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1
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0000063597
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Asymmetric cell division
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Jan YN, Jan LY. Asymmetric cell division. Nature. 392:1998;775-778.
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(1998)
Nature
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Jan, Y.N.1
Jan, L.Y.2
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2
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0032524321
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A notch affair
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Bray S. A notch affair. Cell. 93:1998;499-503.
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(1998)
Cell
, vol.93
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Bray, S.1
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3
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0032101002
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The notch ligand, jagged-1, influences the development of primitive hematopoietic precursor cells
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of outstanding interest. Notch1 and Notch2 and their ligands are transmembrane proteins intimately involved in developmental decisions (e.g. nerve, eye and ovary development in Drosophila). These receptors have now been detected on primitive haemopoietic cells and one of their ligands, jagged-1 has been shown to enhance primitive cell proliferation. These results are not only of interest in terms of stem cell development but also for ex vivo expansion strategies for therapeutic use of stem cells.
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Varnum-Finney B, Purton LE, Yu M, Brashemstein C, Flowers D, Staats S, Moore KA, Leroux I, Mann R, Gray G, et al. The notch ligand, jagged-1, influences the development of primitive hematopoietic precursor cells. of outstanding interest Blood. 91:1998;4084-4091 Notch1 and Notch2 and their ligands are transmembrane proteins intimately involved in developmental decisions (e.g. nerve, eye and ovary development in Drosophila). These receptors have now been detected on primitive haemopoietic cells and one of their ligands, jagged-1 has been shown to enhance primitive cell proliferation. These results are not only of interest in terms of stem cell development but also for ex vivo expansion strategies for therapeutic use of stem cells.
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(1998)
Blood
, vol.91
, pp. 4084-4091
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Varnum-Finney, B.1
Purton, L.E.2
Yu, M.3
Brashemstein, C.4
Flowers, D.5
Staats, S.6
Moore, K.A.7
Leroux, I.8
Mann, R.9
Gray, G.10
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4
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0031899677
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Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines
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of special interest. These studies using cell lines have shown that Notch inhibition of development is dependent on the cytokine stimulus used to initiate differentiation, exemplifying the levels of complexity which are part of the signal transduction process regulating differentiation in haemopoietic cells.
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Bigas A, Martin DIK, Milner LA. Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines. of special interest Mol Cell Biol. 18:1998;2324-2333 These studies using cell lines have shown that Notch inhibition of development is dependent on the cytokine stimulus used to initiate differentiation, exemplifying the levels of complexity which are part of the signal transduction process regulating differentiation in haemopoietic cells.
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(1998)
Mol Cell Biol
, vol.18
, pp. 2324-2333
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Bigas, A.1
Martin, D.I.K.2
Milner, L.A.3
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5
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0031027475
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Leptin stimulates fetal and adult erythroid and myeloid development
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of special interest. In embryonal stem cell differentiation assays, day 3 sees the genesis of the first pluripotent haemopoietic stem cells; at day 3.5 the leptin receptor is first expressed. Cultures of murine fetal liver and adult bone marrow demonstrate significant colony formation from several distinct lineages in response to leptin.
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Mikhail AA, Beck EX, Shafer A, Barut B, Gbur JS, Zupancic TJ, Schweitzer AC, Cioffi JA, Lacaud G, Ouyang B, et al. Leptin stimulates fetal and adult erythroid and myeloid development. of special interest Blood. 89:1997;1507-1512 In embryonal stem cell differentiation assays, day 3 sees the genesis of the first pluripotent haemopoietic stem cells; at day 3.5 the leptin receptor is first expressed. Cultures of murine fetal liver and adult bone marrow demonstrate significant colony formation from several distinct lineages in response to leptin.
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(1997)
Blood
, vol.89
, pp. 1507-1512
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Mikhail, A.A.1
Beck, E.X.2
Shafer, A.3
Barut, B.4
Gbur, J.S.5
Zupancic, T.J.6
Schweitzer, A.C.7
Cioffi, J.A.8
Lacaud, G.9
Ouyang, B.10
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6
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0030007116
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Novel B219/OB receptor isoforms - Possible role of leptin in hematopoiesis and reproduction
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Cioffi JA, Shafer AW, Zupancic TJ, Smithgbur J, Mikhail A, Platika D, Snodgrass HR. Novel B219/OB receptor isoforms - possible role of leptin in hematopoiesis and reproduction. Nat Med. 2:1996;585-589.
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(1996)
Nat Med
, vol.2
, pp. 585-589
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Cioffi, J.A.1
Shafer, A.W.2
Zupancic, T.J.3
Smithgbur, J.4
Mikhail, A.5
Platika, D.6
Snodgrass, H.R.7
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7
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0029960265
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Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopolesis in mice lacking the thrombopoietin receptor c-Mpl
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Alexander W, Roberts AW, Nicola NA, Li R, Metcalf D. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopolesis in mice lacking the thrombopoietin receptor c-Mpl. Blood. 87:1996;2162-2170.
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(1996)
Blood
, vol.87
, pp. 2162-2170
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Alexander, W.1
Roberts, A.W.2
Nicola, N.A.3
Li, R.4
Metcalf, D.5
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8
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0029684417
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Low levels of erythroid and myeloid progenitors in thrombopoietin- And c-mpl-deficient mice
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Carver-Moore K, Broxmeyer HE, Luoh S-M, Cooper S, Peng J, Burstein SA, Moore MW, de Sauvage FJ. Low levels of erythroid and myeloid progenitors in thrombopoietin- and c-mpl-deficient mice. Blood. 88:1996;803-808.
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(1996)
Blood
, vol.88
, pp. 803-808
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Carver-Moore, K.1
Broxmeyer, H.E.2
Luoh S-M3
Cooper, S.4
Peng, J.5
Burstein, S.A.6
Moore, M.W.7
De Sauvage, F.J.8
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9
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0032477741
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Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin
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of special interest. Earlier studies on thrombopoietin (TPO) effects on stem cells have been extended here. Analysis of the numbers of stem cells in vivo (markedly decreased compared to those in controls) and their long term repopulating ability (decreased compared to that in controls) of TPO receptor null stem cells demonstrates TPO plays a key role in stem cell production via direct effects on stem cells. The stroma derived from TPO receptor null mice supports normal haemopoiesis.
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Kimura S, Roberts AW, Metcalf D, Alexander WS. Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin. of special interest Proc Natl Acad Sci USA. 95:1998;1195-1200 Earlier studies on thrombopoietin (TPO) effects on stem cells have been extended here. Analysis of the numbers of stem cells in vivo (markedly decreased compared to those in controls) and their long term repopulating ability (decreased compared to that in controls) of TPO receptor null stem cells demonstrates TPO plays a key role in stem cell production via direct effects on stem cells. The stroma derived from TPO receptor null mice supports normal haemopoiesis.
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(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 1195-1200
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Kimura, S.1
Roberts, A.W.2
Metcalf, D.3
Alexander, W.S.4
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10
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0030884466
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Recombinant human C-MPL ligand (thrombopoietin) not only acts on megakaryocyte progenitors, but also on erythroid and multipotential progenitors in vitro
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Tanimukai S, Kimura T, Sakabe H, Ohmizono Y, Kato T, Miyazaki H, Yamagishi H, Sonoda Y. Recombinant human C-MPL ligand (thrombopoietin) not only acts on megakaryocyte progenitors, but also on erythroid and multipotential progenitors in vitro. Exp Hematol. 25:1997;1025-1033.
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(1997)
Exp Hematol
, vol.25
, pp. 1025-1033
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Tanimukai, S.1
Kimura, T.2
Sakabe, H.3
Ohmizono, Y.4
Kato, T.5
Miyazaki, H.6
Yamagishi, H.7
Sonoda, Y.8
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11
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0031028327
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Hepatocyte growth factor is constitutively produced by human bone marrow stromal cells and indirectly promotes hematopoiesis
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Takai K, Hara J, Matsumoto K, Hosoi G, Osugi Y, Tawa A, Okada S, Nakamura T. Hepatocyte growth factor is constitutively produced by human bone marrow stromal cells and indirectly promotes hematopoiesis. Blood. 89:1997;1560-1565.
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(1997)
Blood
, vol.89
, pp. 1560-1565
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Takai, K.1
Hara, J.2
Matsumoto, K.3
Hosoi, G.4
Osugi, Y.5
Tawa, A.6
Okada, S.7
Nakamura, T.8
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12
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0030951587
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Altered hematopoiesis, behaviour, and sexual function in μ opioid receptor-deficient mice
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of special interest. This brief report makes an important link between the drug target for the analgesic opioids used in pain relief and haemopoiesis. This infers that a degree of central regulation of haemopoiesis is possible.
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Tian MT, Broxmeyer HE, Fan Y, Lai ZN, Zhang SW, Aronica S, Cooper S, Bigsby RM, Steinmetz R, Engle SJ, et al. Altered hematopoiesis, behaviour, and sexual function in μ opioid receptor-deficient mice. of special interest J Exp Med. 185:1997;1517-1522 This brief report makes an important link between the drug target for the analgesic opioids used in pain relief and haemopoiesis. This infers that a degree of central regulation of haemopoiesis is possible.
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(1997)
J Exp Med
, vol.185
, pp. 1517-1522
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Tian, M.T.1
Broxmeyer, H.E.2
Fan, Y.3
Lai, Z.N.4
Zhang, S.W.5
Aronica, S.6
Cooper, S.7
Bigsby, R.M.8
Steinmetz, R.9
Engle, S.J.10
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14
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0031906950
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Immunofluorescence characterization of key extracellular matrix proteins in murine bone marrow in situ
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of special interest. These authors have used immunofluorescence labelling to analyse the location of extracellular matrix proteins within the murine bone marrow. Collagen Types I and IV and fibronectin were localised to the microenvironment region favoured by homing stem cells. This type of extracellular matrix - stem cell interaction may be a key interaction in presentation of soluble cytokines to stem cells, and in adhesion molecule - stem cell interactions. Fibronectin distribution is very different between mice and men; nonetheless, this paper highlights the roles of specific niches or areas containing specific extracellular matrix components.
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Nilsson SK, Debatis ME, Dooner MS, Madri JA, Quesenberry PJ, Becker PS. Immunofluorescence characterization of key extracellular matrix proteins in murine bone marrow in situ. of special interest J Histochem Cytochem. 46:1998;371-377 These authors have used immunofluorescence labelling to analyse the location of extracellular matrix proteins within the murine bone marrow. Collagen Types I and IV and fibronectin were localised to the microenvironment region favoured by homing stem cells. This type of extracellular matrix - stem cell interaction may be a key interaction in presentation of soluble cytokines to stem cells, and in adhesion molecule - stem cell interactions. Fibronectin distribution is very different between mice and men; nonetheless, this paper highlights the roles of specific niches or areas containing specific extracellular matrix components.
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(1998)
J Histochem Cytochem
, vol.46
, pp. 371-377
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Nilsson, S.K.1
Debatis, M.E.2
Dooner, M.S.3
Madri, J.A.4
Quesenberry, P.J.5
Becker, P.S.6
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15
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0032100451
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Suppression of hematopoietic activity in tenascin-c-deficient mice
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Ohta M, Sakai T, Saga Y, Aizawa S, Saito M. Suppression of hematopoietic activity in tenascin-c-deficient mice. Blood. 91:1998;4074-4083.
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(1998)
Blood
, vol.91
, pp. 4074-4083
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Ohta, M.1
Sakai, T.2
Saga, Y.3
Aizawa, S.4
Saito, M.5
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16
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0031571328
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Thrombopoietin promotes adhesion of primitive human hemopoietic cells to fibronectin and vascular cell adhesion molecule-1 - role of activation of very late antigen (VLA)-4 and VLA-5
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of special interest. This paper demonstrates thrombopoietin activation of an integrin with a role in steady state haemopoiesis. It also shows, using a human leukaemic cell line, that increased adhesion involves cyclic AMP production, protein kinase C and phosphatidylinositol 3-kinase (PI3-K) activation - exemplifying the difficulty in unravelling the signals regulating adhesion, survival and proliferation.
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Cui L, Ramsfjell V, Borge OJ, Veiby OP, Lok S, Jacobsen SEW. Thrombopoietin promotes adhesion of primitive human hemopoietic cells to fibronectin and vascular cell adhesion molecule-1 - role of activation of very late antigen (VLA)-4 and VLA-5. of special interest J Immunol. 159:1997;1961-1969 This paper demonstrates thrombopoietin activation of an integrin with a role in steady state haemopoiesis. It also shows, using a human leukaemic cell line, that increased adhesion involves cyclic AMP production, protein kinase C and phosphatidylinositol 3-kinase (PI3-K) activation - exemplifying the difficulty in unravelling the signals regulating adhesion, survival and proliferation.
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(1997)
J Immunol
, vol.159
, pp. 1961-1969
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Cui, L.1
Ramsfjell, V.2
Borge, O.J.3
Veiby, O.P.4
Lok, S.5
Jacobsen, S.E.W.6
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17
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0031440743
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Antibodies to VLA4 integrin mobilize long-term repopulating cells and augment cytokine-induced mobilization in primates and mice
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Craddock CF, Nakamoto B, Andrews RG, Priestley GV, Papayannopoulou T. Antibodies to VLA4 integrin mobilize long-term repopulating cells and augment cytokine-induced mobilization in primates and mice. Blood. 90:1997;4779-4788.
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(1997)
Blood
, vol.90
, pp. 4779-4788
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Craddock, C.F.1
Nakamoto, B.2
Andrews, R.G.3
Priestley, G.V.4
Papayannopoulou, T.5
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18
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0031026475
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The chemokine SDF-1 is a chemoattractant for human CD34(+) hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34(+) progenitors to peripheral blood
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+ progenitor cells are shown, for the first time, to undergo chemotaxis in response to an agonist. The agonist, stroma-derived factor 1 (SDF-1), is produced by stromal cells and its receptor is upregulated by cytokines such as IL-3. The stem cell can again be seen as being 'instructed' to give different responses by signalling pathways which display crosstalk.
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+ progenitor cells are shown, for the first time, to undergo chemotaxis in response to an agonist. The agonist, stroma-derived factor 1 (SDF-1), is produced by stromal cells and its receptor is upregulated by cytokines such as IL-3. The stem cell can again be seen as being 'instructed' to give different responses by signalling pathways which display crosstalk.
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(1997)
J Exp Med
, vol.185
, pp. 111-120
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Aiuti, A.1
Webb, I.J.2
Bleul, C.3
Springer, T.4
Gutierrez Ramos, J.C.5
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19
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0029758113
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
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Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, Kitamura Y, Yoshida N, Kikutani H, Kishimoto T. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature. 382:1996;635-638.
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(1996)
Nature
, vol.382
, pp. 635-638
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Nagasawa, T.1
Hirota, S.2
Tachibana, K.3
Takakura, N.4
Nishikawa, S.5
Kitamura, Y.6
Yoshida, N.7
Kikutani, H.8
Kishimoto, T.9
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20
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2642710893
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The chemokine receptor CXCR-4 is expressed on CD34(+) hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1
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of special interest. Primitive cells do indeed express stroma-derived factor 1 (SDF-1) receptors and, perhaps just as significantly, so do primary leukaemic cells. Therefore SDF-1 may have a role in movements of acute myeloid leukaemia cells within the body.
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Mohle R, Bautz F, Rafii S, Moore MAS, Brugger W, Kanz L. The chemokine receptor CXCR-4 is expressed on CD34(+) hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1. of special interest Blood. 91:1998;4523-4530 Primitive cells do indeed express stroma-derived factor 1 (SDF-1) receptors and, perhaps just as significantly, so do primary leukaemic cells. Therefore SDF-1 may have a role in movements of acute myeloid leukaemia cells within the body.
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(1998)
Blood
, vol.91
, pp. 4523-4530
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Mohle, R.1
Bautz, F.2
Rafii, S.3
Moore, M.A.S.4
Brugger, W.5
Kanz, L.6
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21
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0032507962
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
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of special interest. The stroma-derived factor 1 (SDF-1) receptor, CXCR4, is shown to be critical in stem cell biology.
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Zou Y-R, Kottmann AH, Kuroda M, Taniuchi I, Littman DR. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. of special interest Nature. 393:1998;595-599 The stroma-derived factor 1 (SDF-1) receptor, CXCR4, is shown to be critical in stem cell biology.
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(1998)
Nature
, vol.393
, pp. 595-599
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Zou Y-R1
Kottmann, A.H.2
Kuroda, M.3
Taniuchi, I.4
Littman, D.R.5
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22
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0030942527
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A common precursor for primitive erythropoiesis and definitive haematopoiesis
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Kennedy M, Firpo M, Chol K, Wall C, Robertson S, Kabrun N, Keller G. A common precursor for primitive erythropoiesis and definitive haematopoiesis. Nature. 386:1997;488-493.
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(1997)
Nature
, vol.386
, pp. 488-493
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Kennedy, M.1
Firpo, M.2
Chol, K.3
Wall, C.4
Robertson, S.5
Kabrun, N.6
Keller, G.7
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23
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0030867904
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Interleukin 3-dependent survival by the Akt protein kinase
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of special interest. Interleukin 3 and other cytokines suppress apoptosis. Here evidence is presented that the signal transduction pathway responsible involves protein kinase B (Akt). What remains a key question is whether primary stem cells, as opposed to cell lines, utilise this cytokine/adhesion- molecule-stimulated signal transduction pathway for survival signalling.
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Zhou SY, Baltimore D, Cantley LC, Kaplan DR, Franke TF. Interleukin 3-dependent survival by the Akt protein kinase. of special interest Proc Natl Acad Sci USA. 94:1997;11345-11350 Interleukin 3 and other cytokines suppress apoptosis. Here evidence is presented that the signal transduction pathway responsible involves protein kinase B (Akt). What remains a key question is whether primary stem cells, as opposed to cell lines, utilise this cytokine/adhesion- molecule-stimulated signal transduction pathway for survival signalling.
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(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 11345-11350
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Zhou, S.Y.1
Baltimore, D.2
Cantley, L.C.3
Kaplan, D.R.4
Franke, T.F.5
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24
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2642684541
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Targeted disruption of SHIP leads to hemopoietic perturbations lung pathology, and a shortened life span
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of outstanding interest. The SHIP-1 protein is tyrosine phosphorylated and activated by the action of many cytokines. The SHIP-1 deficient mouse is, perhaps predictably, impaired in myelopoiesis and lymphopoiesis yet the mice are still viable. Myeloid progenitor cells in these mice show increased sensitivity to low doses of cytokine. It will be interesting to see the effect of the loss of this protein on the survival and proliferation of stem cells, given its key regulatory role in governing concentrations of a second messenger intimately associated with signalling for survival.
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Helgason CD, Damen JE, Rosten P, Grewal R, Sorensen P, Chappel SM, Borowski A, Jirik F, Krystal G, Humphries RK. Targeted disruption of SHIP leads to hemopoietic perturbations lung pathology, and a shortened life span. of outstanding interest Genes Dev. 12:1998;1610-1620 The SHIP-1 protein is tyrosine phosphorylated and activated by the action of many cytokines. The SHIP-1 deficient mouse is, perhaps predictably, impaired in myelopoiesis and lymphopoiesis yet the mice are still viable. Myeloid progenitor cells in these mice show increased sensitivity to low doses of cytokine. It will be interesting to see the effect of the loss of this protein on the survival and proliferation of stem cells, given its key regulatory role in governing concentrations of a second messenger intimately associated with signalling for survival.
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(1998)
Genes Dev
, vol.12
, pp. 1610-1620
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Helgason, C.D.1
Damen, J.E.2
Rosten, P.3
Grewal, R.4
Sorensen, P.5
Chappel, S.M.6
Borowski, A.7
Jirik, F.8
Krystal, G.9
Humphries, R.K.10
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25
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0032076183
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Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses
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-/- mice.
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-/- mice.
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(1998)
Cell
, vol.93
, pp. 373-383
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Rodig, S.J.1
Meraz, M.A.2
White, J.M.3
Lampe, P.A.4
Riley, J.K.5
Arthur, C.D.6
King, K.L.7
Sheehan, K.C.F.8
Yin, L.9
Pennica, D.10
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26
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18244432009
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Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
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of outstanding interest. Along with [27] this paper shows that key haemopoietically active cytokines require JAK2 to stimulate formation of myeloid colonies. Jak2-deficient mice fibroblasts also fail to respond to interferon γ (see annotation to [25]).
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Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U, Pfeffer K. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. of outstanding interest Cell. 93:1998;397-409 Along with [27] this paper shows that key haemopoietically active cytokines require JAK2 to stimulate formation of myeloid colonies. Jak2-deficient mice fibroblasts also fail to respond to interferon γ (see annotation to [25]).
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(1998)
Cell
, vol.93
, pp. 397-409
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Neubauer, H.1
Cumano, A.2
Muller, M.3
Wu, H.4
Huffstadt, U.5
Pfeffer, K.6
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27
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0032076542
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Jak2 is essential for signaling through a variety of cytokine receptors
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of outstanding interest. See annotation to [26].
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Parganas E, Wang D, Stravopodis D, Topham DJ, Marine J-C, Teglund S, Vanin EF, Bodner S, Colamonici OR, van Deursen JM, et al. Jak2 is essential for signaling through a variety of cytokine receptors. of outstanding interest Cell. 93:1998;385-395 See annotation to [26].
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(1998)
Cell
, vol.93
, pp. 385-395
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Parganas, E.1
Wang, D.2
Stravopodis, D.3
Topham, D.J.4
Marine J-C5
Teglund, S.6
Vanin, E.F.7
Bodner, S.8
Colamonici, O.R.9
Van Deursen, J.M.10
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28
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0030024563
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Targeted disruption of the mouse Stat1 results in compromised innate immunity to viral disease
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Durbin JE, Hackenmiller R, Simon MC, Levy DE. Targeted disruption of the mouse Stat1 results in compromised innate immunity to viral disease. Cell. 84:1996;443-450.
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Cell
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Durbin, J.E.1
Hackenmiller, R.2
Simon, M.C.3
Levy, D.E.4
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29
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13344282731
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Targeted disruption of the STAT1 gene in mice reveals unexpected physiological specificity in the JAK-STAT signaling pathway
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Meraz MA, White JM, Sheehan KCF, Bach EA, Rodig SJ, Dighe AS, Kaplan DH, Riley JK, Greenlund AC, Campbell D, et al. Targeted disruption of the STAT1 gene in mice reveals unexpected physiological specificity in the JAK-STAT signaling pathway. Cell. 84:1996;431-442.
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(1996)
Cell
, vol.84
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Meraz, M.A.1
White, J.M.2
Sheehan, K.C.F.3
Bach, E.A.4
Rodig, S.J.5
Dighe, A.S.6
Kaplan, D.H.7
Riley, J.K.8
Greenlund, A.C.9
Campbell, D.10
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30
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0030935260
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Targeted disruption of the mouse STAT3 gene leads to early embryonic lethality
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of special interest. Stat3 is activated by a number of cytokines which promote haemopoiesis (e.g. leptin, granulocyte colony-stimulating factor [G-CSF]), IL-6 and IL-10). Stat3 deficiency leads to early embryonic death, demonstrating that it has a critical role in early development.
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Takeda K, Noguchi K, Shi W, Tanaka T, Matsumoto M, Yoshida N, Kishimoto T, Akira S. Targeted disruption of the mouse STAT3 gene leads to early embryonic lethality. of special interest Proc Natl Acad Sci USA. 94:1997;3801-3804 Stat3 is activated by a number of cytokines which promote haemopoiesis (e.g. leptin, granulocyte colony-stimulating factor [G-CSF]), IL-6 and IL-10). Stat3 deficiency leads to early embryonic death, demonstrating that it has a critical role in early development.
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(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 3801-3804
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Takeda, K.1
Noguchi, K.2
Shi, W.3
Tanaka, T.4
Matsumoto, M.5
Yoshida, N.6
Kishimoto, T.7
Akira, S.8
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31
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0000943469
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Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
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of outstanding interest. A key paper describing the functional role of two highly related Stat proteins using single and double gene knockouts. Stat5a and Stat5b are activated by a wide range of cytokines, including thrombopoietin and IL-3 (which stimulate primitive haemopoietic cells) as well as growth hormone and prolactin. Previous reports have indicated altered development with each gene deleted singly but here myeloid cells are, relatively, remarkably unimpaired by the loss of these proteins.
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Teglund S, McKay C, Schuetz E, van Deursen JM, Stravopodis D, Wang D, Brown M, Bodner S, Grosveld G, Ihle JN. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. of outstanding interest Cell. 93:1998;841-850 A key paper describing the functional role of two highly related Stat proteins using single and double gene knockouts. Stat5a and Stat5b are activated by a wide range of cytokines, including thrombopoietin and IL-3 (which stimulate primitive haemopoietic cells) as well as growth hormone and prolactin. Previous reports have indicated altered development with each gene deleted singly but here myeloid cells are, relatively, remarkably unimpaired by the loss of these proteins.
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Cell
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Teglund, S.1
McKay, C.2
Schuetz, E.3
Van Deursen, J.M.4
Stravopodis, D.5
Wang, D.6
Brown, M.7
Bodner, S.8
Grosveld, G.9
Ihle, J.N.10
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Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors
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Klingmuller U, Wu H, Hsiao JG, Toker A, Duckworth BC, Cantley LC, Lodish HF. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc Natl Acad Sci USA. 94:1997;3016-3021.
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Klingmuller, U.1
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Duckworth, B.C.5
Cantley, L.C.6
Lodish, H.F.7
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Familial erythrocytosis genetically linked to erythropoietin receptor gene
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De la Chapelle A, Sistonen P, Lehvaslaiho H, Ikkala E, Juvonen E. Familial erythrocytosis genetically linked to erythropoietin receptor gene. Lancet. 341:1993;82-84.
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0028171065
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Interaction of II-2R-beta and gamma χ chains with JAK1 and JAK3 - implications for xscid and xcid
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Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O, et al. Interaction of II-2R-beta and gamma χ chains with JAK1 and JAK3 - implications for xscid and xcid. Science. 266:1994;1042-1045.
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Friedmann, M.6
Berg, M.7
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35
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Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia
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of special interest. This paper describes a knock-in mutant mouse with potential for describing a human disease, severe congenital neutropenia which progresses to leukaemia.
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Hermans MHA, Ward AC, Antonissen C, Karis A, Lowenberg B, Touw IP. Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia. of special interest Blood. 92:1998;32-39 This paper describes a knock-in mutant mouse with potential for describing a human disease, severe congenital neutropenia which progresses to leukaemia.
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Blood
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Hermans, M.H.A.1
Ward, A.C.2
Antonissen, C.3
Karis, A.4
Lowenberg, B.5
Touw, I.P.6
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36
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0001325237
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The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor
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Hershey GKK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. New Eng J Med. 337:1997;1720-1725.
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Hershey, G.K.K.1
Friedrich, M.F.2
Esswein, L.A.3
Thomas, M.L.4
Chatila, T.A.5
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37
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0030797548
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A deletion mutation in the SHZ-N domain of shp-2 severely suppresses hematopoietic cell development
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Qu CK, Shi ZQ, Shen R, Tsai FY, Orkin SH, Feng GS. A deletion mutation in the SHZ-N domain of shp-2 severely suppresses hematopoietic cell development. Mol Cell Biol. 17:1997;5499-5507.
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Qu, C.K.1
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Shen, R.3
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Feng, G.S.6
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38
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Negative regulation of granulocyte differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO(MTGB)
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of special interest. The leukaemogenic chimeric protein AML1/ETO blocks granulocytic differentiation and up-regulates ear-2. AML1 contains a runt domain, runt being a key regulator of development in Drosophila. Overexpression of ear-2 (a mammalian homolog of Drosophila seven-up) can block granulocyte colony-stimulating factor (G-CSF)-stimulated differentiation and G-CSF can down regulate ear2 levels. It remains to be seen how this long-term effect of G-CSF on ear-2 is mediated but this may well be one strand of the multiple pathways leading in concert to granulocytic differentiation.
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Ahn MY, Huang G, Bae SC, Wee HJ, Kim WY, Ito Y. Negative regulation of granulocyte differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO(MTGB). of special interest Proc Natl Acad Sci USA. 95:1998;1812-1817 The leukaemogenic chimeric protein AML1/ETO blocks granulocytic differentiation and up-regulates ear-2. AML1 contains a runt domain, runt being a key regulator of development in Drosophila. Overexpression of ear-2 (a mammalian homolog of Drosophila seven-up) can block granulocyte colony-stimulating factor (G-CSF)-stimulated differentiation and G-CSF can down regulate ear2 levels. It remains to be seen how this long-term effect of G-CSF on ear-2 is mediated but this may well be one strand of the multiple pathways leading in concert to granulocytic differentiation.
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Proc Natl Acad Sci USA
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Ahn, M.Y.1
Huang, G.2
Bae, S.C.3
Wee, H.J.4
Kim, W.Y.5
Ito, Y.6
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39
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0032540012
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PPAR gamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
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of special interest. Retinoid receptors are already known to play a major role in myeloid differentiation and in leukaemogenesis (e.g. the hallmark of acute promyelocytic leukaemia is the chimeric PML - retinoic acid receptor alpha [RARα] oncogene). It remains to be seen if agonists for the peroxisome proliferator-activated receptor γ (PPARγ) potentiate primary cell differentiation or development, and whether expression or activation of PPARγ is a key regulator at any stage of haemopoiesis.
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Tontonoz P, Nagy L, Alvarez JGA, Thomazy VA, Evans RM. PPAR gamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. of special interest Cell. 93:1998;241-252 Retinoid receptors are already known to play a major role in myeloid differentiation and in leukaemogenesis (e.g. the hallmark of acute promyelocytic leukaemia is the chimeric PML - retinoic acid receptor alpha [RARα] oncogene). It remains to be seen if agonists for the peroxisome proliferator-activated receptor γ (PPARγ) potentiate primary cell differentiation or development, and whether expression or activation of PPARγ is a key regulator at any stage of haemopoiesis.
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(1998)
Cell
, vol.93
, pp. 241-252
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Tontonoz, P.1
Nagy, L.2
Alvarez, J.G.A.3
Thomazy, V.A.4
Evans, R.M.5
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40
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0030972497
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Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation
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Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 16:1997;2004-2013.
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EMBO J
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Morgan, B.1
Sun, L.2
Avitahl, N.3
Andrikopoulos, K.4
Ikeda, T.5
Gonzales, E.6
Wu, P.7
Neben, S.8
Georgopoulos, K.9
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41
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0032560018
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Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors
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Kelley CM, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K, Morgan BA. Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. Curr Biol. 8:1998;508-515.
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(1998)
Curr Biol
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, pp. 508-515
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Kelley, C.M.1
Ikeda, T.2
Koipally, J.3
Avitahl, N.4
Wu, L.5
Georgopoulos, K.6
Morgan, B.A.7
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42
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15144358621
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Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin
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Hahm K, Cobb BS, McCarty AS, Brown KE, Klug CA, Lee R, Akashi K, Weissman IL, Fisher AG, Smale ST. Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. Genes Dev. 12:1998;782-796.
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Genes Dev
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, pp. 782-796
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Hahm, K.1
Cobb, B.S.2
McCarty, A.S.3
Brown, K.E.4
Klug, C.A.5
Lee, R.6
Akashi, K.7
Weissman, I.L.8
Fisher, A.G.9
Smale, S.T.10
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43
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0031907815
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Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes
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of special interest. Importantly perhaps for regulation of differentiation in stem cells, RNA splicing can be altered as cells differentiate. A key question for future years is whether this change in RNA splicing is directly controlled by the microenvironment in which stem cells are found.
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Klug CA, Morrison SJ, Masek M, Hahm K, Smale ST, Weissman IL. Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes. of special interest Proc Natl Acad Sci USA. 95:1998;657-662 Importantly perhaps for regulation of differentiation in stem cells, RNA splicing can be altered as cells differentiate. A key question for future years is whether this change in RNA splicing is directly controlled by the microenvironment in which stem cells are found.
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(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 657-662
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Klug, C.A.1
Morrison, S.J.2
Masek, M.3
Hahm, K.4
Smale, S.T.5
Weissman, I.L.6
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44
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0030831130
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Identification of clonogenic common lymphoid progenitors in mouse bone marrow
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of special interest. The T/B common lymphoid precursor is identified in this report. The evidence suggests these cells cannot undergo myeloid differentiation but a single cell could be cultured in vitro to yield progeny which form B cells (within the soft gel assays) and T cells (using intrathymic injections of the progeny). The cytokines required to stimulate the growth of these progenitors were stem cell factor, IL-7, and Flt3 ligand. The further characterisation of conditions to generate and grow these cells will be of great potential benefit for understanding and manipulating the immune system (which is derived from multipotent cells).
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Kondo M, Weissman IL, Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. of special interest Cell. 91:1997;661-672 The T/B common lymphoid precursor is identified in this report. The evidence suggests these cells cannot undergo myeloid differentiation but a single cell could be cultured in vitro to yield progeny which form B cells (within the soft gel assays) and T cells (using intrathymic injections of the progeny). The cytokines required to stimulate the growth of these progenitors were stem cell factor, IL-7, and Flt3 ligand. The further characterisation of conditions to generate and grow these cells will be of great potential benefit for understanding and manipulating the immune system (which is derived from multipotent cells).
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(1997)
Cell
, vol.91
, pp. 661-672
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Kondo, M.1
Weissman, I.L.2
Akashi, K.3
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