Differential expression pattern of retinoid X receptors in adult murine testicular cells implies varying roles for these receptors in spermatogenesis

Biology of Reproduction

Volumn 58, Issue 6, 1998, Pages 1351-1356

  Gaemers, Ingrid C ^a,d   Van Pelt, Ans M M ^a   Van Der Saag, Paul T ^b   Hoogerbrugge, Jos W ^c   Themmen, Axel P N ^c   De Rooij, Dirk G ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b HUBRECHT INSTITUTE   (Netherlands)

^c ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^d Department of Radiotherapy   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; MESSENGER RNA; RETINOID X RECEPTOR; RIBONUCLEASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; LEYDIG CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPERMATID; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOGONIUM; TESTIS CELL;

ANIMALIA; MURINAE; MYOIDEA;

EID: 0031838680     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod58.6.1351     Document Type: Article

References (23)

1. Mangelsdorf DJ, Evans RM. The RXR heterodimers and orphan receptors. Cell 1995; 83:841-850.
2. Kastner P, Chambon P, Leid M. Role of nuclear retinoic acid receptors in the regulation of gene expression. In: Blomhoff R (ed.), Vitamin A in Health and Disease. New York: Marcel Dekker Inc.; 1994: 189-238.
3. Brocard J, Kastner P, Chambon P. Two novel RXRα isoforms from mouse testis. Biochem Biophys Res Commun 1996; 229:211-218.
4. Mangelsdorf DJ, Borgmeyer U, Heyman RA, Zhou JY, Ong ES, Oro AE, Kakizuka A, Evans RM. Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev 1992; 6:329-344.
5. Zhang X, Lehmann J, Hoffmann B, Dawson MI, Cameron J, Graupner G, Hermann T, Tran P, Pfahl M. Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid. Nature 1992; 358:587-591.
6. Gaemers IC, Van Pelt AMM, Van der Saag PT, Hoogerbrugge JW, Themmen APN, De Rooij DG. Effect of retinoid status on the mRNA expression of nuclear retinoid receptors RARα, -β, -γ and RXRα, -β, -γ in the mouse testis. Endocrinology 1997; 138:1554-1551.
7. De Rooij DG, Van Pelt AMM, Van de Kant HJG, Van der Saag PT, Peters AHFM, Heyting C, De Boer P. Role of retinoids in spermatogonial proliferation and differentiation and the meiotic prophase. In: Bartke A (ed.), Function of Somatic Cells in the Testis. New York: Springer-Verlag; 1994: 345-361.
8. Kastner P, Mark M, Leid M, Gansmuller A. Abnormal spermatogenesis in RXR-β mutant mice. Genes Dev 1996; 10:80-92.
9. Lohnes D, Kastner P, Dierich A, Mark M, LeMeur M, Chambon P. Function of RARγ in the mouse. Cell 1993; 73:643-658.
10. Lufkin T, Lohnes D, Mark M, Dierich A, Gorry P, Gaub M-P, LeMeur M, Chambon P. High postnatal lethality and testis degeneration in retinoic acid receptor α mutant mice. Proc Natl Acad Sci USA 1993; 90:7225-7229.
11. Luo J, Pasceri P, Conlon RA, Rossant J, Giguere V. Mice lacking all isoforms of retinoic acid receptor β develop normally and are susceptible to the teratogenic effects of retinoic acid. Mech Dev 1995; 53: 61-71.
12. Kastner P, Mark M, Chambon P. Nonsteroid nuclear receptors: what are the genetic studies telling us about their role in real life? Cell 1995; 83:859-869.
13. Oakberg EF. Spermatogonial stem cell renewal in the mouse. Anat Rec 1971; 169:515-532.
14. Van Pelt AMM, De Rooij DG. Synchronization of the seminiferous epithelium after vitamin A replacement in vitamin A-deficient mice. Biol Reprod 1990; 43:363-367.
15. Rochette-Egly C, Lutz Y, Pfister V, Heyberger S, Scheuer I, Chambon P, Gaub MP. Detection of retinoid X receptors using specific monoclonal and polyclonal antibodies. Biochem Biophys Res Commun 1994; 204:525-536.
16. Grootegoed JA, Jutte NHPM, Rommerts FFG, Van der Molen HJ, Ohno S. Concanavalin A-induced attachment of spermatogenic cells to Sertoli cells in vitro. Exp Cell Res 1982; 139:472-475.
17. Grootegoed JA, Jansen R, Van der Molen HJ. Effect of glucose on ATP dephosphorylation in rat spermatids. J Reprod Fertil 1986; 77: 99-107.
18. Auffray C, Rougeon F. Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. Eur J Biochem 1980; 107:303-314.
19. Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T, Chen J-Y, Staub A, Garnier J-M, Mader S, Chambon P. Purification, cloning and RXR identity of a Hela cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell 1992; 68:377-395.
20. Jonk LJC. Isolation and developmental expression of retinoic acid regulated genes. The Netherlands: Utrecht University; 1993. PhD Thesis.
21. Sugawara A, Yen PM, Qi Y, Lechan RM, Chin WW. Isoform-specific retinoid-X receptor (RXR) antibodies detect differential expression of RXR proteins in the pituitary gland. Endocrinology 1995; 136:1766-1774.
22. Nagata T, Kanno Y, Ozata K, Taketo M. The mouse Rxrb gene encoding RXRβ: genomic organization and two mRNA isoforms generated by alternative splicing of transcripts initiated from CpG island promoters. Gene 1994; 142:183-189.
23. Gaemers IC. Retinoids: their role in spermatogenesis. The Netherlands: Utrecht University; 1996. Ph.D. Thesis.