메뉴 건너뛰기




Volumn 88, Issue 3, 1996, Pages 977-984

Detection and quantification of melphalan-DNA adducts at the single cell level in hematopoietic tumor cells

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CELL DNA; FLUORESCEIN ISOTHIOCYANATE; FLUORESCENT DYE; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN G ANTIBODY; MELPHALAN; MONOCLONAL ANTIBODY;

EID: 0029744782     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.3.977.977     Document Type: Article
Times cited : (26)

References (37)
  • 1
    • 0025914150 scopus 로고
    • Concepts of remission, curability and lineage involvement in relationship to the problems of minimal residual leukemia
    • Jasmin C, Charpentier A, Marion S, Proctor SJ: Concepts of remission, curability and lineage involvement in relationship to the problems of minimal residual leukemia. Baillieres Clin Haematol 4:599, 1991
    • (1991) Baillieres Clin Haematol , vol.4 , pp. 599
    • Jasmin, C.1    Charpentier, A.2    Marion, S.3    Proctor, S.J.4
  • 2
    • 0027567880 scopus 로고
    • Stem cell origins of leukemia and curability
    • Greaves MF: Stem cell origins of leukemia and curability. Br J Cancer 67:412, 1993
    • (1993) Br J Cancer , vol.67 , pp. 412
    • Greaves, M.F.1
  • 3
    • 0026723149 scopus 로고
    • Mechanisms of action of, and modes of resistance to, alkylating agents used in the treatment of hematological malignancies
    • Hall AG, Tilby MJ: Mechanisms of action of, and modes of resistance to, alkylating agents used in the treatment of hematological malignancies. Blood Rev 6:163, 1992
    • (1992) Blood Rev , vol.6 , pp. 163
    • Hall, A.G.1    Tilby, M.J.2
  • 4
    • 0030591663 scopus 로고    scopus 로고
    • DNA adducts from chemotherapeutic agents
    • in press
    • Lawley PD, Phillips DH: DNA adducts from chemotherapeutic agents. Mutat Res 1996 (in press)
    • (1996) Mutat Res
    • Lawley, P.D.1    Phillips, D.H.2
  • 5
    • 0023142479 scopus 로고
    • Immunological detection of DNA caused by melphalan using monoclonal antibodies
    • Tilby MJ, Styles JM, Dean CJ: Immunological detection of DNA caused by melphalan using monoclonal antibodies. Cancer Res 47:1542, 1987
    • (1987) Cancer Res , vol.47 , pp. 1542
    • Tilby, M.J.1    Styles, J.M.2    Dean, C.J.3
  • 6
    • 0029142953 scopus 로고
    • A monoclonal antibody that recognizes alkali-stabilized melphalan-DNA adducts and its application in immunofluorescence microscopy
    • Tilby MJ, McCartney H, Cordell J, Frank AJ, Dean CJ: A monoclonal antibody that recognizes alkali-stabilized melphalan-DNA adducts and its application in immunofluorescence microscopy. Carcinogenesis 16:1895, 1995
    • (1995) Carcinogenesis , vol.16 , pp. 1895
    • Tilby, M.J.1    McCartney, H.2    Cordell, J.3    Frank, A.J.4    Dean, C.J.5
  • 7
    • 0026646849 scopus 로고
    • The reaction of melphalan with deoxyguanosine and deoxyguanylic acid
    • Osborne MR, Lawley PD: The reaction of melphalan with deoxyguanosine and deoxyguanylic acid. Chem Biol Interact 84:189, 1992
    • (1992) Chem Biol Interact , vol.84 , pp. 189
    • Osborne, M.R.1    Lawley, P.D.2
  • 8
    • 0027514969 scopus 로고
    • Alkylation of DNA by melphalan with special reference to adenine derivatives and adenine-guanine cross-linking
    • Osborne MR, Lawley PD: Alkylation of DNA by melphalan with special reference to adenine derivatives and adenine-guanine cross-linking. Chem Biol Interact 89:49, 1993
    • (1993) Chem Biol Interact , vol.89 , pp. 49
    • Osborne, M.R.1    Lawley, P.D.2
  • 9
    • 0025239832 scopus 로고
    • Alkylation of DNA by melphalan in relation to immunoassay of melphalan-DNA adducts: Characterization of monoalkylated and cross-linked products from reaction of melphalan with dGMP and GMP
    • Tilby MJ, Lawley PD, Farmer PB: Alkylation of DNA by melphalan in relation to immunoassay of melphalan-DNA adducts: Characterization of monoalkylated and cross-linked products from reaction of melphalan with dGMP and GMP. Chem Biol Interact 73:183, 1990
    • (1990) Chem Biol Interact , vol.73 , pp. 183
    • Tilby, M.J.1    Lawley, P.D.2    Farmer, P.B.3
  • 10
    • 0027411418 scopus 로고
    • Application of a sensitive immunoassay to the study of DNA adducts formed in peripheral blood mononuclear cells of a patient undergoing high-dose melphalan therapy
    • Tilby MJ, Newell DR, Viner C, Selby PJ, Dean CJ: Application of a sensitive immunoassay to the study of DNA adducts formed in peripheral blood mononuclear cells of a patient undergoing high-dose melphalan therapy. Eur J Cancer 29A:681, 1993
    • (1993) Eur J Cancer , vol.29 A , pp. 681
    • Tilby, M.J.1    Newell, D.R.2    Viner, C.3    Selby, P.J.4    Dean, C.J.5
  • 12
    • 0027527219 scopus 로고
    • Drug-induced DNA modification in buccal cells of cancer patients receiving carboplatin and cisplatin combination chemotherapy, as determined by an immunocytochemical method: Inter-individual variation and correlation with disease response
    • Blommaert FA, Michael C, Terheggen PMAB, Muggiam FM, Kortes V, Schomagel JH, Hart AAM, den Engelse L: Drug-induced DNA modification in buccal cells of cancer patients receiving carboplatin and cisplatin combination chemotherapy, as determined by an immunocytochemical method: Inter-individual variation and correlation with disease response. Cancer Res 53:5669, 1993
    • (1993) Cancer Res , vol.53 , pp. 5669
    • Blommaert, F.A.1    Michael, C.2    Terheggen, P.M.A.B.3    Muggiam, F.M.4    Kortes, V.5    Schomagel, J.H.6    Hart, A.A.M.7    Den Engelse, L.8
  • 14
    • 0025363447 scopus 로고
    • Correlation between cell killing by cis-diamminedichloroplatinum (II) in six mammalian cell lines and binding of cis-diamminedichloroplatinum (II)-DNA antiserum
    • Terheggen PMAB, Emondt JY, Floot BGJ, Dijkman R, Schrier PI, den Engelse L, Begg AC: Correlation between cell killing by cis-diamminedichloroplatinum (II) in six mammalian cell lines and binding of cis-diamminedichloroplatinum (II)-DNA antiserum. Cancer Res 50:3556, 1990
    • (1990) Cancer Res , vol.50 , pp. 3556
    • Terheggen, P.M.A.B.1    Emondt, J.Y.2    Floot, B.G.J.3    Dijkman, R.4    Schrier, P.I.5    Den Engelse, L.6    Begg, A.C.7
  • 15
    • 0023774905 scopus 로고
    • Monitoring of interaction of cis-diamminedichloroplatinum (II) and cis-diammine-(1,1-cyclobutanedicarboxylato) platinum (II) with DNA in cells from platinum-treated cancer patients
    • Terheggen PMAB, Dijkman R, Begg AC, Dubbelman R, Floot BGJ, Hart, AAM, den Engelse L: Monitoring of interaction of cis-diamminedichloroplatinum (II) and cis-diammine-(1,1-cyclobutanedicarboxylato) platinum (II) with DNA in cells from platinum-treated cancer patients. Cancer Res 48:5597, 1988
    • (1988) Cancer Res , vol.48 , pp. 5597
    • Terheggen, P.M.A.B.1    Dijkman, R.2    Begg, A.C.3    Dubbelman, R.4    Floot, B.G.J.5    Hart, A.A.M.6    Den Engelse, L.7
  • 16
    • 0023549423 scopus 로고
    • Immunocytological detection of interaction products of cis-diamminedichloroplatinum (II) and cis-diammine-(1,1-cyclobutanedicarboxylato) platinum (II) with DNA in rodent tissue sections
    • Terheggen PMAB, Floot BGJ, Scherer E, Begg AC, Fichtinger-Schepman A-MJ, den Engelse L: Immunocytological detection of interaction products of cis-diamminedichloroplatinum (II) and cis-diammine-(1,1-cyclobutanedicarboxylato) platinum (II) with DNA in rodent tissue sections. Cancer Res 47:6719, 1987
    • (1987) Cancer Res , vol.47 , pp. 6719
    • Terheggen, P.M.A.B.1    Floot, B.G.J.2    Scherer, E.3    Begg, A.C.4    Fichtinger-Schepman, A.-M.J.5    Den Engelse, L.6
  • 17
    • 0028177052 scopus 로고
    • 6-alkylguanines in the nuclear DNA of human lymphocytes and leukemia cells: Analysis at the single-cell level
    • 6-alkylguanines in the nuclear DNA of human lymphocytes and leukemia cells: Analysis at the single-cell level. Br J Cancer 69:698, 1994
    • (1994) Br J Cancer , vol.69 , pp. 698
    • Thomale, J.1    Seiler, F.2    Muller, M.R.3    Seeber, S.4    Rajewsky, M.F.5
  • 18
    • 0027380294 scopus 로고
    • Quantification of specific DNA-alkylation products in individual cells by monoclonal antibodies and digital imaging of intensified nuclear fluorescence
    • Seiler F, Kirstein U, Eberle G, Hochleitner K, Rajewsky MF: Quantification of specific DNA-alkylation products in individual cells by monoclonal antibodies and digital imaging of intensified nuclear fluorescence. Carcinogenesis 14:1907, 1993
    • (1993) Carcinogenesis , vol.14 , pp. 1907
    • Seiler, F.1    Kirstein, U.2    Eberle, G.3    Hochleitner, K.4    Rajewsky, M.F.5
  • 20
    • 0026060834 scopus 로고
    • Sensitive detection of DNA modifications induced by cisplatin and carboplatin in-vitro and in-vivo using a monoclonal antibody
    • Tilby MJ, Johnson C, Knox RJ, Cordell J, Roberts JJ, Dean CJ: Sensitive detection of DNA modifications induced by cisplatin and carboplatin in-vitro and in-vivo using a monoclonal antibody. Cancer Res 15:123, 1991
    • (1991) Cancer Res , vol.15 , pp. 123
    • Tilby, M.J.1    Johnson, C.2    Knox, R.J.3    Cordell, J.4    Roberts, J.J.5    Dean, C.J.6
  • 22
    • 0022838278 scopus 로고
    • Isolation and characterization of a chinese hamster ovary cell line resistant to bifunctional nitrogen mustards
    • Robson CN, Alexander J, Harris AL, Hickson, ID: Isolation and characterization of a chinese hamster ovary cell line resistant to bifunctional nitrogen mustards. Cancer Res 46:6290, 1986
    • (1986) Cancer Res , vol.46 , pp. 6290
    • Robson, C.N.1    Alexander, J.2    Harris, A.L.3    Hickson, I.D.4
  • 23
    • 0023234707 scopus 로고
    • Formation and removal of DNA cross-links induced by melphalan and nitrogen mustard in relation to drug-induced cytotoxicity in human melanoma cells
    • Hansonn J, Lewensohn R, Ringborg U, Nilsson B: Formation and removal of DNA cross-links induced by melphalan and nitrogen mustard in relation to drug-induced cytotoxicity in human melanoma cells. Cancer Res 47:2631, 1987
    • (1987) Cancer Res , vol.47 , pp. 2631
    • Hansonn, J.1    Lewensohn, R.2    Ringborg, U.3    Nilsson, B.4
  • 24
    • 0018102806 scopus 로고
    • Differences between melphalan and nitrogen mustard in the formation and removal of DNA cross-links
    • Ross WE, Ewig RAG, Kohn KW: Differences between melphalan and nitrogen mustard in the formation and removal of DNA cross-links. Cancer Res 38:1502, 1978
    • (1978) Cancer Res , vol.38 , pp. 1502
    • Ross, W.E.1    Ewig, R.A.G.2    Kohn, K.W.3
  • 25
    • 0026692190 scopus 로고
    • Nitrogen mustard-DNA interaction in melphalan-resistant mammary carcinoma cells with elevated intracellular glutathione and glutathione-S-transferace activity
    • Alaoui-Jamali MA, Panasci L, Centurioni GM, Schexter R, Lehnert S, Batist G: Nitrogen mustard-DNA interaction in melphalan-resistant mammary carcinoma cells with elevated intracellular glutathione and glutathione-S-transferace activity. Cancer Chemother Pharmacol 30:341, 1992
    • (1992) Cancer Chemother Pharmacol , vol.30 , pp. 341
    • Alaoui-Jamali, M.A.1    Panasci, L.2    Centurioni, G.M.3    Schexter, R.4    Lehnert, S.5    Batist, G.6
  • 27
    • 0026592534 scopus 로고
    • Factors influencing DNA migration from individual cells subjected to gel electrophoresis
    • Olive PL, Wlodek D, Durand RE, Banath JP: Factors influencing DNA migration from individual cells subjected to gel electrophoresis. Exp Cell Res 198:259, 1992
    • (1992) Exp Cell Res , vol.198 , pp. 259
    • Olive, P.L.1    Wlodek, D.2    Durand, R.E.3    Banath, J.P.4
  • 28
    • 0025053510 scopus 로고
    • Antibodies to DNA alkylation adducts as analytical tools in chemical carcinogenesis
    • Wild CP: Antibodies to DNA alkylation adducts as analytical tools in chemical carcinogenesis. Mutat Res 233:219, 1990
    • (1990) Mutat Res , vol.233 , pp. 219
    • Wild, C.P.1
  • 29
    • 0027233855 scopus 로고
    • Antisera specific for carcinogen-DNA adducts and carcinogen-modified DNA: Application for detection of xenobiotics in biological samples
    • Poirier MC: Antisera specific for carcinogen-DNA adducts and carcinogen-modified DNA: Application for detection of xenobiotics in biological samples. Mutat Res 288:31, 1988
    • (1988) Mutat Res , vol.288 , pp. 31
    • Poirier, M.C.1
  • 30
    • 0023924241 scopus 로고
    • Application of new techniques for the detection of carcinogen adducts to human population monitoring
    • Santella RM: Application of new techniques for the detection of carcinogen adducts to human population monitoring. Mutat Res 205:271, 1988
    • (1988) Mutat Res , vol.205 , pp. 271
    • Santella, R.M.1
  • 31
    • 10144243535 scopus 로고    scopus 로고
    • The role of p53 in the anti-cancer effect of alkylating agents: p53 induction by measured levels of specific DNA adducts
    • abstr
    • Gould KA, M'Cartney H, Lawley PD, Golding BT, Tilby MJ: The role of p53 in the anti-cancer effect of alkylating agents: p53 induction by measured levels of specific DNA adducts. Br J Cancer 73:39, 1996 (abstr, suppl XXVI)
    • (1996) Br J Cancer , vol.73 , Issue.26 SUPPL. , pp. 39
    • Gould, K.A.1    M'Cartney, H.2    Lawley, P.D.3    Golding, B.T.4    Tilby, M.J.5
  • 32
    • 10144232997 scopus 로고
    • Novel monoclonal antibodies for the analysis of melphalan-DNA adducts in cells
    • Tilby MJ, McCartney H, Cordell J, Dean CJ: Novel monoclonal antibodies for the analysis of melphalan-DNA adducts in cells. Br J Cancer 69:32, 1994 (suppl XXI)
    • (1994) Br J Cancer , vol.69 , Issue.21 SUPPL. , pp. 32
    • Tilby, M.J.1    McCartney, H.2    Cordell, J.3    Dean, C.J.4
  • 34
    • 0019147613 scopus 로고
    • Cytotoxicity as an indicator for transport mechanisms: Evidence that murine progenitor cells lack a high-affinity leucine carrier that transports melphalan in murine L1210 leukemia cells
    • Vistica DT: Cytotoxicity as an indicator for transport mechanisms: Evidence that murine progenitor cells lack a high-affinity leucine carrier that transports melphalan in murine L1210 leukemia cells. Blood 56:427, 1980
    • (1980) Blood , vol.56 , pp. 427
    • Vistica, D.T.1
  • 35
    • 0025880971 scopus 로고
    • Drug-target interactions: Only the first step in the commitment to a programmed cell death?
    • Dive C, Hickman JA: Drug-target interactions: only the first step in the commitment to a programmed cell death? Br J Cancer 64:197, 1991
    • (1991) Br J Cancer , vol.64 , pp. 197
    • Dive, C.1    Hickman, J.A.2
  • 36
    • 10144227974 scopus 로고    scopus 로고
    • Measurement of melphalan DNA adducts in individual multiple myeloma cells using a novel immunofluorescence staining technique and image analysis
    • Frank AJ, Tilby MJ: Measurement of melphalan DNA adducts in individual multiple myeloma cells using a novel immunofluorescence staining technique and image analysis. Proc Am Assoc Cancer Res 37:174, 1996
    • (1996) Proc Am Assoc Cancer Res , vol.37 , pp. 174
    • Frank, A.J.1    Tilby, M.J.2
  • 37
    • 0023571558 scopus 로고
    • Short course intermediate dose intravenous melphalan therapy in myeloma-relation to emergence of drug resistance (phase II study)
    • Sviland L, Leggat H, Harris AL, Bird G, Proctor SJ: Short course intermediate dose intravenous melphalan therapy in myeloma-relation to emergence of drug resistance (phase II study). Acta Hematol 78:233, 1987
    • (1987) Acta Hematol , vol.78 , pp. 233
    • Sviland, L.1    Leggat, H.2    Harris, A.L.3    Bird, G.4    Proctor, S.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.