DNA adducts in human breast tissue: Association with N- acetyltransferase-2 (NAT2) and NAT1 genotypes

Cancer Epidemiology Biomarkers and Prevention

Volumn 7, Issue 11, 1998, Pages 1019-1025

  Pfau, Wolfgang ^a   Stone, Elaine M ^b   Brockstedt, Ulrike ^a   Carmichael, Paul L ^c   Marquardt, Hans ^a   Phillips, David H ^b  

^a University of Medical School Hamburg Eppendorf   (Germany)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE;

ACETYLATOR PHENOTYPE; ADOLESCENT; ADULT; AGED; ARTICLE; BREAST; BREAST CANCER; CLINICAL ARTICLE; DNA ADDUCT; DNA BINDING; DNA MODIFICATION; FEMALE; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; THIN LAYER CHROMATOGRAPHY;

EID: 0031734633     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. El-Bayoumy, K. Environmental carcinogens that may be involved in human breast cancer etiology. Chem. Res. Toxicol., 5: 585-590, 1992.
2. Biggs, P J., Warren, W , Venitt, S , and Stratton, M. R. Does a genotoxic carcinogen contribute to human breast cancer? The value of mutational spectra in unravelling the aetiology of cancer. Mutagenesis, 8: 275-283, 1993.
3. Perera, F. P. Molecular epidemiology insights into cancer susceptibility, risk assessment, and prevention J Natl. Cancer Inst (Bethesda). 88: 496-509, 1996.
4. Rohan, T E , and Baron, J A. Cigarette smoking and breast cancer. Am. J. Epidemiol., 129: 36-42, 1989.
5. Vatten, L J , and Kvinnsland, S. Cigarette smoking and risk of breast cancer a prospective study of 24329 Norwegian women. Eur J Cancer, 26. 830-833, 1990.
6. Smith, S J., Deacon, J M., and Chilvers, C E. D. Alcohol, smoking, passive smoking, and caffeine in relation to breast cancer risk in young women Br. J. Cancer, 70-112-119, 1994.
7. Brunet, J., Ghadirian, P., Rebbeck, T. R, Lerman, C , Garber, J. E., Tonin, P N , Abrahamson, J , Foulkes, W. D., Daly, M., Wagner-Costalas, J., Gowin, A., Olopade, O. I., Moslehi, R., Liede, A., Futreal, P. A , Weber, B. L , Lenoir, G M., Lynch, H. T , and Narod, S A. Effect of smoking on breast cancer in cameras of mutant BRCA1 or BRCA2 genes. J. Natl. Cancer Inst. (Bethesda), 90: 761-766. 1998
8. Morabia, A , Berstein, M., Hertier, S., and Khatchatrian, N. Relation of breast cancer with passive and active exposure to tobacco smoke Am. J. Epidemiol., 143 918-928, 1996
9. Ambrosone, C B., Freudenheim, J L., Graham, S., Marshall, J R., Vena, J. E., Brasure, J. R., Michalek, A. M , Laughin, R., Nemoto, T , Gillenwater, K. A , Harrington, A. M., and Shields, P. G. Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer J. Am. Med Assoc., 276: 1494-1501, 1996.
10. Millikan, R. C., Pittman, G S., Newman, B., Tse, C. J , Selmin, O , Rockhill, B., Savitz, D., Moorman, P G., and Bell, D Cigarette smoking, N-acetyltransferases 1 and 2, and breast cancer nsk Cancer Epidemiol. Biomark. Prev., 7: 371-378, 1998.
11. 32P-postlabeling test for DNA damage. Proc. Natl Acad Sci USA, 78: 6126-6129, 1981.
12. Perera, F. P., Estabrook, A., Hewer, A., Channing, K., Rundle, A , Mooney, L. A., Whyatt, R., and Phillips, D. H. Carcinogen-DNA adducts in human breast tissue. Cancer Epidemiol. Biomark Prev., 4. 233-238, 1995
13. Li, D , Wang, M., Dhingra, K., and Hittelman, W. N Aromatic DNA adducts in adjacent tissues of breast cancer patients clues to breast cancer etiology Cancer Res , 56: 287-293, 1996.
14. 32P-labelled nucleoside 3′,5′-bisphosphate adducts of polycyclic aromatic hydrocarbons J Chromatogr , 570: 65-76, 1991.
15. Coles, C., Condie, A , Chetty, U , Steel, C. M., Evans, H. J., and Prosser, J. p53 mutations in breast cancer. Cancer Res., 52: 5291-5298, 1992.
16. Beland, F. A , and Kadlubar, F F. Metabolic activation and DNA adducts of aromatic amines and nitroaromatic hydrocarbons. In C. S. Cooper and P L Grover (eds.), Chemical Carcinogenesis and Mutagenesis, Vol I, pp 267-325 Berlin, Springer-Verlag, 1990.
17. Pfau, W , O'Hare, M. J., Grover, P L., and Phillips. D H. Metabolic activation of the food mutagens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-d]quinoline (MeIQ) to DNA binding species in human mammary epithelial cells. Carcinogenesis (Lond.), 13: 907-909, 1992.
18. Carmichael, P. L., Stone, E. M., Grover, P. L., Gusterson, B. A., and Phillips, D H. Metabolic activation and DNA binding of food mutagens and other environmental carcinogens in human mammary epithelial cells Carcinogenesis (Lond.), 17; 1769-1772, 1996.
19. Swaminathan, S , Frederickson, S M., and Hatcher, J. F Metabolic activation of N-hydroxy-4-acetylaminobiphenyl by cultured human breast epithelial cell line MCF 10A. Carcinogenesis (Lond.), 15: 611-617, 1994.
20. Sadrieh, S., Davis, C. D , and Snyderwine, E. G. N-Acetyltransferase expression and metabolic activation of the food-derived heterocyclic amines in the human mammary gland. Cancer Res 56: 2683-2687, 1996
21. Vatsis, K. P , and Weber, W. W. Human N-acetyltransferases. In: F C Kauffman (eds.), Conjugation-Deconjugation Reactions in Drug Metabolism and Toxicity, pp. 109-130. Berlin: Springer-Verlag, 1994.
22. Badawi, A. F., Hirvonen, A., Bell, D. A., Lang, N P , and Kadlubar, F. F. Role of aromatic amine acetyltransferases, NAT1 and NAT2, in carcinogen-DNA adduct formation in the human urinary bladder. Cancer Res, 55: 5230-5237, 1995
23. Grant, D. M., Hughes, N. C , Janezic, S. A., Goodfellow, G. H , Chen, H. J., Gaedigk, A., Yu, V. L , and Grewal, R. Human acetyltransferase polymorphisms. Mutat. Res , 376. 61-70, 1997
24. 12P-postlabeling analysis of aromatic carcinogen: DNA adducts. Cancer Res , 45. 5656-5662, 1985.
25. 32P-Postlabeling analysis of DNA adducts formed by food-derived heterocyclic amines: evidence for incomplete hydrolysis and a procedure for adduct simplification. Carcinogenesis (Lond.), 15: 877-882, 1994.
26. 32P-postlabelling test for structurally diverse DNA adducts. Carcinogenesis (Lond), 7: 1543-1555, 1986
27. Bell, D A., Badawi, A F., Lang, N. P , Ilett, K. F., Kadlubar, F. F., and Hirvonen, A. Polymorphism in the N-acetyltransferase (NAT1) polyadenylation signal: association of NATI*10 allele with higher N-acetylation activity in the bladder and colon tissue Cancer Res., 55: 5226-5229, 1995.
28. Hughes, N. C., Janezic, S. A., McQueen, K. L., Jewett, M. A. S., Castriano, T., Bell, D A., and Grant, D. M Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosahcylate as an in vivo and in vitro probe Pharmacogenetics, 8. 55-66, 1998.
29. Bell, D. A , Taylor, J. A., Butler, M. A., Stephens, E. A., Wiest, J , Brubaker, L. H., Kadlubar, F. F , and Lucier, G W. Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans. Carcinogenesis (Lond.), 14: 1689-1692, 1993.
30. Probst-Hensch, N. M , Haile, R W , Li, D S., Sahamoto, G T., Louie, A D., Lin, B K., Frankl, H D , Lee, E. R., and Lin, H J. Lack of association between the polyadenylation polymorphism in NAT1 (acetyltransferase 1) gene and colorectal adenomas Carcinogenests (Lond), 17: 2125-2129, 1996
31. Bulovskaya, L. N., Krupin, R. G , Bochina, T. A., and Pavlova, M. V. Acetylalor phenotype in patients with breast cancer. Oncology, 35: 185-188, 1978.
32. Ladero, J M., Fernandez, M. J , Palmeiro, R., Munoz, J J , Jara, C., Lazaro, C., and Perez-Manga, G Hepatic acetylator polymorphism in breast cancer patients. Oncology, 44, 341-344, 1987
33. Ilett, K F., Detcon, P., Ingram, D M., and Castleden, W M Acetylation phenotype is not associated with breast cancer Cancer Res., 50: 6649-6651, 1990.
34. Agundez, J. A. G., Ladero, J. M., Olivera, M., Abildua, R., Roman, J. M., and Benitez, J Genetic analysis of the arylamine N-acetyltransferase polymorphism in breast cancer patients. Oncology, 52: 7-11, 1995.
35. Chern, H. D., Huang, C S , Wang, C. Y , Shen, C-Y., and Chang, K. J Association of N-acetyltransferase polymorphism with susceptibility of breast cancer in Taiwan Proc Am Assoc. Cancer Res , 38: 1441, 1997
36. Phillips, D. H., Hewer, A., Martin, C. N , Garner, R. G , and King, M. M. Correlation of DNA adduct levels in human lung with cigarette smoking. Nature (Lond.), 336: 790-792, 1988.
37. 32P-Postlabelling analysis of DNA adducts in human and rat mammary epithelial cells. Carcinogenesis (Lond.), 9. 1071-1077, 1988.
38. Hunter, D. J , Hankinson, S. E., Hough, H , Gertig, D M , Garcia-Closas, M , Spiegelman, D , Manson, J. E., Colditz, G. A , Willett, W. C., Speizer, F. E., and Kelsey, K. A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer Carcinogenesis (Lond.), 18: 2127-2131, 1997.
39. Falck, F. Y , Ricci, A , and Wolf, M. S. Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. Arch. Environ. Health, 47, 143-146, 1992.
40. Martin, F. L., Carmichael, P. L., Crofton-Sleigh, C., Vemtt, S , Phillips, D. H , and Grover, P L Genotoxicity of human mammary lipid. Cancer Res., 56: 5342-5346, 1996.
41. Vineis, P., Bartsch, H., Caporaso, N., Harrington, A M , Kadlubar, F. F., Landi, M. T , Malaveille, C , Shields, P. G., Skipper, P., Talaska, G., and Tannenbaum, S. R. Genetically based N-acetyltransferase metabolic polymorphism and low-level environmental exposure to carcinogens. Nature (Lond.), 369: 154-156, 1994.