Protection from procarbazine-induced testicular damage by hormonal pretreatment does not involve arrest of spermatogonial proliferation

Cancer Research

Volumn 57, Issue 6, 1997, Pages 1091-1097

  Meistrich, Marvin L ^a   Wilson, Gene ^a   Zhang, Yun ^a   Kurdoglu, Belma ^a,b   Terry, Nicholas H A ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; PROCARBAZINE; TESTOSTERONE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; MALE; MALE STERILITY; NONHUMAN; PRIORITY JOURNAL; RAT; REPRODUCTIVE TOXICITY; SPERMATOGENESIS; SPERMATOGONIUM;

ANIMALS; CELL DIVISION; DNA REPLICATION; DRUG ADMINISTRATION SCHEDULE; DRUG IMPLANTS; ESTRADIOL; GROWTH INHIBITORS; INFERTILITY, MALE; MALE; PROCARBAZINE; RATS; SPERMATOGENESIS; SPERMATOGONIA; TESTOSTERONE;

EID: 0030968289     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. da Cunha, M. F., Meistrich, M. L., Fuller, L. M., Cundiff, J. H., Hagemeister, F. B., Velasquez, W. S., MacLaughlin, P., Riggs, S. A., Cabanillas, F. F., and Salvador, P. G. Recovery of spermatogenesis after treatment for Hodgkin's disease: limiting dose of MOPP chemotherapy. J. Clin. Oncol., 2: 571-577, 1984.
2. Pryzant, R. M., Meistrich, M. L., Wilson, E., Brown, B., and McLaughlin, P. Long-term reduction in sperm count after chemotherapy with and without radiation therapy for non-Hodgkin's lymphomas. J. Clin. Oncol., 11: 239-247, 1993.
3. Centola, G. M., Keller, J. W., Henzler, M., and Rubin, P. Effect of low-dose testicular irradiation on sperm count and fertility in patients with testicular seminoma. J. Androl., 15: 608-613, 1994.
4. Velez de la Calle, J. F., and Jegou, B. Protection by steroid contraceptives against procarbazine-induced sterility and genotoxicity in male rats. Cancer Res., 50: 1308-1315, 1990.
5. Meistrich, M. L., Parchuri, N., Wilson, G., Kurdoglu, B., and Kangasniemi, M. Hormonal protection from cyclophosphamide-induced inactivation of rat stem spermatogonia. J. Androl., 16: 334-341, 1995.
6. Schlappack, O. K., Delic, J. I., Harwood, J. R., and Stanley, J. A. Protection from radiation-induced damage to spermatogenesis in the androgen-pretreated rat. Radiother. Oncol., 12: 219-224, 1988.
7. Delic, J. I., Bush, C., and Peckham, M. J. Protection from procarbazine-induced damage of spermatogenesis in the rat by androgen. Cancer Res., 46: 1909-1914, 1986.
8. Delic, J. I., Harwood, J. R., and Stanley, J. A. Time dependence for the protective effect of androgen from procarbazine-induced damage to rat spermatogenesis. Cancer Res., 47: 1344-1347, 1987.
9. Glode, L. M., Shannon, J. M., Malik, N., and Nett, T. Protection of rat spermatogenic epithelium from damage induced by procarbazine chemotherapy. Br. J. Cancer, 62: 61-64, 1990.
10. 1 hybrid rats. J. Androl., 14: 257-266, 1993.
11. Meistrich, M. L., Wilson, G., Ye, W-S., Kurdoglu, B., Parchuri, N., and Terry, N. H. A. Hormonal protection from procarbazine-induced testicular damage is selective for survival and recovery of stem spermatogonia. Cancer Res., 54: 1027-1034, 1994.
12. Weissenberg, R., Lahav, M., Raanani, P., Singer, R., Regev, A., Sagiv, M., Giler, S., and Theodor, E. Clomiphene citrate reduces procarbazine-induced sterility in a rat model. Br. J. Cancer, 71: 48-51, 1995.
13. Ward, J. A., Robinson, J., Furr, B. J. A., Shalet, S. M., and Morris, I. D. Protection of spermatogenesis in rats from the cytotoxic procarbazine by the depot formulation of Zoladex, a gonadotropin-releasing hormone agonist. Cancer Res., 50: 568-574, 1990.
14. Kangasniemi, M., Wilson, G., Huhtaniemi, I., and Meistrich, M. L. Protection against procarbazine-induced testicular damage by GnRH-agonist and antiandrogen treatment in the rat. Endocrinology, 136: 3677-3680, 1995.
15. Kangasniemi, M., Wilson, G., Parchuri, N., Huhtaniemi, I., and Meistrich, M. L. Rapid protection of rat spermatogenic stem cells against procarbazine by treatment with a gonadotropin-releasing hormone antagonist (Nal-Glu) and an antiandrogen (flutamide). Endocrinology, 136: 2881-2888, 1995.
16. Schally, A. V., Paz-Bouza, J. I., Schlosser, J. V., Karashima, T., Debeljuk, L., Gandle, B., and Sampson, M. Protective effects of analogs of luteinizing hormone-releasing hormone against x-radiation-induced testicular damage in rats. Proc. Natl. Acad. Sci. USA, 84: 851-855, 1987.
17. Jegou, B., Velez de la Calle, J. F., and Bauche, F. Protective effect of medroxyprogesterone acetate plus testosterone against radiation-induced damage to the reproductive function of male rats and their offspring. Proc. Natl. Acad. Sci. USA, 88: 8710-8714, 1991.
18. Kurdoglu, B., Wilson, G., Parchuri, N., Ye, W-S., and Meistrich, M. L. Protection from radiation-induced damage to spermatogenesis by hormone treatment. Radiat. Res., 139: 97-102, 1994.
19. Glode, L. M., Robinson, J., and Gould, S. F. Protection from cyclophosphamide-induced testicular damage with an analogue of gonadotropin-releasing hormone. Lancet, 1: 1132-1134, 1981.
20. Meistrich, M. L. Relationship between spermatogonial stem cell survival and testis function after cytotoxic therapy. Br. J. Cancer, 53 (Suppl. VII): 89-101, 1986.
21. van Alphen, M. M. A., van de Kant, H. J., and de Rooij, D. G. Protection from radiation-induced damage of spermatogenesis in the rhesus monkey (Macaca mulatta) by follicle-stimulating hormone. Cancer Res., 49: 533-536, 1989.
22. van Alphen, M. M. A., van de Kant, H. J., and de Rooij, D. G. Follicle-stimulating hormone stimulates spermatogenesis in the adult monkey. Endocrinology, 123: 1449-1455, 1988.
23. van Beek, M. E. A. B., Davids, J. A. G., and de Rooij, D. G. Variation in the sensitivity of the mouse spermatogonial stem cell population during the cycle of the seminiferous epithelium. Radiat. Res., 108: 282-295, 1986.
24. de Rooij, D. G., Lok, D., and Weenk, D. Feedback regulation of the proliferation of the undifferentiated spermatogonia in the Chinese hamster by the differentiating spermatogonia. Cell Tissue Kinet., 18: 71-81, 1985.
25. Clermont, Y., and Harvey, S. C. Duration of the cycle of the seminiferous epithelium of normal hypophysectomized and hypophysectomized hormone-treated albino rats. Endocrinology, 76: 80-89, 1965.
26. Ewing, L. L., Desjardins, C., Irby, D. C., and Robaire, B. Synergistic interaction of testosterone and oestradiol inhibits spermatogenesis in rats. Nature (Lond.), 269: 409-411, 1977.
27. Meistrich, M. L., Wilson, G., Ye, W-S., Thrash, C., and Huhtaniemi, I. Relationship among hormonal treatments, suppression of spermatogenesis, and testicular protection from chemotherapy-induced damage. Endocrinology, 137: 3823-3831, 1996.
28. Leblond, C. P., and Clermont, Y. Definition of the stages of the cycle of the seminiferous epithelium in the rat. Ann. NY Acad. Sci., 55: 548-573, 1952.
29. Abercrombie, M. Estimation of nuclear population from microtome sections. Anat. Rec., 94: 239-247, 1946.
30. Terry, N. H. A., White, R. A., Meistrich, M. L., and Calkins, D. P. Evaluation of flow cytometric methods for determining population potential doubling times using cultured cells. Cytometry, 12: 234-241, 1991.
31. Carlton, J. C., Terry, N. H. A., and White, R. A. Measuring potential doubling times of murine tumors using flow cytometry. Cytometry, 12: 645-650, 1991.
32. Meistrich, M. L., Lake, S., Steinmetz, L. L., and Gledhill, B. L. Flow cytometry of DNA in mouse sperm and testis nuclei. Mutat. Res., 49: 383-396, 1978.
33. Toppari, J., Eerola, E., and Parvinen, M. Flow cytometric DNA analysis of defined stages of rat seminiferous epithelial cycle during in vitro differentiation. J. Androl., 6: 325-333, 1985.
34. Rosiepen, G., Weinbauer, G. F., Schlatt, S., Behre, H. M., and Nieschlag, E. Duration of the cycle of the seminiferous epithelium, estimated by the 5-bromodeoxyuridine technique, in laboratory and feral rats. J. Reprod. Fertil., 100: 299-306, 1994.
35. Huckins, C. The spermatogonial stem cell population in adult rats. I. Their morphology, proliferation, and maturation. Anat. Rec., 169: 533-558, 1971.
36. Huckins, C. Cell cycle properties of differentiating spermatogonia in adult Sprague-Dawley rats. Cell Tissue Kinet, 4: 139-154, 1971.
37. Hess, R. A. Quantitative and qualitative characteristics of the stages and transitions in the cycle of the rat seminiferous epithelium: light microscopic observations of perfusion-fixed and plastic-embedded testes. Biol. Reprod., 43: 525-542, 1990.
38. White, R. A., and Meistrich, M. L. A comment on "A method to measure the duration of DNA synthesis and the potential doubling time from a single sample". Cytometry, 7: 486-490, 1986.
39. Meistrich, M. L., Finch, M., da Cunha, M. F., Hacker, U., and Au, W. W. Damaging effects of 14 chemotherapeutic drugs on mouse testis cells. Cancer Res., 42: 122-131, 1982.
40. Meistrich, M. L., and van Beek, M. E. A. B. Spermatogonial stem cells: assessing their survival and ability to produce differentiated cells. In: R. E. Chapin and J. Heindel (eds.), Methods in Toxicology, Vol. 3A, pp. 106-123. New York: Academic Press, 1993.
41. Terry, N. H. A., Meistrich, M. L., Roubein, L. D., Lynch, P. M., Dubrow, R. A., and Rich, T. A. Cellular kinetics in rectal cancer. Br. J. Cancer, 72: 435-441, 1995.
42. 1 rat. Biol. Reprod., 54: 1200-1208, 1996.
43. Meistrich, M. L., and Kangasniemi, M. Hormone treatment after irradiation stimulates recovery of rat spermatogenesis from surviving spermatogonia. J. Androl., 18: in press, 1997.