Syndrome-AC: Non-insulin-dependent diabetes mellitus and the anabolic/catabolic paradox

Medical Hypotheses

Volumn 51, Issue 5, 1998, Pages 429-438

  Provonsha, S ^a,b   Wade, C ^a   Sherma, A ^a  

^a KAISER PERMANENTE   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE PHASE PROTEIN; FATTY ACID; GLUCAGON; GLUCOSE; HYDROCORTISONE; PROTEIN; VEGETABLE PROTEIN;

ADULT; ARTICLE; CATABOLISM; CLINICAL ARTICLE; DIET; DIET THERAPY; FATTY ACID BLOOD LEVEL; FEMALE; GLUCAGON BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HUMAN; HYDROCORTISONE BLOOD LEVEL; INSULIN RESISTANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; STARVATION;

EID: 0031736539     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-9877(98)90040-8     Document Type: Article

References (58)

1. Parker D R, Weiss S T, Troisi R, Cassano P A, Vokonas P S, Landsbert L. Relationship of dietary saturated fatty acids and body, habitus to serum insulin concentrations: the Normative Aging Study. Am J Clin Nutr 1993; 58: 129-136.
2. Marshall J A, Hamman R F, Baxter J. High-fat, low-carbohydrate diet and the etiology of non-insulin dependent diabetes mellitus: The San Luis Valley Diabetes Study. Am J Epidemiol 1991; 13: 590-603.
3. Low C C, Grossman E B, Gumbiner B. Potentiation of effects of weight loss by monounsaturated fatty acids in obese NIDDM patients. Diabetes 1996; 45: 569-575.
4. Feld C J, Ryan E A, Thomson A, Clandinin T. Dietary fat composition alters membrane phospholipid composition, insulin binding, and glucose metabolism in adipocytes from control and diabetic animals. J Bio Chem 1990; 256: 11143-11150.
5. Hubbard R, Kosch C, Sanchez A, Sabate J, Berk L, Shavlik G. Effect of dietary protein on serum insulin and glucagon levels in hyper- and normocholesterolemic men. Atherosclerosis 1989; 76: 55-61.
6. Starke A, Erhardt G, Berger M, Zimmermann H. Elevated pancreatic glucagon in obesity. Diabetes 1984; 33: 277-280.
7. Sherwin R, Fisher M, Hendler R, Felig P. Hyperglucagonemia and blood glucose regulation in normal, obese and diabetic subjects. N Engl J Med 1976; 294: 455-461.
8. Ratzmann K, Schulz B, Witt S, Ziegler M. Pancreatic glucagon response to glucose in obesity with normal and impaired carbohydrate tolerance. Int J Obesity 1981; 5: 163-169.
9. Seidell J C, Bjorntorp P, Sjostrom L, Kvist H, Sannerstedt R. Visceral fat accumulation in men is positively associated with insulin, glucose and c-peptide levels, but negatively with testosterone levels. Metabolism 1990; 39: 897-901.
10. Schmidt M I, Watson R L, Duncan B B et al. Clustering of dyslipidemia, hyperuricemia, diabetes and hypertension and its association with fasting insulin and central and overall obesity in a general population: Atherosclerosis risk in communities study investigators. Metabolism 1996; 45: 699-706.
11. Krotkiewski M, Bjorntorp P, Sjostrom L et al. Impact of obesity on metabolism in men and women: importance of regional adipose tissue distribution. J Clin Invest 1983; 72: 1150-1162.
12. Bajorunas D R, Dresler C M, Horowitz G D et al. Basal glucagon replacement in chronic glucagon deficiency increases insulin resistance. Diabetes 1986; 35: 556-562.
13. DeFronzo R A, Ferrannini E. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerotic cardiovascular disease. Diabetes Care 1991; 14: 173-194.
14. Borghi V C, Wajchenberg B L, Cesar F P. Plasma glucagon suppressibility after oral glucose in obese subjects with normal and impaired glucose intolerance. Metabolism 1984; 33: 1068-1074.
15. Oppert J M, Nadeau A, Tremblay A, Despres J P, Germain T, Deriaz O, Bouchard C. Plasma glucose, insulin, and glucagon before and after long-term overfeeding in identical twins. Metabolism 1995; 44: 96-105.
16. Unger R H, Orci L. Glucagon and the A Cell. N Engl J Med 1981; 304: 1518-1524.
17. Flakoll P J, Borel M J, Wentzel L S, Williams P E, Lacy D B, Abumrad N N. The role of glucagon in the control of protein and amino acid metabolism in vivo. Metabolism 1994; 43: 1509-1516.
18. Unger R H. Alpha- and beta-cell interrelationships in health and disease. Metabolism 1974; 23: 581-593.
19. Charlton M R, Adey D B, Nair K S. Evidence for a catabolic role of glucagon during an amino acid load. J Clin Invest 1996; 98: 90-99.
20. Bouchard C. Personal communication.
21. Cahill G F. Starvation in man. N Engl J Med 1970; 282: 668-675.
22. Borel M J, Williams P E, Jabbour K, Levenhagen D, Kaiser E, Flakoll P J. Glutamine alters insulin-mediated glucose metabolism in vivo. From the 22nd ASPEN Clinical Congress, 1998.
23. Gray R, Butler P, Beers T, Kryshak E, Rizza R. Comparison of the ability of bread versus bread plus meat to treat and prevent subsequent hypoglycemia in patients with insulin dependent diabetes mellitus. J Clin Endocrinol Metab 1996, 81: 1508-1511.
24. US Department of Agriculture handbook 8.
25. Rifkin H, Porte D. Ellenberg and Rifkin's Diabetes Mellitus: Theory and Practice, 4th edn. New York: Elsevier Science, 1990.
26. Zawadzki J K, Wolfe R R, Mott D M, Lillioja S, Howard B V, Bogardus C. Increased rate of cori cycle in obese subjects with NIDDM and effect of weight reduction. Diabetes 1988; 37: 154-159.
27. Kolehmainen E. Mechanisms of the myelin basic protein-induced insulin and glucagon release from isolated rat pancreatic islets. Neurochem Int 1995; 26: 357-367.
28. Willerson J T, Hutcheson D, Faloona G R, Leshin S J, Unger R H. Serum glucagon and insulin levels and their relationship to blood glucose values in patients with acute myocardial infarction and coronary insufficiency. Am J Med 1974; 57: 747-752.
29. Hotamisligil G S, Shargill N S, Spiegelman B M. Adipose tissue expression of tumor necrosis factor alpha: direct role in obesity-linked insulin resistance. Science 1993; 259: 87-90.
30. Raina N, Cameron R G, Jeejeebhoy K N. Gastrointestinal, hepatic, and metabolic effects of enterai and parenteral nutrition in rats infused with tumor necrosis factor. J Parenteral Enteral Nutr 1997; 21: 7-13.
31. Stith R D, Luo J. Endocrine and carbohydrate responses to interleukin-6 in vivo. Circulatory Shock 1994; 44: 210-215.
32. Kjeldsen-Kragh J, Mellbye O J, Haugen M et al. Changes in laboratory variables in rheumatoid arthritis patients during a trial of fasting and one-year vegetarian diet. Scand J Rheumatol 1995; 24: 85-93.
33. Donovan U M, Gibson R S. Iron and zinc status of young women aged 14 to 19 years consuming vegetarian and omnivorous diets. J Am Coll Nutr 1995; 14: 463-472.
34. Alexander D, Ball M J, Mann J. Nutrient intake and haematological status of vegetarians and age-sex matched omnivores. Eur J Clin Nutr 1994; 48: 538-546.
35. Rogers J T. Ferritin translation by interlukin-6: the role of sequences upstream of the start codons of the heavy and light subunit genes. Blood 1996; 87: 2525-2537.
36. Slag M F, Ahmed M, Gannon M, Nuttall F Q. Meal stimulation of cortisol secretion: a protein-induced effect. Metabolism 1981; 30: 1104-1108.
37. Fischer K D, Dhanvantari S, Drucker D J, Brubaker P L. Intestinal growth is associated with elevated levels of glucagon-like peptide 2 in diabetic rats. Am J Physiol 1997; 273: E815-D820.
38. Schteingart D E, McKenzie A K, Victoria R S, Tsao H S. Suppression, of insulin secretion by protein deprivation in obesity. Metabolism 1979; 28: 943-949.
39. Tataranni P A, Baier L J, Paolisso G, Howard B V, Ravussin E. Role of lipids in development of noninsulin-dependent diabetes mellitus: lessons learned from Pima Indians. Lipids 1996; 31 (Suppl): S267-270.
40. Misbin R. Dietary regulation of insulin receptors in obesity. J Nutr 1981; 111: 475-479.
41. Chen Y-D I, Coulston A, Jhou Ming-You, Hollenbeck C B, Reaven G M. Why do low-fat high carbohydrate diets accentuate postprandial lipemia in patients with NIDDM? Diabetes Care 1995; 18: 10-15.
42. Rebrin K, Steil G, Mittelman S, Bergman R. Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. J Clin Invest 1996; 98: 741-749.
43. Consoli A, Nurjhan N, Reilly J J, Bier D, Gerich J. Mechanisms of increased gluconeogenesis in non-insulin-dependent diabetes mellitus. J Clin Invest 1990; 86: 2038-2045.
44. Frohman L A, Bernardis L L. Effect of hypothalmic stimulation on plasma glucose, insulin, and glucagon levels. Am J Physiol 1971; 221:1596-1603.
45. Peiris A, Mueller R, Smith G, Strove M, Kissebah A. Splanchnic insulin metabolism in obesity: influence of body fat distribution. J Clin Invest 1986; 78: 1648-1657.
46. Eisenstein A B, Strack I, Gallo-Torres H, Georgiadis A, Miller O N. Increased glucagon secretion in protein-fed rats: lack of relationship to plasma amino acids. Am J Physiol 1979; 236: E20-27.
47. Gelfand R A, Sherwin R S. Nitrogen conservation in starvation revisited: protein sparing with intravenous fructose. Metabolism 1986; 35: 37-44.
48. Lefebvre P J. Glucagon and its family revisited. Diabetes Care 1995; 18: 715-726.
49. Roden M, Perseghin G, Petersen K F et al. The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans. J Clin Invest 1996; 97: 642-648.
50. Reaven G M. Banting Lecture 1988 - Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-1607.
51. Tessari P, Inchiostro S, Barazzoni R et al. Hyperglucagonemia stimulates phenylalanine oxidation in humans. Diabetes 1996; 45: 463-470.
52. Moustaid N, Jones B H, Taylor J W. Insulin increases lipogenic enzyme activity in human adipocytes in primary culture. J Nutr 1996; 126: 865-870.
53. Toth M J, Poehlman E T. Sympathetic nervous system activity and resting metabolic rate in vegetarians. Metabolism 1994; 43: 621-625.
54. Fricker, J, Rozen R, Melchior J, Apfelbaum M. Energy-metabolism adaptation in obese adults on a very-low-calorie diet. Am J Clin Nutr 1991; 53: 826-830.
55. Wilson M A. Southwestern internal medicine conference: Treatment of obesity. Am J Med Sci 1990; 299: 62-68.
56. Barr S I, Janelle K C, Prior J C. Vegetarian diets, dietary restraint, and subclinical ovulatory disturbances: prospective 6-mo study. Am J Clin Nutr 1994; 60: 887-894.
57. Gerich J. On the causes and consequences of abnormal glucagon secretion in human diabetes mellitus. In: Foa P P, Bajaj J S, Foa N L, eds, Glucagon: Its Role in Physiology and Clinical Medicine. New York: Springer-Verlag, 1977: 617-641.
58. Snowdon D A, Phillips R L. Does a vegetarian diet reduce the occurrence of diabetes? Am J Public Health 1985; 75: 507-512.