Inhibition of transforming growth factor-β1 and UV light-induced apoptosis by prostanoids in primary cultures of rat hepatocytes

Toxicology and Applied Pharmacology

Volumn 152, Issue 1, 1998, Pages 240-250

  Kroll, Bernd ^a   Kunz, Susanne ^a   Tu, Naxin ^a   Schwarz, Leslie R ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; PROSTACYCLIN; PROSTAGLANDIN F2 ALPHA; PROSTANOID; PROTEIN P53; TRANSFORMING GROWTH FACTOR BETA1;

APOPTOSIS; ARTICLE; CELL PROTECTION; DNA DETERMINATION; DOSE RESPONSE; LIVER CELL CULTURE; NONHUMAN; RAT; TUMOR SUPPRESSOR GENE; ULTRAVIOLET RADIATION;

EID: 0031767984     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8513     Document Type: Article

References (72)

1. Ballif, B. A., Mincek, N. V., Barratt, J. T., Wilson, M. L., and Simmons, D.L. (1996). Interaction of cyclooxygenases with an apoptosis- and autoimmunity-associated protein. Proc. Natl. Acad. Sci. USA 93, 5544-5549.
2. Bates, S., and Vousden, K. H. (1996). p53 in signaling checkpoint arrest or apoptosis. Curr. Opin. Genet. Dev. 6, 12-19.
3. Bayly, A. C., Roberts, R. A., and Dive, C. (1994). Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin. J. Cell Biol. 125, 197-203.
4. Bender, K., Blattner, C., Knebel, A., Iordanov, M., Herrlich, P., and Rahmsdorf, H. J. (1997). UV-induced signal transduction. J. Photochem. Photobiol 37, 1-17.
5. Benedetti, A., Di Sario, A., Baroni, G. S., and Jezequel, A. M. (1995). Transforming growth factor β1 increases the number of apoptotic bodies and decreases intracellular pH in isolated periportal and perivenular rat hepatocytes. Hepatology 22, 1488-1498.
6. 1-induced injury of rat hepatocytes in primary culture: Possible role of cAMP. J. Gastroentol. Hepatol. 7, 608-613.
7. Berry, N. M., and Friend, D. S. (1969). High yield preparation of isolated rat liver parenchymal cells. A biochemical and fine structural study. J. Cell Biol. 43, 506-520.
8. Boe, R., Gjertsen, B. T., Vintermayer, O. K., Houge, G., Lanotte, M., and Doskeland, S. O. (1991). The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Exp. Cell Res. 195, 237-246.
9. Bour, E. S., Ward, L. K., Cornman, G. A., and Isom, H. C. (1996). Tumor necrosis factor-α-induced apoptosis in hepatocytes in long-term culture. Am. J. Pathol. 148, 485-495.
10. Buja, L. M., Eigenbrodt, M. L., and Eigenbrodt, E. H. (1993). Apoptosis and necrosis: Basic types and mechanisms of cell death. Arch. Pathol. Lab. Med. 117, 1208-1214.
11. Bursch, W., Lauer, B., Timmermann-Trosiener, T., Barthel, G., Schuppler, J., and Schulte-Hermann, R. (1984). Controlled cell death (apoptosis) of normal and putative neoplastic cells in rat liver following withdrawal of tumor promoters. Carcinogenesis 5, 53-58.
12. Bursch, W., Oberhammer, F., Jirtle, R. L., Askari, M., Sedivy, R., GraslKraupp, B., Purchio, A. F., and Schulte-Hermann, R. (1993). Transforming growth factor-β1 as a signal for induction of cell death by apoptosis. Br. J. Cancer 67, 531-536.
13. 4 induced lipid peroxidation in rat liver and its significance for hepatoprotection. Hepatology 9, 830-838.
14. Cain, K. Inayat-Hussain, S.H., Couet, C., and Cohen, G.M. (1996b). A cleavage-site-directed inhibitor of interleukin-1β-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes. Biochem. J. 314, 27-32.
15. Cain, K., Inayat-Hussain, S. H., Couet, C., Qin, H.-M., and Oberhammer, F. A. (1996a). A novel method for detecting apoptosis shows that hepatocytes undergo a time dependent increase in DNA cleavage and chromatin condensation which is augmented after TGF-β1 treatment. Cytometry 23, 312-321.
16. Denda, A., Ura, H., Tsujiuchi, T., Tsutsumi, M., Eimoto, H., Takashima, Y., Kitazawa, S., Kinugasa, T., and Konishi, Y. (1989). Possible involvement of arachidonic acid metabolism in phenobarbital promotion of hepatocarcinogenesis. Carcinogenesis 10, 1929-1935.
17. 4 on phospholipid and protein biosynthesis by prostacyclin. Biochem. Pharmacol. 40, 1477-1483.
18. Dixit, V. M. (1996). Role of ICE-proteases in apoptosis. Adv. Exp. Med. Biol. 406, 113-117.
19. 1 delay in cells overexpressing prostaglandin endoperoxide synthase-2. Cancer Res. 56, 733-737.
20. Fasciati, R., and Maier, P. (1997). EGF- and CPA-induced mitogenic stimuli are differentially downregulated by TGF-β1 in cultured rat hepatocytes. Carcinogenesis 18, 911-917.
21. 2. Biochim. Biophys. Acta 1261, 19-24.
22. Gebhardt, R., and Jung, W. (1982). Biliary secretion of sodium fluorescein in primary monolayer cultures of adult rat hepatocytes and its stimulation by nicotinamid. J. Cell Sci. 56, 233-244.
23. Gressner, A. M., Polzar, B., Lahme, B., and Mannherz, H.-G. (1996). Induction of rat liver parenchymal cell apoptosis by hepatic myofibroblasts via transforming growth factor β. Hepatology 23, 571-581.
24. Hale, A. J., Smith, C. A., Sutherland, L. C., Stoneman, V. E. A., Longthorne, V. L., Culhane, A. C., and Williams, G. T. (1996). Apoptosis: Molecular regulation of cell death. Eur. J. Biochem. 236, 1-26.
25. Herrmann, M., Lorenz, H.-M., Voll, R., Grünke, M., Woith, W., and Kalden, J. R. (1994). A rapid and simple method for the isolation of apoptotic DNA fragments. Nucleic Acids Res. 22, 5506-5507.
26. Jones, B. A., Rao, Y. P., Stravitz, R. T., and Gores, G. J. (1997). Bile salt-induced apoptosis involves activation of protein kinase C. Am. J. Physiol. 35, G1109-G1115.
27. Kano, A., Watanabe, Y., Takeda, N., Aizawa, S., and Akaike, T. (1997). Analysis of IFNγ-induced cell cycle arrest and cell death in hepatocytes. J. Biochem. 121, 677-683.
28. Kerr, J. F. R., Wyllie, A. H., and Currie, A. R. (1972). A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239-257.
29. Koebe, H.-G., Pahernik, S., Eyer, P., and Schildberg, F.-W. (1994). Collagen gel immobilization: A useful cell culture technique for long-term metabolic studies on human hepatocytes. Xenobiotica 24, 95-107.
30. Kreamer, B. L., Staecker, J. L., Sawada, N., Sattler, G. L., Hsia, M. T. S., and Pilot, H. C. (1986). Use of a low-speed iso-density Percoll centrifugation method to increase the viability of isolated rat hepatocyte preparations. In Vitro Cell. Dev. Biol. 22, 201-211.
31. Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
32. Leibold, E., Greim, H., and Schwarz, L. R. (1994). Inhibition of intercellular communication of rat hepatocytes by nafenopin: involvement of protein kinase C. Carcinogenesis 15, 1265-1269.
33. Leist, M., Gantner, F., Bohlinger, I., Germann, P. G., Tiegs, G., and Wendel, A. (1994). Murine hepatocyte apoptosis induced in vitro and in vivo by TNFα requires transcriptional arrest. J. Immunol. 153, 1778-1788.
34. 1 and S phases of adult rat hepatocytes in vitro. J. Biol. Chem. 271, 11484-11492.
35. Lu, X., Xie, W., Reed, D., Bradshaw, W. S., and Simmons, D. L. (1995). Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken emryo fibroblastes. Proc. Natl. Acad. Sci. USA 92, 7961-7965.
36. 2: Favorable effects on rat liver injury. Gastroenterology 102, 572-576.
37. Massagué, J. (1996). TGFβ signaling: Receptors, transducers, and mad proteins. Cell 85, 947-950.
38. 1 to rat hepatocytes. Biochem. Biophys. Res. Commun. 184, 654-660.
39. 4-induced necrosis in isolated rat liver cells. Res. Commun. Chem. Pathol. Pharmacol. 75, 173-184.
40. Oberhammer, F. A., Bursch, W., Parzefall, W., Breit, P., Erber, E., Stadler, M., and Schulte-Hermann, R. (1991). Effect of transforming growth factor β on cell death of cultured rat hepatocytes. Cancer Res. 51, 2478-2485.
41. Oberhammer, F. A., Bursch, W., Tiefenbacher, R., Fröschl, G., Pavelka, M., Purchio, T., and Schulte-Hermann, R. (1993). Apoptosis is induced by transforming growth factor-β1 within 5 hours in regressing liver without significant fragmentation of the DNA. Hepatology 18, 1238-1246.
42. Oberhammer, F. A., Nagy, P., Tiefenbacher, R., Fröschl, G., Bouzahzah, B., Thorgeirsson, S. S., and Carr, B. (1996). The antiandrogen cyproterone acetate induces synthesis of transforming growth factor β1 in the parenchymal cells of the liver accompanied by an enhanced sensitivity to undergo apoptosis and necrosis without inflammation. Hepatology 23, 329-337.
43. Oberhammer, F. A., Pavelka, M., Sharma, S., Tiefenbacher, R., Purchio, A. F., Bursch, W., and Schulte-Hermann, R. (1992). Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1. Proc. Natl. Acad. Sci. USA 89, 5408-5412.
44. Oberhammer, F. A., and Qin, H.-M. (1995). Effect of three tumour promoters on the stability of hepatocyte cultures and apoptosis after transforming growth factor-β1. Carcino genesis 16, 1363-1371.
45. Ohno, K., Ammann, P., Fasciati, R., and Maier, P. (1995). Transforming growth factor β1 preferentially induces apoptotic cell death in rat hepatocytes cultured under pericentral-equivalent conditions. Toxicol. Appl. Pharmacol. 132, 227-236.
46. Ohno, K., and Maier, P. (1995). Tumor necrosis factor a differentially modulates the cellular response of rat hepatocytes in periportal- and pericentral-equivalent cultures. Eur. J. Pharmacol. 292, 205-214.
47. Patel, T., Bronk, S. F., and Gores, G. J. (1994). Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes. J. Clin. Invest. 94, 2183-2192.
48. Pritchard, D. J., and Butler, W. H. (1989). Apoptosis: The mechanism of cell death in dime thylnitrosamine-induced hepatotoxicity. J. Pathol. 158, 253-260.
49. Püschel, G. P., and Jungermann, K. (1994). Integration of function in the hepatic acinus: Intercellular communication in neural and humoral control of liver metabolism. Prog. Liver Dis. 12, 19-46.
50. 2 actions in rat hepatocytes are mediated via different signalling pathways. Eur. J. Biochem. 218, 1083-1089.
51. Quiroga, J., and Prieto, J. (1993). Liver cytoprotection by prostaglandins. Pharmacol. Ther. 58, 67-92.
52. Sánchez, A., Álvarez, A. M., Benito, M., and Fabregat, I. (1996). Apoptosis induced by transforming growth factor-β in fetal hepatocyte primary cultures. J. Biol. Chem. 271, 7416-7422.
53. Sanderson, N., Factor, V., Nagy, P., Kopp, J., Kondaiah, P., Wakefield, L., Roberts, A. B., Sporn, M. B., and Thorgeirsson, S. S. (1995). Hepatic expression of mature transforming growth factor β 1 in transgenic mice results in multiple tissue lesions. Proc. Natl. Acad. Sci. USA 92, 2572-2576.
54. Schulte-Hermann, R., Bursch, W., and Grasl-Kraupp, B. (1995). Active cell death (apoptosis) in liver biology and disease. In Progress in Liver Disease (J. L. Boyer and R. K. Ockner, Eds.), Vol. 13, pp. 1-35. W. B. Saunders, Philadelphia.
55. Schulte-Hermann, R., Timmermann-Trosiener, I., Barthel, G., and Bursch, W. (1990). DNA synthesis, apoptosis and phenotipic expression as determinants of growth and altered foci in rat liver during phenobarbital promotion. Cancer Res. 50, 5127-5135.
56. 2α) in cultured Kupffer cells. Naunyn-Schmiedeberg's Arch. Pharmakol. 355, R159.
57. Seglen, P. O. (1976). Preparation of isolated rat liver cells. Methods Cell Biol. 13, 29-83.
58. Sheiner, P. A. (1995). Prostaglandins in liver transplantation. Hepatology 21, 592-593.
59. Shiff, S. J., Koutsos, M. I., Qiao, L., and Rigas, B. (1996). Nonsteroidal anti-inflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: Effects on cell cycle and apoptosis. Exp. Cell Res. 222, 179-188.
60. Sinclair, S., and Levy, G. (1990). Eicosanoids and the liver. Ital. J. Gastroenterol. 22, 205-213.
61. Terrell, T. G., Working, P. K., Chow, C. P., and Green, J. D. (1993). Pathology of recombinant human transforming growth factor-β1 in rats and rabbits. Int. Rev. Exp. Pathol. 34B, 43-67.
62. Topinka, J., Andrae, U., Schwarz, L. R., and Wolff, T. (1993). Cyproterone acetate generates DNA adducts in rat liver and in primary rat hepatocyte cultures. Carcinogenesis 14, 423-427.
63. Tsujii, M., and DuBois, R. N. (1995). Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 83, 493-501.
64. Tsuji, K., and Ogawa, K. (1994). Recovery from ultraviolet-induced growth arrest of primary rat hepatocytes by p53 antisense oligonucleotide treatment. Mol. Carcinog. 9, 167-174.
65. Vassault, A. (1984). Lactat dehydrogenase UV-method with pyruvate and NADH. In Methods of Enzymatic Analysis (H. U. Bergmeyer, Ed.), Vol. 3, pp. 118-126. Verlag Chemie, Weinheim.
66. Vaux, D. L., and Strasser, A. (1996). The molecular biology of apoptosis. Proc. Natl. Acad. Sci. USA 93, 2239-2244.
67. Wörner, W., and Schrenk, D. (1996). Influence of liver tumor promoters on apoptosis in rat hepatocytes induced by 2-acetylaminofluorene, ultraviolet light, or transforming growth factor β1. Cancer Res. 56, 1272-1278.
68. Wyllie, A. H. (1995). Death gets a brake. Nature 369, 272-273.
69. Yamamoto, M., Ogawa, K., Morita, M., Fukuda, K., and Komatsu, Y. (1996). The herbal medicine inchin-ko-to inhibits liver cell apoptosis induced by transforming growth factor β1. Hepatology 23, 552-559.
70. Yasuda, H., Mine, T., Shibata, H., Eto Y., Hasegawa, Y., Takeuchi, T., Asano, S., and Kojima, I. (1993). Activin A: An autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes. J. Clin. Invest. 92, 1491-1496.
71. Yingling, J. M., Wang, X.-F., and Bassing, C. H. (1995). Signaling by the transforming growth factor-β receptors. Biochim. Biophys. Acta 1242, 115-136.
72. Zhang, Y.-Q., Kanzake, M., Mashima, H., Mine, T., and Kojima, I. (1996). Norepinephrine reverses the effects of activin a on DNA-synthesis and apoptosis in cultured rat hepatocytes. Hepatology 23, 288-293.