Signalling in lymphocyte development

Current Opinion in Immunology

Volumn 8, Issue 2, 1996, Pages 191-198

  Owen, Michael J ^a   Venkitaraman, Ashok R ^b  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR;

B LYMPHOCYTE; CELL MATURATION; LYMPHOCYTE PROLIFERATION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMOCYTE;

EID: 0029922696     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(96)80057-4     Document Type: Article

References (64)

1. Georgopoulos K, Bigby M, Wang J-H, Molnar A, Wu P, Winandy S, Sharpe A: The Ikaros gene is required for the development of all lymphoid lineages. Cell 1994, 79:143-156. Gene-targetting experiments identify a transcription factor, Ikaros, which acts as a master switch in haematopoiesis, directing cells along the lymphoid lineage. This discovery opens the way to the identification of the signal-transduction pathway that regulates Ikaros and thus controls lymphopoiesis.
2. Zhuang Y, Soriano P, Weintraub H: The helix-loop-helix gene E2A is required for B cell formation. Cell 1994, 79:875-864.
3. Bain G, Maandag ECR, Izon DJ, Amsen D, Kruisbeek AM, Weintraub BC, Krop I, Schlissel MS, Feeney AJ, Van der Valk M et al.: E2A protein are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 1994, 79:885-892.
4. Sun X-H: Constitutive expression of the Id1 gene impairs mouse B cell development. Cell 1994, 79:893-900.
5. Suzuki H, Kündig TM, Furlonger C, Wakeham A, Timms E, Matsuyama T, Schmits R, Simard JJL, Ohashi S, Griesser H et al.: Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β. Science 1995, 268:1472-1476.
6. Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW: interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995, 3:521-530.
7. ••].
8. ••].
9. ••].
10. ••], establishes that the interaction of IL-7 with the heterodimeric IL-7Rαγ plays a non-redundant role in the development of B and T lymphocytes.
11. Corcoran AE, Smart FS, Cowling RJ, Crompton T, Owen MJ, Venkitaraman AR: The interleukin-7 receptor a chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis. EMBO J 1996, in press.
12. + B precursor cells by two distinct signals derived from IL-7 receptor and c-Kit in a fully defined medium. J Exp Med 1995, 182:315-323.
13. Zeng Y-X, Takahashi H, Shibata M, Hirokawa K: JAK3 janus kinase is involved in interleukin 7 signal pathway. FEBS Lett 1994, 353:289-293.
14. Ihle JN: Cytokine receptor signalling. Nature 1995, 377:591-594.
15. Macchi P, Villa A, Gilliani S, Sacco MG, Frattini A, Porta F, Ugazio AG, Johnston JA, Candotti F, O'Shea JJ et al.: Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 1995, 377:65-68. A 'natural' human knock-out with a disrupted Jak-3 gene illustrates the importance of the JAK/STAT signal-transduction pathway in T-cell development.
16. Russell SM, Tayebi N, Nakajima H, Riedy MC, Roberts JL, Aman JM, Migone T-S, Noguchi M, Markert ML, Buckley RH et al.: Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 1995, 270:797-800.
17. Thomis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ: Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 1995, 270:794-797.
18. Nosaka T, Van Deursen JMA, Tripp RA, Thierfelder WE, Witthuhn BA, McMickle AP, Doherty PC, Grosveld GC, Ihle JN: Defective lymphoid development in mice lacking Jak3. Science 1995, 270:800-802.
19. Mombaerts P, Clarke AR, Rudnicki MA, Iacomini J, Itohara S, Lafaille JJ, Wang L, Ichikawa Y, Jaenisch R, Hooper ML, Tonegawa S: Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature 1992, 360:225-231.
20. Malissen M, Gillet A, Ardouin L, Bourvier G, Trucy J, Ferrier P, Vivier E, Malissen B: Altered T cell development in mice with a targeted mutation of the CD3-ε gene. EMBO J 1995, 14:4641-4653.
21. Fehling HJ, Krotkova A, Saint-Ruf C, Von Boehmer H: Crucial role of the pre-T-cell receptor a gene in development of αβ but not γδ T cells. Nature 1995, 375:795-798. αβ T cell, but not γδ T-cell, development is impaired in mice lacking the pre-TCR α gene. This paper underscores the similarity between early stages of B-cell and T-cell cell development by demonstrating the importance of the pre-TCR just as previous knockout studies have for the pre-B cell receptor.
22. Jacobs H, Vandeputte D, Tolkamp L, De Vries E, Borst J, Bems A: CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo. Eur J Immunol 1994, 24:934-939.
23. Levelt CN, Wang B, Ehrfeld A, Terhorst C, Eichmann K: Regulation of T cell receptor (TCR)-β locus allelic exclusion and initiation of TCR-α locus rearrangement in immature thymocytes by signaling through the CD3 complex. Eur J Immunol 1995, 25:1257-1261.
24. Shinkai Y, Ma A, Cheng H-L, Alt FW: CD3ε and CD3ζ cytoplasmic domains can independently generate signals for T cell development and function. Immunity 1995, 2:401-404.
25. Anderson SJ, Levin SD, Perlmutter RM: Involvement of the protein tyrosine kinase p56lck in T cell signaling and thymocyte development. Adv Immunol 1994, 56:151-178.
26. lck deficient mice: allelic exclusion of the TcRβ locus is incomplete but thymocyte development is not restored by TcRβ or TcRαβ transgenes. Eur J Immunol 1995 25:1312-1318.
27. Mombaerts P, Anderson SJ, Perlmutter RM, Mak TW, Tonegawa S: An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. Immunity 1994, 1:261-267.
28. Lin W-C, Desiderio S: Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation. Science 1993, 260:953-959.
29. -/- mice. J Exp Med 1994, 180:1517-1521.
30. + thymocytes in RAG-deficient mice through a T cell receptor β chain-independent pathway. J Exp Med 1995, 181:1187-1195.
31. Danska JS, Pflumio F, William CJ, Huner O, Dick JE, Guidos CJ: Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agents. Science 1994, 266:450-455.
32. Verbeek S, Izon D, Hofhuis F, Robanus-Maandag E, te Riele H, Van de Watering M, Oosterwegel M, Wilson A, MacDonald HR, Clevers H: An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature 1995, 374:70-74.
33. Melchers F, Haasner D, Grawunder U, Kalberer C, Karasuyama H, Winkler T, Rolink AG: Roles of IgH and L chain and of surrogate H and L chains in the development of cells of the B lymphocyte lineage. Annu Rev Immunol 1994, 12:209-225.
34. Papavasiliou F, Misulovin Z, Suh H, Nussenzweig MC: The role of Ig beta in precursor B cell transition and allelic exclusion. Science 1995, 268:408-410. This paper demonstrates that the cytoplasmic domain of Igβ is sufficient for signalling via the pre-BCR during development and that this function is dependent on the tyrosine residues in its ITAM motif.
35. Papavasiliou F, Jankovic M, Suh H, Nussenzweig MC: The cytoplasmic domain of immunoglobulin (Ig) alpha and Ig beta can independently induce the precursor B cell transition and allelic exclusion. J Exp Med 1995, 182:1389-1394.
36. Hibbs ML, Tarlinton DM, Armes J, Grail D, Hodgson G, Maglitto R, Stacker SA, Dunn AR: Multiple defects in the immune system of Lyn-deficlent mice, culminating in autoimmune disease. Cell 1995, 83:310-311. Signalling by the Lyn tyrosine kinase is shown to have an essential role in the normal function of mature B cells, but not in their development.
37. Tarakhovsky A, Turner M, Schaal S, Mee PJ, Duddy LP, Rajewsky K, Tybulewicz VLJ: Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature 1995, 374:467-470.
38. Zhang R, Alt FW, Davidson L, Orkin SH, Swat W: Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 1995, 374:470-473.
39. •].
40. ••], demonstrates a critical role for Syk in pre-BCR signalling during B-cell development.
41. Aoki Y, Isselbacher K, Pillai S: Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells. Proc Natl Acad Sci USA 1994, 91:10606-10609.
42. De Weers M, Brouns GS, Hinshelwood S, Kinnon C, Schuurman RK, Hendriks RW, Borst J: B-cell antigen receptor stimulation activates the human Bruton's tyrosine kinase, which is deficient in X-linked agammaglobulinemia. J Biol Chem 1994, 269:23857-23860.
43. Tsukada S, Simon MI, Witte ON, Katz A: Binding of beta-gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase. Proc Natl Acad Sci USA 1994, 91:11256-11260.
44. Yao L, Kawakami Y, Kawakami T: The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C. Proc Natl Acad Sci USA 1994, 9113:9175-9179
45. Cory GO, Lovering RC, Hinshelwood S, MacCarthy-Morrogh L, Levinsky RJ, Kinnon C: The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase. J Exp Med 1995 182:611-615.
46. Conley ME, Parolini O, Rohrer J, Campana D: X-linked agammaglobulinaemia: new approaches to old questions based on identification of the defective gene. Immunol Rev 1994, 138:5-21.
47. •].
48. •], shows that a null mutation in murine Btk neverthless causes a phenotype resembling Xid more than XLA.
49. Grawunder U, Leu TMJ, Schatz DG, Werner A, Rolink AG, Melchers F, Winkler TH: Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement. Immunity 1995, 3:601-608.
50. ras signal-transduction pathway is shown to be involved in positive selection. This process may be biochemically distinguishable from negative selection.
51. ••], this result shows that the MAPK cascade is important in T-cell development as well as activation, and that the signal-transduction pathways that mediate positive and negative selection may be different.
52. Negishi I, Motoyama N, Nakayama K-I, Nakayama K, Senju S, Hatakeyama S, Zhang Q, Chan AC, Loh DY: Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 1995, 376:435-438. The ZAP-70 protein tyrosine kinase is shown in knock-out mice to be essential for the transduction of TCR-mediated signals that lead to both positive and negative selection. These results complement studies of human SCID patients with a disrupted ZAP-70 gene [53,54], although the two phenotypes exhibit interesting differences.
53. Elder ME, Lin D, Clever J, Chan AC, Hope TJ, Weiss A, Parslow TG: Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science 1994, 264:1596-1599.
54. + thymic selection in humans lacking Zap-70 kinase. Cell 1994, 76:947-958.
55. Fischer K-D, Zmuidzinas A, Gardner S, Barbacid M, Bernsteink A, Guidos C: Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+CD8+ thymocytes. Nature 1995, 374:474-477.
56. + thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection. J Exp Med 1995, 181:927-941.
57. Bories J-C, Willerford DM, Grévin D, Davidson L, Camus A, Martin P, Stéhelin D, Alt FW: Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene. Nature 1995, 377:635-638.
58. Muthusamy N, Barton K, Leiden JM: Defective activation and survival of T cells lacking the Ets-1 transcription factor. Nature 1995, 377:639-642.
59. Ma A, Pena JC, Chang B, Margosian E, Davidson L, Alt FW, Thompson CB: Bclx regulates the survival of double-positive thymocytes. Proc Natl Acad Sci USA 1995, 92:4763-4767.
60. Calman BJ, Szychowski S, Chan FK-M, Cado D, Winoto A: A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity 1995, 3:273-282.
61. Cyster JG, Goodenow CC: Protein tyrosine phosphatase 1C negatively regulates antigen receptor signalling in B lymphocytes and determines thresholds for negative selection. Immunity 1995, 2:13-24. This paper provides evidence for a model in which the choice between deletion or anergy during negative selection is determined by a signalling threshold set by modulators of BCR signalling.
62. Doody GM, Justement LB, Delibrias CC, Matthews RJ, Lin J, Thomas ML, Fearon DT: A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. Science 1995, 269:242-244.
63. Rickert RC, Rajewsky K, Roes J: Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 1995, 376:352-355.
64. Marshall CJ: Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 1995, 80:179-185.