharmacol. 54: 373-380
-
(1997)
Biochem. Pharmacol.
, vol.54
, pp. 373-380
-
-
Sorensen, M.1
Sehested, M.2
Jensen, P.B.3
-
50
-
-
0025390935
-
Mopac - A semi-empirical molecular orbital program
-
Stewart, J. J. P. (1990) Mopac - a semi-empirical molecular orbital program. J. Comput. Aided Mol. Des. 4: 1-45
-
(1990)
J. Comput. Aided Mol. Des.
, vol.4
, pp. 1-45
-
-
Stewart, J.J.P.1
-
51
-
-
16044372680
-
On the molecular mechanism of chloroquines anti-malarial action
-
Sullivan, D. J., Gluzman, I. Y., Russell, D. G., Goldberg, D. E. (1996) On the molecular mechanism of chloroquines anti-malarial action. Proc. Natl Acad. Sci. USA 93: 11865-11870
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 11865-11870
-
-
Sullivan, D.J.1
Gluzman, I.Y.2
Russell, D.G.3
Goldberg, D.E.4
-
52
-
-
0028051573
-
Identification of differentially transcribed RNA and DNA helicase-related genes of Plasmodium falciparum
-
Thelu, J., Burnod, J., Bracchi, V., Ambroisethomas, P. (1994) Identification of differentially transcribed RNA and DNA helicase-related genes of Plasmodium falciparum. DNA Cell Biol. 1: 1109-1115
-
(1994)
DNA Cell Biol.
, vol.1
, pp. 1109-1115
-
-
Thelu, J.1
Burnod, J.2
Bracchi, V.3
Ambroisethomas, P.4
-
53
-
-
0001651665
-
Improved nucleophilic displacement in N-methylpyrrolidinone as a solvent
-
Tyman, J., Ghorbanian, S., Muir, M., Tychopoulos, V. (1989) Improved nucleophilic displacement in N-methylpyrrolidinone as a solvent. Synth. Commun. 19: 179-188
-
(1989)
Synth. Commun.
, vol.19
, pp. 179-188
-
-
Tyman, J.1
Ghorbanian, S.2
Muir, M.3
Tychopoulos, V.4
-
54
-
-
0026762480
-
Bisquinolines 1. N, N-Bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria
-
Vennerstrom, J. L., Ellis, W. Y., Ager Jr, A. L., Anderson, S. L., Gerena, L., Milhous, W. K. (1992) Bisquinolines 1. N, N-Bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria. J. Med. Chem. 35: 2129-2134
-
(1992)
J. Med. Chem.
, vol.35
, pp. 2129-2134
-
-
Vennerstrom, J.L.1
Ellis, W.Y.2
Ager Jr., A.L.3
Anderson, S.L.4
Gerena, L.5
Milhous, W.K.6
-
55
-
-
0030884415
-
Quinoline resistance mechanisms in Plasmodium falciparum: The debate goes on
-
Ward, S. A., Bray, P. G., Hawley, S. R. (1997) Quinoline resistance mechanisms in Plasmodium falciparum: the debate goes on. Parasitology 114: S125-S136
-
(1997)
Parasitology
, vol.114
-
-
Ward, S.A.1
Bray, P.G.2
Hawley, S.R.3
-
56
-
-
0023153789
-
Anti-malarial interaction with ferriprotoporphyrin IX and its interrelationship to activity of blood schinzontocides
-
Warhurst, D. C. (1987) Anti-malarial interaction with ferriprotoporphyrin IX and its interrelationship to activity of blood schinzontocides. Ann. Trop. Med. Parasitol. 81: 65-67
-
(1987)
Ann. Trop. Med. Parasitol.
, vol.81
, pp. 65-67
-
-
Warhurst, D.C.1
-
57
-
-
0021343377
-
Effectiveness of amodiaquine as a treatment of chloroquine-resistant Plasmodium falciparum infections in Kenya
-
Watkins, W. M., Spencer, H. C., Kariuki, D. M., Sixsmith, D. G., Boriga, D. A., Kipingor, T., Koech, D. K. (1984) Effectiveness of amodiaquine as a treatment of chloroquine-resistant Plasmodium falciparum infections in Kenya. Lancet 1: 357-359
-
(1984)
Lancet
, vol.1
, pp. 357-359
-
-
Watkins, W.M.1
Spencer, H.C.2
Kariuki, D.M.3
Sixsmith, D.G.4
Boriga, D.A.5
Kipingor, T.6
Koech, D.K.7
-
58
-
-
0022515017
-
Synthesis, anti-malarial activity and quantitative structure-activity relationships of tebuquine and a series of related 5-[(7-chloro-4-quinolynyl)amino]-3-[(alkylamino)m-ethyl][1,1′-biphenyl]-2- ols and N-oxides
-
Werbel, L. M., Cook, D. P., Elslager, E. F., Hung, J. H., Johnson, J. L., Kesten, S. J., McNamara, D. J., Ortwine, D. F., Worth, D. F. (1986) Synthesis, anti-malarial activity and quantitative structure-activity relationships of tebuquine and a series of related 5-[(7-chloro-4-quinolynyl)amino]-3-[(alkylamino)m-ethyl][1,1′-biphenyl]-2- ols and N-oxides. J. Med. Chem. 29: 924-939
-
(1986)
J. Med. Chem.
, vol.29
, pp. 924-939
-
-
Werbel, L.M.1
Cook, D.P.2
Elslager, E.F.3
Hung, J.H.4
Johnson, J.L.5
Kesten, S.J.6
McNamara, D.J.7
Ortwine, D.F.8
Worth, D.F.9
-
59
-
-
0345017903
-
Biotransformation Reactions
-
Wermuth, C. G. (ed.) Academic Press, London
-
Wermuth, C. G., Testa, B. (1996) Biotransformation Reactions in The Practice of Medicinal Chemistry. Wermuth, C. G. (ed.) Academic Press, London, pp 615-642
-
(1996)
The Practice of Medicinal Chemistry
, pp. 615-642
-
-
Wermuth, C.G.1
Testa, B.2
-
60
-
-
0023255934
-
Pharmacokinetics of intravenous amodiaquine
-
White, N. J., Looareesuwan, S., Edwards, G., Phillips, R. E., Karbwang, J., Nicholl, D., Bunch, C., Warell, D. A. (1987) Pharmacokinetics of intravenous amodiaquine. B. J. Clin. Pharmacol. 23: 127-135
-
(1987)
B. J. Clin. Pharmacol.
, vol.23
, pp. 127-135
-
-
White, N.J.1
Looareesuwan, S.2
Edwards, G.3
Phillips, R.E.4
Karbwang, J.5
Nicholl, D.6
Bunch, C.7
Warell, D.A.8
-
61
-
-
1842618625
-
Steric and rotational constraints in the X-ray structure of the anti-malarial drug amodiaquine
-
Yennawar, H. P., Viswamitra, M. A. (1991) Steric and rotational constraints in the X-ray structure of the anti-malarial drug amodiaquine. Curr. Sci. 61: 39-43
-
(1991)
Curr. Sci.
, vol.61
, pp. 39-43
-
-
Yennawar, H.P.1
Viswamitra, M.A.2
|