Synthesis and screening of conformationally restricted and conformationally free N-(tertiary aminoalkyl)dithiocarbamic acids and esters as inhibitors of neuronal nitric oxide synthase

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 10, 1998, Pages 1759-1766

  Sassaman, Mark B ^a   Giovanelli, John ^b   Sood, Virendar K ^c   Eckelman, William C ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Dithiocarbamic acid; Dithiocarbamic ester; Inhibitors; Nitric oxide synthase; Tetrahydrobiopterin

Indexed keywords

ARGININE; DITHIOCARBAMIC ACID DERIVATIVE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; TETRAHYDROBIOPTERIN;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; RAT;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; BIOPTERIN; ENZYME INHIBITORS; HUMANS; NEURONS; NITRIC OXIDE SYNTHASE; NITROARGININE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOCARBAMATES;

EID: 0031759374     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00132-1     Document Type: Article

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