In Vivo Release Profiles of Leuprolide Acetate from Microcapsules Prepared with Polylactic Acids or Copoly(Lactic/Glycolic) Acids and in Vivo Degradation of These Polymers

Chemical and Pharmaceutical Bulletin

Volumn 36, Issue 7, 1988, Pages 2576-2581

  Ogawa, Yasuaki ^a   Okada, Hiroaki ^a   Yamamotc, Masaki ^a   Shimamoto, Tsugio ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

biodegradation; copoly(lactic glycolic) acid; in vitro in vivo release comparison; in vivo release; injectable controlled release formulation; leu prolide acetate; one month release; polylactic acid

Indexed keywords

LEUPRORELIN; MICROCAPSULE; POLYGLACTIN; POLYLACTIC ACID;

ANIMAL EXPERIMENT; BIOAVAILABILITY; DRUG RELEASE; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; SUSTAINED RELEASE PREPARATION;

ANIMAL; ANTINEOPLASTIC AGENTS; CAPSULES; EXCIPIENTS; GONADORELIN; LACTATES; LEUPROLIDE; MALE; MOLECULAR WEIGHT; POLYMERS; RATS;

EID: 0023695440     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.36.2576     Document Type: Article

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