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of special interest. Hybrid resistance is the phenomenon by which F1 (AxB) NK cells reject parental (A or B) bone marrow grafts. In this study bone marrow chimeras were prepared using F1 (BALB/c x B6) cells injected into BALB/c mice or F1 cells injected into B6 mice, to assess whether F1 NK cells developing in the parental host would be tolerant of parental targets. Both sets of chimeras were challenged with a mixture of B6 and BALB/c cells labeled with fluorescein isothiocyanate. In both cases, parental targets syngeneic to the host were removed less effectively by the F1 NK cells developing in that parental host, suggesting that the F1 NK cells were tolerant to the host; however, in vitro lymphokine-activated killer cell (LAK) cultures of the F1 NK cells from chimeras showed no such specificity.
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Cloning of minimally divergent allelic forms of the natural killer (NK) receptor Ly-49C, differentially controlled by host genes in the MHC and NK gene complexes
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Cloning and characterization of 5E6(Ly-49C), a receptor molecule expressed on a subset of murine natural killer cells
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Stoneman ER, Bennett M, An J, Chesnut KA, Wakeland EK, Scheerer JB, Siciliano MJ, Kumar V, Mathew PA. Cloning and characterization of 5E6(Ly-49C), a receptor molecule expressed on a subset of murine natural killer cells. J Exp Med. 182:1995;305-313.
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18
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Brennan J, Lemieux S, Freeman JD, Mager DL, Takei F. Heterogeneity among Ly-49C natural killer (NK) cells: characterization of highly related receptors with differing functions and expression patterns. J Exp Med. 184:1996;2085-2090.
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Brennan, J.1
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Valiante NM, Lienert K, Shilling HG, Smits BJ, Parham P. Killer cell receptors: keeping pace with MHC class I evolution. Immunol Rev. 155:1997;155-164.
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Dohring C, Scheidegger D, Samardis J, Cella M, Colonna M. A human killer inhibitory receptor specific for HLA-A. J Immunol. 156:1996;3098-3101.
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21
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The natural killer cell receptor specific for HLA-A allotypes: A novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer
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Pende D, Biassoni R, Cantoni C, Verdiani S, Falco M, Di Donato C, Accame L, Bottino C, Moretta A, Moretta L. The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer. J Exp Med. 184:1996;505-518.
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Wagtmann N, Rajagopalan S, Winter CC, Peruzzi M, Long EO. Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer. Immunity. 3:1995;801-809.
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CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, HLA-B and HLA-C allotypes
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Phillips JH, Chang C, Mattson J, Gumperz JE, Parham P, Lanier LL. CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, HLA-B and HLA-C allotypes. Immunity. 5:1996;163-172.
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25
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CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells
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Soderstrom K, Corliss B, Lanier LL, Phillips JH. CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells. J Immunol. 159:1997;1072-1075.
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Soderstrom, K.1
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0031472210
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Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells
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Vance RE, Tanamachi DM, Hanke T, Raulet DH. Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells. Eur J Immunol. 27:1997;3236-3241.
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Vance, R.E.1
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27
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HLA-G recognition by human natural killer cells. Involvement of CD94 both as inhibitory and as activating receptor complex
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Pende D, Sivori S, Accame L, Pareti L, Falco M, Geraghty D, Le Bouteiller P, Moretta L, Moretta A. HLA-G recognition by human natural killer cells. Involvement of CD94 both as inhibitory and as activating receptor complex. Eur J Immunol. 27:1997;1875-1880.
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Pende, D.1
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28
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0032546001
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HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
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+ NK clones. This paper demonstrated that the predominant ligand of CD94 - NKG2A, NKG2B or NKG2C is HLA-E.
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+ NK clones. This paper demonstrated that the predominant ligand of CD94 - NKG2A, NKG2B or NKG2C is HLA-E.
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Braud, V.M.1
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Mouse natural killers cells express gp49B1, a structural homologue of human killer inhibitory receptors
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Wang LL, Mehta IK, LeBlanc PA, Yokoyama WM. Mouse natural killers cells express gp49B1, a structural homologue of human killer inhibitory receptors. J Immunol. 158:1997;13-17.
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Rojo S, Burshtyn DN, Long EO, Wagtmann N. Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells. J Immunol. 158:1997;9-12.
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Arm JP, Nwankwo C, Austen KF. Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor. J Immunol. 159:1997;2342-2349.
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Ciccone E, Pende D, Viale O, Di Donato C, Tripodi G, Orengo AM, Guardiola J, Moretta A, Moretta L. Evidence of a natural killer (NK) cell repertoire for (allo) antigen recognition: Definition of five distinct NK-determined allospecificities in humans. J Exp Med. 175:1992;709-718.
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0031406018
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Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors
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of outstanding interest. In this study, natural killer (NK) cell clones were derived from two human donors and the killer inhibitory receptors (KIRs) expressed by each donor were analyzed. The repertoires from these donors were distinct from each other, as one donor expressed one KIR MHC-ligand and expressed mainly the CD94 - NKG2A receptor on NK cells; while the other expressed three KIR MHC-ligands and used the immunoglobulin superfamily receptors as NK inhibitory receptors. NK cells from the donor expressing mainly the CD94 - NKG2A receptor, which is more broadly reactive than the immunoglobulin superfamily inhibitory receptors, were unable to lyse target cells from the other donor. These results suggest that NK cells bearing CD94 - NKG2A receptors may be tolerant to most HLA-expressing targets.
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Valiante NM, Uhrberg M, Shilling HG, Lienert-Weidenbach K, Arnett KL, D'Andrea A, Phillips JH, Lanier LL, Parham P. Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. of outstanding interest Immunity. 7:1997;739-751 In this study, natural killer (NK) cell clones were derived from two human donors and the killer inhibitory receptors (KIRs) expressed by each donor were analyzed. The repertoires from these donors were distinct from each other, as one donor expressed one KIR MHC-ligand and expressed mainly the CD94 - NKG2A receptor on NK cells; while the other expressed three KIR MHC-ligands and used the immunoglobulin superfamily receptors as NK inhibitory receptors. NK cells from the donor expressing mainly the CD94 - NKG2A receptor, which is more broadly reactive than the immunoglobulin superfamily inhibitory receptors, were unable to lyse target cells from the other donor. These results suggest that NK cells bearing CD94 - NKG2A receptors may be tolerant to most HLA-expressing targets.
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Valiante, N.M.1
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36
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Natural killer cell tolerance in mice with mosaic expression of major histocompatibility complex class I transgene
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- cells were separated, before culture in IL-2. These data suggest that NK cell tolerance is dependent on constant NK cell interactions with MHC molecules in their environment.
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- cells were separated, before culture in IL-2. These data suggest that NK cell tolerance is dependent on constant NK cell interactions with MHC molecules in their environment.
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39
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