Electroporation of mammalian skin: A mechanism to enhance transdermal drug delivery

Proceedings of the National Academy of Sciences of the United States of America

Volumn 90, Issue 22, 1993, Pages 10504-10508

  Prausnitz, Mark R ^a   Bose, Vanu G ^a   Langer, Robert ^a,b   Weaver, James C ^b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

Author keywords

Electropermeabilization; Iontophoresis; Lipid bilayer; Stratum corneum; Tissue

Indexed keywords

ANIMALIA; MAMMALIA;

ANIMAL TISSUE; ARTICLE; DRUG DELIVERY SYSTEM; ELECTROPORATION; HUMAN; HUMAN TISSUE; IONTOPHORESIS; LIPID BILAYER; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN; STRATUM CORNEUM; TISSUE; TRANSDERMAL DRUG ADMINISTRATION;

ADMINISTRATION, CUTANEOUS; ANIMAL; CADAVER; CELL MEMBRANE PERMEABILITY; ELECTROPORATION; EPIDERMIS; FLUORESCEINS; HUMAN; IN VITRO; MEMBRANE POTENTIALS; RATS; SKIN PHYSIOLOGY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027379355     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.90.22.10504     Document Type: Article

References (26)

1. Champion, R. H., Burton, J. L. & Ebling, F. J. G., eds. (1992) Textbook of Dermatology (Blackwell, London).
2. Bronaugh, R. L. & Maibach, H. I., eds. (1989) Percutaneous Absorption, Mechanisms - Methodology - Drug Delivery (Dekker, New York).
3. Hadgraft, J. & Guy, R. H., eds. (1989) Transdermal Drug Delivery: Developmental Issues and Research Initiatives (Dekker, New York).
4. Cullander, C. & Guy, R. H. (1992) Adv. Drug Delivery Rev. 8, 291-329.
5. Bouwstra, J. A., de Vries, M. A., Gooris, G. S., Bras, W., Brussee, J. & Ponec, M. (1991) J. Controlled Release 15, 209-220.
6. Elias, P. M. (1991) J. Controlled Release 15, 199-208.
7. Neumann, E., Sowers, A. E. & Jordan, C. A., eds. (1989) Etectroporation and Electrofusion in Cell Biology (Plenum, New York).
8. Chang, D. C., Chassy, B. M., Saunders, J. A. & Sowers, A. E., eds. (1992) Guide to Electroporation and Electrofusion (Academic, New York).
9. Okino, M. & Mohri, H. (1987) Jpn. J. Cancer Res. 78, 1319-1321.
10. Powell, K. T., Morgenthaler, A. W. & Weaver, J. C. (1989) Biophys. J. 56, 1163-1171.
11. Mir, L. M., Orlowski, S., Belehradek, J. & Paoletti, C. (1991) Eur. J. Cancer 27, 68-72.
12. Titomirov, A. V., Sukharev, S. & Kistanova, E. (1991) Biochim. Biophys. Acta 1088, 131-134.
13. Gummer, C. L. (1989) in Transdermal Drug Delivery: Developmental Issues and Research Initiatives, eds. Hadgraft, J. & Guy, R. H. (Dekker, New York), pp. 177-186.
14. Friend, D. R. (1992) J. Controlled Release 18, 235-248.
15. Suzuki, H. K. & Mathews, A. (1966) Stain Technol. 41, 57-60.
16. Sontag, W. (1980) Calcif. Tissue Int. 32, 63-68.
17. Wagner, J. G. (1975) Fundamentals of Clinical Pharmacokinetics (Drug Intelligence Publ., Hamilton, IL).
18. Goldstein, L., ed. (1977) Introduction to Comparative Physiology (Holt, Rinehart and Winston, New York).
19. Furry, J. W. (1985) Preparation, Properties and Applications of Calcein in a Highly Pure Form (Iowa State Univ. Press, Ames, IA).
20. Benz, R. & Zimmermann, U. (1980) Bioelectrochem. Bioenerg. 7, 723-739.
21. Hibino, M., Shigemori, M., Itoh, H., Nagayama, K. & Kinosita, K. (1991) Biophys. J. 59, 209-220.
22. Weaver, J. C. & Barnett, A. (1992) in Guide to Electroporation and Electrofusion, eds. Chang, D. C., Chassy, B. M., Saunders, J. A. & Sowers, A. E. (Academic, New York), pp. 91-118.
23. Wearley, L., Liu, J. C. & Chien, Y. W. (1989) J. Controlled Release 9, 231-242.
24. Green, P., Shroot, B., Bernerd, F., Pilgrim, W. R. & Guy, R. H. (1992) J. Controlled Release 20, 209-218.
25. Reilly, J. P. (1992) Electrical Stimulation and Electropathology (Cambridge Univ. Press, New York).
26. Webster, J. G., ed. (1988) Encyclopedia of Medical Devices (Wiley, New York).