Studies of the antagonist actions of (RS)-2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid (ATPO) on non-NMDA receptors in cultured rat neurones

British Journal of Pharmacology

Volumn 125, Issue 7, 1998, Pages 1517-1528

  Dai, W M ^a   Ebert, B ^b   Madsen, U ^b   Lambert, J D C ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

(2S,4R) 4 methylglutamic acid; (RS) 2 amino 3 5 tert butyl 3 (phosphonomethoxy) 4 isoxazolyl propionic acid (ATPO); AMPA; Concanavalin A; Cultured neurones; Cyclothiazide; GYKI 53655; Kainate

Indexed keywords

1 (4 AMINOPHENYL) 3,4 DIHYDRO 4 METHYL 3 METHYLCARBAMOYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; CONCANAVALIN A; CYCLOTHIAZIDE; ISOXAZOLE DERIVATIVE; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; NERVE CELL CULTURE; NEWBORN; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; RECEPTOR DOWN REGULATION;

EID: 0031737059     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702236     Document Type: Article

References (54)

1. AUDINAT, E., LAMBOLEZ, B. & ROSSIER, J. (1996). Functional and molecular analysis of glutamate-gated channels by patch-clamp and RT-PCR at the single cell level. Neurochem. Int., 28, 119 -136.
2. BETTLER B., EGEBJERG J., SHARMA, G., PECHT, G., HERMANS-BORGMEYER, I., MOLL, C., STEVENS, C.F. & HEINEMANN, S. (1992). Cloning of a putative glutamate receptor: a low affinity kainate binding subunit. Neuron. 8, 257-265.
3. BETTLER, B. & MULLE, C. (1995). Neurotransmitter receptors II. AMPA and kainate receptors. Neuropharmacology. 34, 123-139.
4. BLEAKMAN, D., BALLYK, B.A., SCHOEPP, D.D., PALMER, A.J., BATH, C.P., SHARPE, E.F., WOOLLEY, M.L., BUFTON, H.R., KAMBOJ, R.K., TARNAWA, I. & LODGE, D. (1996). Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereospecificity and selectivity profiles. Neuropharmacology, 35, 1689-1702.
5. BLISS, T.V.P. & COLLINGRIDGE, G.L. (1993). A synaptic model of memory: long-term potentiation in the hippocampus. Nature, 361, 31-39.
6. BREWER, G.J. & COTMAN, C.W. (1989). Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen. Brain Res., 494, 65-74.
7. CHOI, D.W. (1992). Excitotoxic cell death. J. Neurobiol., 23, 1261-1276.
8. CLARKE, V.R.J., BALLYK, B.A., HOO, K.H., MANDELZYS, A., PELLIZZARI, A., BATH, C.P., THOMAS, J., SHARPE, E.F., DAVIES, C.H., ORNSTEIN, P.L., SCHOEPP, D.D., KAMBOJ, R.K., COLLINGRIDGE, G.L., LODGE, D. & BLEAKMAN, D. (1997). A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature, 389, 599-603.
9. DAI, W.-M., EBERT, B., MADSEN, U. & LAMBERT, J.D.C. (1997). Studies of the interactions of (2S,4R)-4-methylglutamate and ATPO with AMPA and kainate receptors on cultured rat neurones. Br. J. Pharmacol., 122, 61P.
10. DANYSZ, W., PARSONS, C.G., BRESINK, I. & QUACK, G. (1995). Glutamate in CNS disorders - a revived target for drug development? Drugs News Perspectives, 8, 261-277.
11. DINGLEDINE, R., MCBAIN, C.J. & MCNAMARA, J.O. (1990). Excitatory amino acid receptors in epilepsy. Trends Pharmacol. Sci., 11, 334-338.
12. EGEBJERG, J., BETTLER, B., HERMANS-BORGMEYER, I. & HEINEMANN, S. (1991). Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA. Nature, 351, 745-748.
13. FLECK, M.W., BÄHRING, R., PATNEAU, D.K. & MAYER, M.L. (1996). AMPA receptor heterogeneity in rat hippocampal neurons revealed by differential sensitivity to cyclothiazide. J. Neurophysiol., 75, 2322-2333.
14. FLETCHER, E.J. & LODGE, D. (1996). New developments in the molecular pharmacology of 2-amino-3-hydroxy-5-methyl-4-isoxazole propionate and kainate receptors. Pharmacol. Ther., 70, 65-89.
15. FRERKING, M., BORGES, S. & WILSON, M. (1997). Are some minis multiquantal? J. Neurophysiol., 78, 1293-1304.
16. 2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron, 15, 193-204.
17. GU, Z.-Q., HESSON, D.P., PELLETIER, J.C. & MACCECCHINI, M.-L. (1995). Synthesis, resolution, and biological evaluation of the four stereoisomers of 4-methylglutamic acid: selective probes of kainate receptors. J. Med. Chem., 38, 2518-2520.
18. HAMILL, O.P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F.J. (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch., 391, 85-100.
19. HERB, A., BURNASHEV, N., WERNER, P., SAKMANN, B., WISDEN, W. & SEEBURG, P. (1992). The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distinctly related subunits. Neuron, 8, 775-785.
20. HOLLMANN, M. & HEINEMANN, S. (1994). Cloned glutamate receptors. Annu. Rev. Neurosci., 17, 31-108.
21. JENSEN, M.S. & LAMBERT, J.D.C. (1984). Modulation of the responses to the GABA-mimetics, THIP and piperidine-4-sulphonic acid, by agents which interact with benzodiazepine receptors. Neuropharmacology, 23, 1441-1450.
22. JOHANSEN,T.H., CHAUDHARY, A. & VERDOORN, T.A. (1995). Interactions among GYKI-52466, cyclothiazide, and aniracetam at recombinant AMPA and kainate receptors. Mol. Pharmacol., 48, 946-955.
23. JONES, K.A., WILDING, T.J., HUETTNER, J.E. & COSTA, A.-M. (1997). Desensitization of kainate receptors by kainate, glutamate and diastereomers of 4-methylglutamate. Neuropharmacology, 36, 853-863.
24. JØRGENSEN, M., TYGESEN, C.K. & ANDERSEN, P.H. (1995). Ionotropic glutamate receptors-focus on non-NMDA receptors. Pharmacol. Toxicol., 76, 312-319.
25. A receptor ligand, 4-PIOL, on cultured hippocampal neurones. Br. J. Pharmacol., 104, 85-90.
26. KROGSGAARD-LARSEN, P. (1992). GABA and glutamate receptors as therapeutic targets in neurodegenerative disorders. Pharmacol. Toxicol., 70, 95-104.
27. LERMA, J., MORALES, M., VICENTE, M.A. & HERRERAS, O. (1997). Glutamate receptors of the kainate type and synaptic transmission. Trends Neurosci., 20, 9-13.
28. MADSEN, U., BANG-ANDERSEN, B., BREHM, L., CHRISTENSEN, I.T., EBERT, B., KRISTOFFERSEN, I.T.S., LANG, Y. & KROGSGAARD-LARSEN, P. (1996). Synthesis and pharmacology of highly selective carboxy and phosphono isoxazole amino acid AMPA receptor antagonists. J. Med. Chem., 39, 1682-1691.
29. MELDRUM, B. & GARTHWAITE, J. (1990). Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol. Sci., 11, 379-387.
30. MONAGHAN, D.T., BRIDGES, R.J. & COTMAN, C.W. (1989). The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu. Rev. Pharmacol. Toxicol., 29, 365-402.
31. PARSONS, C.G., GRUNER, R. & ROZENTAL, J. (1994). Comparative patch clamp studies on the kinetics and selectivity of glutamate receptor antagonism by 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) and 1-(4-amino-phenyl)-4-methyl-7,8-methyl-endioxyl-5H-2,3-benzodiazepine (GYKI 52466). Neuropharmacology, 33, 589-604.
32. PARTIN, K.M. & MAYER, M.L. (1996). Negative allosteric modulation of wild-type and mutant AMPA receptors by GYKI 53655. Mol. Pharmacol., 49, 142-148.
33. PARTIN, K.M., PATNEAU, D.K., WINTERS, C.A., MAYER, M.L. & BUONANNO, A. (1993). Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A. Neuron, 11, 1069-1082.
34. PATERNAIN, A.V., MORALES, M. & LERMA, J. (1995). Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons. Neuron, 14, 185-189.
35. PATERNAIN, A.V., VICENTE, A., NIELSEN, E.O. & LERMA, J. (1996). Comparative antagonism of kainate-activated kainate and AMPA receptors in hippocampal neurons. Eur. J. Neurosci., 8, 2129-2136.
36. PATNEAU, D.K. & MAYER, M.L. (1991). Kinetic analysis of interactions between kainate and AMPA: evidence for activation of a single receptor in mouse hippocampal neurons. Neuron, 6, 785-798.
37. PATNEAU, D.K., VYKLICKY, JR., L. & MAYER, M.L. (1993). Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate. J. Neurosci., 13, 3496-3509.
38. PUCHALSKI, R.B., LOUIS, J., BROSE, N., TRAYNELIS, S.F., EGEBJERG, J., KUKEKOV, V., WENTHOLD, R.J., ROGERS, S.W., LIN, F., MORAN, T., MORRISON, J.H. & HEINEMANN, S.F. (1994). Selective RNA editing and subunit assembly of native glutamate receptors. Neuron, 13, 131-147.
39. RENARD, A., CRÉPEL, F. & AUDINAT, E. (1995). Evidence for two types of non-NMDA receptors in rat cerebellar Purkinje cells maintained in slice cultures. Neuropharmacology, 34, 335-346.
40. RUANO, D., LAMBOLEZ, B., ROSSIER, J., PATERNAIN, A.V. & LERMA, J. (1995). Kainate receptor subunits expressed in single cultured hippocampal neurons: molecular and functional variants by RNA editing. Neuron, 14, 1009-1017.
41. SOMMER, B., BURNASHEV, N., VERDOORN, T.A., KEINÄNEN, K., SAKMANN, B. & SEEBURG, P.H. (1992). A glutamate receptor channel with high affinity for domoate and kainate. EMBO J., 11, 1651-1656.
42. SOMMER, B., KEINÄNEN, K., VERDOORN, T.A., WISDEN, W., BURNASHEV, N., HERB, A., KÖHLER, M., TAKAGI, T., SAKMANN, B. & SEEBURG, P.H. (1990). Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science, 249, 1580-1585.
43. VERDOORN, T.A., BURNASHEV, N., MONYER, H., SEEBURG, P.H. & SAKMANN, B. (1991). Structural determinants of ion flow through recombinant glutamate receptor channels. Science, 252, 1715-1718.
44. WAHL, P., NIELSEN, B., KROGSGAARD-LARSEN, P., HANSEN, J.J., SCHOUSBOE, A. & MILEDI, R. (1992). Stereoselective effects of AMOA on non-NMDA receptors expressed in Xenopus oocytes. J. Neurosci. Res., 33, 392-397.
45. WAHL, P., ANKER, C., TRAYNELIS, S.F., EGEBJERG, J., RASMUSSEN, J.S., KROGSGAARD-LARSEN, P. & MADSEN, U. (1998). Antagonist properties of a phosphono isoxazole amino acid at glutamate R1-4 (R,S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl) propionic acid receptor subtypes. Mol. Pharmacol., 53, 590-596.
46. WATKINS, J.C. & EVANS, R.H. (1981). Excitatory amino acid transmitters. Annu. Rev. Pharmacol. Toxicol., 21, 165-204.
47. WENTHOLD, R.J., TRUMPY, V.A., ZHU, W.S. & PETRALIA, R.S. (1994). Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-selective antibodies. J. Biol. Chem., 269, 1332-1339.
48. WERNER, P., VOIGT, M., KEINÄNEN, K., WISDEN, W. & SEEBURG, P.H. (1991). Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells. Nature, 351, 742-744.
49. WESTBROOK, G.L. (1994). Glutamate receptor update. Curr. Opin. Neurobiol., 4, 337-346.
50. WILDING, T.J. & HUETTNER, J.E. (1997). Activation and desensitization of hippocampal kainate receptors. J. Neurosci., 17, 2713-2721.
51. WONG, L.A. & MAYER, M.L. (1993). Differential modulation by cyclothiazide and concanavalin A of desensitization by native α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors. Mol. Pharmacol., 44, 504-510.
52. YAMADA, K.A. & TANG, C.-M. (1993). Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents. J. Neurosci., 13, 3904-3915.
53. YUE, K.T., MACDONALD, J.F., PEKHLETSKI, R. & HAMPSON, D.R. (1995). Differential effects of lectins on recombinant glutamate receptors. Eur. J. Pharmacol. Mol. Pharmacol., 291, 229-235.
54. ZHOU, L.-M., GU, Z.-Q., COSTA, A.M., YAMADA, K.A., MANSSON, P.E., GIORDANO, T., SKOLNICK, P. & JONES, K.A. (1997). (2S,4R)-4-Methylglutamic acid (SYM 2081): a selective, high-affinity ligand for kainate receptors. J. Pharmacol. Exp. Ther., 280, 422-427.